CN101535498B - 电化学法测定血液样品中Xa因子抑制剂的方法和设备 - Google Patents

电化学法测定血液样品中Xa因子抑制剂的方法和设备 Download PDF

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Publication number
CN101535498B
CN101535498B CN2007800408199A CN200780040819A CN101535498B CN 101535498 B CN101535498 B CN 101535498B CN 2007800408199 A CN2007800408199 A CN 2007800408199A CN 200780040819 A CN200780040819 A CN 200780040819A CN 101535498 B CN101535498 B CN 101535498B
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factor
reagent
thrombin
sample
test element
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CN101535498A (zh
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C·霍恩
L·多尔格
M·克尔齐休克
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2007800408199A 2006-10-31 2007-10-27 电化学法测定血液样品中Xa因子抑制剂的方法和设备 Active CN101535498B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06123234.4 2006-10-31
EP06123234A EP1918718A1 (de) 2006-10-31 2006-10-31 Verfahren und Vorrichtungen zur elektrochemischen Bestimmung von Faktor Xa-Inhibitoren in Blutproben
PCT/EP2007/009347 WO2008052718A1 (de) 2006-10-31 2007-10-27 Verfahren und vorrichtungen zur elektrochemischen bestimmung von faktor xa-inhibitoren in blutproben

Publications (2)

Publication Number Publication Date
CN101535498A CN101535498A (zh) 2009-09-16
CN101535498B true CN101535498B (zh) 2012-11-14

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CN2007800408199A Active CN101535498B (zh) 2006-10-31 2007-10-27 电化学法测定血液样品中Xa因子抑制剂的方法和设备

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US (2) US8636894B2 (enExample)
EP (2) EP1918718A1 (enExample)
JP (1) JP5395669B2 (enExample)
CN (1) CN101535498B (enExample)
CA (1) CA2667957C (enExample)
ES (1) ES2444011T3 (enExample)
WO (1) WO2008052718A1 (enExample)

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EP2471945A1 (de) * 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung
JP5946139B2 (ja) * 2011-03-16 2016-07-05 学校法人 芝浦工業大学 抗凝固薬測定用センサ
EP2818871A1 (en) * 2013-06-28 2014-12-31 Roche Diagniostics GmbH Means and methods for universal calibration of anti-Factor Xa tests
US10048281B2 (en) 2014-09-26 2018-08-14 Abbott Point Of Care Inc. Cartridge device with segmented fluidics for assaying coagulation in fluid samples
EP3198281B1 (en) 2014-09-26 2023-01-25 Abbott Point Of Care, Inc. Ellagic acid formulations for use in coagulation assays
CN106999931B (zh) 2014-09-26 2020-08-18 雅培医护站股份有限公司 具有用于测定流体样本中的凝结的微环境传感器的微制造设备
CN107107057B (zh) 2014-09-26 2020-12-15 雅培医护站股份有限公司 用于流体样本中的凝结测定的盒设备识别
EP3198270A1 (en) 2014-09-26 2017-08-02 Abbott Point Of Care, Inc. Cartridge device with fluidic junctions for coagulation assays in fluid samples
WO2016049506A1 (en) * 2014-09-26 2016-03-31 Abbott Point Of Care Inc. Sensors for assaying coagulation in fluid samples
ES2911898T3 (es) 2014-09-26 2022-05-23 Abbott Point Of Care Inc Dispositivo de cartucho de canal único para ensayos de coagulación de sangre en muestras de fluidos
CN104714036B (zh) * 2015-04-01 2016-06-01 成都协和生物技术有限责任公司 抗凝血酶iii活性测定试剂盒的制备方法
CN105203479A (zh) * 2015-09-21 2015-12-30 山东万邦赛诺康生化制药股份有限公司 用血凝仪测定肝素或低分子量肝素效价的方法
JP7009998B2 (ja) * 2016-01-29 2022-01-26 ソニーグループ株式会社 血液凝固系解析装置、血液凝固系解析システム、血液凝固系解析方法及び血液凝固系解析装置用パラメーターの決定方法
AU2017344760A1 (en) * 2016-10-20 2019-05-02 Universal Biosensors Pty Ltd Non-biohazardous solutions and methods for testing analysers
US12073926B2 (en) 2020-09-21 2024-08-27 Instrumentation Laboratory Company Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample
CN117309966A (zh) * 2022-06-22 2023-12-29 广州好芝生物科技有限公司 血液样本中Xa因子抑制剂的检测方法及装置
CN115032164B (zh) * 2022-08-10 2022-12-06 山东省食品药品检验研究院 一种肝素钠中是否含有凝血因子Xa直接抑制剂的检测方法

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CA2070813C (en) 1990-11-05 1996-10-29 Hendrik Coenraad Hemker A method to determine the concentration of anticoagulants
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
US5601995A (en) * 1992-09-04 1997-02-11 Gradipore Limited Apparatus and method for detecting coagulation in blood samples
KR100305306B1 (ko) * 1993-02-17 2001-11-22 존 펑크하우저 건식화학캐스케이드면역분석법및친화도분석법
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
HUT76346A (en) * 1994-04-26 1997-08-28 Selectide Corp Factor xa inhibitors
NL1006429C2 (nl) * 1997-06-27 1998-12-29 Univ Maastricht Werkwijze voor het bepalen van het heparinegehalte.
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
AU5062100A (en) * 1999-06-14 2001-01-02 Novo Nordisk A/S Fviia/tf activity inhibiting compounds
AU2431800A (en) * 1999-12-15 2001-06-25 Pentapharm Ag Hematological assay and reagent
US6438498B1 (en) * 2000-02-10 2002-08-20 I-Stat Corporation System, method and computer implemented process for assaying coagulation in fluid samples
CA2400651A1 (en) * 2000-02-21 2001-08-30 F. Hoffmann-La Roche Ag Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting
US20030146113A1 (en) * 2000-02-21 2003-08-07 Volker Unkrig Electrochemical sensor for determining blood clotting, corresponding system for measuring blood clotting and method for determining blood clotting
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实施例1-4，7，8.
权利要求1，5，9，12.

Also Published As

Publication number Publication date
WO2008052718A1 (de) 2008-05-08
CA2667957A1 (en) 2008-05-08
EP2079849B1 (de) 2013-11-20
ES2444011T3 (es) 2014-02-21
JP5395669B2 (ja) 2014-01-22
US9594042B2 (en) 2017-03-14
EP1918718A1 (de) 2008-05-07
CN101535498A (zh) 2009-09-16
EP2079849A1 (de) 2009-07-22
US20140106383A1 (en) 2014-04-17
CA2667957C (en) 2013-03-05
US20090236238A1 (en) 2009-09-24
US8636894B2 (en) 2014-01-28
HK1137783A1 (en) 2010-08-06
JP2010508499A (ja) 2010-03-18

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