CN101421409A - 补体调控基因中预测年龄相关性黄斑变性的变体 - Google Patents

补体调控基因中预测年龄相关性黄斑变性的变体 Download PDF

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Publication number
CN101421409A
CN101421409A CN200780012906.3A CN200780012906A CN101421409A CN 101421409 A CN101421409 A CN 101421409A CN 200780012906 A CN200780012906 A CN 200780012906A CN 101421409 A CN101421409 A CN 101421409A
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gene
cfh
polymorphism
protein
amd
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CN200780012906.3A
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English (en)
Chinese (zh)
Inventor
R·L·阿利科麦茨
G·S·哈格曼
M·C·迪安
A·M·戈尔德
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University of Iowa Research Foundation UIRF
Columbia University in the City of New York
National Institutes of Health NIH
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University of Iowa Research Foundation UIRF
Columbia University in the City of New York
National Institutes of Health NIH
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Publication of CN101421409A publication Critical patent/CN101421409A/zh
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200780012906.3A 2006-02-13 2007-02-13 补体调控基因中预测年龄相关性黄斑变性的变体 Pending CN101421409A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77298906P 2006-02-13 2006-02-13
US60/772,989 2006-02-13

Publications (1)

Publication Number Publication Date
CN101421409A true CN101421409A (zh) 2009-04-29

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Country Link
EP (1) EP1989319A4 (https=)
JP (1) JP5290772B2 (https=)
CN (1) CN101421409A (https=)
AU (1) AU2007215218B2 (https=)
CA (1) CA2638916A1 (https=)
IL (1) IL193396A (https=)
NZ (1) NZ570431A (https=)
WO (1) WO2007095185A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102707068A (zh) * 2012-05-31 2012-10-03 北京大学 补体h因子用作甲基苯丙胺成瘾患者的基因表达产物中的应用
CN106999559A (zh) * 2014-12-19 2017-08-01 儿童医院医疗中心 与移植相关血栓性微血管病相关的方法和组合物
CN109082460A (zh) * 2018-09-27 2018-12-25 领航基因科技（杭州）有限公司 应用于snp分型的非竞争性探针设计方法、检测方法及应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8012683B2 (en) 2006-02-13 2011-09-06 University Of Iowa Research Foundation Variants in complement regulatory genes predict age-related macular degeneration
US20120141994A1 (en) * 2009-04-29 2012-06-07 Deangelis Margaret M Methods and compositions for prognosing and detecting age-related macular degeneration
CA2781595C (en) 2009-07-10 2016-07-05 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating macular degeneration
WO2011053774A1 (en) * 2009-10-30 2011-05-05 Alcon Research, Ltd. Single nucleotide polymorphisms and genes associated with age-related macular degeneration
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
US9475806B2 (en) 2013-03-14 2016-10-25 Novartis Ag Complement factor B inhibitors and uses there of
CN105849090A (zh) 2013-10-30 2016-08-10 诺华股份有限公司 2-苄基-苯并咪唑补体因子b抑制剂及其用途
EP3102701A1 (en) * 2014-02-07 2016-12-14 Novartis AG Impact of genetic factors on disease progression and response to anti-c5 antibody in geographic atrophy
CN116507741A (zh) * 2020-08-20 2023-07-28 基因组评论股份有限公司 年龄相关性黄斑变性诊断用生物标记物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001051A1 (en) 1983-09-02 1985-03-14 Molecular Biosystems, Inc. Oligonucleotide polymeric support system
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
EP0758403B1 (en) 1994-05-05 1998-06-24 Beckman Instruments, Inc. Oligonucleotide repeat arrays
US5985567A (en) 1997-08-15 1999-11-16 Beckman Coulter, Inc. Hybridization detection by pretreating bound single-stranded probes
US6013789A (en) 1998-02-20 2000-01-11 Beckman Coulter, Inc. Covalent attachment of biomolecules to derivatized polypropylene supports
JP2008520242A (ja) * 2004-11-18 2008-06-19 イェール ユニバーシティ 視覚障害を処置するための方法および組成物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102707068A (zh) * 2012-05-31 2012-10-03 北京大学 补体h因子用作甲基苯丙胺成瘾患者的基因表达产物中的应用
CN106999559A (zh) * 2014-12-19 2017-08-01 儿童医院医疗中心 与移植相关血栓性微血管病相关的方法和组合物
CN109082460A (zh) * 2018-09-27 2018-12-25 领航基因科技（杭州）有限公司 应用于snp分型的非竞争性探针设计方法、检测方法及应用
CN109082460B (zh) * 2018-09-27 2021-07-13 领航基因科技（杭州）有限公司 应用于snp分型的非竞争性探针设计方法、检测方法及应用

Also Published As

Publication number Publication date
EP1989319A2 (en) 2008-11-12
IL193396A0 (en) 2009-05-04
AU2007215218A1 (en) 2007-08-23
NZ570431A (en) 2011-12-22
EP1989319A4 (en) 2009-11-11
IL193396A (en) 2013-03-24
CA2638916A1 (en) 2007-08-23
WO2007095185A3 (en) 2008-09-25
JP2009526524A (ja) 2009-07-23
WO2007095185A2 (en) 2007-08-23
AU2007215218B2 (en) 2013-09-19
JP5290772B2 (ja) 2013-09-18

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