CN101456868B - 从萘夫西林钠水溶液中析出萘夫西林酸结晶的方法 - Google Patents
从萘夫西林钠水溶液中析出萘夫西林酸结晶的方法 Download PDFInfo
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- CN101456868B CN101456868B CN2008100802897A CN200810080289A CN101456868B CN 101456868 B CN101456868 B CN 101456868B CN 2008100802897 A CN2008100802897 A CN 2008100802897A CN 200810080289 A CN200810080289 A CN 200810080289A CN 101456868 B CN101456868 B CN 101456868B
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- CN
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- Prior art keywords
- nafcillin
- crystal
- water solution
- acid
- sodium water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- OCXSDHJRMYFTMA-KMFBOIRUSA-M nafcillin sodium monohydrate Chemical compound O.[Na+].C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C([O-])=O)=O)C(OCC)=CC=C21 OCXSDHJRMYFTMA-KMFBOIRUSA-M 0.000 title claims abstract description 36
- 229960000515 nafcillin Drugs 0.000 title claims abstract description 35
- GPXLMGHLHQJAGZ-JTDSTZFVSA-N nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 title claims abstract description 35
- 239000002253 acid Substances 0.000 title claims abstract description 34
- 229960001775 nafcillin sodium Drugs 0.000 title claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 239000013078 crystal Substances 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 19
- 238000002425 crystallisation Methods 0.000 claims abstract description 24
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 17
- 238000005406 washing Methods 0.000 claims abstract description 15
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000008213 purified water Substances 0.000 claims abstract description 9
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000008025 crystallization Effects 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 12
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 8
- 239000006210 lotion Substances 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- 239000000178 monomer Substances 0.000 claims description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 5
- 229920002554 vinyl polymer Polymers 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 239000000243 solution Substances 0.000 abstract description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract description 4
- 239000007864 aqueous solution Substances 0.000 abstract description 4
- 239000013557 residual solvent Substances 0.000 abstract description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 239000002535 acidifier Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003208 petroleum Substances 0.000 abstract 1
- 239000012065 filter cake Substances 0.000 description 5
- 239000011229 interlayer Substances 0.000 description 5
- 239000012266 salt solution Substances 0.000 description 5
- 238000001291 vacuum drying Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229940049954 penicillin Drugs 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- PTTPXKJBFFKCEK-UHFFFAOYSA-N 2-Methyl-4-heptanone Chemical compound CC(C)CC(=O)CC(C)C PTTPXKJBFFKCEK-UHFFFAOYSA-N 0.000 description 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 description 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010071699 Infectious pleural effusion Diseases 0.000 description 1
- 206010024652 Liver abscess Diseases 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010041925 Staphylococcal infections Diseases 0.000 description 1
- 150000001263 acyl chlorides Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 206010014665 endocarditis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- -1 open and stir Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2008100802897A CN101456868B (zh) | 2008-12-30 | 2008-12-30 | 从萘夫西林钠水溶液中析出萘夫西林酸结晶的方法 |
Applications Claiming Priority (1)
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CN2008100802897A CN101456868B (zh) | 2008-12-30 | 2008-12-30 | 从萘夫西林钠水溶液中析出萘夫西林酸结晶的方法 |
Publications (2)
Publication Number | Publication Date |
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CN101456868A CN101456868A (zh) | 2009-06-17 |
CN101456868B true CN101456868B (zh) | 2010-10-06 |
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CN2008100802897A Active CN101456868B (zh) | 2008-12-30 | 2008-12-30 | 从萘夫西林钠水溶液中析出萘夫西林酸结晶的方法 |
Country Status (1)
Country | Link |
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CN (1) | CN101456868B (zh) |
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- 2008-12-30 CN CN2008100802897A patent/CN101456868B/zh active Active
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CN101456868A (zh) | 2009-06-17 |
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Owner name: LONGCH GROUP GUARDDIAN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANXI BOKANG PHARMACEUTICAL CO., LTD. OF NCPC Effective date: 20140409 |
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Effective date of registration: 20140409 Address after: 030021 No. 1, Chemical Road, Jinyuan District, Shanxi, Taiyuan Patentee after: North Pharmaceutical Group Shanxi Bokang Pharmaceutical Co.,Ltd. Address before: 030021 No. 1, Chemical Road, Jinyuan District, Shanxi, Taiyuan Patentee before: North Pharmaceutical Group Shanxi Bokang Pharmaceutical Co.,Ltd. |
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Effective date of registration: 20191119 Address after: 100176 No.1, dize North Street, Beijing Economic and Technological Development Zone Patentee after: Beijing shengkejia Electronic Co., Ltd Address before: 030021 No. 1, Chemical Road, Jinyuan District, Shanxi, Taiyuan Patentee before: Langzhi Group Bokang Pharmaceutical Co., Ltd. |
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Effective date of registration: 20201120 Address after: No.8, Industrial Avenue, furniture base, Longling Industrial Park, Nankang District, Ganzhou City, Jiangxi Province Patentee after: LONCH GROUP JIANGXI PHARMACEUTICAL Co.,Ltd. Address before: 100176 No.1, dize North Street, Beijing Economic and Technological Development Zone Patentee before: Beijing shengkejia Electronic Co.,Ltd. |
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