AU2007288203B2 - 2-phenoxy pyrimidinone analogues - Google Patents
2-phenoxy pyrimidinone analogues Download PDFInfo
- Publication number
- AU2007288203B2 AU2007288203B2 AU2007288203A AU2007288203A AU2007288203B2 AU 2007288203 B2 AU2007288203 B2 AU 2007288203B2 AU 2007288203 A AU2007288203 A AU 2007288203A AU 2007288203 A AU2007288203 A AU 2007288203A AU 2007288203 B2 AU2007288203 B2 AU 2007288203B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- dihydro
- fluorophenyl
- compound
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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Landscapes
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| GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| WO2008024438A2 (en) | 2006-08-23 | 2008-02-28 | Neurogen Corporation | 2-phenoxy pyrimidinone analogues |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| HRP20191298T1 (hr) | 2013-09-09 | 2019-10-18 | Peloton Therapeutics, Inc. | Arileteri i njihove uporabe |
| WO2016023830A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives |
| US10512626B2 (en) | 2015-03-11 | 2019-12-24 | Peloton Therapeautics, Inc. | Compositions for use in treating glioblastoma |
| WO2016144826A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
| US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
| EP3267792A4 (en) | 2015-03-11 | 2018-09-26 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
| WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
| WO2020146449A1 (en) * | 2019-01-08 | 2020-07-16 | Texas Tech University System | Small molecule analogs of the protein e4orf1 in the treatment and prevention of metabolic disorders |
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| WO2005049613A1 (en) * | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| WO2006047516A2 (en) * | 2004-10-26 | 2006-05-04 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
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| US5124331A (en) * | 1988-03-02 | 1992-06-23 | Yoshitomi Pharmaceutical Industries, Ltd. | 3,4-dihydrothieno[2,3-d]pyrimidine compounds and their pharmaceutical use |
| US5202328A (en) * | 1991-03-06 | 1993-04-13 | Merck & Co., Inc. | Substituted fused pyrimidinones |
| ATE227293T1 (de) * | 1996-05-15 | 2002-11-15 | Pfizer | 2,3-disubstituierte-(5,6)-heteroarylkondensiert - pyrimidin-4-one |
| CN1255043A (zh) | 1997-05-08 | 2000-05-31 | 英国阿格里沃有限公司 | 杀真菌剂 |
| US6627755B1 (en) * | 1997-06-09 | 2003-09-30 | Pfizer Inc | Quinazolin-4-one AMPA antagonists |
| IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| AU2002214546A1 (en) | 2000-09-29 | 2002-04-08 | Cor Therapeutics, Inc. | Bicyclic pyrimidin-4-one based inhibitors of factor xa |
| BR0207216A (pt) * | 2001-02-14 | 2004-03-09 | Warner Lambert Co | Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz |
| WO2002076946A2 (en) | 2001-03-26 | 2002-10-03 | Novartis Ag | Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain. |
| EP1430161B1 (de) * | 2001-09-28 | 2005-06-15 | DaimlerChrysler AG | Hochfester duplex-/triplex-leichtbaustahl und seine verwendung |
| AU2002358700A1 (en) | 2001-12-26 | 2003-07-15 | Bayer Aktiengesellschaft | Urea derivatives as vr1- antagonists |
| ATE533743T1 (de) | 2002-05-17 | 2011-12-15 | Janssen Pharmaceutica Nv | Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1 |
| AU2003238157A1 (en) | 2002-06-18 | 2003-12-31 | Sankyo Company, Limited | Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof |
| AU2003273856A1 (en) | 2002-09-24 | 2004-04-19 | Bayer Healthcare Ag | Vr1 antagonists for the treatment of urological disorders |
| GB0223730D0 (en) | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
| WO2004037176A2 (en) | 2002-10-21 | 2004-05-06 | Bristol-Myers Squibb Company | Quinazolinones and derivatives thereof as factor xa inhibitors |
| WO2004087053A2 (en) * | 2003-03-25 | 2004-10-14 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| GB0326633D0 (en) | 2003-11-14 | 2003-12-17 | Merck Sharp & Dohme | Therapeutic agents |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| CA2607929A1 (en) | 2005-05-11 | 2006-11-16 | Merck Sharp & Dohme Limited | 2,3-substituted fused bicyclic pyrimidin-4(3h)-ones modulating the function of the vanilloid-1 receptor (vr1) |
| GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| CN1318429C (zh) * | 2005-07-25 | 2007-05-30 | 华中师范大学 | 具有杀菌活性的取代噻吩并[3',2':5,6]吡啶并[4,3－d]嘧啶－4(3H)－酮及制备 |
| CA2628441A1 (en) | 2005-11-04 | 2007-05-18 | Hydra Biosciences, Inc. | Compounds for modulating trpv3 function |
| WO2008024438A2 (en) | 2006-08-23 | 2008-02-28 | Neurogen Corporation | 2-phenoxy pyrimidinone analogues |
| US20080090845A1 (en) * | 2006-08-23 | 2008-04-17 | Neurogen Corporation | Haloalkyl-substituted pyrimidinone derivatives |
| CN101558069A (zh) * | 2006-11-06 | 2009-10-14 | 神经能质公司 | 顺式环己基取代的嘧啶酮衍生物 |
| WO2008156607A1 (en) | 2007-06-12 | 2008-12-24 | Neurogen Corporation | Substituted pyrimidinones |
| WO2009100403A1 (en) | 2008-02-07 | 2009-08-13 | Neurogen Corporation | Substituted aryl pyrimidinones |
| WO2009121036A2 (en) | 2008-03-27 | 2009-10-01 | Neurogen Corporation | Substituted aryl pyrimidinone derivatives |
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2007
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2009
- 2009-02-15 IL IL197043A patent/IL197043A0/en unknown
- 2009-02-20 SV SV2009003173A patent/SV2009003173A/es not_active Application Discontinuation
- 2009-02-20 NI NI200900023A patent/NI200900023A/es unknown
- 2009-02-23 GT GT200900040A patent/GT200900040A/es unknown
- 2009-03-18 CO CO09028167A patent/CO6150167A2/es unknown
- 2009-03-20 NO NO20091182A patent/NO20091182L/no not_active Application Discontinuation
- 2009-03-20 CR CR10675A patent/CR10675A/es not_active Application Discontinuation
- 2009-03-23 MA MA31732A patent/MA30720B1/fr unknown
-
2011
- 2011-08-22 US US13/215,195 patent/US8759361B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005049613A1 (en) * | 2003-11-14 | 2005-06-02 | Merck Sharp & Dohme Limited | Bicyclic pyrimidin-4-(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (vr1) |
| WO2006047516A2 (en) * | 2004-10-26 | 2006-05-04 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104292229A (zh) | 2015-01-21 |
| BRPI0716582A2 (pt) | 2013-10-08 |
| WO2008024438A3 (en) | 2008-11-27 |
| JP5421108B2 (ja) | 2014-02-19 |
| ZA200901163B (en) | 2010-08-25 |
| CN101506210A (zh) | 2009-08-12 |
| CA2660957C (en) | 2016-10-11 |
| US8759361B2 (en) | 2014-06-24 |
| MA30720B1 (fr) | 2009-09-01 |
| KR20090043583A (ko) | 2009-05-06 |
| ES2399928T3 (es) | 2013-04-04 |
| JP2010502576A (ja) | 2010-01-28 |
| US8003656B2 (en) | 2011-08-23 |
| AU2007288203A1 (en) | 2008-02-28 |
| US20090069347A1 (en) | 2009-03-12 |
| NO20091182L (no) | 2009-05-14 |
| US20120208829A1 (en) | 2012-08-16 |
| MX2009002066A (es) | 2009-03-06 |
| WO2008024438A2 (en) | 2008-02-28 |
| SV2009003173A (es) | 2010-08-10 |
| NI200900023A (es) | 2010-03-05 |
| CR10675A (es) | 2009-04-17 |
| GT200900040A (es) | 2010-03-16 |
| CA2660957A1 (en) | 2008-02-28 |
| EA200900330A1 (ru) | 2009-08-28 |
| EP2061794B1 (en) | 2012-12-05 |
| EP2061794A2 (en) | 2009-05-27 |
| CO6150167A2 (es) | 2010-04-20 |
| IL197043A0 (en) | 2009-11-18 |
| EP2061794A4 (en) | 2010-09-08 |
| TW200825089A (en) | 2008-06-16 |
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