CN101415446A - 生产超极化的羧酸盐和磺酸盐的方法 - Google Patents

生产超极化的羧酸盐和磺酸盐的方法 Download PDF

Info

Publication number
CN101415446A
CN101415446A CNA2007800124375A CN200780012437A CN101415446A CN 101415446 A CN101415446 A CN 101415446A CN A2007800124375 A CNA2007800124375 A CN A2007800124375A CN 200780012437 A CN200780012437 A CN 200780012437A CN 101415446 A CN101415446 A CN 101415446A
Authority
CN
China
Prior art keywords
carboxylate
compositions
sulfonate
solution
pyruvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800124375A
Other languages
English (en)
Chinese (zh)
Inventor
M·H·勒切
M·卡尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN101415446A publication Critical patent/CN101415446A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2007800124375A 2006-03-29 2007-03-21 生产超极化的羧酸盐和磺酸盐的方法 Pending CN101415446A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20061435 2006-03-29
NO20061435 2006-03-29

Publications (1)

Publication Number Publication Date
CN101415446A true CN101415446A (zh) 2009-04-22

Family

ID=38541547

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800124375A Pending CN101415446A (zh) 2006-03-29 2007-03-21 生产超极化的羧酸盐和磺酸盐的方法

Country Status (5)

Country Link
US (1) US20100233096A1 (https=)
EP (1) EP1998813A2 (https=)
JP (1) JP2009531422A (https=)
CN (1) CN101415446A (https=)
WO (1) WO2007111515A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117180458A (zh) * 2023-08-31 2023-12-08 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020765A2 (en) * 2006-08-18 2008-02-21 Ge Healthcare As Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
EP2117607A4 (en) * 2007-01-11 2012-08-08 Huntington Medical Res Inst PICTURES AND METHOD FOR THEIR USE
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
JP2010534498A (ja) * 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
CN101854956B (zh) * 2007-08-27 2013-01-23 通用电气健康护理有限公司 包含超极化13c-醋酸盐的成像介质及其应用
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
KR101858269B1 (ko) * 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제
US20140328766A1 (en) * 2010-08-24 2014-11-06 Ge Healthcare Limited Composition and method for generating a metabolic profile using 13c-mr detection
EP2872520B1 (en) * 2012-07-13 2016-09-14 Bracco Imaging S.p.A Triarylmethyl radicals
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) * 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
IL143927A0 (en) * 1998-12-30 2002-04-21 Nycomed Amersham Plc Nmr spectroscopic in vitro assay using hyperpolarization
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
WO2006011809A1 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
CN101031811A (zh) * 2004-07-30 2007-09-05 通用电气医疗集团股份有限公司 肿瘤成像方法
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117180458A (zh) * 2023-08-31 2023-12-08 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用
CN117180458B (zh) * 2023-08-31 2024-08-09 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用

Also Published As

Publication number Publication date
JP2009531422A (ja) 2009-09-03
WO2007111515A2 (en) 2007-10-04
US20100233096A1 (en) 2010-09-16
EP1998813A2 (en) 2008-12-10
WO2007111515A3 (en) 2008-04-24

Similar Documents

Publication Publication Date Title
CN101415446A (zh) 生产超极化的羧酸盐和磺酸盐的方法
JP5475995B2 (ja) 動的核分極（ｄｎｐ）法
KR101502180B1 (ko) 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
JP2009517688A5 (https=)
CN101378784B (zh) 产生有机胺的超极化羧酸盐的方法
CN101970014A (zh) 包含超极化的13c-乳酸盐的成像介质及其用途
CN101932340A (zh) 生产超极化的氨基酸和氨基磺酸的方法
JP5535435B2 (ja) ラジカル及び、ｄｎｐ処理における常磁性試薬としてのその使用
CN101951963B (zh) Mr成像剂、成像介质和其中使用该成像介质的成像方法
CN101316616B (zh) 应用三苯甲基自由基和顺磁金属离子的动态核极化（dnp）的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20090422