JP2009531422A5 - - Google Patents
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- Publication number
- JP2009531422A5 JP2009531422A5 JP2009502708A JP2009502708A JP2009531422A5 JP 2009531422 A5 JP2009531422 A5 JP 2009531422A5 JP 2009502708 A JP2009502708 A JP 2009502708A JP 2009502708 A JP2009502708 A JP 2009502708A JP 2009531422 A5 JP2009531422 A5 JP 2009531422A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxylate
- composition
- sulfonate
- solution
- hyperpolarised
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000007942 carboxylates Chemical class 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 9
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 7
- 150000001767 cationic compounds Chemical class 0.000 claims 5
- 229910001411 inorganic cation Inorganic materials 0.000 claims 5
- 241000255925 Diptera Species 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 230000005298 paramagnetic effect Effects 0.000 claims 4
- TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 claims 3
- 150000001734 carboxylic acid salts Chemical class 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 claims 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 2
- 230000008014 freezing Effects 0.000 claims 2
- 238000007710 freezing Methods 0.000 claims 2
- UHBYWPGGCSDKFX-VKHMYHEASA-N gamma-carboxy-L-glutamic acid Chemical compound OC(=O)[C@@H](N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-VKHMYHEASA-N 0.000 claims 2
- ODBLHEXUDAPZAU-UHFFFAOYSA-N isocitric acid Chemical compound OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 claims 2
- 229940049920 malate Drugs 0.000 claims 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical group OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 claims 2
- 230000010287 polarization Effects 0.000 claims 2
- GJAWHXHKYYXBSV-UHFFFAOYSA-N quinolinic acid Chemical compound OC(=O)C1=CC=CN=C1C(O)=O GJAWHXHKYYXBSV-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- QQZOPKMRPOGIEB-UHFFFAOYSA-N 2-Oxohexane Chemical class CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 claims 1
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims 1
- XNIHZNNZJHYHLC-UHFFFAOYSA-N 2-oxohexanoic acid Chemical compound CCCCC(=O)C(O)=O XNIHZNNZJHYHLC-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 claims 1
- 150000002602 lanthanoids Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 150000003871 sulfonates Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20061435 | 2006-03-29 | ||
| PCT/NO2007/000109 WO2007111515A2 (en) | 2006-03-29 | 2007-03-21 | Method to produce hyperpolarised carboxylates and sulphonates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009531422A JP2009531422A (ja) | 2009-09-03 |
| JP2009531422A5 true JP2009531422A5 (https=) | 2010-04-08 |
Family
ID=38541547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009502708A Withdrawn JP2009531422A (ja) | 2006-03-29 | 2007-03-21 | 過分極カルボン酸塩及びスルホン酸塩の製造方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100233096A1 (https=) |
| EP (1) | EP1998813A2 (https=) |
| JP (1) | JP2009531422A (https=) |
| CN (1) | CN101415446A (https=) |
| WO (1) | WO2007111515A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2051739A2 (en) * | 2006-08-18 | 2009-04-29 | GE Healthcare AS | Imaging medium comprising lactate and hyperpolarised 13c-pyruvate |
| WO2008086534A1 (en) * | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| US7470813B2 (en) | 2007-03-30 | 2008-12-30 | Ge Healthcare Limited | Method for the production of pyruvic acid |
| CN101970014A (zh) * | 2007-07-26 | 2011-02-09 | 通用电气医疗集团英国有限公司 | 包含超极化的13c-乳酸盐的成像介质及其用途 |
| PL2180902T3 (pl) * | 2007-08-27 | 2012-07-31 | Ge Healthcare Ltd | Ośrodek obrazujący zawierający hiperpolaryzowany ¹³C-octan oraz jego zastosowanie |
| EP2072061A1 (en) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| JP2011514313A (ja) * | 2008-02-04 | 2011-05-06 | ジーイー・ヘルスケア・リミテッド | 過分極アミノ酸及びアミノスルホン酸の製造方法 |
| AU2010230330B2 (en) | 2009-04-02 | 2015-06-25 | Ge Healthcare Limited | Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection |
| JP5879333B2 (ja) | 2010-05-03 | 2016-03-08 | ジーイー・ヘルスケア・リミテッド | Ｌｄｈ活性を決定するための過分極乳酸塩造影剤 |
| US20140328766A1 (en) * | 2010-08-24 | 2014-11-06 | Ge Healthcare Limited | Composition and method for generating a metabolic profile using 13c-mr detection |
| US9381257B2 (en) * | 2012-07-13 | 2016-07-05 | Bracco Imaging S.P.A. | Triarylmethyl radicals |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| ES2814555T3 (es) | 2016-11-28 | 2021-03-29 | Bayer Pharma AG | Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética |
| KR102934987B1 (ko) | 2018-11-23 | 2026-03-09 | 바이엘 악티엔게젤샤프트 | 조영 매체의 제형 및 그의 제조 방법 |
| CN117180458B (zh) * | 2023-08-31 | 2024-08-09 | 中国科学院精密测量科学与技术创新研究院 | 草酰乙酸在溶融动态核极化中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3175940B2 (ja) * | 1990-02-12 | 2001-06-11 | ニコムド イノベーション アーベー | トリアリールメチルラジカルおよび磁気共鳴造影法における不活性炭素フリーラジカルの用途 |
| GB9020091D0 (en) * | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| GB9307027D0 (en) * | 1993-04-02 | 1993-05-26 | Nycomed Innovation Ab | Free radicals |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US7501236B1 (en) * | 1998-12-30 | 2009-03-10 | Ge Healthcare Limited | NMR spectroscopic in vitro assay using hyperpolarization |
| NO20023357D0 (no) * | 2002-04-19 | 2002-07-11 | Amersham Health As | Blanding |
| NZ552898A (en) * | 2004-07-30 | 2011-02-25 | Ge Healthcare As | Method of producing a composition, composition and its use |
| WO2006011810A2 (en) * | 2004-07-30 | 2006-02-02 | Ge Healthcare As | Mr imaging method for the discrimination between healthy and tumour tissue |
| PL1962912T3 (pl) * | 2005-12-16 | 2013-03-29 | Ge Healthcare As | Sposób wytwarzania hiperpolaryzowanych karboksylanów amin organicznych |
-
2007
- 2007-03-21 US US12/294,937 patent/US20100233096A1/en not_active Abandoned
- 2007-03-21 WO PCT/NO2007/000109 patent/WO2007111515A2/en not_active Ceased
- 2007-03-21 JP JP2009502708A patent/JP2009531422A/ja not_active Withdrawn
- 2007-03-21 EP EP07747570A patent/EP1998813A2/en not_active Withdrawn
- 2007-03-21 CN CNA2007800124375A patent/CN101415446A/zh active Pending
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