CN101530100A - Isothiazolone agricultural bactericide - Google Patents
Isothiazolone agricultural bactericide Download PDFInfo
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- CN101530100A CN101530100A CN200910022209A CN200910022209A CN101530100A CN 101530100 A CN101530100 A CN 101530100A CN 200910022209 A CN200910022209 A CN 200910022209A CN 200910022209 A CN200910022209 A CN 200910022209A CN 101530100 A CN101530100 A CN 101530100A
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- isothiazolone
- isothiazolinone
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Abstract
The invention discloses an isothiazolone agricultural bactericide and application thereof. The isothiazolone consists of 5-chlorine-2-methyl-4-isothiazolin-3-ketone(CMI) and 2-methyl-4- isothiazolin-3-ketone(MI). The content of an active component in the bactericide is 0.01 to 14 percent, preferably 0.1 to 5 percent. The agricultural bactericide can be prepared into an aqueous preparation for preventing and controlling bacteria/fungi of fruit trees and grain plants, as well as rice-blast germ diseases. The relative toxicity index of the isothiazolone to kitazine is 147; the relative toxicity index of the isothiazolone to bismerthiazol for rice bacterial blight germs is 1634.6; the indoor toxicity EC50 of the isothiazolone to apple-tree canker germs is 1.16 mg/l; and the indoor toxicity EC90 of the isothiazolone is 11.25 mg/l. Therefore, the isothiazolone shows good activity.
Description
Technical field
The present invention relates to a kind of isothiazolone agricultural bactericide and application thereof, its active component content is 0.01%～14%, is preferably 0.1%～5%.This disinfectant use in agriculture can be mixed with the aqua formulation, and fruit tree, cereal class, vegetable plant bacterium, fungal disease are had the better prevention effect.
Background technology
Isothiazolinone is made up of 5-chloro-2-methyl-4-isothiazoline-3-ketone (CMI) and 2-methyl-4-isothiazoline-3-ketone (MI), trade name: CIT/MIT, triumphant pine, card pine, Kathon, isothiazolinone, CAS NO:26172-55-4/2682-20-4, molecular formula: C
4H
5NOS/C
4H
4ClNOS, molecular weight: 115.16/149.59.Isothiazolinone acute oral toxicity LD
503800mg/kg (mouse), acute oral toxicity: LD
505000mg/kg (rabbit).
(2-methyl-4-isothiazoline-3-ketone) (MI) (5-chloro-2-methyl-4-isothiazoline-3-ketone) (CMI)
Isothiazolinone is a kind of wide spectrum, efficient, low toxicity, non-oxidative bactericide, works to kill livestock acting on by the key that disconnects bacterium and algae protein matter.Isothiazolinone can promptly irreversibly suppress its growth with after microorganism contacts, thereby causes the death of microbial cell, and common bacteria, fungi, algae etc. are had very strong inhibition and killing action.The efficient of killing livestock height, degradability is good, has residual, handling safety, the characteristics that stability is strong of not producing.
Isothiazolinone now is used for cosmetics, personal care articles, the antisepsis and sterilization mildew-resistant of products such as daily use chemicals, shampoo for example, hair conditioner, product shave, foundation cream, lotion, the cream frost, baby products, product such as sunscreen products and cleaning agent (needing the product of water flushing) also is used for coating, water-based polymer, metal cutting solution, adhesive, printing paste, printing ink, dyestuff, mill base, printing paste, printing and dyeing assistant, textile auxiliary, paraffin liquid, timber, process hides, water treatment, industrial circulating water, slurrying, papermaking, power plant, iron and steel, smelt, oil, oil refining, oil-field flooding, chemical industry, plastics, rubber, pharmacy, fiber, the antisepsis and sterilization of industries such as weaving.
Isothiazolinone is used for controlling plant diseases and does not appear in the newspapers, show that through a large amount of lab screenings and field control effectiveness test isothiazolinone has the better prevention effect to the important disease in the agricultural productions such as paddy rice bacterial leaf spot, rice blast, apple valsa canker, citrus bacterial canker disease, oranges and tangerines sour rot.Because isothiazolinone has unique mechanism of action to pathogen, the control of using it for plant disease is to alleviating the pathogen resistance, and the assurance agricultural production is normally carried out significant.
Summary of the invention
The object of the present invention is to provide a kind of isothiazolone agricultural bactericide, this bactericide is good to the plurality of plant diseases bactericidal effect, and drug cost is low.
Another object of the present invention is to provide the isothiazolone agricultural bactericide preparation formulation.
A further object of the present invention is to provide isothiazolone agricultural bactericide to use.
For realizing this purpose, technical scheme of the present invention is to solve like this:
The disinfectant use in agriculture of isothiazolone-containing, the weight percentage of isothiazolinone are 0.01%～14%, and less preferred is 0.05%～10%, preferably 0.1%～5%.
The preparation formulation that isothiazolone agricultural bactericide of the present invention can be prepared according to the known method of those skilled in the art of the present technique is the aqua formulation.
For the aqua formulation, those skilled in the art are familiar with the use corresponding adjuvants and finish the present invention very much.Wherein isothiazolinone is 0.01%～14%, and emulsifier is 0.01%～20%, and water is surplus.Emulsifier such as calcium dodecyl benzene sulfonate (agricultural newborn 500#), Nongru-700 # (common name: alkyl phenol formaldehyde resin polyoxyethylene ether), the newborn 2201# of farming, Span-60# (common name: sorbitan monostearate), Tween-60# (common name: the sorbitan monostearate APEO), TX-10 (common name: octyl phenol polyoxy ethene (10) ether), penetrating agent JFC (fatty alcohol-polyoxyethylene ether), the newborn 1601# of farming (common name: phenethyl phenol polyoxyethylene poly-oxygen propylene aether), the newborn 600# of farming, the newborn 400# of farming, in the dodecyl benzyl dimethyl ammonium chloride one or more, water is deionized water.
The invention provides the new purposes of isothiazolinone disinfecting agent, can be used for preventing and treating fruit tree, cereal class, vegetable plant bacterium, fungal disease, compared with prior art, be better than kitazine, Yekuzuo bactericide now commonly used, to rice blast fungus, isothiazolinone is 147 to the relative virus force index of kitazine; To Xanthomonas oryzae, isothiazolinone is 1634.6 to the relative virus force index of Yekuzuo, and isothiazolinone is to the indoor virulence EC of apple valsa canker germ
50Be 1.16mg/l, EC
90Be 11.25mg/l, show higher activity.
Embodiment
Below in conjunction with embodiment content of the present invention is described further.
Example of formulations 1:
Take by weighing 12% isothiazolinone, 3%TX-10, deionized water add to 100% weight portion.Above-mentioned raw materials makes 12% isothiazolinone aqua after mix, stirring and dissolving is complete.
Example of formulations 2:
Take by weighing 5% isothiazolinone, 0.5% agricultural newborn 500#, 3% Nongru-700 #, deionized water and add to 100% weight portion.Above-mentioned raw materials makes 5% isothiazolinone aqua after mix, stirring and dissolving is complete.
Example of formulations 3:
Take by weighing 0.05% isothiazolinone, 3% penetrating agent JFC, deionized water and add to 100% weight portion.Above-mentioned raw materials makes 0.05% isothiazolinone aqua after mix, stirring and dissolving is complete.
Example of formulations 4:
Take by weighing 2% isothiazolinone, 3% penetrating agent JFC, deionized water and add to 100% weight portion.Above-mentioned raw materials makes 2% isothiazolinone aqua after mix, stirring and dissolving is complete.
Biological Examples 1:
With the paddy rice rice blast fungus is target, adopts the mycelial growth rate method, measures the indoor activity of isothiazolinone to rice blast fungus.
Table 1 isothiazolinone is to the inhibitory action of rice blast mycelia growth
Table 2 Isoprothiolane is to the inhibitory action of rice blast mycelia growth
By table 1, table 2 as can be known, to rice blast fungus, isothiazolinone is 147 to the relative virus force index of kitazine, and the activity of isothiazolinone is higher than kitazine, and isothiazolinone has active preferably to rice blast fungus.
Biological Examples 2:
With the Xanthomonas oryzae is target, adopts nephelometry, measures the indoor activity of isothiazolinone to Xanthomonas oryzae.
Table 3 isothiazolinone is to the value-added inhibitory action of Xanthomonas oryzae
Table 4 Yekuzuo is to the value-added inhibitory action of Xanthomonas oryzae
By table 3, table 4 as can be known, to Xanthomonas oryzae, isothiazolinone is 1634.6 to the relative virus force index of Yekuzuo, and the activity of isothiazolinone is higher than Yekuzuo far away, and isothiazolinone shows higher activity to Xanthomonas oryzae.
Biological Examples 3:
With the apple valsa canker germ is target, adopts Plating, measures the indoor activity of isothiazolinone to the apple valsa canker germ.
Table 5 isothiazolinone is to the apple rot pathogen Toxicity Determination
As known from Table 5, isothiazolinone is to the indoor virulence EC of apple valsa canker germ
50Be 1.16mg/l, EC
90Be 11.25mg/l, show active preferably.
In sum, bactericide of the present invention is that a kind of bactericidal effect is good, can be used for preventing and treating fruit tree, standing grain Cereal, vegetable plant bacterium, fungal disease are to rice blast fungus, rice leaf spot bacteria, apple The kitazine that the fruit tree putrefaction disease germ is better than now commonly using, Yekuzuo bactericide are to showing higher work The property, efficient, the safety requirements of suitable pesticidal preparations.
Claims (9)
1, a kind of isothiazolone agricultural bactericide is characterized in that: the weight percentage of isothiazolinone is 0.01%～14% in the bactericide.
2, the disinfectant use in agriculture of isothiazolone-containing according to claim 1 is characterized in that: the weight percentage of isothiazolinone is 0.05%～10%.
3, the disinfectant use in agriculture of isothiazolone-containing according to claim 2 is characterized in that: the weight percentage of isothiazolinone is 0.1%～5%.
4, the described isothiazolone agricultural bactericide of claim 1 is the aqua formulation.
5, isothiazolone agricultural bactericide according to claim 4 is characterized in that each composition weight percentage composition is:
Isothiazolinone 0.01%～14%
Emulsifier 0.01%～20%
Water surplus.
6, isothiazolone agricultural bactericide according to claim 5 is characterized in that: the isothiazolinone weight percentage is 0.05%～10%.
7, isothiazolone agricultural bactericide according to claim 6 is characterized in that: the isothiazolinone weight percentage is 0.1%～5%.
8, isothiazolone agricultural bactericide according to claim 5 is characterized in that: described emulsifier be in calcium dodecyl benzene sulfonate, Nongru-700 #, agricultural newborn 2201#, Span-60#, Tween-60#, TX-10, penetrating agent JFC, agricultural newborn 1601#, agricultural newborn 600#, agricultural newborn 400#, the dodecyl benzyl dimethyl ammonium chloride one or more.
9, the application of one of any described isothiazolone agricultural bactericide of claim 1 to 8 in control fruit tree, cereal class, vegetable plant bacterium, fungal disease.
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| CN 200910022209 CN101530100B (en) | 2009-04-27 | 2009-04-27 | Isothiazolone agricultural bactericide |
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| CN 200910022209 CN101530100B (en) | 2009-04-27 | 2009-04-27 | Isothiazolone agricultural bactericide |
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| CN101530100B CN101530100B (en) | 2013-06-19 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334475A (en) * | 2010-07-26 | 2012-02-01 | 四川稼得利科技开发有限公司 | Auxiliary agent with which suspending agent can automatically disperse in water |
| CN103027055A (en) * | 2012-11-12 | 2013-04-10 | 青岛金康生物科技有限公司 | Moss-algae killer and production method thereof |
| CN103125498A (en) * | 2011-11-30 | 2013-06-05 | 安徽省蓝天化工有限公司 | Preparation method of isothiazolinone germicide and algicide agent |
| CN104397018A (en) * | 2014-11-14 | 2015-03-11 | 天津大港油田滨港集团博弘石油化工有限公司 | Isothiazolinone water treatment bactericide and preparation method thereof |
| CN109221175A (en) * | 2018-09-30 | 2019-01-18 | 高菠 | A kind of bakanae disease of rice microbicide compositions and preparation method |
| CN109897012A (en) * | 2019-03-08 | 2019-06-18 | 西安临港科技创新发展有限公司 | A kind of benziothiazolinone complex and its preparation method and application with bactericidal activity |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1236542A (en) * | 1999-05-04 | 1999-12-01 | 王兴民 | Application of isothiazolinone derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101796952A (en) * | 2009-02-06 | 2010-08-11 | 上海科王新型材料研究中心 | Isothiazolinone disinfecting agent |
-
2009
- 2009-04-27 CN CN 200910022209 patent/CN101530100B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1236542A (en) * | 1999-05-04 | 1999-12-01 | 王兴民 | Application of isothiazolinone derivatives |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102334475A (en) * | 2010-07-26 | 2012-02-01 | 四川稼得利科技开发有限公司 | Auxiliary agent with which suspending agent can automatically disperse in water |
| CN103125498A (en) * | 2011-11-30 | 2013-06-05 | 安徽省蓝天化工有限公司 | Preparation method of isothiazolinone germicide and algicide agent |
| CN103027055A (en) * | 2012-11-12 | 2013-04-10 | 青岛金康生物科技有限公司 | Moss-algae killer and production method thereof |
| CN103027055B (en) * | 2012-11-12 | 2014-05-21 | 青岛金康生物科技有限公司 | Moss-algae killer and production method thereof |
| CN104397018A (en) * | 2014-11-14 | 2015-03-11 | 天津大港油田滨港集团博弘石油化工有限公司 | Isothiazolinone water treatment bactericide and preparation method thereof |
| CN109221175A (en) * | 2018-09-30 | 2019-01-18 | 高菠 | A kind of bakanae disease of rice microbicide compositions and preparation method |
| CN109897012A (en) * | 2019-03-08 | 2019-06-18 | 西安临港科技创新发展有限公司 | A kind of benziothiazolinone complex and its preparation method and application with bactericidal activity |
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| CN101530100B (en) | 2013-06-19 |
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