CN101497632B - 一种合成香豆素-3-膦酸酯衍生物的方法 - Google Patents
一种合成香豆素-3-膦酸酯衍生物的方法 Download PDFInfo
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- CN101497632B CN101497632B CN2009100254204A CN200910025420A CN101497632B CN 101497632 B CN101497632 B CN 101497632B CN 2009100254204 A CN2009100254204 A CN 2009100254204A CN 200910025420 A CN200910025420 A CN 200910025420A CN 101497632 B CN101497632 B CN 101497632B
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- Prior art keywords
- coumarin
- chromen
- phosphonate derivative
- reaction
- methyl
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
溶剂 | 甲醇 | 无水乙醇 | 乙腈 | 氯仿 | 二氯甲烷 | 1,2-二氯乙烷 | 甲苯 | 醋酸 |
产率(%) | 14 | 15 | 10 | 8 | 5 | 6 | 6 | 25 |
温度(℃) | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 | 100 |
产率(%) | 2 | 5 | 10 | 12 | 20 | 21 | 25 | 26 | 20 |
醋酸锰(mmol) | 1 | 2 | 3 | 4 |
产率(%) | 26 | 32 | 40 | 40 |
反应时间(h) | 0.5 | 1 | 1.5 | 2 |
产率(%) | 40 | 50 | 58 | 65 |
Claims (6)
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CN2009100254204A CN101497632B (zh) | 2009-03-04 | 2009-03-04 | 一种合成香豆素-3-膦酸酯衍生物的方法 |
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CN2009100254204A CN101497632B (zh) | 2009-03-04 | 2009-03-04 | 一种合成香豆素-3-膦酸酯衍生物的方法 |
Publications (2)
Publication Number | Publication Date |
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CN101497632A CN101497632A (zh) | 2009-08-05 |
CN101497632B true CN101497632B (zh) | 2012-01-25 |
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CN2009100254204A Expired - Fee Related CN101497632B (zh) | 2009-03-04 | 2009-03-04 | 一种合成香豆素-3-膦酸酯衍生物的方法 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103254236A (zh) * | 2013-05-28 | 2013-08-21 | 苏州大学 | 一种4-芳基香豆素-3-膦酸酯衍生物的制备方法 |
CN105037428B (zh) * | 2015-07-10 | 2017-01-25 | 河南工业大学 | 一种香豆素‑3‑膦酸酯衍生物的制备方法 |
CN108864185B (zh) * | 2018-07-09 | 2020-05-08 | 苏州大学 | β-膦酰基烯胺衍生物及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1524866A (zh) * | 2003-09-16 | 2004-09-01 | 中国科学院上海有机化学研究所 | 苯并烯醇膦酸内酯化合物及其制备方法 |
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1524866A (zh) * | 2003-09-16 | 2004-09-01 | 中国科学院上海有机化学研究所 | 苯并烯醇膦酸内酯化合物及其制备方法 |
Non-Patent Citations (2)
Title |
---|
Rajendra K. Singh, et al..An efficient synthesis of diethyl coumarin-3-phosphonates.《Journal of Heterocyclic Chemistry》.1985,第22卷1713-1714. * |
Xue-Jun Mu, et al..Manganese(III) Acetate Promoted Regioselective Phosphonation of Heteroaryl Compounds.《Organic Letters》.2006,第8卷(第23期),5291-5293. * |
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Granted publication date: 20120125 Termination date: 20140304 |