CN101524079B - Sterilizing composition compositing difenoconazole and iprodione - Google Patents
Sterilizing composition compositing difenoconazole and iprodione Download PDFInfo
- Publication number
- CN101524079B CN101524079B CN2009100209181A CN200910020918A CN101524079B CN 101524079 B CN101524079 B CN 101524079B CN 2009100209181 A CN2009100209181 A CN 2009100209181A CN 200910020918 A CN200910020918 A CN 200910020918A CN 101524079 B CN101524079 B CN 101524079B
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- Prior art keywords
- iprodione
- difenoconazole
- composition
- agent
- bactericidal composition
- Prior art date
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- ONUFESLQCSAYKA-UHFFFAOYSA-N iprodione Chemical compound O=C1N(C(=O)NC(C)C)CC(=O)N1C1=CC(Cl)=CC(Cl)=C1 ONUFESLQCSAYKA-UHFFFAOYSA-N 0.000 title claims abstract description 66
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Abstract
The invention discloses a sterilizing composition containing difenoconazole and iprodione, which is characterized in that the weight part ratio of the two components based on active components is 1-60:1-80. An appropriate amount of addition agent or a carrier is added into the composition to be made into wettable powders, water dispersible granules, suspending agent, aqueous emulsion or microemusion. The invention is used for preventing and curing fungal diseases on fruit trees.
Description
Technical field:
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains Difenoconazole and iprodione, be used to prevent and treat the multiple diseases on the fruit tree.
Technical background:
Difenoconazole, English name are (difenoconazole), and chemical name is 1-(2-[4-(4-chlorobenzene oxygen)-2-chlorphenyl]-4-methyl isophthalic acid, 3-dioxin-pentane-2-ylmethyl)-H-1,2, and the 4-triazole.
Structural formula is:
Difenoconazole is the triazole bactericidal agent by Syngenta Co.,Ltd's exploitation.It has protection, treatment and systemic activity, is sterol demethylation inhibitor, suppresses the biosynthesis of cell wall sterol, stops fungi growth.Fungicidal spectrum is wide, and foliar treatment or seed treatment can improve output and the guaranteed quality of crop.
Difenoconazole is to Ascomycotina; Basidiomycotina and the imperfect fungus that comprises Alternaria, Ascochyta, the mould genus of tail spore, Colletotrichum, ball seat Pseudomonas, Phoma, Ramularia, Venturia, Erysiphaceae, Uredinales is planted the biography pathogen with some has lasting protection and therapeutic activity; Simultaneously to cercospora leaf spot of sugar beet; Wheat glume blight, leaf blight, rust and by several kinds of microbial mildews of causing a disease, apple scab, powdery mildew, grape powdery mildew; Target, leaf spot of peanut, net blotch etc. all has better therapeutic effect.
Iprodione, English name (iprodione), chemical name 3-(3, the 5-dichlorophenyl)-N-isopropyl-2,4-dioxo imidazoline-1-carboxylic acid amides, molecular formula: C
13H
13C
12N
3O
3
Structural formula is:
Iprodione is the dicarboximide series bactericidal agent of Ainwunt Crop Scientifique exploitation, and main CKIs kinases is controlled the cell signal of many cell functions, comprises that carbohydrate combines to get into the interference effect of fungal cell's component.Therefore, it both can suppress fungus spore germination and generation, also can suppress mycelial growth.Promptly all influential to pathogen each developmental stage in the history of life.Can absorb therapeutic action through root.It has the fungi control efficiency of resistance good to the benzimidazole systemic fungicide; Main controlling object is that Botrytis, clump stalk spore genus, Penicillium, Sclerotinia, Alternaria, long scholar spore belong to, silk nuclear spore genus, Phoma, Cercospora etc. cause various crop, fruit tree and fruit storage disease all have good preventive and therapeutic effect like the gray mold of the stalk break on grape grey mould, the tone fruit trees, alternaria leaf spot of apple, pears black spot, early blight of tomato, strawberry, vegetables etc.
In addition, no matter be Difenoconazole, or iprodione, the same with many efficient germicides, long-term, the continuous single use problem that all can develop immunity to drugs.How to prolong the useful life of these medicaments, delaying the disease drug resistance generation is the problem that people pay special attention at present.
The relevant report of not seeing Difenoconazole and iprodione product as yet at present.
Summary of the invention
For postponing Difenoconazole, the drug-fast generation of iprodione or development; And overcome disease drug resistance such as alternaria leaf spot of apple, sigatoka and increase; The problem that peasant's dosage increases year by year, and have obvious role in synergism behind Difenoconazole and the iprodione.
The ratio of weight and number that a kind of microbicide compositions active component is Difenoconazole and iprodione is 1～60: 1～80.
The described bactericidal composition weight percentage that contains Difenoconazole and iprodione is 10% to 81%.
The described bactericidal composition that contains Difenoconazole and iprodione can be made into wetting powder, water dispersible granules, suspending agent, aqueous emulsion or microemulsion.
The described bactericidal composition that contains Difenoconazole and iprodione contains Difenoconazole 1～60%, iprodione 1～80%, auxiliary agent and excipients 15～90%.
Described auxiliary agent and excipients can be emulsifier, dispersant, wetting agent, solvent, disintegrant, antifreeze, antifoaming agent, thickener, filler.
Described emulsifier is selected from: farming breast 500
#(alkyl benzene calcium sulfonate), OP series phosphate (NPE phosphate), 600
#Phosphate (phenyl phenol polyoxy ethyl ether phosphate), styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether disulfonic acid magnesium salts, triethanolamine salt, farming breast 400
#(benzyl dimethyl phenol polyoxy ethyl ether), farming breast 600
#(phenyl phenol polyoxy ethyl ether), Nongru-700
#(alkylphenol-formaldehyde resin polyoxy ethyl ether), farming breast 1600
#(phenethyl phenol polyoxy ethyl polypropylene-base ether), ethylene oxide-propylene oxide block copolymer, OP series (NPE), By series (castor oil polyoxyethylene ether), farming breast 33
#In (alkylaryl polyoxyethylene polyoxypropylene ether), sapn series (sorbitan monostearate), tween series (sorbitan fatty acid ester APEO), the AEO series (the pure APEO of fat) one or more.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, APES formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, APES, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, DBSA, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described solvent is selected from: N, one or more in dinethylformamide, cyclohexanone, toluene, xylol, dimethyl sulfoxide (DMSO), methyl alcohol, ethanol, 3-methyl cyclohexanol ketenes, N-octylpyrrolidone, N-pyrrolidones, propyl alcohol, butanols, ethylene glycol, diethylene glycol, EGME, butyl ether, ethyl acetate, vegetable oil, the acetonitrile.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described antifoaming agent is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention can be used for preventing and treating the multiple diseases on the fruit tree, and is especially outstanding to the disease-controlling effect on apple, banana, the grape.
The characteristics and the beneficial effect of the present composition are: 1, composition shows fabulous synergistic effect in certain ratio range, and the protection effect of composition is significantly improved than its single agent.2, because two single thinner architectural differences of this composition are very big, the mechanism of action is different fully, does not have mutual pesticide resistance, can delay two single agent and use the pesticide resistance problem that is produced separately.3, composition high-efficiency low-toxicity, alternative high-toxic pesticide, environmental pollution is little.4, the composition fungicidal spectrum is wide, and the lasting period is long, has reduced agricultural chemicals dosage and access times, has reduced the control cost.
Embodiment
The present invention is explained further that the percentage among the embodiment all is weight percentage below in conjunction with embodiment, the treatment dosage of biologically-active moiety is active constituent content, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.Pass through Toxicity Determination earlier, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.On this basis, carry out field trial again.
Practice routine monophenyl ether methyl cyclic-azole and iprodione different proportion and use Toxicity Determination with alternaria leaf spot of apple
This EE is in plant protection institute of Shandong Agricultural University, and after the effective inhibition concentration scope of each medicament was confirmed in prerun, each medicament was established 5 dosage respectively by active constituent content and handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament alternaria leaf spot of apple.Measure colony diameter with the right-angled intersection method behind the 96h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.Result of the test is as shown in table 1:
Table 1 Difenoconazole, iprodione and use toxicity test analysis of results table with to alternaria leaf spot of apple
Can know that by table 1 Difenoconazole, iprodione are to the EC of alternaria leaf spot of apple
50Be respectively 0.2561 μ g/mL and 0.7345 μ g/mL.The virulence of Difenoconazole is higher than the virulence of iprodione.1: 1,1: 2,1: 4,1: 6,1: 8 synergy ratio of Difenoconazole and iprodione proportioning is respectively 1.22,1.57,1.94,1.60,1.41; Both proportionings are to show as certain synergistic effect at 1: 2,1: 4,1: 6 o'clock, and it is comparatively reasonable to explain that Difenoconazole and iprodione were mixed in the scope at 1: 2～1: 6.
Practice example two and implement the prescription example
Embodiment 1～2 wetting powder
Above-mentioned formulation material is mixed, in stirred tank, evenly stir, behind airslide disintegrating mill, mix again, promptly can be made into the wetting powder of the present composition.
Embodiment 150% Difenoconazole iprodione wettable powder
Get difenoconazole technical material 10%, the former medicine 40% of iprodione, polycarboxylate 5%, neopelex 5%, white carbon black 5%, kaolin 35% makes 50% Difenoconazole iprodione wettable powder by above-mentioned production technology.
Embodiment 260% Difenoconazole iprodione wettable powder
Get difenoconazole technical material 15%, the former medicine 45% of iprodione, sodium lignin sulfonate 3%, APES 4%, Nekal BX 3%, white carbon black 5%, diatomite 25% makes 60% Difenoconazole iprodione wettable powder by above-mentioned production technology.
Embodiment 3～4 water dispersible granules
Formulation material is mixed, pulverize, carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis, process the water dispersible granules of the present composition through mediating, adding then with micro jet.
Embodiment 350% Difenoconazole iprodione water dispersible granules
Get difenoconazole technical material 9%, the former medicine 41% of iprodione, alkyl benzene sulfonate calcium salt 6%, lauryl sodium sulfate 7%, succinic acid 4%, starch 2%, kaolin 31% is processed 50% Difenoconazole iprodione water dispersible granules by above-mentioned production technology.
Embodiment 460% Difenoconazole iprodione water dispersible granules
Get difenoconazole technical material 12%, the former medicine 48% of iprodione, polycarboxylate 5%; Wetting and penetrating agent F4%, neopelex 5%, citric acid 3%; Starch 2%, kaolin 21% is processed 60% Difenoconazole iprodione water dispersible granules by above-mentioned production technology.
Embodiment 5～6 suspending agents
With all the other components except that crossing active ingredient such as wetting dispersing agent, antifreezing agent, thickener, water in the formulation material; Mix through high speed shear, add active ingredient, ball milling is 2～3 hours in ball mill; Make particle diameter all below 5 μ m, make the suspending agent of the present composition.
Embodiment 520% Difenoconazole iprodione suspending agent
Get difenoconazole technical material 5%, the former medicine 15% of iprodione, polyaryl phenol polyethenoxy ether phosphate alkylammonium salt 5%; Propane diols 5%; Polyvinyl alcohol 0.3%, silicone defoaming agent 0.1%, citric acid 0.2%; Water is mended to 100%, processes 60% Difenoconazole iprodione suspending agent by above-mentioned production technology.
Embodiment 630% Difenoconazole iprodione suspending agent
Get difenoconazole technical material 6%, the former medicine 24% of iprodione, polycarboxylate 3%; Wetting and penetrating agent F 4%, ethylene glycol 8%, aluminium-magnesium silicate 0.5%; Silicone defoaming agent 0.1%, propane diols 4%, citric acid 0.2%; Water is mended to 100%, processes 60% Difenoconazole iprodione suspending agent by above-mentioned production technology.
Embodiment 7～8 aqueous emulsions
Above-mentioned formulation material is mixed, active ingredient, solvent, emulsifier are added together, make and be dissolved into even oil phase; Water, antifreeze, thickener, antifoaming agent are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, can make present composition aqueous emulsion.
Embodiment 735% Difenoconazole iprodione aqueous emulsion
Get Difenoconazole 5%, iprodione 30%, N-Methyl pyrrolidone 8%, farming breast 500
#2%, the farming breast 1600
#2%, OP-10 phosphate 2%, ethylene glycol 4%, silicone compound 0.4%, water are mended to 100%, make 35% Difenoconazole iprodione aqueous emulsion by above-mentioned production technology.
Embodiment 845% Difenoconazole iprodione aqueous emulsion
Get Difenoconazole 9%, iprodione 36%, N-Methyl pyrrolidone 10%, farming breast 600
#2%, the farming breast 500
#4%, 600
#Phosphate 2%, ethylene glycol 4%, silicone compound 0.4%, water are mended to 100%, make 45% Difenoconazole iprodione aqueous emulsion.
Embodiment 9～10 microemulsions
Emulsifier and water are mixed and made into water, and the former medicine that will be dissolved in then in the solvent under agitation adds water, processes present composition microemulsion.
Embodiment 930% Difenoconazole iprodione microemulsion
Difenoconazole 5%, iprodione 25%, vegetable oil 5%, N-Methyl pyrrolidone 5%, farming breast 600
#7%, the farming breast 500
#8%, sorbester p17
#3%, 600
#Phosphate 4%, ethylene glycol 5%, silicone compound 0.2%, water are mended to 100g, process 30% Difenoconazole iprodione microemulsion by above-mentioned production technology.
Embodiment 1040% Difenoconazole iprodione microemulsion
Difenoconazole 8%, iprodione 32%, vegetable oil 4%, N-Methyl pyrrolidone 6%, farming breast 500
#6%, the farming breast 400
#8%, OP-103%, OP series phosphate 4%, ethylene glycol 4%, silicone compound 0.2%, water are mended to 100%, process 40% Difenoconazole iprodione microemulsion by above-mentioned production technology.
Practice routine three field medicine effect tests
Difenoconazole iprodione control alternaria leaf spot of apple
The present invention tests and converted water April 25 by every mu of medication amount of formulation and carry out even spraying for 60 kilograms, and dispenser is 4 times altogether, each dispenser 10 days at interval, and after the 4th dispenser, preventive effect such as table 2:
The table 2 Difenoconazole iprodione control alternaria leaf spot of apple test of pesticide effectiveness
| Handle medicament | Extension rate | Preventive effect (%) before the medicine for the third time | Preventive effect (%) before the 4th medicine | 20 days preventive effects (%) behind the 4th medicine |
| Embodiment 1 | 3500 times | 75.2 | 87.7 | 91.2 |
| Embodiment 3 | 3000 times | 73.5 | 88.3 | 90.2 |
| Embodiment 5 | 1500 times | 76.7 | 92.1 | 91.2 |
| Embodiment 7 | 2500 times | 70.6 | 88.5 | 92.9 |
| Embodiment 9 | 2000 times | 75.5 | 89.2 | 94.8 |
| 10% difenoconazole water dispersible granule | 1800 times | 73.8 | 85.4 | 84.7 |
| 50% iprodione wettable powder | 1500 times | 69.5 | 84.1 | 83.9 |
Find out by table 2; The bactericidal composition of Difenoconazole of the present invention and iprodione has the better prevention effect to alternaria leaf spot of apple; The inventor finds in test; Said composition is to apple tree safety, and 20 days preventive effects behind the apple marssonina leaf spot last medicine are reached more than 75%, and 20 days preventive effects behind the apple scab last medicine are reached more than 80%.
The Difenoconazole iprodione is prevented and treated the sigatoka test of pesticide effectiveness
The present invention tests and converted water July 3 by every mu of medication amount of formulation and carry out even spraying for 50 kilograms, and dispenser is 3 times altogether, each dispenser 10 days at interval, and investigation result such as table 3:
Table 3 Difenoconazole iprodione is prevented and treated the sigatoka test of pesticide effectiveness
| Handle medicament | Extension rate | The preceding preventive effect (%) of the medicine second time | Preventive effect (%) before the medicine for the third time | 10 days preventive effects (%) behind the medicine for the third time |
| Embodiment 2 | 3500 times | 73.51 | 84.30 | 94.24 |
| Embodiment 4 | 3000 times | 74.20 | 83.56 | 93.67 |
| Embodiment 6 | 1500 times | 73.06 | 84.75 | 94.28 |
| Embodiment 8 | 2500 times | 71.24 | 83.19 | 93.05 |
| Embodiment 10 | 2000 times | 74.36 | 85.27 | 93.17 |
| 10% difenoconazole water dispersible granule | 1000 times | 67.43 | 79.64 | 83.79 |
| 25% iprodione suspending agent | 500 times | 68.85 | 81.08 | 84.83 |
The present composition has good control efficiency to sigatoka, and preventive effect all is higher than the contrast medicament, in test dosage scope, to crop safety, the banana freckle preventive effect is reached more than 85%.
In sum, the bactericidal composition of Difenoconazole and iprodione, have a medicine control more, to crop safety, environmental pollution is little, quick-acting good, the lasting period is long advantage; Compare with single agent, enlarged fungicidal spectrum, reduced the medication number of times; Environmentally safe, reduced cost.So R&D and promotion of the present invention has crucial meaning.
Claims (6)
1. microbicide compositions, it is characterized in that: the active component in the composition is Difenoconazole and iprodione, the weight ratio of Difenoconazole and two kinds of active components of iprodione is 1 in the composition: 2-6.
2. the bactericidal composition that contains Difenoconazole and iprodione according to claim 1 is characterized in that: the active component weight percentage in the composition is 10% to 81%.
3. the bactericidal composition that contains Difenoconazole and iprodione according to claim 1 is characterized in that: the said composition active component adds auxiliary agent and is mixed with wetting powder, water dispersible granules, suspending agent, aqueous emulsion or microemulsion.
4. Difenoconazole and the iprodione bactericidal composition of containing according to claim 3, it is characterized in that: described auxiliary agent is emulsifier, dispersant, wetting agent, solvent, disintegrant, antifreeze, antifoaming agent, thickener.
5. described each of claim 1 to 4 contains the purposes that Difenoconazole and iprodione bactericidal composition are used to prevent and treat the fungal disease of fruit tree.
6. the described purposes of claim 5, it is characterized in that: described fungal disease comprises alternaria leaf spot of apple, sigatoka, banana crown rot, grape powdery mildew, grape grey mould.
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| US3755350A (en) * | 1970-10-06 | 1973-08-28 | Rhone Poulenc Sa | Substituted 3-phenyl hydantoins useful as fungicides |
| US5266585A (en) * | 1981-05-12 | 1993-11-30 | Ciba-Geigy Corporation | Arylphenyl ether derivatives, compositions containing these compounds and use thereof |
| CN101011053A (en) * | 2006-12-15 | 2007-08-08 | 江苏东宝农药化工有限公司 | Bactericide composition formulation with synergistic effect |
| CN101278677A (en) * | 2007-04-06 | 2008-10-08 | 葛尧伦 | Fungicide composition containing Difenoconazole and Thiophanate-methyl |
-
2009
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3755350A (en) * | 1970-10-06 | 1973-08-28 | Rhone Poulenc Sa | Substituted 3-phenyl hydantoins useful as fungicides |
| US5266585A (en) * | 1981-05-12 | 1993-11-30 | Ciba-Geigy Corporation | Arylphenyl ether derivatives, compositions containing these compounds and use thereof |
| CN101011053A (en) * | 2006-12-15 | 2007-08-08 | 江苏东宝农药化工有限公司 | Bactericide composition formulation with synergistic effect |
| CN101278677A (en) * | 2007-04-06 | 2008-10-08 | 葛尧伦 | Fungicide composition containing Difenoconazole and Thiophanate-methyl |
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