CN101448823A - Azd1152的马来酸酯（盐）共晶体 - Google Patents
Azd1152的马来酸酯（盐）共晶体 Download PDFInfo
- Publication number
- CN101448823A CN101448823A CNA2007800179575A CN200780017957A CN101448823A CN 101448823 A CN101448823 A CN 101448823A CN A2007800179575 A CNA2007800179575 A CN A2007800179575A CN 200780017957 A CN200780017957 A CN 200780017957A CN 101448823 A CN101448823 A CN 101448823A
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- China
- Prior art keywords
- azd1152
- acid ester
- salt
- maleic acid
- eutectic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- GBJVVSCPOBPEIT-UHFFFAOYSA-N AZT-1152 Chemical compound N=1C=NC2=CC(OCCCN(CC)CCOP(O)(O)=O)=CC=C2C=1NC(=NN1)C=C1CC(=O)NC1=CC=CC(F)=C1 GBJVVSCPOBPEIT-UHFFFAOYSA-N 0.000 title claims 10
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| GB0609621.8 | 2006-05-16 |
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| CN101448823A true CN101448823A (zh) | 2009-06-03 |
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| AU (1) | AU2007251304A1 (https=) |
| BR (1) | BRPI0712791A2 (https=) |
| CA (1) | CA2650519A1 (https=) |
| CL (1) | CL2007001388A1 (https=) |
| EC (1) | ECSP088890A (https=) |
| GB (1) | GB0609621D0 (https=) |
| IL (1) | IL194862A0 (https=) |
| MX (1) | MX2008014550A (https=) |
| NO (1) | NO20084580L (https=) |
| RU (1) | RU2008149242A (https=) |
| SA (1) | SA07280243B1 (https=) |
| TW (1) | TW200813026A (https=) |
| UA (1) | UA95108C2 (https=) |
| UY (1) | UY30351A1 (https=) |
| WO (1) | WO2007132227A1 (https=) |
| ZA (1) | ZA200809172B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102869361A (zh) * | 2009-09-11 | 2013-01-09 | 安姆根有限公司 | 用于治疗耐抗有丝分裂剂的癌症的n-4(-((3-(2-氨基-4-嘧啶基)-2-吡啶基)氧基)苯基)-4-(4-甲基-2-噻吩基)-1-酞嗪胺 |
| CN105555315A (zh) * | 2013-09-16 | 2016-05-04 | 阿斯利康(瑞典)有限公司 | 治疗性聚合物纳米颗粒及其制备和使用方法 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003055491A1 (en) * | 2001-12-24 | 2003-07-10 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| CA2526285A1 (en) * | 2003-05-15 | 2004-12-23 | Arqule, Inc. | Inhibitors of p38 and methods of using the same |
| EP2258704A1 (en) * | 2004-10-19 | 2010-12-08 | ArQule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
| WO2007123892A2 (en) * | 2006-04-17 | 2007-11-01 | Arqule Inc. | Raf inhibitors and their uses |
| EP2361254A1 (en) * | 2008-12-05 | 2011-08-31 | ArQule, Inc. | Raf inhibitors and their uses |
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| HRP20210319T1 (hr) | 2014-03-26 | 2021-04-30 | Astex Therapeutics Ltd. | Kombinacije inhibitora fgfr i inhibitora igf1r |
| RU2715236C2 (ru) | 2014-03-26 | 2020-02-26 | Астекс Терапьютикс Лтд | Комбинации |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| TWI719960B (zh) | 2015-02-10 | 2021-03-01 | 英商阿斯迪克治療公司 | 新穎組成物 |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| EP3353164B1 (en) | 2015-09-23 | 2021-11-03 | Janssen Pharmaceutica, N.V. | Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer |
| US11155555B2 (en) | 2015-09-23 | 2021-10-26 | Janssen Pharmaceutica Nv | Compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003055491A1 (en) * | 2001-12-24 | 2003-07-10 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| SI1847539T1 (sl) * | 2002-12-24 | 2010-01-29 | Astrazeneca Ab | Kinazolinski derivati |
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2006
- 2006-05-16 GB GBGB0609621.8A patent/GB0609621D0/en not_active Ceased
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2007
- 2007-05-10 TW TW096116652A patent/TW200813026A/zh unknown
- 2007-05-14 EP EP07732795A patent/EP2027114A1/en not_active Withdrawn
- 2007-05-14 MX MX2008014550A patent/MX2008014550A/es active IP Right Grant
- 2007-05-14 KR KR1020087029569A patent/KR20090009297A/ko not_active Withdrawn
- 2007-05-14 CN CNA2007800179575A patent/CN101448823A/zh active Pending
- 2007-05-14 JP JP2009510536A patent/JP2009537498A/ja active Pending
- 2007-05-14 UA UAA200813934A patent/UA95108C2/ru unknown
- 2007-05-14 AU AU2007251304A patent/AU2007251304A1/en not_active Abandoned
- 2007-05-14 CA CA002650519A patent/CA2650519A1/en not_active Abandoned
- 2007-05-14 SA SA07280243A patent/SA07280243B1/ar unknown
- 2007-05-14 BR BRPI0712791-0A patent/BRPI0712791A2/pt not_active IP Right Cessation
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- 2008-11-03 NO NO20084580A patent/NO20084580L/no not_active Application Discontinuation
- 2008-11-14 EC EC2008008890A patent/ECSP088890A/es unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102869361A (zh) * | 2009-09-11 | 2013-01-09 | 安姆根有限公司 | 用于治疗耐抗有丝分裂剂的癌症的n-4(-((3-(2-氨基-4-嘧啶基)-2-吡啶基)氧基)苯基)-4-(4-甲基-2-噻吩基)-1-酞嗪胺 |
| CN105555315A (zh) * | 2013-09-16 | 2016-05-04 | 阿斯利康(瑞典)有限公司 | 治疗性聚合物纳米颗粒及其制备和使用方法 |
| CN105555315B (zh) * | 2013-09-16 | 2019-05-07 | 阿斯利康(瑞典)有限公司 | 治疗性聚合物纳米颗粒及其制备和使用方法 |
Also Published As
| Publication number | Publication date |
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| ECSP088890A (es) | 2008-12-30 |
| AU2007251304A1 (en) | 2007-11-22 |
| CL2007001388A1 (es) | 2008-01-18 |
| CA2650519A1 (en) | 2007-11-22 |
| UA95108C2 (en) | 2011-07-11 |
| WO2007132227A1 (en) | 2007-11-22 |
| GB0609621D0 (en) | 2006-06-21 |
| EP2027114A1 (en) | 2009-02-25 |
| NO20084580L (no) | 2009-02-05 |
| US20080045481A1 (en) | 2008-02-21 |
| RU2008149242A (ru) | 2010-06-27 |
| UY30351A1 (es) | 2008-01-02 |
| MX2008014550A (es) | 2008-11-27 |
| US7625910B2 (en) | 2009-12-01 |
| KR20090009297A (ko) | 2009-01-22 |
| ZA200809172B (en) | 2009-12-30 |
| JP2009537498A (ja) | 2009-10-29 |
| BRPI0712791A2 (pt) | 2012-09-04 |
| AR060963A1 (es) | 2008-07-23 |
| SA07280243B1 (ar) | 2010-12-01 |
| TW200813026A (en) | 2008-03-16 |
| IL194862A0 (en) | 2009-08-03 |
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Application publication date: 20090603 |