JP2009531422A - 過分極カルボン酸塩及びスルホン酸塩の製造方法 - Google Patents

過分極カルボン酸塩及びスルホン酸塩の製造方法 Download PDF

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Publication number
JP2009531422A
JP2009531422A JP2009502708A JP2009502708A JP2009531422A JP 2009531422 A JP2009531422 A JP 2009531422A JP 2009502708 A JP2009502708 A JP 2009502708A JP 2009502708 A JP2009502708 A JP 2009502708A JP 2009531422 A JP2009531422 A JP 2009531422A
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Prior art keywords
carboxylate
sulfonate
composition
solution
hyperpolarized
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JP2009502708A
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Japanese (ja)
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JP2009531422A5 (https=
Inventor
レルチェ，マティルダ・エイチ
カールソン，マグナス
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ジーイー・ヘルスケア・アクスイェ・セルスカプ
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Publication of JP2009531422A publication Critical patent/JP2009531422A/ja
Publication of JP2009531422A5 publication Critical patent/JP2009531422A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009502708A 2006-03-29 2007-03-21 過分極カルボン酸塩及びスルホン酸塩の製造方法 Withdrawn JP2009531422A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20061435 2006-03-29
PCT/NO2007/000109 WO2007111515A2 (en) 2006-03-29 2007-03-21 Method to produce hyperpolarised carboxylates and sulphonates

Publications (2)

Publication Number Publication Date
JP2009531422A true JP2009531422A (ja) 2009-09-03
JP2009531422A5 JP2009531422A5 (https=) 2010-04-08

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ID=38541547

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JP2009502708A Withdrawn JP2009531422A (ja) 2006-03-29 2007-03-21 過分極カルボン酸塩及びスルホン酸塩の製造方法

Country Status (5)

Country Link
US (1) US20100233096A1 (https=)
EP (1) EP1998813A2 (https=)
JP (1) JP2009531422A (https=)
CN (1) CN101415446A (https=)
WO (1) WO2007111515A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008020765A2 (en) * 2006-08-18 2008-02-21 Ge Healthcare As Imaging medium comprising lactate and hyperpolarised 13c-pyruvate
EP2117607A4 (en) * 2007-01-11 2012-08-08 Huntington Medical Res Inst PICTURES AND METHOD FOR THEIR USE
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
JP2010534498A (ja) * 2007-07-26 2010-11-11 ジーイー・ヘルスケア・ユーケイ・リミテッド 方法及び該方法で使用するためのイメージング媒体
CN101854956B (zh) * 2007-08-27 2013-01-23 通用电气健康护理有限公司 包含超极化13c-醋酸盐的成像介质及其应用
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
KR101858269B1 (ko) * 2010-05-03 2018-05-15 지이 헬쓰케어 리미티드 락테이트 탈수소효소 활성의 측정을 위한 과분극화된 락테이트 조영제
US20140328766A1 (en) * 2010-08-24 2014-11-06 Ge Healthcare Limited Composition and method for generating a metabolic profile using 13c-mr detection
EP2872520B1 (en) * 2012-07-13 2016-09-14 Bracco Imaging S.p.A Triarylmethyl radicals
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法
CN117180458B (zh) * 2023-08-31 2024-08-09 中国科学院精密测量科学与技术创新研究院 草酰乙酸在溶融动态核极化中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012024A1 (en) * 1990-02-12 1991-08-22 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in mri
GB9020091D0 (en) * 1990-09-14 1990-10-24 Nycomed As Contrast media
GB9307027D0 (en) * 1993-04-02 1993-05-26 Nycomed Innovation Ab Free radicals
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
IL143927A0 (en) * 1998-12-30 2002-04-21 Nycomed Amersham Plc Nmr spectroscopic in vitro assay using hyperpolarization
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
WO2006011809A1 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
CN101031811A (zh) * 2004-07-30 2007-09-05 通用电气医疗集团股份有限公司 肿瘤成像方法
PL1962912T3 (pl) * 2005-12-16 2013-03-29 Ge Healthcare As Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych

Also Published As

Publication number Publication date
CN101415446A (zh) 2009-04-22
WO2007111515A2 (en) 2007-10-04
US20100233096A1 (en) 2010-09-16
EP1998813A2 (en) 2008-12-10
WO2007111515A3 (en) 2008-04-24

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