CN101495499B - 编码类异戊烯修饰酶的多核苷酸和其使用方法 - Google Patents
编码类异戊烯修饰酶的多核苷酸和其使用方法 Download PDFInfo
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- CN101495499B CN101495499B CN2006800246664A CN200680024666A CN101495499B CN 101495499 B CN101495499 B CN 101495499B CN 2006800246664 A CN2006800246664 A CN 2006800246664A CN 200680024666 A CN200680024666 A CN 200680024666A CN 101495499 B CN101495499 B CN 101495499B
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- nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310335874.8A CN103667370B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201710271576.5A CN106939323B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201610412819.8A CN105950667A (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69706705P | 2005-07-05 | 2005-07-05 | |
| US60/697,067 | 2005-07-05 | ||
| PCT/US2006/025572 WO2007005604A2 (en) | 2005-07-05 | 2006-06-29 | Polynucleotides encoding isoprenoid modifying enzymes and methods of use thereof |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310335874.8A Division CN103667370B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201710271576.5A Division CN106939323B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201610412819.8A Division CN105950667A (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101495499A CN101495499A (zh) | 2009-07-29 |
| CN101495499B true CN101495499B (zh) | 2013-09-04 |
Family
ID=37605033
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800246664A Active CN101495499B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201710271576.5A Active CN106939323B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201610412819.8A Pending CN105950667A (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201310335874.8A Active CN103667370B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710271576.5A Active CN106939323B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201610412819.8A Pending CN105950667A (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
| CN201310335874.8A Active CN103667370B (zh) | 2005-07-05 | 2006-06-29 | 编码类异戊烯修饰酶的多核苷酸和其使用方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8163980B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP1919514B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2009504138A (cg-RX-API-DMAC7.html) |
| KR (2) | KR101444090B1 (cg-RX-API-DMAC7.html) |
| CN (4) | CN101495499B (cg-RX-API-DMAC7.html) |
| AP (1) | AP3827A (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0612411B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2613469C (cg-RX-API-DMAC7.html) |
| DK (1) | DK1919514T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2386554T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL188376A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008000200A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1919514T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1919514E (cg-RX-API-DMAC7.html) |
| SG (1) | SG176459A1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI1919514T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007005604A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200800889B (cg-RX-API-DMAC7.html) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8828684B2 (en) | 2004-07-27 | 2014-09-09 | The Regents Of The University Of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| SI1919514T1 (sl) * | 2005-07-05 | 2012-08-31 | Univ California | Polinukleotidi, ki kodirajo encime, ki modificirajo izoprenoid, in postopki za njihovo uporabo |
| EP2024504B2 (en) | 2006-05-26 | 2022-12-14 | Amyris, Inc. | Production of isoprenoids |
| BRPI0716954B1 (pt) | 2006-09-26 | 2024-04-30 | The Regents Of The University Of California | Microrganismos geneticamente modificados capazes de produzir um isoprenóide |
| US8268553B2 (en) | 2007-06-01 | 2012-09-18 | Sapphire Energy, Inc. | High throughput screening of genetically modified photosynthetic organisms |
| US9695372B2 (en) | 2007-09-11 | 2017-07-04 | Sapphire Energy, Inc. | Methods of producing organic products with photosynthetic organisms |
| EP2444415A1 (en) * | 2010-10-20 | 2012-04-25 | Genoplante-Valor | 1-Deoxy-D-xylulose 5-phosphate synthase alleles responsible for enhanced terpene biosynthesis |
| BR112014010559B1 (pt) * | 2011-11-01 | 2021-11-16 | Firmenich Sa | Citocromo p450 e seu uso para oxidação enzimática de terpenos |
| JP5827601B2 (ja) | 2012-07-04 | 2015-12-02 | 住友ゴム工業株式会社 | 特定の蛋白質の発現を光応答転写因子により調整する方法、光応答転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
| EP2892919A1 (en) * | 2012-09-07 | 2015-07-15 | Sanofi | Fusion proteins for treating a metabolic syndrome |
| PL224377B1 (pl) * | 2012-11-02 | 2016-12-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczep Trichoderma atroviride, sposób otrzymywania i zastosowanie szczepu Trichoderma atroviride jako środka biobójczego |
| RU2654670C2 (ru) * | 2013-09-19 | 2018-05-21 | Фирмениш Са | Способ получения ароматических спиртов |
| JP6475336B2 (ja) * | 2014-08-21 | 2019-02-27 | チュン−アン ユニヴァーシティ インダストリー−アカデミー コーポレーション ファウンデーションChung−Ang University Industry−Academy Cooperation Foundation | rDNA NTS基盤の遺伝子多重挿入カセットセット、及びそれを用いたGRAS等級の組換え酵母菌株 |
| US11697830B2 (en) * | 2015-04-15 | 2023-07-11 | Ramon Gonzalez | Iterative platform for the synthesis of alpha functionalized products |
| US20180142273A1 (en) * | 2015-04-15 | 2018-05-24 | William Marsh Rice University | Iterative platform for the synthesis of alpha functionalized products |
| CN105177007B (zh) * | 2015-10-30 | 2017-11-10 | 上海交通大学 | 一种调控基因在非分泌型腺毛中表达的启动子及其应用 |
| CN105274109B (zh) * | 2015-10-30 | 2017-12-29 | 上海交通大学 | 一种调控基因在非分泌型腺毛中表达的启动子及其应用 |
| CN105483236A (zh) * | 2015-12-26 | 2016-04-13 | 吉林省农业科学院 | 转基因植物中cry1C基因的LAMP检测引物组、试剂盒及检测方法 |
| CN105567685B (zh) * | 2016-01-18 | 2018-07-13 | 上海交通大学 | AaPDR3基因启动子及其应用 |
| MX2019003063A (es) * | 2016-09-20 | 2019-10-14 | 22Nd Century Ltd Llc | Promotores específicos de tricoma para la manipulación de cannabinoides y otros compuestos en tricomas glandulares. |
| WO2018111194A1 (en) * | 2016-12-16 | 2018-06-21 | Temasek Life Sciences Laboratory Limited | Targets for improving terpene production in rhodosporidium toruloides |
| MX2019011323A (es) | 2017-03-24 | 2020-01-27 | Trait Biosciences Inc | Biosintesis y aislamiento in vivo de alto nivel de cannabinoides solubles en agua en sistemas de plantas. |
| US11905543B2 (en) | 2017-07-11 | 2024-02-20 | Trait Biosceinces, Inc. | In vivo generation of water-soluble acetylated cannabinoid glycoside compounds in plant cell suspension cultures |
| AU2018301674B2 (en) | 2017-07-11 | 2024-03-28 | Trait Biosciences, Inc. | Generation of water-soluble cannabinoid compounds in yeast and plant cell suspension cultures and compositions of matter |
| US11946059B2 (en) | 2017-07-11 | 2024-04-02 | Trait Biosciences, Inc. | In vivo generation of water-soluble cannabinoids in plant cell suspension cultures |
| CN113302298B (zh) | 2018-11-09 | 2025-02-25 | 银杏生物制品公司 | 罗汉果甙的生物合成 |
| US20230066313A1 (en) * | 2020-01-23 | 2023-03-02 | Amyris, Inc. | Amorpha-4,11-diene 12-monooxygenase variants and uses thereof |
| CN111621508B (zh) * | 2020-06-11 | 2022-07-01 | 云南中烟工业有限责任公司 | 烟草萜类合成酶NtTPS7基因及其载体与应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0982404A1 (en) * | 1998-08-27 | 2000-03-01 | Wallaart, Thorvald Eelco | DNA encoding amorpha-4,11-diene synthase |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5451513A (en) | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| US5639870A (en) * | 1992-03-27 | 1997-06-17 | International Flower Developments Pty., Ltd. | Genetic sequences encoding flavonoid pathway enzymes and uses therefor |
| FR2689905B1 (fr) * | 1992-04-13 | 1995-07-13 | Orsan | Procede de clonage d'une sequence d'adn codant pour une nadph cytochrome p450 reductase et sequences d'adn codant pour une nadph-cytochrome p450 reductase, notamment de plantes. |
| US5576198A (en) | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| US5545817A (en) | 1994-03-11 | 1996-08-13 | Calgene, Inc. | Enhanced expression in a plant plastid |
| US5545818A (en) | 1994-03-11 | 1996-08-13 | Calgene Inc. | Expression of Bacillus thuringiensis cry proteins in plant plastids |
| RU2370541C2 (ru) | 1994-12-09 | 2009-10-20 | Имерджент Продакт Дивелопмент Юк Лимитед | Vgc2 днк salmonella typhimurium, мутантная бактерия, обладающая пониженной способностью к адаптации к условиям окружающей среды, и способ ее получения |
| HUP0002926A3 (en) * | 1997-03-07 | 2005-11-28 | Syngenta Participations Ag | Cytochrome p450 monooxygenases |
| US6900012B1 (en) | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
| US6083731A (en) * | 1997-06-24 | 2000-07-04 | Washington State University Research Foundation | Recombinant materials and methods for the production of limonene hydroxylases |
| US6080849A (en) | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| US6645747B1 (en) | 1999-09-21 | 2003-11-11 | E. I. Du Pont De Nemours And Company | Cis-prenyltransferases from plants |
| US6369212B1 (en) | 2000-02-07 | 2002-04-09 | Korea Kumbo Petrochemical Co., Ltd. | Cytochrome P450 gene highly expressed in the incompatible interaction |
| EP1354955A4 (en) * | 2000-12-28 | 2005-01-05 | Toyota Motor Co Ltd | PROCESS FOR PREPARING PRENYL ALCOHOL |
| GB0105924D0 (en) | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
| US7405057B2 (en) * | 2001-03-09 | 2008-07-29 | Board Of Trustees Of The University Of Kentucky | Cytochrome P450s and uses thereof |
| AUPR446701A0 (en) * | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| WO2003025193A1 (en) | 2001-09-17 | 2003-03-27 | Plant Research International B.V. | Plant enzymes for bioconversion |
| US20040162420A1 (en) * | 2002-10-16 | 2004-08-19 | U.S. Smokeless Tobacco Company | Cloning of cytochrome p450 genes from nicotiana |
| US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US6733996B2 (en) | 2002-08-26 | 2004-05-11 | Trustees Of Dartmouth College | Methods for regulating gene expression using light |
| SI1919514T1 (sl) * | 2005-07-05 | 2012-08-31 | Univ California | Polinukleotidi, ki kodirajo encime, ki modificirajo izoprenoid, in postopki za njihovo uporabo |
| WO2007048235A1 (en) * | 2005-10-24 | 2007-05-03 | National Research Council Of Canada | A novel gene encoding amorphadiene hydroxylase and a process to produce artemisinic alcohol therewith |
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2006
- 2006-06-29 SI SI200631367T patent/SI1919514T1/sl unknown
- 2006-06-29 CN CN2006800246664A patent/CN101495499B/zh active Active
- 2006-06-29 EP EP06785959A patent/EP1919514B1/en active Active
- 2006-06-29 KR KR1020087002992A patent/KR101444090B1/ko active Active
- 2006-06-29 ES ES06785959T patent/ES2386554T3/es active Active
- 2006-06-29 PT PT06785959T patent/PT1919514E/pt unknown
- 2006-06-29 PL PL06785959T patent/PL1919514T3/pl unknown
- 2006-06-29 KR KR1020137011897A patent/KR101487304B1/ko active Active
- 2006-06-29 EP EP12158465.0A patent/EP2489672B1/en active Active
- 2006-06-29 CA CA2613469A patent/CA2613469C/en active Active
- 2006-06-29 WO PCT/US2006/025572 patent/WO2007005604A2/en not_active Ceased
- 2006-06-29 SG SG2011081403A patent/SG176459A1/en unknown
- 2006-06-29 MX MX2008000200A patent/MX2008000200A/es active IP Right Grant
- 2006-06-29 ZA ZA200800889A patent/ZA200800889B/xx unknown
- 2006-06-29 CN CN201710271576.5A patent/CN106939323B/zh active Active
- 2006-06-29 DK DK06785959.5T patent/DK1919514T3/da active
- 2006-06-29 BR BRPI0612411A patent/BRPI0612411B8/pt active IP Right Grant
- 2006-06-29 ES ES12158465.0T patent/ES2621657T3/es active Active
- 2006-06-29 US US11/917,875 patent/US8163980B2/en active Active
- 2006-06-29 CN CN201610412819.8A patent/CN105950667A/zh active Pending
- 2006-06-29 JP JP2008519611A patent/JP2009504138A/ja not_active Withdrawn
- 2006-06-29 CN CN201310335874.8A patent/CN103667370B/zh active Active
- 2006-06-29 AP AP2013006962A patent/AP3827A/en active
-
2007
- 2007-12-24 IL IL188376A patent/IL188376A/en active IP Right Grant
-
2012
- 2012-03-21 US US13/426,387 patent/US8759632B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0982404A1 (en) * | 1998-08-27 | 2000-03-01 | Wallaart, Thorvald Eelco | DNA encoding amorpha-4,11-diene synthase |
Non-Patent Citations (3)
| Title |
|---|
| Yung-Jin Chang等.Amorpha-4,11-diene Synthase of Artemisia annua: cDNA Isolation and Bacterial Expression of a Terpene Synthase Involved in Artemisinin Biosynthesis.《Archives of Biochemistry and Biophysics》.2000,第383卷(第2期),178-184页. * |
| Yung-JinChang等.Amorpha-4 11-diene Synthase of Artemisia annua: cDNA Isolation and Bacterial Expression of a Terpene Synthase Involved in Artemisinin Biosynthesis.《Archives of Biochemistry and Biophysics》.2000 |
| 罗永明 等.植物萜类化合物的生物合成途径及其关键酶的研究进展.《江西中医学院学报》.2003,第15卷(第1期),45-51页. * |
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