CN108888750A - Cordyceps sinensis pueraria lobata compound with function of blood sugar reduction - Google Patents
Cordyceps sinensis pueraria lobata compound with function of blood sugar reduction Download PDFInfo
- Publication number
- CN108888750A CN108888750A CN201810832598.9A CN201810832598A CN108888750A CN 108888750 A CN108888750 A CN 108888750A CN 201810832598 A CN201810832598 A CN 201810832598A CN 108888750 A CN108888750 A CN 108888750A
- Authority
- CN
- China
- Prior art keywords
- cordyceps sinensis
- compound
- cordyceps
- polysaccharide
- function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Immunology (AREA)
Abstract
The invention belongs to pharmaceutical technology fields, and in particular to a kind of cordyceps sinensis pueraria lobata compound with function of blood sugar reduction, the cordyceps sinensis pueraria lobata compound includes the ingredient of following weight ratio：Cordyceps sinensis polysaccharide compound 25-35%, kudzu-vine root powder 15-25%, Chinese yam 10-20%, okra 10-20%, soy peptide powder 8-12%, lotus leaf 8-12%, surplus are medical or health care of food auxiliary material.The present invention more preferably plays the drug effect of Cordyceps sinensis polysaccharide compound by the raw materials such as compatibility Soyprotein peptide, while further through the particularity of Cordyceps sinensis polysaccharide compound, realization kudzu-vine root powder, Soyprotein peptide, Chinese yam, okra, and lotus leaf effect further enhances；It realizes comprehensive reducing blood lipid, blood pressure and blood glucose, is proved in practice more excellent to hypoglycemic effect is reduced.And the present invention uses security level highest, it can the foodstuff raw material for not limiting dosage carries out reasonable compatibility, has both effect and safety, without side-effects, and without dose limit.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of cordyceps sinensis pueraria lobata compound with function of blood sugar reduction.
Background technique
Diabetes are a kind of serious chronic diseases, when pancreas can not produce enough insulin or human body can not be effectively
When using generated insulin, it just will appear diabetes.Diabetes seriously threaten human health, with living standard by
Gradually improving, social population's Aging Problem is more serious, and the number of patients of diabetes is all being risen every year with the speed of quickening, it
The disease incidence increasingly increased has seriously threatened human health, affects people's lives quality, therefore develop with health care function
The antidiabetic drug of energy is extremely urgent.
Cordyceps sinensis polysaccharide contained in cordyceps sinensis is that cordyceps sinensis in-vivo content is most abundant, one of most important bioactive substance,
With extensive pharmacological action.Resource increasingly failure in recent years, people attempt culture cordyceps mycelia, fructification makees natural cs
Substitution, has obtained different degrees of approval.First class national new drug cordyceps are to use to isolate cordyceps sinensis from natural cs
Strain, the fermentation of artificial medium body and solid culture are made.
Cordyceps militaris is Ascomycota, meat seat mesh, cordyceps sinensis Cordycepps, the type sepecies of Cordyceps also known as northern Chinese caterpillar Fungus, Cordceps militaris
Deng.Cordyceps militaris has realized artificial cultivation at present.Cordycepin, cordycepic acid and Cordyceps sinensis polysaccharide compound are the distinctive objects of aweto
Matter is the main indicator of cordyceps sinensis special efficacy.And exactly these indexs, the north grown under the conditions of artificial environment is affluent
Cordyceps sinensis content can be grown higher than life under natural endowment.The protein for the northern Chinese caterpillar Fungus manually cultivated, amino acid, dimension
Raw element equal size meets or exceeds the level of natural cordyceps.Although individual nutrition in the northern Chinese caterpillar Fungus manually cultivated
Ingredient is slightly below natural cordyceps level, but these nutritional ingredients can be improved by research.
As cordyceps sinensis tradition effect is constantly excavated, especially the corresponding pharmacological research of cordyceps sinensis composition and clinical efficacy fruit be all
The affirmative of consumer has been obtained, as the drug of raw material and food has been protected using cordyceps sinensis, health care product is gradually developed and enters market.According to state
Food and medicine Surveillance Authority of family data query as a result, domestic health-care food contg. Chinese caterpillar fungus is largely former grass or to cultivate cordyceps sinensis direct
Sale, or carry out playing the roughing such as powder, tabletting sale, two drawbacks are supplied with health food made of simple cordyceps sinensis.
One to allow for cordyceps sinensis expensive, and single-item reaches that effect same day taking dose is larger, and product price is higher, and
Ordinary consumer is enabled to be difficult to bear；
Second is that being not based on Basic Theories of Chinese Medicine, its maximum efficiency is played by Chinese medicine monarch, minister compatibility, and makes health care efficiency
It is more prominent.
It is mostly sold currently on the market with simple cordyceps sinensis fresh grass, hay raw material, cordyceps sinensis deep processed product kind analogy
Few compared with single and quantity, cordyceps sinensis composition market is largely moved towards based on high-end medical product, seriously constrains the attached of cordyceps sinensis combination
Price markup value and economic benefit.And existing cordyceps sinensis beverage formulation production technology is not reasonable, so that active constituent is destroyed, nutrients
Matter loss is excessive, and unbalanced nutrition, health-care effect are unobvious；In addition excessive auxiliary material is added in process of producing product, as sucrose,
Preservative, artificial color etc. damage consumer's health, are unable to satisfy the demand of consumer's nourishing and health preserving.
Summary of the invention
The present invention is in view of the above-mentioned problems, propose a kind of Cordyceps sinensis polysaccharide compound, Soyprotein peptide, kudzu-vine root powder, Chinese yam, yellow
The compatibility of gumbo and lotus leaf, to solve the defect of prior art worm grass product, reaching with Cordyceps sinensis polysaccharide compound is that monarch part is main
It leads, be equipped with Soyprotein peptide, kudzu-vine root powder, Chinese yam, okra and lotus leaf form, and it is synergistic, blood glucose, blood lipid and blood pressure are reduced,
Especially hypoglycemic purpose.
The technical solution adopted by the present invention is as follows：
The present invention provides a kind of cordyceps sinensis pueraria lobata compound with function of blood sugar reduction, the ingredient including following weight ratio：
Cordyceps sinensis polysaccharide compound 25-35%, kudzu-vine root powder 15-25%, Chinese yam 10-20%, okra 10-20%, soybean peptide
Powder 8-12%, lotus leaf 8-12%, surplus are medical or health care of food auxiliary material,
The Cordyceps sinensis polysaccharide compound includes Cordyceps sinensis polysaccharide and cordyceps sinensis basic ingredient, wherein the cordyceps sinensis basic ingredient is selected from
It is one of following：
The extract or concentrate of cordyceps sinensis powder or fermented cordyceps hypha body；
Wherein cordyceps sinensis is Cordyceps sinensis fungus parasitism and the fungus combination that can generate fructification, including cordyceps sinensis, pupa worm
Other kinds of grass and Cordyceps.
Further, the cordyceps sinensis is Cordyceps militaris.
Further, polysaccharide or liquid fermentation and culture cordyceps mycelium that the Cordyceps sinensis polysaccharide utilizes Cordyceps militaris to extract,
Then Cordyceps sinensis polysaccharide is extracted from fermentation liquid to be purified.
Further, the mass fraction of Cordyceps sinensis polysaccharide is 20%-35% in the Cordyceps sinensis polysaccharide compound.
Further, the cordyceps sinensis Gegen tablets with function of blood sugar reduction are by following weight ratio at being grouped as：Cordyceps sinensis polysaccharide
Compound 30%, kudzu-vine root powder 20%, Chinese yam 15%, okra 15%, soy peptide powder 10%, lotus leaf 10%.
Further, the mass fraction of Cordyceps sinensis polysaccharide is 30% in the Cordyceps sinensis polysaccharide compound.
Further, tablet is made in the cordyceps sinensis pueraria lobata compound.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention is that monarch part dominates, is equipped with Soyprotein peptide with Cordyceps sinensis polysaccharide compound, kudzu-vine root powder, Chinese yam, okra and
Lotus leaf forms, synergistic, and the effective component contained by cordyceps sinensis realizes the synergy of the two as formula basis.Have in cordyceps sinensis
Repetition value in effect component base formula plus the compound prescription of high-content polysaccharide is disease prevention to human body, treats, prolongs
It lengthens one's life in year more accurate, more efficient, more rationally and balanced.Pure polysaccharide high-content also reaches far away above-mentioned expected mesh in practice
Mark, and inventor reaches cordyceps sinensis basis effective ingredient (or the enriched basic of highest threshold values by studying for many years and practice discovery
Effective ingredient) when mixing high-content polysaccharide to the preventing, treating of human diseases, promoting longevity reaches optimum efficiency.And cordyceps sinensis
Human body can be enhanced to the assimilation effect of other substances, thus the effect of promoting other compositions in polysaccharide compound.
The pueraria lobata smell being added in the present invention is sweet, pungent, flat, nontoxic.Cure mainly quench one's thirst, high fever of the body, vomiting, all numbness, rise negative gas,
Solve all poison.Cure the wound it is cold in wind headache, expelling pathogenic factors from muscles and skin delivers perspirations, opens and space between skin and muscles, treat metal-inflicted wound, only rib wind is bitterly.It controls gas on day row and vomits inverse, open
It is eaten under stomach, relieving alcoholism.
Contain a large amount of Puerarin and Flavonoid substances in pueraria lobata, these substances have coronary artery dilator and cerebral artery
Effect, can reduce blood pressure, can dramatically increase the blood supply amount of ischemic tissue, have B1 by health body blocking effect, can obviously subtract
The slow heart is overworked, reduces oxygen consumption of myocardium, can mitigate myocardial ischemia, limitation and diminution myocardial infarct size, Antitachycardiac agents, energy
Cholesterol and blood viscosity are reduced, platelet aggregation is inhibited, improves microcirculation.
More than 10 kinds of amino acid and 10 various trace elements in pueraria lobata also containing human body needs, greasy antipyretic, expelling phlegm and arresting coughing, drop
Blood glucose, can heat-clearing should the pharmacological actions such as cool blood, antibacterial anti-inflammatory, antiallergy, antiviral, anti-diabetic complication；With it is anti-from
By base, anti-oxidant, anticancer and the immunity for enhancing human body and other effects.
Soyprotein peptide, at home and abroad research quickly recover from fatigue it has been confirmed that having, enhance muscle strength, promote energy
Metabolism and weight-reducing, alleviate after drinking sense of discomfort, slow down stress improve attention, norcholesterol, hypoglycemic, blood pressure lowering, drop blood
The healthy functions such as rouge, enhancing immunocompetence, are known as " super amino acid ".
Chinese yam contains a large amount of mucin.Mucin is a kind of mixture of proteinpolysaccharide, and it is special to have to human body
Health-care effect can prevent fatty depositing on angiocarpy, keep blood vessel elasticity, and atherosclerosis is prevented to occur to early；It can subtract
Few subcutaneous fat deposits；It can prevent the atrophy of connective tissue, the generation of the collagen diseases such as prevention rheumatoid arthritis, chorionitis.Its
Contained dopamine has expansion blood vessel, improves sanguimotor critical function.
Contain water soluble pectin and mucin in the mucus of okra, sugar can be slowed down and absorb, lower human body to insulin
Demand, inhibit cholesterol absorption, can improve blood lipid, exclude toxin；Carotenoid abundant in gumbo, can maintain pancreas islet
The normal secretions of element and effect, balance blood sugar.
Lotus leaf has the effect of summer heat relieving and dampness eliminating, invigorating the spleen rising Yang, dissipating stasis and stanching bleeding, and alkaloid therein has effect for reducing blood fat, and
Clinically it is usually used in the treatment of obesity.
The present invention more preferably plays the drug effect of Cordyceps sinensis polysaccharide compound by the raw materials such as compatibility Soyprotein peptide, while further through
The particularity of Cordyceps sinensis polysaccharide compound realizes kudzu-vine root powder, Soyprotein peptide, Chinese yam, okra, the further increasing of lotus leaf effect
By force；It realizes comprehensive reducing blood lipid, blood pressure and blood glucose, is proved in practice more excellent to hypoglycemic effect is reduced.And the present invention is eaten using medicine
Homologous raw material, using security level highest, it can the foodstuff raw material for not limiting dosage carries out reasonable compatibility, has both effect
And safety, it is without side-effects, and without dose limit.
Detailed description of the invention
Fig. 1 is the blood glucose level column diagram of mouse after being administered 4 weeks, compared with negative control group * * P < 0.01；
Fig. 2 is 21 days Mouse oral dosis tolerata area under the curve column diagrams of administration, compared with negative control group * * P <
0.01。
Specific embodiment：
Combined with specific embodiments below, the present invention will be described in detail.
Embodiment 1
Cordyceps sinensis Gegen tablets with function of blood sugar reduction
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after culture 5 days, is extracted the Cordyceps sinensis polysaccharide in culture, is extracted
Method uses the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and is greater than 90%
Cordyceps sinensis polysaccharide.
Another insect-taking grass Mycelium culture is concentrated, and obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, and by weight hundred
Score, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
There are the cordyceps sinensis Gegen tablets of function of blood sugar reduction by the configuration of following mass fraction：
Cordyceps sinensis polysaccharide compound 25%, kudzu-vine root powder 25%, Chinese yam 15%, okra 15%, soy peptide powder 10%, lotus leaf
10%, obtain the cordyceps sinensis Gegen tablets with function of blood sugar reduction.
It is demonstrated experimentally that the obtained cordyceps sinensis compound of the present embodiment can be used as food consumption, blood sugar decreasing effect is good.
Embodiment 2
Cordyceps sinensis Gegen tablets with function of blood sugar reduction
Cordyceps mycelium is taken, liquid fermentation method is cultivated, and after culture 8 days, is extracted the Cordyceps sinensis polysaccharide in culture, is mentioned
Take method using the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then slightly more to cordyceps sinensis
Sugar is purified, and the Cordyceps sinensis polysaccharide that purity is greater than 95% is obtained.
Separately cordyceps mycelium culture is taken to be concentrated, obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, by weight
Percentage, 25% Cordyceps sinensis polysaccharide, 75% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
There are the cordyceps sinensis Gegen tablets of function of blood sugar reduction by the configuration of following mass fraction：
Cordyceps sinensis polysaccharide compound 30%, kudzu-vine root powder 20%, Chinese yam 15%, okra 16%, soy peptide powder 9%, lotus leaf
8%, maltodextrin 2% obtains the cordyceps sinensis pueraria lobata compound with function of blood sugar reduction.Tablet is made in tabletting after preparation.
Embodiment 3
Cordyceps sinensis Gegen tablets with function of blood sugar reduction
Cordyceps mycelium is taken, liquid fermentation method is cultivated, after culture 10 days, the Cordyceps sinensis polysaccharide in culture is extracted,
Extracting method uses the prior art.The present embodiment selection is extracted with water extraction, obtains cordyceps sinensis Thick many candies.Then thick to cordyceps sinensis
Polysaccharide is purified, and it is multiple to obtain Cordyceps sinensis polysaccharide of the purity greater than 99%.
Separately cordyceps mycelium culture is taken to be concentrated, obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, by weight
Percentage, 35% Cordyceps sinensis polysaccharide, 65% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
There are the cordyceps sinensis Gegen tablets of function of blood sugar reduction by the configuration of following mass fraction：
Cordyceps sinensis polysaccharide compound 30%, kudzu-vine root powder 20%, Chinese yam 15%, okra 15%, soy peptide powder 10%, lotus leaf
10%, obtain cordyceps sinensis pueraria lobata compound.Tablet is made in tabletting after preparation.Medicinal or food can also be added during film-making and use it
His auxiliary material, including excipient, thickener, flavoring agent etc..
Embodiment 4
Cordyceps sinensis Gegen tablets with function of blood sugar reduction
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after culture 5 days, is extracted the Cordyceps sinensis polysaccharide in culture, is extracted
Method uses the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and is greater than 90%
Cordyceps sinensis polysaccharide.
Another insect-taking grass Mycelium culture is concentrated, and obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, and by weight hundred
Score, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
There are the cordyceps sinensis Gegen tablets of function of blood sugar reduction by the configuration of following mass fraction：
Cordyceps sinensis polysaccharide compound 30%, kudzu-vine root powder 20%, Chinese yam 15%, okra 15%, soy peptide powder 10%, lotus leaf
10%, obtain the cordyceps sinensis Gegen tablets with function of blood sugar reduction.
Embodiment 5
Cordyceps sinensis Gegen tablets with function of blood sugar reduction
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after culture 5 days, is extracted the Cordyceps sinensis polysaccharide in culture, is extracted
Method uses the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and is greater than 95%
Cordyceps sinensis polysaccharide.
Another insect-taking grass Mycelium culture is concentrated, and obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, and by weight hundred
Score, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
There are the cordyceps sinensis Gegen tablets of function of blood sugar reduction by the configuration of following mass fraction：
Cordyceps sinensis polysaccharide compound 40%, kudzu-vine root powder 20%, Chinese yam 10%, okra 10%, soy peptide powder 10%, lotus leaf
10%, tabletting obtains the cordyceps sinensis Gegen tablets with function of blood sugar reduction.
Embodiment 6
Cordyceps sinensis Gegen tablets with function of blood sugar reduction
Cordyceps mycelia is taken, liquid fermentation method is cultivated, and after culture 5 days, is extracted the Cordyceps sinensis polysaccharide in culture, is extracted
Method uses the prior art, obtains cordyceps sinensis Thick many candies.Then cordyceps sinensis Thick many candies are purified, obtains purity and is greater than 95%
Cordyceps sinensis polysaccharide.
Another insect-taking grass Mycelium culture is concentrated, and obtains cordyceps sinensis culture solution concentrate after 10 times of concentration, and by weight hundred
Score, 30% Cordyceps sinensis polysaccharide, 70% cordyceps sinensis culture solution concentrate configure Cordyceps sinensis polysaccharide compound.
There are the cordyceps sinensis Gegen tablets of function of blood sugar reduction by the configuration of following mass fraction：
Cordyceps sinensis polysaccharide compound 20%, kudzu-vine root powder 30%, Chinese yam 10%, okra 15%, soy peptide powder 15%, lotus leaf
10%, tabletting obtains the cordyceps sinensis Gegen tablets with function of blood sugar reduction.
Embodiment 7：Cordyceps sinensis pueraria lobata compound hypoglycemic experimental study
(1) foundation of diabetic mouse model
Modeling mouse Kunming mouse 60, male are taken, weight 18-22g is drunk after adaptable fed 3 days containing glucose
15% syrup, food is normal, feeds 7 days, models after mouse fasting 12 hours, and modeling drug is alloxan, abdominal cavity note
It penetrates, measures 150mg/kg.Stomach-filling in 3 hours contains 25% glucose 1ml/100g after injection, with glucose kit measurement mouse
Blood glucose value selects blood glucose value >=11.0mmol/L mouse 36, is grouped experiment, and every group 4, in order to facilitate embodiment 1-
6 obtained cordyceps sinensis Gegen tablets are successively named as sample 1-6, dosage 80mg/kg, and negative control group is physiological saline, positive control
Group is melbine 200mg/kg, separately has Cordyceps sinensis polysaccharide compound group (cordyceps sinensis group), by 30% Cordyceps sinensis polysaccharide, 70% worm
Careless culture solution concentrate configures 80mg/kg, separately takes 4 healthy mices (healthy control group).
(2) oral glucose tolerance test
Each group mouse successive administration is after 4 weeks, and fasting 20 hours, blood glucose value was surveyed in tail portion blood sampling, then 20% grape is given in stomach-filling
Sugar juice gives glucose 0.5 hour respectively, and measuring blood sugar of blood extracting value, data processing use again within 1 hour and 2 hours
5 software of graphpad prism.
Test result shows (Fig. 1), the blood glucose level of healthy mice within the scope of the blood glucose level of health, sample 1-4 with
Melbine has significant blood sugar decreasing effect, compared with negative control group by significant difference.
After mouse is administered 21 days, fasting 6 hours, fasting blood sugar is measured, after 1 hour, with the Portugal of 2.5g/kg dosage
Grape sugar juice stomach-filling measures the blood glucose value that mouse takes 0.5,1,2 hour after glucose respectively.
Test result shows (Fig. 2) that blood glucose starts to increase after groups of animals gives glucose, reaches high to 1.0h or so
The elevation amplitude at peak, sample 1-4 is less than negative control group.Sample 1-4 and positive controls are below negative control group, show have
There is the sugar tolerance effect of different degrees of enhancing diabetic mice, sample 5,6 and cordyceps sinensis group inhibit unobvious to blood glucose rise.
Test result shows that the cordyceps sinensis pueraria lobata compound of inventive formulation is expected to become the active drug for the treatment of diabetes.
The above description is only a preferred embodiment of the present invention, not thereby limits scope of patent protection of the invention, all
It is directly or indirectly to be used in other relevant technologies with equivalent structure transformation made by description of the invention and accompanying drawing content
Field similarly includes within the scope of the present invention.
Claims (7)
1. the cordyceps sinensis pueraria lobata compound with function of blood sugar reduction, which is characterized in that the cordyceps sinensis Gegen tablets include following weight ratio
Ingredient：
Cordyceps sinensis polysaccharide compound 25-35%, kudzu-vine root powder 15-25%, Chinese yam 10-20%, okra 10-20%, soy peptide powder 8-
12%, lotus leaf 8-12%, surplus are medical or health care of food auxiliary material,
The Cordyceps sinensis polysaccharide compound includes Cordyceps sinensis polysaccharide and cordyceps sinensis basic ingredient, wherein the cordyceps sinensis basic ingredient is selected from following
One of：
The extract or concentrate of cordyceps sinensis powder or fermented cordyceps hypha body；
Wherein cordyceps sinensis is that Cordyceps sinensis fungus is parasitic and can generate the fungus combination of fructification, including cordyceps sinensis, Cordyceps militaris and
Other kinds of Cordyceps.
2. as described in claim 1 with the cordyceps sinensis pueraria lobata compound of function of blood sugar reduction, which is characterized in that the cordyceps sinensis is pupa
Cordyceps sinensis.
3. as claimed in claim 2 with the cordyceps sinensis pueraria lobata compound of function of blood sugar reduction, which is characterized in that the Cordyceps sinensis polysaccharide
Using Cordyceps militaris extract polysaccharide or liquid fermentation and culture cordyceps mycelium, then from fermentation liquid extract Cordyceps sinensis polysaccharide into
Row purifying.
4. as claimed in claim 2 with the cordyceps sinensis pueraria lobata compound of function of blood sugar reduction, which is characterized in that the Cordyceps sinensis polysaccharide
The mass fraction of Cordyceps sinensis polysaccharide is 20%-35% in compound.
5. as described in claim 1 with the cordyceps sinensis pueraria lobata compound of function of blood sugar reduction, which is characterized in that described that there is drop blood
The cordyceps sinensis Gegen tablets of sugared function are by following weight ratio at being grouped as：Cordyceps sinensis polysaccharide compound 30%, kudzu-vine root powder 20%, Chinese yam
15%, okra 15%, soy peptide powder 10%, lotus leaf 10%.
6. as claimed in claim 5 with the cordyceps sinensis pueraria lobata compound of function of blood sugar reduction, which is characterized in that the Cordyceps sinensis polysaccharide
The mass fraction of Cordyceps sinensis polysaccharide is 30% in compound.
7. the cordyceps sinensis pueraria lobata compound with function of blood sugar reduction as claimed in any one of claims 1 to 6, which is characterized in that institute
It states cordyceps sinensis Gegen tablets and tablet is made.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710646944 | 2017-08-01 | ||
| CN201710646944X | 2017-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108888750A true CN108888750A (en) | 2018-11-27 |
Family
ID=64351725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810832598.9A Pending CN108888750A (en) | 2017-08-01 | 2018-07-26 | Cordyceps sinensis pueraria lobata compound with function of blood sugar reduction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108888750A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675284A (en) * | 2021-01-08 | 2021-04-20 | 深圳市中康生物制药有限公司 | Recombinant diabetes composite plant polypeptide and preparation and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913854A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide albumen peptide complexes and its application |
| CN107280005A (en) * | 2017-06-20 | 2017-10-24 | 安徽阳光药业有限公司 | Sustained-release dropping pill containing Cordyceps militaris and okra and preparation method thereof |
-
2018
- 2018-07-26 CN CN201810832598.9A patent/CN108888750A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913854A (en) * | 2017-01-22 | 2017-07-04 | 楼良水 | Cordyceps sinensis polysaccharide albumen peptide complexes and its application |
| CN107280005A (en) * | 2017-06-20 | 2017-10-24 | 安徽阳光药业有限公司 | Sustained-release dropping pill containing Cordyceps militaris and okra and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 李秀才: "《糖尿病自然疗法》", 30 June 2002, 北京：金盾出版社 * |
| 王杰超 等: "《老年2型糖尿病的防治策略》", 31 March 2015, 石家庄：河北科学技术出版社 * |
| 马丙祥: "《内分泌系统病症药膳》", 31 October 2004, 北京：人民军医出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112675284A (en) * | 2021-01-08 | 2021-04-20 | 深圳市中康生物制药有限公司 | Recombinant diabetes composite plant polypeptide and preparation and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102934809B (en) | Composition prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound | |
| CN101965969A (en) | Health-care food composition with anti-fatigue and immunity-improving functions and preparation method and application thereof | |
| CN102697035A (en) | Cordyceps anti-aging pellet | |
| CN108144040A (en) | The cordyceps sinensis oyster peptide complexes of kidney-tonifying sperm-generating | |
| CN105029605A (en) | Preparation method of jasmine health maintenance enzyme beverage | |
| CN105532998A (en) | Health-care tea containing cordyceps militaris and preparation method thereof | |
| CN105410346A (en) | Cultured penaeus vannamei survival rate improving traditional Chinese medicine preparation and preparation method thereof | |
| CN106244371A (en) | A kind of blood sugar lowering Rhizoma Polygonati grape health care wine and production technology thereof | |
| CN107173656A (en) | A kind of Chinese medicine fruits and vegetables probiotics fermented beverage and preparation method thereof | |
| CN109528814A (en) | A kind of probiotics and its preparation method and application of lactobacillus-fermented Radix Astragali | |
| CN1560062A (en) | Process of extracting puerariae and making food and medicine addied with it | |
| CN101884783B (en) | Wheat bran polypeptide-containing anti-fatigue traditional Chinese medicine and preparation method thereof | |
| CN1235601C (en) | Extractive of ocean star worm, its preparing method and application | |
| CN109043105A (en) | The cordyceps sinensis sea cucumber peptide pressed candy of kidney-tonifying sperm-generating | |
| CN108477367A (en) | The cordyceps sinensis oligopeptide pressed candy of Soboring-up liver-protecting | |
| CN103027139A (en) | Health tea suitable for use in all seasons | |
| CN102492590A (en) | Silkie red bayberry liquor | |
| CN108888750A (en) | Cordyceps sinensis pueraria lobata compound with function of blood sugar reduction | |
| CN104738626B (en) | A kind of Halth-care composition, its preparation method and application with strengthen immunity effect | |
| CN101721403A (en) | Application of fucoxanthin in aspect of losing weight | |
| CN105410243A (en) | Healthcare tea for health preservation in four seasons | |
| CN102119939A (en) | Angiosperm bee pollen water extract for treating fatty liver and preparation method and application thereof | |
| CN102613648B (en) | Preparation method of original ecological bamboo germanium nutrient solution | |
| CN108187032A (en) | Cordyceps sinensis collagen peptide piece | |
| CN101411493B (en) | Cold tea for preventing and treating fatigue type sub-health and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181127 |
|
| RJ01 | Rejection of invention patent application after publication |