CN101405303B - 丙烯酸酯化的透明质酸 - Google Patents

丙烯酸酯化的透明质酸 Download PDF

Info

Publication number
CN101405303B
CN101405303B CN2007800092919A CN200780009291A CN101405303B CN 101405303 B CN101405303 B CN 101405303B CN 2007800092919 A CN2007800092919 A CN 2007800092919A CN 200780009291 A CN200780009291 A CN 200780009291A CN 101405303 B CN101405303 B CN 101405303B
Authority
CN
China
Prior art keywords
hyaluronic acid
acrylated
bacillus
maintained
acryloyl chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800092919A
Other languages
English (en)
Chinese (zh)
Other versions
CN101405303A (zh
Inventor
理查德·A·格罗斯
维尼特·库玛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Biopharma DK AS
Original Assignee
Novozymes Biopharma DK AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes Biopharma DK AS filed Critical Novozymes Biopharma DK AS
Publication of CN101405303A publication Critical patent/CN101405303A/zh
Application granted granted Critical
Publication of CN101405303B publication Critical patent/CN101405303B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
CN2007800092919A 2006-03-14 2007-03-09 丙烯酸酯化的透明质酸 Expired - Fee Related CN101405303B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78258106P 2006-03-14 2006-03-14
US60/782,581 2006-03-14
PCT/US2007/063671 WO2007106738A2 (en) 2006-03-14 2007-03-09 Acrylated hyaluronic acid

Publications (2)

Publication Number Publication Date
CN101405303A CN101405303A (zh) 2009-04-08
CN101405303B true CN101405303B (zh) 2011-11-23

Family

ID=37054621

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800092919A Expired - Fee Related CN101405303B (zh) 2006-03-14 2007-03-09 丙烯酸酯化的透明质酸

Country Status (13)

Country Link
US (1) US20090118423A1 (enExample)
EP (1) EP1999160B1 (enExample)
JP (1) JP5123285B2 (enExample)
CN (1) CN101405303B (enExample)
AT (1) ATE453670T1 (enExample)
AU (1) AU2007226690B2 (enExample)
BR (1) BRPI0708776A2 (enExample)
CA (1) CA2647481A1 (enExample)
DE (1) DE602007004086D1 (enExample)
DK (1) DK1999160T3 (enExample)
ES (1) ES2339181T3 (enExample)
PL (1) PL1999160T3 (enExample)
WO (1) WO2007106738A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101100803B1 (ko) * 2009-04-24 2011-12-29 서울과학기술대학교 산학협력단 리포아마이드가 결합된 고분자화합물과 이의 제조방법
CN103562229A (zh) * 2011-05-30 2014-02-05 诺维信生物制药丹麦公司 高分子量透明质酸的喷雾干燥
JP5714456B2 (ja) * 2011-09-07 2015-05-07 株式会社シード 重合性ヒアルロン酸誘導体、ならびにその重合体を含むヒアルロン酸ヒドロゲルおよびコンタクトレンズ
US9492484B2 (en) * 2012-09-27 2016-11-15 The Regents Of The University Of California Cardiosphere derived cell population and methods of use
CN104224688B (zh) * 2013-06-09 2017-10-10 北京化工大学 负载纳米药物的丙烯酸酯化透明质酸水凝胶及其制备方法
US10335515B2 (en) * 2013-09-25 2019-07-02 The University Of Kansas Hydrogel precursors having nanoparticles
EP2899214A1 (en) * 2014-01-27 2015-07-29 Basf Se Ethylenically unsaturated polysaccharides, method for their production and their use
FR3021537B1 (fr) 2014-05-28 2016-05-27 Oreal Procede cosmetique pour attenuer les rides
FR3021541B1 (fr) * 2014-05-28 2017-10-27 Oreal Procede cosmetique pour attenuer les rides
FR3026298B1 (fr) * 2014-09-30 2017-12-01 Oreal Procede cosmetique pour attenuer les rides
FR3026299B1 (fr) * 2014-09-30 2016-11-25 Oreal Procede cosmetique pour attenuer les rides
FR3026300B1 (fr) * 2014-09-30 2020-01-10 L'oreal Procede cosmetique pour attenuer les rides
CN106967202B (zh) * 2017-03-06 2020-05-22 深圳大学 纳米凝胶酶及其制备和应用
JP2018153296A (ja) * 2017-03-16 2018-10-04 Jsr株式会社 不飽和化合物を含有する組成物
WO2018187184A1 (en) * 2017-04-04 2018-10-11 The Regents Of The University Of California Injectable therapeutic angiogenic material for brain repair
KR101974745B1 (ko) * 2017-10-18 2019-09-06 서울과학기술대학교 산학협력단 그라프트 공중합체와 젤라틴 가교물을 포함하는 히알루론산 하이드로젤 및 이의 제조방법
KR101974744B1 (ko) * 2017-10-12 2019-09-06 서울과학기술대학교 산학협력단 히알루론산 그라프트 공중합체의 가교물을 포함하는 하이드로젤 및 이의 제조방법
KR102103180B1 (ko) * 2017-12-22 2020-04-22 케이비바이오메드 주식회사 히알루론산유도체, 플루란 및 카르복시메틸 셀룰로오스를 포함하는 유착방지용 조성물 및 이의 제조방법
CN111359011A (zh) * 2020-03-31 2020-07-03 东华大学 一种提升酰胺化反应用于制备蛋白质生物墨水的方法
CN113943382B (zh) * 2020-07-16 2023-03-10 孛朗孚(杭州)生物科技有限公司 一种丙烯酸酯类修饰的透明质酸（钠）及其合成方法和应用
CA3206171A1 (en) * 2020-12-30 2022-07-07 Convatec Technologies Inc. Surface treatment system and method for subcutaneous device
CN116874640B (zh) * 2023-07-24 2025-08-08 江南大学 一种长驻留的用于头发修护的透明质酸钠衍生物及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078988A1 (en) * 1999-06-22 2000-12-28 Trustees Of Tufts College Enzyme-mediated polymerization methods and products
US20020192182A1 (en) * 2001-03-12 2002-12-19 Stephen Massia Polysaccharide-based polymerizable hydrogels
US20050129734A1 (en) * 1999-04-12 2005-06-16 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837747A (en) * 1991-10-29 1998-11-17 Vivorx, Inc. Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US6951743B2 (en) * 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
DE60038010T2 (de) * 1999-04-12 2009-03-05 Cornell Research Foundation, Inc. Hydrogel-formendes system mit hydrophoben und hydrophilen komponenten
US6673919B2 (en) * 2001-03-30 2004-01-06 Chisso Cororation Chemically modified hyaluronic acid or salts thereof, and a process for producing thereof
DE60239495D1 (de) * 2001-12-21 2011-04-28 Novozymes Biopharma Dk As Verfahren zur produktion von hyaluronan in einer rekombinanten wirtszelle
US7311879B2 (en) * 2003-08-14 2007-12-25 Hodson Steve J Syringe pump
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050129734A1 (en) * 1999-04-12 2005-06-16 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
WO2000078988A1 (en) * 1999-06-22 2000-12-28 Trustees Of Tufts College Enzyme-mediated polymerization methods and products
US20020192182A1 (en) * 2001-03-12 2002-12-19 Stephen Massia Polysaccharide-based polymerizable hydrogels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Jason A. Burdick等.Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks.《Biomacromolecules》.2004,第6卷(第1期),386-391. *
Kimberly A. Smeds等.Photocrosslinkable polysaccharides for in situ hydrogel formation.《Journal of Biomedical Materials Research》.2000,第54卷(第1期),115-121. *

Also Published As

Publication number Publication date
ATE453670T1 (de) 2010-01-15
JP5123285B2 (ja) 2013-01-23
AU2007226690A1 (en) 2007-09-20
CN101405303A (zh) 2009-04-08
BRPI0708776A2 (pt) 2011-06-14
CA2647481A1 (en) 2007-09-20
WO2007106738A2 (en) 2007-09-20
DE602007004086D1 (de) 2010-02-11
DK1999160T3 (da) 2010-04-26
PL1999160T3 (pl) 2010-06-30
ES2339181T3 (es) 2010-05-17
US20090118423A1 (en) 2009-05-07
AU2007226690B2 (en) 2012-04-19
JP2009530445A (ja) 2009-08-27
EP1999160B1 (en) 2009-12-30
WO2007106738A3 (en) 2008-09-25
EP1999160A2 (en) 2008-12-10

Similar Documents

Publication Publication Date Title
CN101405303B (zh) 丙烯酸酯化的透明质酸
Hintze et al. Chemical modification of hyaluronan and their biomedical applications
US12365768B2 (en) Method for deacetylation of biopolymers
Jin et al. Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran–hyaluronic acid conjugates for cartilage tissue engineering
Schuurmans et al. Hydrolytic (in) stability of methacrylate esters in covalently cross-linked hydrogels based on chondroitin sulfate and hyaluronic acid methacrylate
Murano et al. Hyaluronan: from biomimetic to industrial business strategy
JP2009516765A (ja) 新規ヒアルロン酸誘導体、その製造方法及びその使用
US20080182982A1 (en) Methyl esters of hyaluronic acid
CN113943382B (zh) 一种丙烯酸酯类修饰的透明质酸（钠）及其合成方法和应用
WO2021043349A1 (en) Hydrogel based on crosslinked hydroxyphenyl derivative of hyaluronic acid
Trifan et al. Strategies of hyaluronan chemical modifications for biomedical applications
CN114516923A (zh) 一种双键官能化修饰的透明质酸(钠)及其合成方法和应用
Borzacchiello et al. Physical and chemical hyaluronic acid hydrogels and their biomedical applications
Zhang Surface modification of ultra high molecular weight polyethylene with hyaluronan for total joint replacement application

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: NOVOZYMES BIOLOGICGAL PHARMACEUTICAL DENMARK CO.,L

Free format text: FORMER OWNER: NOVOZYMES BIOPOLYMER AS

Effective date: 20090717

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20090717

Address after: Denmark bagsvaerd

Applicant after: Novozymes Biopharma DK A/S

Address before: Denmark bagsvaerd

Applicant before: Novozymes Biopolymer AS

C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20111123

Termination date: 20150309

EXPY Termination of patent right or utility model