CN101479288B - 囊性纤维化的改进的治疗 - Google Patents

囊性纤维化的改进的治疗 Download PDF

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Publication number
CN101479288B
CN101479288B CN2007800237886A CN200780023788A CN101479288B CN 101479288 B CN101479288 B CN 101479288B CN 2007800237886 A CN2007800237886 A CN 2007800237886A CN 200780023788 A CN200780023788 A CN 200780023788A CN 101479288 B CN101479288 B CN 101479288B
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CN
China
Prior art keywords
deoxynojirimycin
gba2
cftr
inhibitor
pentyl
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Expired - Fee Related
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CN2007800237886A
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English (en)
Chinese (zh)
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CN101479288A (zh
Inventor
J·M·F·G·阿尔特斯
R·G·布特
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Academisch Medisch Centrum
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Academic Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
CN2007800237886A 2006-04-24 2007-04-24 囊性纤维化的改进的治疗 Expired - Fee Related CN101479288B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79408806P 2006-04-24 2006-04-24
US60/794,088 2006-04-24
PCT/NL2007/050177 WO2007123403A1 (en) 2006-04-24 2007-04-24 Improved treatment of cystic fibrosis

Publications (2)

Publication Number Publication Date
CN101479288A CN101479288A (zh) 2009-07-08
CN101479288B true CN101479288B (zh) 2012-06-27

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ID=38283020

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800237886A Expired - Fee Related CN101479288B (zh) 2006-04-24 2007-04-24 囊性纤维化的改进的治疗

Country Status (10)

Country Link
US (1) US8410081B2 (https=)
EP (1) EP2010551B1 (https=)
JP (1) JP2009538276A (https=)
CN (1) CN101479288B (https=)
AT (1) ATE479696T1 (https=)
AU (1) AU2007241622A1 (https=)
BR (1) BRPI0710883A2 (https=)
CA (1) CA2650311A1 (https=)
DE (1) DE602007008870D1 (https=)
WO (1) WO2007123403A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0712494D0 (en) * 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
EP2398321B1 (en) 2009-02-23 2015-11-25 United Therapeutics Corporation Iminosugars and methods of treating viral diseases
EP2400843B1 (en) * 2009-02-24 2015-11-11 United Therapeutics Corporation Iminosugars and methods of treating arenaviral infections
ES2524361T3 (es) * 2009-06-12 2014-12-05 United Therapeutics Corporation Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus
CA2772813A1 (en) * 2009-09-04 2011-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Iminosugars and methods of treating filoviral diseases
JP5653438B2 (ja) * 2009-09-04 2015-01-14 ユナイテッド セラピューティクス コーポレイション オルトミクソウイルス感染の治療方法
CA2772807A1 (en) * 2009-09-04 2011-03-10 The Chancellor, Masters And Scholars Of The University Of Oxford Methods of treating poxviral infections
GB201000499D0 (en) 2010-01-13 2010-03-03 Fleet George W J Treatment of cystic fibrosis
WO2011095772A2 (en) 2010-02-04 2011-08-11 Summit Corporation Plc Novel iminosugar therapeutics
GB201006434D0 (en) 2010-04-19 2010-06-02 Summit Corp Plc Novel iminosugar combinations
LT2753346T (lt) 2011-09-07 2020-08-10 Mount Sinai School Of Medicine Ceramidazė ir ląstelių diferenciacija
ES2897825T3 (es) * 2012-06-01 2022-03-02 Icahn School Med Mount Sinai Niveles de ceramida en el tratamiento y prevención de infecciones
EP2929346A1 (en) * 2012-12-05 2015-10-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Diagnosis of cystic fibrosis
PT2968479T (pt) 2013-03-14 2019-08-07 Icahn School Med Mount Sinai Composições terapêuticas de ceramidase ácida e métodos de fabrico e utilização
EP3442514B1 (en) 2016-04-11 2021-06-16 Spedding Research Solutions Inhibitors of glucosylceramide degradation in the treatment of diseases of the motor units
PL3630725T3 (pl) 2017-06-01 2026-03-23 Idorsia Pharmaceuticals Ltd Postać krystaliczna n-butylodeoksygalaktonojirymycyny
KR20230169989A (ko) * 2021-03-12 2023-12-18 익셉젠 인크. 단백질 발현을 위한 시스템 및 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123055A2 (en) * 2004-06-14 2005-12-29 Musc Foundation For Research Development Methods for treating inflammatory disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE322900T1 (de) 1996-07-15 2006-04-15 Macrozyme Dnm B V Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitoren
AU5799500A (en) * 1999-06-29 2001-01-22 Mcgill University Human alpha 1,2-mannosidase
EP1528056A1 (en) * 2003-10-29 2005-05-04 Academisch Ziekenhuis bij de Universiteit van Amsterdam Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
FR2861991B1 (fr) * 2003-11-07 2008-01-18 Centre Nat Rech Scient Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose
US20100004156A1 (en) * 2005-07-27 2010-01-07 Shalesh Kaushal Small Compounds That Correct Protein Misfolding and Uses Thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123055A2 (en) * 2004-06-14 2005-12-29 Musc Foundation For Research Development Methods for treating inflammatory disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Herman S Overkleeft等.Generation of Specific Deoxynojirimycin-type Inhibitors of the Non-lysosomal Glucosylceramidase.《Journal of Biological Chemistry》.1998,第273卷(第41期),第26524-26525页. *

Also Published As

Publication number Publication date
EP2010551B1 (en) 2010-09-01
DE602007008870D1 (de) 2010-10-14
CN101479288A (zh) 2009-07-08
US8410081B2 (en) 2013-04-02
US20090186862A1 (en) 2009-07-23
AU2007241622A8 (en) 2008-12-04
AU2007241622A1 (en) 2007-11-01
EP2010551A1 (en) 2009-01-07
WO2007123403A1 (en) 2007-11-01
JP2009538276A (ja) 2009-11-05
ATE479696T1 (de) 2010-09-15
BRPI0710883A2 (pt) 2011-08-09
CA2650311A1 (en) 2007-11-01

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Granted publication date: 20120627

Termination date: 20140424