CN101406531A - Chinese medicinal composition for treating dysmenorrhea and preparation method thereof - Google Patents
Chinese medicinal composition for treating dysmenorrhea and preparation method thereof Download PDFInfo
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- CN101406531A CN101406531A CNA2008102354289A CN200810235428A CN101406531A CN 101406531 A CN101406531 A CN 101406531A CN A2008102354289 A CNA2008102354289 A CN A2008102354289A CN 200810235428 A CN200810235428 A CN 200810235428A CN 101406531 A CN101406531 A CN 101406531A
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Abstract
The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating dysmenorrheal and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following medicinal materials in weight portion: 3 to 10 portions of ephedra, 10 to 40 portions of kudzuvine root, 6 to 20 portions of cassia twig, 10 to 30 portions of white paeony root, and 3 to 10 portions of licorice. The traditional Chinese medicine composition for treating the dysmenorrheal has the advantages of quick action, lasting effect, no easy relapse, no adverse reaction, and the like, and particularly has remarkable effect of treating cold-dampness stagnating primary dysmenorrheal.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of dysmenorrhea and preparation method thereof.
Background technology
The doctor trained in Western medicine department of obstetrics and gynecology are divided into two kinds of constitutional and Secondary cases with dysmenorrhea, and primary dysmenorrhea claims primary dysmenorrhea again, is meant that the genitals does not have organic disease person; Secondary dysmenorrhea is meant because pelvic cavity organic disease such as caused dysmenorrheas such as endometriosis, adenomyosis, pelvic inflammatory disease or cervical stenosis.Primary dysmenorrhea sees that with the teenager women secondary dysmenorrhea then is common in the child-bearing period women more.Mainly showing as of dysmenorrhea: the women lower abdomen or flank pain occur before and after menstrual period or menstrual period, even pain and waist sacrum, whenever send out with menstrual cycle, severe patient can be accompanied nausea and vomiting, dripping cold sweat, deadly cold hand and foot, even faints, and brings for women's work and life and seriously influences.This dysmenorrhea of following menstrual phase and coming is one of maximum disease of puzzlement women.Through the physical constants cooperative groups, to the investigation and analysis through constant of 29 provinces and cities in the whole nation, autonomous region's woman month more than 130,000, dysmenorrhea person accounted for 33.19% as far back as national woman month in 1978 in China, slightly account for 45.73%, moderate accounts for 38.81%, and severe accounts for 13.55%, and wherein primary dysmenorrhea accounts for 75%.Both at home and abroad the dysmenorrhea sickness rate is in rising trend every year, and external dysmenorrhea incidence rate is much higher than domestic, has the report U.S. to have among the women of periodically menstruation 90% pain is arranged, and 36% has dysmenorrhea always or often.In U.S.'s dysmenorrhea is the most important reason that maybe can not move absent from duty.Point out 80% dysmenorrhea that has in various degree among the global women according to Britain's one tame authoritative mechanism investigation report.Gynaecologist doctor Kennedy of Oxford University says in the meeting of Britain scientific achievement association: " 2/3rds women suffer from dysmenorrhoea, and 3/4ths sick sending out can't be worked." long-term dysmenorrhea and untimely treatment perhaps comes pain relieving by antalgica, all can bring certain threat to patient's health.Even therefore some people causes infertile.
Chinese medicine thinks, menstrual onset be with woman's kidney qi fill, menarche and to dash wantonly two beniols Sheng be prerequisite, be that internal organs, meridians, QI and blood combined effect are in the normal physiological phenomena of uterus.Therefore, menorrhea is not only the women and is had one of important symbol of motherhood ability, also is the normal reaction of functional activities such as internal organs, meridians, QI and blood.Thereby the diagnosis and treatment primary dysmenorrhea is to improving female individual health, increases work efficiency, quality of life, promotes prenatal and postnatal care, and positive and important meaning is all arranged.
TREATMENT OF DYSMENORRHOEA has multiple therapeutic schemes such as Chinese medicine and Western medicine, treatment by oral administration of medicines and external treatment at present, but clinical patients still is used to first-selected analgesic.This is a kind of method of symptomatic treatment, fundamentally the pain that causes of relieving dysmenorrhea.Other has the expert to point out: analgesic can cause the nervous function disorder, and memory reduces, adverse consequencess such as insomnia.Compare with Western medicine, Chinese medicine is effective in cure definitely, effect is lasting and the few advantage of untoward reaction.
The Chinese Traditional Medicines of specially controlling at present primary dysmenorrhea are few, mainly contain medicines such as TONGJINGBAO KELI, YUEYUESHU CHONGJI, mainly are the respite clinical symptoms, can not effect a radical cure, and need often take medicine.
Summary of the invention
The invention discloses a kind of Chinese medicine composition for the treatment of dysmenorrhea, have advantages such as rapid-action, that effect is lasting, be difficult for recurrence, untoward reaction is few.Particularly remarkable for treatment cold and stagnate type primary dysmenorrhea effect.
Dysmenorrhea can be according to the different mining of clinical syndrome differentiation typing with different compound of Chinese medicine, usually based on depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, benefiting QI and nourishing blood, dispelling cold by warming the meridian.Used Chinese medicine among the present invention, mainly contain promoting the flow of QI in the collateral by warming the meridian, dispersing cold for relieving pain, the effect of the clear interior-heat of holding concurrently, through clinical practice for many years, find that this prescription has better curative effect for cold and stagnate type primary dysmenorrhea, compare, have cheap with existing Chinese medicine preparation, rapid-action, effect is lasting, is difficult for recurrence, the advantage that untoward reaction is few.The pathogenesis complexity of primary dysmenorrhea is various, wherein sees so that the cold and stagnate type more.If because of occupying dark and damp ground for a long time, or the health preserving of just passing through is careless, and sense is cold drenches with rain, and greedy cool drink is cold, or the ground of cold of moving, and cold-damp is hindered in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, objectively causes the cold coagulation menses in uterus, the capable mistake of blood freely, stagnation of QI and blood may bring about pain.
The Chinese medicine composition of treatment dysmenorrhea of the present invention, make by following medicinal materials in weight portion:
Herba Ephedrae 3～10, Radix Puerariae 10～40, Ramulus Cinnamomi 6～20, the Radix Paeoniae Alba 10～30, Radix Glycyrrhizae 3～10.
The preferred parts by weight of above-mentioned five tastes medical material are:
Herba Ephedrae 5, Radix Puerariae 25, Ramulus Cinnamomi 10, the Radix Paeoniae Alba 15, Radix Glycyrrhizae 6.
Above-mentioned Chinese medicine composition also preferably adds following three flavor medical materials, and its weight portion is:
Rhizoma Zingiberis 6～15, Fructus Jujubae 15～30, Gypsum Fibrosum 10～30.
Most preferred prescription is:
Herba Ephedrae 10, Radix Puerariae 40, Ramulus Cinnamomi 15, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 10, Rhizoma Zingiberis 10, Fructus Jujubae 20, Gypsum Fibrosum 30.
Chinese medicine composition of the present invention can prepare with conventional method, as soaks, and decocts, and can take.
Preferred manufacturing procedure comprises: decoct with water, decoction liquor is filtered, is concentrated, and concentrated solution adds pharmaceutic adjuvant and is prepared into various pharmaceutical formulations, preferred particulates agent, powder, tablet, capsule or pill etc.
Described pharmaceutic adjuvant is a conventional adjuvant on the galenic pharmacy, as: filler, diluent, binding agent, lubricant etc.
Be the situation of Chinese medicine composition clinical treatment dysmenorrhea of the present invention below:
One, with reference to of differentiation of symptoms and signs for classification of syndrome standard and the doctor trained in Western medicine dysmenorrhea diagnostic criteria of high Chinese medicine universities and colleges planning teaching material " Gynecology of Chinese Medicine " five editions teaching materials in the new century whole nation about dysmenorrhea, treatment case 52 examples:
(1) patient age distributes
Table 1 age distribution table
At minimum 19 years old of the age in the treatment group, maximum 44 years old, the mean age was 19.56 ± 5.35 years old.
(2) patient's occupation distributes
The professional distribution table of table 2
(3) the dysmenorrhea course of disease distributes
The table 3 dysmenorrhea course of disease distributes
Dysmenorrhea degree: formulate: menstrual period and front and back lower abdomen pain thereof 5 minutes (basis branch) with reference to " practical gynecology " standards of grading; Stomachache 1 minute unbearably; Suffered from abdominal pain obvious 0.5 minute; Felt restless 1 fen; Suffered a shock 2 fens; Pale complexion 0.5 minute; Dripping cold sweat 1 minute; Extreme cold of the limbs 1 minute; Need lie up 1 fen; Influenced work and study 1 minute; Do not alleviate 1 fen with general pain relieving measure; Postponed 0.5 fen with general pain relieving measure pain; Companion's waist was ached 0.5 fen; Companion's nausea and vomiting 0.5 minute; Companion's rectal tenesmus 0.5 minute; Pain at one day with interior 0.5 minute; Every increase of pain phase 1 day 0.5 minute.
(2) dysmenorrhea weight grade scale
Slightly: integration is the 5-7.9 branch
Moderate: integration is the 8-12.9 branch
Severe: integration is the 13-15 branch
Therapeutic Method: medicine is formed and weight: Herba Ephedrae 3～10 grams, Radix Puerariae 10～40 grams, Ramulus Cinnamomi 6～20 grams, the Radix Paeoniae Alba 10～30 grams, Rhizoma Zingiberis 6～15 grams, Radix Glycyrrhizae 3～10 grams, Fructus Jujubae 15～30 grams and Gypsum Fibrosum 10～30 grams.Form proportioning by above medicine, drug immersion 0.5 hour decocts secondary, each 30-40 minute, merges decoction liquor, day clothes two～three times.Every day, potion was each through before serveing on 7 days, serve on 1-3 cycle.
Efficacy determination: with reference to " People's Republic of China's Chinese medicine industry standard-TCM Gynecology disease criterion of therapeutical effect " relevant criterion of State Administration of Traditional Chinese Medicine's issue in 1994.Cure: take medicine back stomachache and other transference cure, 3 menstrual cycle of drug withdrawal do not recur, and pain degree recovers " 0 " branch person.Produce effects: taking medicine obviously alleviates, and all the other transference cures or alleviate refuse to obey that analgesic can adhere to work, pain degree for the treatment integration reduce to before the treatment integration below 1/2.Effectively: stomachache alleviates, all the other symptoms improvements, and the clothes analgesic can be adhered to work, pain degree is reduced to preceding below 1/3 of integration of treatment for the treatment integration.Invalid: stomachache and other symptom do not have the changer
Observed result: in the case of all observations, 3 menstrual cycle of mean treatment are promptly healed, and follow up a case by regular visits to and do not see recurrence in 3-6 month.Pain can alleviate the patient generally takes the 7-10 agent before menstrual cycle after, obeys 2-3 cycle pain continuously and can alleviate fully substantially.If notice that menstrual period and menstruation front and back are warming, general being difficult for recurs.By statistics, this is organized 52 examples and cures 20 examples altogether, produce effects 15 examples, and effective 13 examples, invalid 4 examples, total effective rate reaches 92%.Through x
2Before and after the check treatment remarkable statistical significance is arranged.During the treatment, all patients do not see the obvious adverse reaction report, show that we's treatment dysmenorrhea is safe and effective.
Integral distribution before and after table 4 dysmenorrhea treatment
Two, as stated above, medicine changes into: Herba Ephedrae 3～10 grams, Radix Puerariae 10～40 grams, Ramulus Cinnamomi 6～20 grams, the Radix Paeoniae Alba 10～30 grams, Radix Glycyrrhizae 3～10 grams.Each through before serveing on 7 days, serve on 1-3 cycle.Treatment case 32 examples, concrete data are as follows:
(1) patient age distributes
Table 5 age distribution table
At minimum 19 years old of the age in the treatment group, maximum 44 years old, the mean age was 19.31 ± 4.75 years old.
(2) patient's occupation distributes
The professional distribution table of table 6
(3) the dysmenorrhea course of disease distributes
The table 7 dysmenorrhea course of disease distributes
Observed result: in the case of all observations, 3 menstrual cycle of mean treatment are promptly healed, and follow up a case by regular visits to and do not see recurrence in 3-6 month.Pain can alleviate the patient generally takes the 7-10 agent before menstrual cycle after, obeys 2-3 cycle pain continuously and can alleviate fully substantially.If notice that menstrual period and menstruation front and back are warming, general being difficult for recurs.By statistics, this is organized 32 examples and cures 11 examples altogether, produce effects 10 examples, and effective 6 examples, invalid 5 examples, total effective rate reaches 88%.Through x
2Before and after the check treatment remarkable statistical significance is arranged.During the treatment, all patients do not see the obvious adverse reaction report, show that we's treatment dysmenorrhea is safe and effective.
Integral distribution before and after table 8 dysmenorrhea treatment
The specific embodiment
Embodiment 1
Get Herba Ephedrae 3kg, Radix Puerariae 15kg, Ramulus Cinnamomi 10kg, Radix Paeoniae Alba 10kg, Rhizoma Zingiberis 6kg, Radix Glycyrrhizae 6kg, Fructus Jujubae 20kg, Gypsum Fibrosum 30kg.Add 8 times of water gagings and soaked 0.5 hour, decoct twice, each 30 minutes, merge decocting liquid twice, promptly.
Embodiment 2
Get Herba Ephedrae 6kg, Radix Puerariae 20kg, Ramulus Cinnamomi 15kg, Radix Paeoniae Alba 20kg, Rhizoma Zingiberis 6kg, Radix Glycyrrhizae 6kg, Fructus Jujubae 30kg, Gypsum Fibrosum 15kg.With wherein 1/2nd be ground into fine powder, 3 times of water gagings of another false add decoct twice, each 30 minutes, merge decocting liquid twice, filter.Filtrate is concentrated back and above-mentioned fine powder mix homogeneously, be dried to fine powder, cross 120 mesh sieves, encapsulated.
Embodiment 3
Get Herba Ephedrae 10kg, Radix Puerariae 40kg, Ramulus Cinnamomi 20kg, Radix Paeoniae Alba 20kg, Rhizoma Zingiberis 6kg, Radix Glycyrrhizae 6kg, with wherein 1/2nd be ground into fine powder, 4 times of water gagings of another false add decoct twice, each 40 minutes, merge decocting liquid twice, filter.Filtrate is concentrated back and above-mentioned fine powder mix homogeneously, make the watered pill, be packaged into bag.
Embodiment 4
Herba Ephedrae 10kg, Radix Puerariae 40kg, Ramulus Cinnamomi 15kg, Radix Paeoniae Alba 20kg, Radix Glycyrrhizae 10kg, Rhizoma Zingiberis 10kg, Fructus Jujubae 20kg, Gypsum Fibrosum 30kg.Preparation method is with embodiment 1.
Embodiment 5
Herba Ephedrae 5kg, Radix Puerariae 25kg, Ramulus Cinnamomi 10kg, Radix Paeoniae Alba 15kg, Radix Glycyrrhizae 6kg.Preparation method is with embodiment 1.
Claims (7)
1, a kind of Chinese medicine composition for the treatment of dysmenorrhea is characterized in that being made by following medicinal materials in weight portion:
Herba Ephedrae 3～10, Radix Puerariae 10～40, Ramulus Cinnamomi 6～20, the Radix Paeoniae Alba 10～30 and Radix Glycyrrhizae 3～10.
2, the Chinese medicine composition of claim 1 is characterized in that the ratio of weight and number of each medical material is:
Herba Ephedrae 5, Radix Puerariae 25, Ramulus Cinnamomi 10, the Radix Paeoniae Alba 15 and Radix Glycyrrhizae 6.
3, the Chinese medicine composition of claim 1 is characterized in that also containing following medicinal materials in weight portion:
Rhizoma Zingiberis 6～15, Fructus Jujubae 15～30 and Gypsum Fibrosum 10～30.
4, the Chinese medicine composition of claim 3 is characterized in that the ratio of weight and number of each medical material is:
Herba Ephedrae 10, Radix Puerariae 40, Ramulus Cinnamomi 15, the Radix Paeoniae Alba 20, Radix Glycyrrhizae 10, Rhizoma Zingiberis 10, Fructus Jujubae 20 and Gypsum Fibrosum 30.
5, the preparation method of each Chinese medicine composition in the claim 1 to 4 comprises: medical material is soaked, decocted promptly.
6, the preparation method of each Chinese medicine composition in the claim 1 to 4 comprises: medical material is soaked, decocted, concentrate, add pharmaceutic adjuvant and be prepared into granule, powder, tablet, capsule or pill.
7, each Chinese medicine composition is used to prepare the purposes for the treatment of the dysmenorrhea medicine in the claim 1 to 4.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550667A (en) * | 2013-11-14 | 2014-02-05 | 崔合芳 | Chinese medicinal composition for preventing or treating irregular menstruation after induced abortion |
| CN104524014A (en) * | 2014-12-24 | 2015-04-22 | 胡文杰 | Traditional Chinese medicine composition for treating primary dysmenorrhea with cold-damp stagnation |
| CN105148217A (en) * | 2015-07-21 | 2015-12-16 | 黄太锋 | Decoction for treating dysmenorrhea |
-
2008
- 2008-12-02 CN CN2008102354289A patent/CN101406531B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550667A (en) * | 2013-11-14 | 2014-02-05 | 崔合芳 | Chinese medicinal composition for preventing or treating irregular menstruation after induced abortion |
| CN104524014A (en) * | 2014-12-24 | 2015-04-22 | 胡文杰 | Traditional Chinese medicine composition for treating primary dysmenorrhea with cold-damp stagnation |
| CN105148217A (en) * | 2015-07-21 | 2015-12-16 | 黄太锋 | Decoction for treating dysmenorrhea |
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| CN101406531B (en) | 2011-07-20 |
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