CN101912486B - Medicament for treating dysmenorrheal and preparation method thereof - Google Patents
Medicament for treating dysmenorrheal and preparation method thereof Download PDFInfo
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- CN101912486B CN101912486B CN 201010264652 CN201010264652A CN101912486B CN 101912486 B CN101912486 B CN 101912486B CN 201010264652 CN201010264652 CN 201010264652 CN 201010264652 A CN201010264652 A CN 201010264652A CN 101912486 B CN101912486 B CN 101912486B
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Abstract
The invention discloses a medicament for treating dysmenorrheal, which is characterized by being prepared from the following raw materials in part by weight: 1 to 20 parts of rose, 1 to 20 parts of seville orange flower, 1 to 20 parts of cinnamon, 1 to 20 parts of Chinese eaglewood, 1 to 20 parts of amber and 1 to 20 parts of over 95 percent edible ethanol. The medicament can be used for oral administration and absorbed by the spleen and stomach and can be used for external use and absorbed by skin, and can be absorbed complexly in two modes of oral administration and external use. The medicament has the advantages of addressing both the symptoms and root causes along with reasonable formula, simple compatibility and definite curative effect, and can be used for treating diseases such as dysmenorrheal, postpartum dysuria, lower abdomen pain caused by stasis and the like. The invention also provides a preparation method of the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment dysmenorrhea of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Dysmenorrhea is common gynecological disease and frequently-occurring disease, the cause of disease is many, the pathogenesis complexity, repeatability is big, treat thorny, especially unmarried young woman and menarche the maiden more general, show as gynecologic menstrual or pass through front and back, the hypogastric region distending pain periodically takes place, cold type of pain, causalgia, twinge, dull pain, weigh down pain, angor, spasmic pain, tearing property pain, pain spreads to the sacrum lower back, even relate to thigh and foot, often with General Symptoms: distending pain of the breast, rectal tenesmus, agitation uncomfortable in chest, sad irritability, the frightened insomnia of the heart, headache and dizzy, nausea and vomiting, stomachache diarrhoea, fatigue and weakness, pale complexion, extremity are ice-cold, dripping cold sweat, symptoms such as collapse faintness.High, the scope of its morbidity wide, the cycle is near, painful big, has had a strong impact on numerous women's working and learning, has reduced the quality of life.
Present clinical two kinds of constitutional and the Secondary cases that often it are divided into, primary dysmenorrhea refers to that the genitals does not have obvious pathological changes person more, so claim primary dysmenorrhea again, is more common in adolescent girls, the unmarried and married person of not educating.Many can the alleviation or disappear of this kind dysmenorrhea pain after normal labor.Secondary dysmenorrhea is then many to be had due to the organic disease because of the genitals.Primary disease belongs to the commonly encountered diseases of gynecological clinic, shows according to relevant investigation, and the sickness rate of dysmenorrhea is 33.19%.
Chinese patent CN200710014086.3 discloses a kind of Chinese medicine composition for the treatment of difficult menstruation, and is formulated by a certain percentage by Radix Angelicae Sinensis, Radix Paeoniae Rubra, Oletum Trogopterori, Rhizoma Curcumae, Herba Leonuri, Cortex Cinnamomi, the Cortex Eucommiae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis and Ophicalcitum, is decocted in water for oral dose.Chinese patent CN200710065498.X discloses a kind of Chinese medicine decoction for the treatment of dysmenorrhea, and it is to be raw material with 10 Chinese medicine medicines such as Radix Angelicae Sinensis, Radix Paeoniae Rubra, Pericarpium Citri Reticulatae Viride, Rhizoma Cyperi, Pericarpium Citri tangerinae and Flos Carthami.Chinese patent CN200710060616.8 discloses a kind of Chinese medicine compound percutaneous absorption patch for the treatment of dysmenorrhea, it is made up of following parts by weight proportion raw material, wherein Radix Angelicae Sinensis extract 0.5-3 part adopts the Chinese crude drug Radix Angelicae Sinensis to obtain through carbon dioxide supercritical fluid extraction; Rhizoma Corydalis extract 4-6 part adopts traditional Chinese medicine corydalis tuber to obtain through traditional extraction process; Rhizoma Curcumae Longae extract 1-3 part adopts Chinese crude drug to obtain through carbon dioxide supercritical fluid extraction; Transdermal enhancer 0.5-2 part; Pressure sensitive adhesive 100-150 part.
The Chinese medicine product of above-mentioned treatment dysmenorrhea is paid attention to regulating too much, and used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable; And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the medicine of the treatment dysmenorrhea of determined curative effect, treating both the principal and secondary aspects of a disease, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of dysmenorrhea is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, and 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Cortex Cinnamomi, 1 ~ 20 part of Lignum Aquilariae Resinatum, 1 ~ 20 part of succinum, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, and 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Cortex Cinnamomis, 15 ~ 20 parts of Lignum Aquilariae Resinatum, 15 ~ 20 parts of succinums, content are 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Cortex Cinnamomi, Lignum Aquilariae Resinatum and the succinum of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of dysmenorrhea.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
The present invention is directed to the characteristics of dysmenorrhea, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Cortex Cinnamomi, Lignum Aquilariae Resinatum, succinum for use,, make to contain pure Chinese medicine extraction liquid being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment dysmenorrhea of determined curative effect, treating both the principal and secondary aspects of a disease.
Medicine of the present invention is mended fire from the gater of life with Cortex Cinnamomi, Yiyang the moon that disappears, warm promoting blood circulation; Lignum Aquilariae Resinatum regulating QI sending down the abnormal ascending QI, warm kidney; The succinum mind tranquilizing and the heart calming, the row aquation stasis of blood.Three flavors share, and medicine letter and power is high can reach the effect of warming the meridian and promoting blood circulation.Can be used for the dysmenorrhea patient, especially through lower abdomen pain in preceding or menstrual period, feel sick during pain, vomiting.Medicine of the present invention has the diuresis inducing function of succinum again on the basis of promoting the flow of QI-blood by warming the meridian, so for losing the disease of declaring the uroschesis that causes because of the resistance of the cold coagulation stasis of blood, functioning of bladder puerperal, curative effect is also good.Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, and the strength of eliminating turbid pathogen with aromatics, be amusing appetizing, regulating QI to relieve pain strengthens.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs.
Medicine of the present invention can also be smeared by whole body except for oral administration.Adopt oral administration and externally usedly, drug effect is more remarkable.
The present invention treats that the dysmenorrhea curative effect is obvious, and short treating period can be used for diseases such as dysmenorrhea, puerperal difficulty urination, also can be used for lower abdomen pain that causes because of the stasis of blood etc.Clinical usefulness repeatly, analgesic effect are very prompt.
Medicine of the present invention is through clinical 110 routine patients' clinical verification, and curing number is 99 examples, and significant figure is 5 examples, and invalid number is 16 examples, and total effective rate reaches 95%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain woman, 17 years old, beginning in preceding 2 days of menstrual period lower abdominal distention pain, menstrual period are severe pain frequently.Oral medicine of the present invention, each 10 milliliters, every day 3 times.Oral medicine after 7 days first physiological period pain significantly alleviate.Adhering to taking after 28 days first physiological period pain eliminates substantially.Pay a return visit normal nothing discomfort in menstrual period after 6 months.
Case 2: certain woman, 26 years old, suffer from the dysmenorrhea several years, menstrual period are longer, dysmenorrhea often, accidental severe pain.Once took the Chinese medicine and the Western medicine of a variety of treatment dysmenorrheas, but effect is all not good.External medicine of the present invention is smeared whole body, and every day 2 times, each 10 milliliters, lower abdomen and waist are repeatedly smeared.External after 6 days first physiological period pain significantly alleviate.Adhering to taking after 28 days first physiological period pain eliminates substantially.Pay a return visit after 6 months and shorten 2 days menstrual period, and normal nothing is uncomfortable.
Case 3: certain woman, 32 years old, dysmenorrhea and with severe pain, lip turns white often before the medication not.Once took the Chinese medicine and the Western medicine of a variety of treatment dysmenorrheas, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body, and every day 2 times, each 10 milliliters, lower abdomen and waist are repeatedly smeared.Oral and external after 3 days first physiological period pain significantly alleviate.Adhere to taking after 28 days first physiological period pain and eliminate substantially, complexion is ruddy.Pay a return visit normal nothing discomfort in menstrual period after 6 months.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 15 parts of Cortex Cinnamomis, 15 parts of Lignum Aquilariae Resinatum, 19 parts of succinums adopt the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and are standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and gained filtrate is the medicine of the treatment dysmenorrhea of oral administration or external, carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts of Cortex Cinnamomis, 16 parts of Lignum Aquilariae Resinatum, 20 parts of succinums, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 17 parts of Cortex Cinnamomis, 17 parts of Lignum Aquilariae Resinatum, 20 parts of succinums, content are 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 16 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of Cortex Cinnamomis, 18 parts of Lignum Aquilariae Resinatum, 17 parts of succinums, content are 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 7 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 19 parts of Cortex Cinnamomis, 19 parts of Lignum Aquilariae Resinatum, 19 parts of succinums, content are 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts of Cortex Cinnamomis, 19 parts of Lignum Aquilariae Resinatum, 18 parts of succinums, content are 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. medicine for the treatment of dysmenorrhea is characterized in that it is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, and 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part of Cortex Cinnamomi, 1 ~ 20 part of Lignum Aquilariae Resinatum, 1 ~ 20 part of succinum, content are 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1 is characterized in that it is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, and 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts of Cortex Cinnamomis, 15 ~ 20 parts of Lignum Aquilariae Resinatum, 15 ~ 20 parts of succinums, content are 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that, further contains weight portion and be 1 ~ 5 part azone on the basis of claim 1 or 2 described medicines.
4. the preparation method of claim 1 or 2 described medicines is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Cortex Cinnamomi, Lignum Aquilariae Resinatum and the succinum of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of dysmenorrhea.
5. the preparation method of the described medicine of claim 3 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Cortex Cinnamomi, Lignum Aquilariae Resinatum and the succinum of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the raw material that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) azone step a is extract obtained and described weight proportion adds aqueous solution of alcohol together, stirs 120 minutes, precipitates 2 ~ 4 hours, filter, and gained filtrate sterilization, fill according to quantity must be treated the medicine of dysmenorrhea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010264652 CN101912486B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating dysmenorrheal and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010264652 CN101912486B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating dysmenorrheal and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101912486A CN101912486A (en) | 2010-12-15 |
| CN101912486B true CN101912486B (en) | 2011-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201010264652 Expired - Fee Related CN101912486B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating dysmenorrheal and preparation method thereof |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104431139A (en) * | 2014-10-18 | 2015-03-25 | 全椒贡菊园茶厂 | Chinese rose flower health tea |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052606A (en) * | 1989-12-20 | 1991-07-03 | 王吉全 | A kind of preparation method of curing the pharmaceutical preparation of dysmenorrhea |
| CN1227017C (en) * | 2002-12-31 | 2005-11-16 | 张立中 | Chinese medicine for health of women in menstrual period |
| CN1175894C (en) * | 2003-06-24 | 2004-11-17 | 贵阳高新佰草汇医疗用品有限公司 | Medicinal plaster for treating algomenorrhea and regulating menstrual function |
| CN100515450C (en) * | 2005-09-29 | 2009-07-22 | 王保安 | Medicine for treating difficult menstruation and its preparation |
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