MX2019003063A - Promotores específicos de tricoma para la manipulación de cannabinoides y otros compuestos en tricomas glandulares. - Google Patents

Promotores específicos de tricoma para la manipulación de cannabinoides y otros compuestos en tricomas glandulares.

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Publication number
MX2019003063A
MX2019003063A MX2019003063A MX2019003063A MX2019003063A MX 2019003063 A MX2019003063 A MX 2019003063A MX 2019003063 A MX2019003063 A MX 2019003063A MX 2019003063 A MX2019003063 A MX 2019003063A MX 2019003063 A MX2019003063 A MX 2019003063A
Authority
MX
Mexico
Prior art keywords
specific promoters
trichome specific
cannabinoids
compounds
manipulation
Prior art date
Application number
MX2019003063A
Other languages
English (en)
Inventor
Rushton Paul
Original Assignee
22Nd Century Ltd Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 22Nd Century Ltd Llc filed Critical 22Nd Century Ltd Llc
Publication of MX2019003063A publication Critical patent/MX2019003063A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • C12N15/8223—Vegetative tissue-specific promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03007—Tetrahydrocannabinolic acid synthase (1.21.3.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/03—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with oxygen as acceptor (1.21.3)
    • C12Y121/03008—Cannabidiolic acid synthase (1.21.3.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y121/00—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21)
    • C12Y121/99—Oxidoreductases acting on X-H and Y-H to form an X-Y bond (1.21) with other acceptors (1.21.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03119—(–)-Alpha-pinene synthase (4.2.3.119)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y404/00—Carbon-sulfur lyases (4.4)
    • C12Y404/01—Carbon-sulfur lyases (4.4.1)
    • C12Y404/01026—Olivetolic acid cyclase (4.4.1.26)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente tecnología proporciona promotores específicos de tricomios de genes de enzima de biosíntesis de cannabinoides de Cannabis, secuencias de nucleótidos de los promotores específicos de tricomios y usos de los promotores para modular la producción de cannabinoides y otros compuestos en organismos; la presente tecnología también proporciona genes quiméricos, vectores y células y organismos transgénicos, incluyendo células vegetales y plantas, que comprenden los promotores específicos de tricomios; también se proporcionan métodos para expresar secuencias de ácidos nucleicos en células y organismos usando los promotores específicos de tricomios.
MX2019003063A 2016-09-20 2017-09-14 Promotores específicos de tricoma para la manipulación de cannabinoides y otros compuestos en tricomas glandulares. MX2019003063A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662397212P 2016-09-20 2016-09-20
PCT/US2017/051493 WO2018057385A2 (en) 2016-09-20 2017-09-14 Trichome specific promoters for the manipulation of cannabinoids and other compounds in glandular trichomes

Publications (1)

Publication Number Publication Date
MX2019003063A true MX2019003063A (es) 2019-10-14

Family

ID=61691084

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019003063A MX2019003063A (es) 2016-09-20 2017-09-14 Promotores específicos de tricoma para la manipulación de cannabinoides y otros compuestos en tricomas glandulares.
MX2023009165A MX2023009165A (es) 2016-09-20 2019-03-15 Promotores especificos de tricoma para la manipulacion de cannabinoides y otros compuestos en tricomas glandulares.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023009165A MX2023009165A (es) 2016-09-20 2019-03-15 Promotores especificos de tricoma para la manipulacion de cannabinoides y otros compuestos en tricomas glandulares.

Country Status (13)

Country Link
US (4) US10787674B2 (es)
EP (2) EP3516048B1 (es)
JP (2) JP7220145B2 (es)
CN (2) CN109963941B (es)
AU (1) AU2017332638A1 (es)
CA (1) CA3036968A1 (es)
EA (1) EA201990549A1 (es)
ES (1) ES2940673T3 (es)
MA (1) MA45611A (es)
MX (2) MX2019003063A (es)
SG (1) SG10201913280UA (es)
TW (1) TW201821613A (es)
WO (1) WO2018057385A2 (es)

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US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
BR112021008520A2 (pt) * 2018-10-31 2021-08-03 Baymedica, Inc. análogos de canabinoide e métodos para sua preparação
WO2020182866A1 (en) * 2019-03-12 2020-09-17 Perpetuum Cropscience Bvba Cannabinoid precursor production
EP3994261A4 (en) * 2019-07-01 2023-10-18 22nd Century Limited, LLC CANNABIS TERPENE SYNTHASE PROMOTERS FOR MANIPULATION OF TERPENE BIOSYNTHESIS IN TRICHOMS
US20220298522A1 (en) * 2019-07-30 2022-09-22 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
CA3196683A1 (en) * 2020-11-12 2022-05-19 Marcus GEISSLER Production of cannabinoids/phytocannabinoids with a plant extract
JP2024505756A (ja) * 2021-02-03 2024-02-07 アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー 植物毛状突起における毛状突起密度の増加および代謝物の輸送の改善の方法
CN113234726B (zh) * 2021-06-21 2022-07-22 贵州省烟草科学研究院 一种烟草腺毛特异性启动子pNtTCP9a及其应用
CN113528365B (zh) * 2021-07-13 2023-04-07 浙江寿仙谷医药股份有限公司 产大麻二酚的重组酿酒酵母、其构建方法以及应用
US12103950B2 (en) 2022-01-27 2024-10-01 University Of Connecticut Transgenic plants that overexpress a R2R3-MYB transcription factor gene and methods for producing the same

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Also Published As

Publication number Publication date
US20230383303A1 (en) 2023-11-30
WO2018057385A3 (en) 2018-05-03
CN109963941B (zh) 2023-12-15
EP3516048A2 (en) 2019-07-31
US10787674B2 (en) 2020-09-29
US11649463B2 (en) 2023-05-16
CN109963941A (zh) 2019-07-02
US20190225975A1 (en) 2019-07-25
EP4194550A3 (en) 2023-09-06
CN117587015A (zh) 2024-02-23
US20210040492A1 (en) 2021-02-11
WO2018057385A2 (en) 2018-03-29
MA45611A (fr) 2019-05-15
CA3036968A1 (en) 2018-03-29
EP3516048A4 (en) 2020-07-29
EA201990549A1 (ru) 2019-10-31
JP2019533436A (ja) 2019-11-21
MX2023009165A (es) 2023-08-18
US20230374531A1 (en) 2023-11-23
EP4194550A2 (en) 2023-06-14
ES2940673T3 (es) 2023-05-10
JP2022180445A (ja) 2022-12-06
TW201821613A (zh) 2018-06-16
JP7220145B2 (ja) 2023-02-09
SG10201913280UA (en) 2020-03-30
AU2017332638A1 (en) 2019-04-11
EP3516048B1 (en) 2023-01-11

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