CN101422505B - Foot-and-mouth disease vaccine and immunological stress resistance agent of other livestock and poultry and use thereof - Google Patents
Foot-and-mouth disease vaccine and immunological stress resistance agent of other livestock and poultry and use thereof Download PDFInfo
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- CN101422505B CN101422505B CN2008101439152A CN200810143915A CN101422505B CN 101422505 B CN101422505 B CN 101422505B CN 2008101439152 A CN2008101439152 A CN 2008101439152A CN 200810143915 A CN200810143915 A CN 200810143915A CN 101422505 B CN101422505 B CN 101422505B
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Abstract
The invention aims to provide an anti immune stress agent for foot-and-mouth disease and other animal plagues, and the percent concentration of each component is as follows: liquorice extract: 5 to 10 percent, oligoisomaltose: 3 to 5 percent, vitamin C: 0.5 to 1 percent, carries (such as bran) and the like: 84 to 92 percent. The stress agent can also prepare functional complete feed, concentratedfeed or pre-mixed feeding stuffs. The anti immune stress agent has the advantages of effectively preventing allergy and body temperature raising after vaccination, promoting appetite, raising growth rate by over 8 percent, raising antibody level by over 30 percent, cutting down raising period for 3 to 5 days. The raw material used by the anti immune stress agent is simple and is suitable for massproduction.
Description
Technical field
The present invention relates to animal health and biological medicine and functional feed field, develop a kind of foot and mouth disease and veterinary vaccines immunological stress resistance agent, functional feed and application thereof.
Background technology
Immunological stress occurs allergy individually after being meant the animal inoculation vaccine, the minority fervescence, and most anorexia, (utilization as saccharide sharply increases, and gluconeogenesis and glycogenolysis quicken in the liver in the metabolism change; Elimination of nitrogen increases, and peripheral protein decomposes acceleration, and the skeletal muscle deposition reduces, and acute phase protein is synthetic to be increased), growth slows down, the phenomenon of breeding cycle prolongation.The immunological stress of pig occurs allergy individually after being meant vaccination, the minority fervescence, and food appears subtracting in major part, and growth slows down, the phenomenon that breeding cycle prolongs 3-5 days.In the Swine Production, the vaccine that piglet and fattening pig need inoculate has the 5-6 kind, and inoculation times has 8-10 time, and particularly before 60 ages in days, immunological stress intensity is bigger, to piglet growth development impact maximum.
Immunological stress also influences the prevention and control of applying usefulness and great eqpidemic disease of vaccine.Foot and mouth disease is acute, hot, the height contagious disease of artiodactyl beast (pig, cattle, sheep, camel, deer etc.) of the infecting both domestic animals and human that caused by foot and mouth disease virus.The primary disease infectiousness is extremely strong, propagates rapidly, often causes and is very popular, and produces particularly to herding that the cause of raising pigs causes very big harm, becomes the disease of the primary quarantine of whole world animal quarantine.The measure inoculation that prevention is mainly taked to foot and mouth disease at present, but foot-and-mouth disease vaccine systemic immune response especially severe, most masses are unwilling to pig, cattle, sheep inoculation, and prevention brings certain difficulty to foot and mouth disease.As Zhongning County in 2002 whole county piglet is imposed the inoculation of 5 part swine fever freeze-dried vaccines, 2mL foot and mouth disease oil seepage, and wear ear tag, often occur anaphylactic shock reaction after the immunity, through promptly separating applying treatment, seriously suffering from pig and die instantly individually; After Heihe City township in Heilongjiang Province's carries out foot-and-mouth disease vaccine injection, there were 13 sheep morbidities on October 15th, 2002, wherein had 3 sheep diseases feelings more serious, and scream, do not rise with crouching, accelerated breathing, visual mucous hyperemia, muscular tremor, the cud air-blowing, foam appears in bicker; Yang She town, Zhangjagang City, Jiangsu Province veterinary station has carried out the foot and mouth disease immunity afternoon on October 16th, 2003 to more than 180 goat that the 12 groups of Qian Renxiang in this city east, town village raise, in back 5 days of the immunity dead 13.
Immunological stress resistance agent and function corresponding forage have immunological stress resistance, improve the animal daily gain, improve feed conversion rate, improve function such as animal immune function.Therefore, particularly the stress agent and the function corresponding forage thereof of foot-and-mouth disease resistant vaccine is significant for the exploitation immunological stress resistance agent.
Summary of the invention
Purpose of the present invention aims to provide the immunological stress resistance agent of a kind of foot and mouth disease and other veterinary vaccines
Second purpose of the present invention provides the functional feed of the immunological stress resistance of foot and mouth disease and other veterinary vaccines
The 3rd purpose of the present invention provides the application process of immunological stress resistance agent and functional feed.
The objective of the invention is to realize by following manner:
A kind of foot and mouth disease and other veterinary vaccines immunological stress resistance agent comprise: Radix Glycyrrhizae extract, oligomeric isomaltose, vitamin C, carrier; Radix Glycyrrhizae extract accounts for the 5-10% of stress agent gross mass, and oligomeric isomaltose accounts for the 3-5% of stress agent gross mass, and vitamin C accounts for the 0.5-1% of stress agent gross mass, and carrier accounts for the 84-92% of stress agent gross mass.
Described carrier is: the bran dregs of rice or Maifanitum or zeolite powder
A kind of foot and mouth disease and other veterinary vaccines immunological stress resistance functional feed are that the functional complete feedstuff of immunological stress resistance, the functional concentrate feed of immunological stress resistance or immunological stress resistance functional premixing close material.
The functional complete feedstuff of described immunological stress resistance is to contain Radix Glycyrrhizae extract 500-1000 gram in complete feed per ton, oligomeric isomaltose 300-500 gram, vitamin C 50-100 gram; It is that Radix Glycyrrhizae extract, oligomeric isomaltose, ascorbic content are to restrain with Radix Glycyrrhizae extract 500-1000 in concentrated feed per ton or premixed feed that functional concentrate feed of described immunological stress resistance or immunological stress resistance functional premixing close material, oligomeric isomaltose 300-500 gram, vitamin C 50-100 gram multiply by their cycles of concentration respectively.
The application process of described foot and mouth disease and other veterinary vaccines immunological stress resistance agent is following steps: added immunological stress resistance agent mixing of the present invention in the 0.5-1.5% ratio in 4-8 days in former complete feedstuff of feeding before foot-and-mouth disease vaccine, the swine Fever Vaccine injection, fed 4-8 days, vaccinate continues to feed 8-15 days more then.
The application process of described foot and mouth disease and other veterinary vaccines immunological stress resistance functional feed is following steps: preceding 4-8 days the functional complete feedstuff 4-8 of the above-mentioned immunological stress resistance that begins to feed days of foot-and-mouth disease vaccine or swine Fever Vaccine injection, continue after the vaccinate to feed 8-15 days then again.
Described Radix Glycyrrhizae extract is available from Chinese Xi'an brilliant development in science and technology company limited difficult to understand.
Premixed feed is by trace element (ferrum, copper, manganese, zinc, iodine, selenium), and vitamin (A, D, E and B1, B2 etc.), aminoacid and disease-resistant growth-promoting medicine and carrier uniform mixing are by a certain percentage formed.And concentrated feed also claims the albumen concentrated feed, contains following material in its raw material: mineral comprises calcium hydrogen phosphate, stone powder (calcium powder) or conch meal; Trace element (as copper sulfate, manganese sulfate etc.); Aminoacid, antioxidant, antibiotic, protein feeds and multivitamin etc.
As required, with Radix Glycyrrhizae extract, oligomeric isomaltose, vitamin C and complete feed, concentrated feed or premixed feed mix homogeneously according to the above ratio promptly get foot and mouth disease and other veterinary vaccines immunological stress resistance functional feed.
The principle of the invention is that Radix Glycyrrhizae and extract thereof have the effect of glucocorticoid sample, thereby has antianaphylactic effect, the generation of energy inflammation-inhibiting medium and the work of release and inflammation-inhibiting medium are in order to mitigation symptoms, the present invention utilizes Radix Glycyrrhizae and proposition thereof to get this characteristic of thing just, thereby eliminates the particularly anaphylaxis that causes of foot-and-mouth disease vaccine of vaccine; On the other hand, Radix Glycyrrhizae and the effect of extract glucocorticoid thereof generate if life-time service also can influence antibody, and therefore, functional feed of the present invention service time was the best with 15 days; Oligomeric isomaltose also has the immunity of enhancement, improves the effect of antibody horizontal; VC etc. also generate with immunologic function antibody and are closely related, and also have anti-stress effect simultaneously.
The invention has the beneficial effects as follows: anaphylaxis, fervescence that effective vaccine immunological stress is caused, have appetite stimulator, improve the speed of growth more than 8%, antibody horizontal improves more than 20%, shortens breeding cycle 3-5 days.The raw material that the present invention uses is simple, easy to prepare, nontoxic, has no side effect, and is suitable for large-scale production, and cost-saved, is the particularly good method of foot-and-mouth disease vaccine immunological stress of vaccine immunological stress.
The specific embodiment
Following embodiment and embodiment are intended to further specify the present invention rather than restriction the present invention.
Prepare foot and mouth disease and veterinary vaccines immunological stress resistance agent by following percentage ratio: Radix Glycyrrhizae extract 5-10%, oligomeric isomaltose 3-5%, vitamin C 0.5-1%, bran dregs of rice 84-92%.
Prepare foot and mouth disease and veterinary vaccines immunological stress resistance functional feed by following addition: in complete feed per ton, contain Radix Glycyrrhizae extract 500-1000 gram, oligomeric isomaltose 300-500 gram, vitamin C 50-100 gram obtains the functional complete feedstuff of immunological stress resistance; Radix Glycyrrhizae extract, oligomeric isomaltose, ascorbic content are to restrain with Radix Glycyrrhizae extract 500-1000 in concentrated feed perhaps per ton or the premixed feed, oligomeric isomaltose 300-500 gram, vitamin C 50-100 gram multiply by their cycles of concentration respectively, obtains functional concentrate feed of immunological stress resistance or premix.
Embodiment 1:
Choose 24 of piglets, 12.4 kilograms of average weights are divided into three groups of A, B, C at random, 8 every group.The basis adequate diet is: corn 66%, Testa Tritici 8%, bean cake 22%, premix material 4%; In aforementioned basal diet, add immunological stress resistance agent 0.75% mix homogeneously of the present invention and obtain the immunological stress resistance functional feed.A organizes injecting normal saline, B group injection foot-and-mouth disease vaccine, and preceding 5 days immunological stress resistance functional feeds of feeding of C group injection inoculation vaccine, vaccinate continues to feed 10 days then.Measuring body temperature after the vaccinate in 2 hours and 12 hours respectively changes.A group body temperature does not change, and feed intake is normal; B raise respectively 1 degree and 0.7 degree have in second day crib and surplus expect; C organizes raise respectively 0.5 degree and 0.3 degree, and grazing speed was slower in second day, but did not have the material of remaining in the groove.Weigh after 10 days, measure feedstuff-meat ratio and daily gain respectively as following table:
Table 1: resist and exempt from stress agent to the daily gain of piglet and the influence of feedstuff-meat ratio
The above results shows that beneficial effect of the present invention significantly improves daily gain for better to have solved fervescence and allergy that foot-and-mouth disease vaccine causes, reduces feedstuff-meat ratio.
Embodiment 2
The functional complete feedstuff of immunological stress resistance of the present invention is fed, and all the other conditions are same as embodiment 1, and immunological stress resistance is respond well.
Claims (3)
1. a foot and mouth disease and other veterinary vaccines immunological stress resistance agent is characterized in that described immunological stress resistance agent is grouped into by following one-tenth: Radix Glycyrrhizae extract, oligomeric isomaltose, vitamin C, carrier; Radix Glycyrrhizae extract accounts for the 5-10% of described immunological stress resistance agent gross mass, oligomeric isomaltose accounts for the 3-5% of described immunological stress resistance agent gross mass, vitamin C accounts for the 0.5-1% of described immunological stress resistance agent gross mass, and carrier accounts for the 84-92% of described immunological stress resistance agent gross mass.
2. a kind of foot and mouth disease according to claim 1 and other veterinary vaccines immunological stress resistance agent is characterized in that described carrier is: the bran dregs of rice or Maifanitum or zeolite powder.
3. a foot and mouth disease and other veterinary vaccines immunological stress resistance functional feed is characterized in that described functional feed is that the functional complete feedstuff of immunological stress resistance, the functional concentrate feed of immunological stress resistance or immunological stress resistance functional premixing close material; The functional complete feedstuff of described immunological stress resistance is to contain Radix Glycyrrhizae extract 500-1000 gram in complete feed per ton, oligomeric isomaltose 300-500 gram, vitamin C 50-100 gram; It is that Radix Glycyrrhizae extract, oligomeric isomaltose, ascorbic content are to restrain with Radix Glycyrrhizae extract 500-1000 in concentrated feed per ton or premixed feed that functional concentrate feed of described immunological stress resistance or immunological stress resistance functional premixing close material, oligomeric isomaltose 300-500 gram, vitamin C 50-100 gram multiply by their cycles of concentration respectively.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101439152A CN101422505B (en) | 2008-12-12 | 2008-12-12 | Foot-and-mouth disease vaccine and immunological stress resistance agent of other livestock and poultry and use thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101439152A CN101422505B (en) | 2008-12-12 | 2008-12-12 | Foot-and-mouth disease vaccine and immunological stress resistance agent of other livestock and poultry and use thereof |
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| CN101422505A CN101422505A (en) | 2009-05-06 |
| CN101422505B true CN101422505B (en) | 2010-12-29 |
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| CN2008101439152A Active CN101422505B (en) | 2008-12-12 | 2008-12-12 | Foot-and-mouth disease vaccine and immunological stress resistance agent of other livestock and poultry and use thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102132766A (en) * | 2011-03-08 | 2011-07-27 | 塔里木大学 | Application of potenline-containing licorice extract in preparing animal feed or drinking water |
| CN109619286A (en) * | 2018-12-12 | 2019-04-16 | 长沙绿叶生物科技有限公司 | A kind of anti-vaccine immunity stress agent of broiler chicken and its application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223882A (en) * | 1998-01-20 | 1999-07-28 | 曹丽文 | Immunization powder |
| CN1618311A (en) * | 2003-11-17 | 2005-05-25 | 张静兴 | Method for prodn. composite herb medicine forage additive for pig |
| CN1225187C (en) * | 2003-04-16 | 2005-11-02 | 四川省川大三康生物工程股份有限公司 | Composite feed additive without antibiotic |
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2008
- 2008-12-12 CN CN2008101439152A patent/CN101422505B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1223882A (en) * | 1998-01-20 | 1999-07-28 | 曹丽文 | Immunization powder |
| CN1225187C (en) * | 2003-04-16 | 2005-11-02 | 四川省川大三康生物工程股份有限公司 | Composite feed additive without antibiotic |
| CN1618311A (en) * | 2003-11-17 | 2005-05-25 | 张静兴 | Method for prodn. composite herb medicine forage additive for pig |
Non-Patent Citations (3)
| Title |
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| 王光明等.动物接种疫苗后产生应激反应的处理.《黑龙江畜牧兽医》.2007,(第12期),第85页. * |
| 王文博等.甘草粗提物对螂的抗应激及免疫保护功效研究.《淡水渔业》.2007,第37卷(第4期),第3-6页. * |
| 秦俊文等.中草药抗应激作用的研究.《中兽医学杂志》.2000,(第4期),第30-31页. * |
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Effective date of registration: 20210114 Address after: 410125 Mapoling, Furong district, Changsha City, Hunan Province Patentee after: CHANGSHA LVYE BIOTECHNOLOGY Co.,Ltd. Address before: 410128, No. 1, Nongda Road, Furong district, Hunan, Changsha Patentee before: Hunan Agricultural University Patentee before: CHANGSHA LVYE BIOTECHNOLOGY Co.,Ltd. |
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