CN101415446A - 生产超极化的羧酸盐和磺酸盐的方法 - Google Patents

生产超极化的羧酸盐和磺酸盐的方法 Download PDF

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Publication number
CN101415446A
CN101415446A CNA2007800124375A CN200780012437A CN101415446A CN 101415446 A CN101415446 A CN 101415446A CN A2007800124375 A CNA2007800124375 A CN A2007800124375A CN 200780012437 A CN200780012437 A CN 200780012437A CN 101415446 A CN101415446 A CN 101415446A
Authority
CN
China
Prior art keywords
carboxylate
compositions
sulfonate
solution
pyruvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800124375A
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English (en)
Chinese (zh)
Inventor
M·H·勒切
M·卡尔森
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GE Healthcare AS
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GE Healthcare AS
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Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Publication of CN101415446A publication Critical patent/CN101415446A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNA2007800124375A 2006-03-29 2007-03-21 生产超极化的羧酸盐和磺酸盐的方法 Pending CN101415446A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20061435 2006-03-29
NO20061435 2006-03-29

Publications (1)

Publication Number Publication Date
CN101415446A true CN101415446A (zh) 2009-04-22

Family

ID=38541547

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800124375A Pending CN101415446A (zh) 2006-03-29 2007-03-21 生产超极化的羧酸盐和磺酸盐的方法

Country Status (5)

Country Link
US (1) US20100233096A1 (https=)
EP (1) EP1998813A2 (https=)
JP (1) JP2009531422A (https=)
CN (1) CN101415446A (https=)
WO (1) WO2007111515A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117180458A (zh) * 2023-08-31 2023-12-08 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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EP2051739A2 (en) * 2006-08-18 2009-04-29 GE Healthcare AS Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
PL2180902T3 (pl) * 2007-08-27 2012-07-31 Ge Healthcare Ltd Ośrodek obrazujący zawierający hiperpolaryzowany ¹³C-octan oraz jego zastosowanie
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
JP5879333B2 (ja) 2010-05-03 2016-03-08 ジーイー・ヘルスケア・リミテッド Ｌｄｈ活性を決定するための過分極乳酸塩造影剤
US20140328766A1 (en) * 2010-08-24 2014-11-06 Ge Healthcare Limited Composition and method for generating a metabolic profile using 13c-mr detection
US9381257B2 (en) * 2012-07-13 2016-07-05 Bracco Imaging S.P.A. Triarylmethyl radicals
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
KR102934987B1 (ko) 2018-11-23 2026-03-09 바이엘 악티엔게젤샤프트 조영 매체의 제형 및 그의 제조 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3175940B2 (ja) * 1990-02-12 2001-06-11 ニコムド イノベーション アーベー トリアリールメチルラジカルおよび磁気共鳴造影法における不活性炭素フリーラジカルの用途
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US7501236B1 (en) * 1998-12-30 2009-03-10 Ge Healthcare Limited NMR spectroscopic in vitro assay using hyperpolarization
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
NZ552898A (en) * 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
WO2006011810A2 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Mr imaging method for the discrimination between healthy and tumour tissue
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117180458A (zh) * 2023-08-31 2023-12-08 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用
CN117180458B (zh) * 2023-08-31 2024-08-09 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用

Also Published As

Publication number Publication date
US20100233096A1 (en) 2010-09-16
JP2009531422A (ja) 2009-09-03
EP1998813A2 (en) 2008-12-10
WO2007111515A2 (en) 2007-10-04
WO2007111515A3 (en) 2008-04-24

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Open date: 20090422