CN101506210A - 2-苯氧基嘧啶酮类似物 - Google Patents

2-苯氧基嘧啶酮类似物 Download PDF

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Publication number
CN101506210A
CN101506210A CNA2007800309530A CN200780030953A CN101506210A CN 101506210 A CN101506210 A CN 101506210A CN A2007800309530 A CNA2007800309530 A CN A2007800309530A CN 200780030953 A CN200780030953 A CN 200780030953A CN 101506210 A CN101506210 A CN 101506210A
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China
Prior art keywords
compound
alkyl
fluorophenyl
salt
hydrate
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Pending
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CNA2007800309530A
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English (en)
Chinese (zh)
Inventor
R·贝克赛-瓦特拉姆
S·M·凯普托斯蒂
J·徐
B·L·谢纳尔
M·戈什
C·A·布卢姆
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Neurogen Corp
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Neurogen Corp
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Publication of CN101506210A publication Critical patent/CN101506210A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
CNA2007800309530A 2006-08-23 2007-08-22 2-苯氧基嘧啶酮类似物 Pending CN101506210A (zh)

Applications Claiming Priority (2)

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US82325806P 2006-08-23 2006-08-23
US60/823,258 2006-08-23

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CN201410468406.2A Pending CN104292229A (zh) 2006-08-23 2007-08-22 2-苯氧基嘧啶酮类似物

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US (2) US8003656B2 (cg-RX-API-DMAC7.html)
EP (1) EP2061794B1 (cg-RX-API-DMAC7.html)
JP (1) JP5421108B2 (cg-RX-API-DMAC7.html)
KR (1) KR20090043583A (cg-RX-API-DMAC7.html)
CN (2) CN101506210A (cg-RX-API-DMAC7.html)
AU (1) AU2007288203B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0716582A2 (cg-RX-API-DMAC7.html)
CA (1) CA2660957C (cg-RX-API-DMAC7.html)
CO (1) CO6150167A2 (cg-RX-API-DMAC7.html)
CR (1) CR10675A (cg-RX-API-DMAC7.html)
EA (1) EA200900330A1 (cg-RX-API-DMAC7.html)
ES (1) ES2399928T3 (cg-RX-API-DMAC7.html)
GT (1) GT200900040A (cg-RX-API-DMAC7.html)
IL (1) IL197043A0 (cg-RX-API-DMAC7.html)
MA (1) MA30720B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009002066A (cg-RX-API-DMAC7.html)
NI (1) NI200900023A (cg-RX-API-DMAC7.html)
NO (1) NO20091182L (cg-RX-API-DMAC7.html)
SV (1) SV2009003173A (cg-RX-API-DMAC7.html)
TW (1) TW200825089A (cg-RX-API-DMAC7.html)
WO (1) WO2008024438A2 (cg-RX-API-DMAC7.html)
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US8759361B2 (en) 2014-06-24
EP2061794A4 (en) 2010-09-08
JP5421108B2 (ja) 2014-02-19
US8003656B2 (en) 2011-08-23
AU2007288203B2 (en) 2013-01-17
WO2008024438A3 (en) 2008-11-27
GT200900040A (es) 2010-03-16
IL197043A0 (en) 2009-11-18
CA2660957C (en) 2016-10-11
ES2399928T3 (es) 2013-04-04
KR20090043583A (ko) 2009-05-06
WO2008024438A2 (en) 2008-02-28
BRPI0716582A2 (pt) 2013-10-08
EP2061794A2 (en) 2009-05-27
NI200900023A (es) 2010-03-05
US20120208829A1 (en) 2012-08-16
EP2061794B1 (en) 2012-12-05
AU2007288203A1 (en) 2008-02-28
CO6150167A2 (es) 2010-04-20
MA30720B1 (fr) 2009-09-01
JP2010502576A (ja) 2010-01-28
SV2009003173A (es) 2010-08-10
CN104292229A (zh) 2015-01-21
EA200900330A1 (ru) 2009-08-28
US20090069347A1 (en) 2009-03-12
CR10675A (es) 2009-04-17
NO20091182L (no) 2009-05-14
ZA200901163B (en) 2010-08-25
TW200825089A (en) 2008-06-16
CA2660957A1 (en) 2008-02-28
MX2009002066A (es) 2009-03-06

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