CN101410399B - 美罗培南中间体的制备方法 - Google Patents

美罗培南中间体的制备方法 Download PDF

Info

Publication number
CN101410399B
CN101410399B CN2007800111835A CN200780011183A CN101410399B CN 101410399 B CN101410399 B CN 101410399B CN 2007800111835 A CN2007800111835 A CN 2007800111835A CN 200780011183 A CN200780011183 A CN 200780011183A CN 101410399 B CN101410399 B CN 101410399B
Authority
CN
China
Prior art keywords
compound
solvent
preparation
acetate
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800111835A
Other languages
English (en)
Chinese (zh)
Other versions
CN101410399A (zh
Inventor
西野敬太
古贺照义
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of CN101410399A publication Critical patent/CN101410399A/zh
Application granted granted Critical
Publication of CN101410399B publication Critical patent/CN101410399B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2007800111835A 2006-03-28 2007-03-27 美罗培南中间体的制备方法 Expired - Fee Related CN101410399B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006089253A JP2009143808A (ja) 2006-03-28 2006-03-28 メロペネム中間体の単離方法
JP089253/2006 2006-03-28
PCT/JP2007/056344 WO2007116728A1 (fr) 2006-03-28 2007-03-27 Procede de production d'un intermediaire du meropenem

Publications (2)

Publication Number Publication Date
CN101410399A CN101410399A (zh) 2009-04-15
CN101410399B true CN101410399B (zh) 2012-05-30

Family

ID=38581026

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800111835A Expired - Fee Related CN101410399B (zh) 2006-03-28 2007-03-27 美罗培南中间体的制备方法

Country Status (4)

Country Link
JP (1) JP2009143808A (fr)
CN (1) CN101410399B (fr)
TW (1) TW200738718A (fr)
WO (1) WO2007116728A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009215270A (ja) * 2008-03-13 2009-09-24 Savior Lifetec Corp 結晶性カルバペネム化合物及びその製造法
US8729260B2 (en) * 2010-05-19 2014-05-20 Savior Lifetec Corporation Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem
JP6478447B2 (ja) * 2013-03-29 2019-03-06 大阪有機化学工業株式会社 アダマンチル（メタ）アクリレート系化合物の製造方法
CN103275082B (zh) * 2013-06-05 2016-01-20 浙江工业大学 一种美罗培南的制备方法
CN111039945B (zh) * 2019-12-30 2021-04-20 山东安弘制药有限公司 一种保护美罗培南的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0599512B1 (fr) * 1992-11-17 1999-03-24 Sankyo Company Limited Dérivé de carbapénème cristallin
JPH06157532A (ja) * 1992-11-17 1994-06-03 Sankyo Co Ltd 結晶性カルバペネム化合物
JP2779614B1 (ja) * 1997-04-15 1998-07-23 旭化成工業株式会社 ε−ヘキサニトロヘキサアザイソウルチタンの製法
ES2370829T3 (es) * 2004-06-02 2011-12-23 Sandoz Ag Producto intermedio de meropenem en forma cristalina.

Also Published As

Publication number Publication date
JP2009143808A (ja) 2009-07-02
WO2007116728A1 (fr) 2007-10-18
TW200738718A (en) 2007-10-16
CN101410399A (zh) 2009-04-15

Similar Documents

Publication Publication Date Title
CN101410399B (zh) 美罗培南中间体的制备方法
ES2426407T3 (es) Compuestos de pirrolo[2,3-d]pirimidina
Iso et al. A Novel 1. BETA.-Methylcarbapenem Antibiotic, S-4661. Synthesis and Structure-activity Relationships of 2-(5-Substituted Pyrrolidin-3-ylthio)-1. BETA.-methylcarbapenems.
JP2020528918A (ja) アンドロゲン受容体の標的化分解のための化合物および方法
KR20010052615A (ko) 옥사졸리디논 유도체, 이것의 제조 방법 및 이것을함유하는 약학 조성물
CA2668369C (fr) Antibacteriens de type 5-hydroxymethyl-oxazolidin-2-one
JP7307823B2 (ja) エリグルスタット及びその中間化合物の合成方法
CA3008006A1 (fr) Composes de biarylmonobactame et procedes d'utilisation correspondants pour le traitement d'infections bacteriennes
AU2018345523A1 (en) Chromane monobactam compounds for the treatment of bacterial infections
EP1931684A2 (fr) Hybrides antibactériens a base d'oxazolidinone-quinolone
IE55767B1 (en) Epimerization of malonic acid esters
EP3341379A1 (fr) Inhibiteurs de l'ezh2
EP3083602A1 (fr) Inhibiteurs de kinase apparentés à la n-acylpipéridine éther tropomyosine
TR201807959T4 (tr) 1-(Piperazın-1-il)-2- ([1,2,4] triazol-1-il)-etanon türevleri.
JP2012517991A (ja) ベンゾイルアミノヘテロシクリル化合物の製造方法
WO2002080841A2 (fr) Composes chimiques
FR2524890A1 (fr) Nouveaux derives de carbapenem, compositions pharmaceutiques les contenant, composes intermediaires pour leur preparation, et leurs procedes de production
CA1340604C (fr) Methode pour preparer des composes 7-[2-(2-aminothiazol-4-y1)-2-hydroxyiminoacetamido]-3-cephemes
SE461734B (sv) Nya karbapenem-antibiotika samt foerfarande foer framstaellning daerav
WO2004089943A1 (fr) Derives de [3.1.0] bicyclohexylphenyl-oxazolidinone antimicrobiens et leurs analogues
DE69523058T2 (de) Carbapenem-derivate
CN102659713B (zh) 头孢地尼侧链酸活性酯的制备方法
EP0332156A2 (fr) Composés de céphem et procédés pour leur préparation
CN103193796B (zh) 一种头霉素中间体化合物及其制备方法
JPWO2004043961A1 (ja) 経口投与用カルバペネム化合物の製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120530

Termination date: 20140327