CN101411725A - Anti-tumor halobios medicine for improving immunity function, and preparation method thereof - Google Patents
Anti-tumor halobios medicine for improving immunity function, and preparation method thereof Download PDFInfo
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- CN101411725A CN101411725A CNA2007101819000A CN200710181900A CN101411725A CN 101411725 A CN101411725 A CN 101411725A CN A2007101819000 A CNA2007101819000 A CN A2007101819000A CN 200710181900 A CN200710181900 A CN 200710181900A CN 101411725 A CN101411725 A CN 101411725A
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Abstract
The invention discloses a marine biological medicine for improving the function of immunity and resisting tumor and a preparation method thereof. The marine biological medicine is prepared through mixing raw materials of 80 to 125 grams of pearl, 125 to 135 grams of oyster and 100 to 135 grams of spirulina and auxiliary materials of magnesium stearate and carboxymethyl starch sodium. The preparation method has simple operation and low preparation cost; and the medicine has the characteristics of improving immunity function , resisting tumor, having no toxicity or side effect and the like, and is an effective medicine for improving immunity function of and resisting tumor.
Description
Technical field
The invention belongs to medical technical field, specifically, relate to that to adopt marine organisms Margarita, Concha Ostreae, spirulina be a kind of raising immunologic function, anti-tumor halobios medicine of raw material and preparation method thereof.
Background technology
At present, the compound preparation of making as raw material with Margarita, Concha Ostreae, spirulina etc.Margarita has good beauty functions and medical value widely.Compendium of Material Medica is rolled up six or four and is described below: " the Margarita salty in the mouth, sweet cold nontoxic, relieving palpitation point order.Be coated with face, make us moist good color.Be coated with brothers, peeling skin hangnail weighs down expectorant, removes speckle, stopping leak.Remove children's's fever (of children) accompanied by fear, the peace soul.The nebulousurine of only passing out semen is separated pox and is treated poison.Concha Ostreae multiple medicinal has been known to China physician, and Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is to put down in writing Concha Ostreae like this: its meat, sweet temperature is nontoxic, cooks that it is deficient to control, and separates erysipelas in the accent, mends married woman's vim and vigour.Eat raw with Rhizoma Zingiberis Recens vinegar, control erysipelas, dysphoria with smothery sensation is quenched the thirst after drinking.Process maximum phase of an eclipse U.S., make us the U.S. color of thin skin." wherein natural taurine, thought multiple function such as have the blood of falling ester, anticoagulant, raising body immunity enhance metabolism by medical circle, therefore to anticancer and prevent that the cancerous cell diffusion from also having curative effect preferably.Spirulina is described as the 21 century mankind's optimum food and health product by FAO (Food and Agriculture Organization of the United Nation) and World Health Organization (WHO) because of its abundant nutritive value, spirulina contains the growth of promotion cell, improve immunity, antitumor, radioprotective, defying age, endonuclease activity and DNA reparation are synthesized the important natural bioactivity substance that functions such as potentiation are arranged, this product adopts modern medicinal agents to learn a skill above-mentioned three kinds of ocean things is developed into Chinese traditional compound medicine, has and calms the nerves, regulates immunity and antitumor efficacy.
Summary of the invention
The object of the present invention is to provide a kind of be used to improve immunologic function, antineoplastic Chinese medicine, make it have tangible antitumor curative effect, and the characteristics that have no side effect.
A kind of raising immunologic function, anti-tumor halobios medicine and preparation method thereof, it is characterized in that: it is made by following raw materials according: Margarita, Concha Ostreae, spirulina, the ratio of their prescription weight is: 125g-80g:125g-135g:100g-135g; More than prescription adds magnesium stearate 3.5g, carboxymethylstach sodium 17.5g, makes 1000.
Described a kind of preparation method that improves immunologic function, anti-tumor halobios medicine is characterized in that: preparation process:
(1), with Margarita, Concha Ostreae, three kinds of raw material pulverize separately of spirulina 100 orders that sieve, 80 orders sieve magnesium stearate, two kinds of adjuvant pulverize separately of carboxymethylstach sodium again;
(2), the 100 order raw materials that will sieve: Margarita, Concha Ostreae, spirulina are pressed recipe quantity: 125:125:100,110:125:125,95:130:130,80:135:135; Adopt the fixed funnel method, a, by lubricant be angle of repose 47.4% Pulvis Talci as flowability, binding agent is 40% ethanol, disintegrating agent is 5% and 10% dried starch, CMS-Na 1%-0.5%; B, be in proper order: 4%, 5%, 6% by ethanol, Pulvis Talci, three factors vary scopes of carboxymethylstach sodium; 3%, 4%, 5%; 1%, 1.5%, 2%; Make moist granulation;
(3), the 100 order raw materials that will sieve: Margarita, Concha Ostreae, spirulina are pressed recipe quantity: 125:125:100,110:125:125,95:130:130,80:135:135; Adopt the fixed funnel method, a, by lubricant be angle of repose 47.4% Pulvis Talci as flowability, binding agent is 40% ethanol, disintegrating agent is 5% and 10% dried starch, CMS-Na1%-0.5%; B, be in proper order: 4%, 5%, 6% by ethanol, Pulvis Talci, three factors vary scopes of carboxymethylstach sodium; 3%, 4%, 5%; 1%, 1.5%, 2%; Make moist granulation and drop in the mixer, incorporation time 15-20 minute, after the check, put filling machine and be packed in the capsule, packing, warehouse-in with sieve 80 order magnesium stearate 3.5g, carboxymethylstach sodium 17.5g.
The invention has the beneficial effects as follows: preparation method of the present invention is simple to operate, and cost of manufacture is low, and this medicine has the immunologic function of raising, antitumor active drug.
The specific embodiment
Below in conjunction with embodiment the present invention is described.
Prescription drug: Margarita 125g, Concha Ostreae 125g, spirulina 100g, magnesium stearate 3.5g, carboxymethylstach sodium 17.5g, make 1000, every weight is: 0.371g.
Prescription drug: Margarita 110g, Concha Ostreae 125g, spirulina 125g, magnesium stearate 3.5g, carboxymethylstach sodium 17.5g, make 1000, every weight is: 0.381g.
Prescription drug: Margarita 95g, Concha Ostreae 130g, spirulina 130g, magnesium stearate 3.5g, carboxymethylstach sodium 17.5g, make 1000, every weight is: 0.376g.
Prescription drug: Margarita 80g, Concha Ostreae 135g, spirulina 135g, magnesium stearate 3.5g, carboxymethylstach sodium 17.5g, make 1000, every weight is: 0.371g.
Preparation process, (1), with Margarita, Concha Ostreae, three kinds of raw material pulverize separately of spirulina 100 orders that sieve, 80 orders sieve magnesium stearate, two kinds of adjuvant pulverize separately of carboxymethylstach sodium again;
(2), the 100 order raw materials that will sieve: Margarita, Concha Ostreae, spirulina are pressed recipe quantity: 125:125:100,110:125:125,95:130:130,80:135:135; Adopt the fixed funnel method, a, by lubricant be angle of repose 47.4% Pulvis Talci as flowability, binding agent is 40% ethanol, disintegrating agent is 5% and 10% dried starch, CMS-Na1%-0.5%; B, be in proper order: 4%, 5%, 6% by ethanol, Pulvis Talci, three factors vary scopes of carboxymethylstach sodium; 3%, 4%, 5%; 1%, 1.5%, 2%; Make moist granulation;
(3), the 100 order raw materials that will sieve: Margarita, Concha Ostreae, spirulina are pressed recipe quantity: 125:125:100,110:125:125,95:130:130,80:135:135; Adopt the fixed funnel method, a, by lubricant end the angle be 47.4% Pulvis Talci as flowability, binding agent is 40% ethanol, disintegrating agent is 5% and 10% dried starch, CMS-Na1%-0.5%; B, be in proper order: 4%, 5%, 6% by ethanol, Pulvis Talci, three factors vary scopes of carboxymethylstach sodium; 3%, 4%, 5%; 1%, 1.5%, 2%; Make moist granulation and drop in the mixer, incorporation time 15-20 minute, after the check, put filling machine and be packed in the capsule, packing, warehouse-in with sieve 80 order magnesium stearate 3.5g, carboxymethylstach sodium 17.5g.
The present invention carries out the pharmacological toxicology test, and the maximum tolerated dose that shows the mice oral administration is more than 10g/kg, and subcutaneous injection administration maximum tolerated dose is greater than 5g/kg.Show that from result of the test the present invention can make macrophage phagocytosis of mice obviously increase, mice spleen weight and thymic weight coefficient increase, and absorbing in the body of calcium increases.
Claims (2)
1, a kind of raising immunologic function, anti-tumor halobios medicine and preparation method thereof, it is characterized in that: it is made by following raw materials according: Margarita, Concha Ostreae, spirulina, the ratio of their prescription weight is: 125g-80g:125g-135g:100g-135g; More than prescription adds magnesium stearate 3.5g, carboxymethylstach sodium 17.5g, makes 1000.
2, a kind of preparation method that improves immunologic function, anti-tumor halobios medicine according to claim 1 is characterized in that: preparation process:
(1), with Margarita, Concha Ostreae, three kinds of raw material pulverize separately of spirulina 100 orders that sieve, 80 orders sieve magnesium stearate, two kinds of adjuvant pulverize separately of carboxymethylstach sodium again;
(2), the 100 order raw materials that will sieve: Margarita, Concha Ostreae, spirulina are pressed recipe quantity: 125:125:100,110:125:125,95:130:130,80:135:135; Adopt the fixed funnel method, a, by lubricant end the angle be 47.4% Pulvis Talci as flowability, binding agent is 40% ethanol, disintegrating agent is 5% and 10% dried starch, CMS-Na1%-0.5%; B, be in proper order: 4%, 5%, 6% by ethanol, Pulvis Talci, three factors vary scopes of carboxymethylstach sodium; 3%, 4%, 5%; 1%, 1.5%, 2%; Make moist granulation;
(3), the 100 order raw materials that will sieve: Margarita, Concha Ostreae, spirulina are pressed recipe quantity: 125:125:100,110:125:125,95:130:130,80:135:135; Adopt the fixed funnel method, a, by lubricant end the angle be 47.4% Pulvis Talci as flowability, binding agent is 40% ethanol, disintegrating agent is 5% and 10% dried starch, CMS-Na1%-0.5%; B, be in proper order: 4%, 5%, 6% by ethanol, Pulvis Talci, three factors vary scopes of carboxymethylstach sodium; 3%, 4%, 5%; 1%, 1.5%, 2%; Make moist granulation and drop in the mixer, incorporation time 15-20 minute, after the check, put filling machine and be packed in the capsule, packing, warehouse-in with sieve 80 order magnesium stearate 3.5g, carboxymethylstach sodium 17.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101819000A CN101411725B (en) | 2007-10-15 | 2007-10-15 | Anti-tumor halobios medicine for improving immunity function, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101819000A CN101411725B (en) | 2007-10-15 | 2007-10-15 | Anti-tumor halobios medicine for improving immunity function, and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101411725A true CN101411725A (en) | 2009-04-22 |
| CN101411725B CN101411725B (en) | 2012-04-18 |
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| CN2007101819000A Expired - Fee Related CN101411725B (en) | 2007-10-15 | 2007-10-15 | Anti-tumor halobios medicine for improving immunity function, and preparation method thereof |
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| CN (1) | CN101411725B (en) |
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- 2007-10-15 CN CN2007101819000A patent/CN101411725B/en not_active Expired - Fee Related
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| CN101411725B (en) | 2012-04-18 |
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