CN101405278A - 新颖的杂环NF-κB抑制剂 - Google Patents

新颖的杂环NF-κB抑制剂 Download PDF

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Publication number
CN101405278A
CN101405278A CNA2007800092336A CN200780009233A CN101405278A CN 101405278 A CN101405278 A CN 101405278A CN A2007800092336 A CNA2007800092336 A CN A2007800092336A CN 200780009233 A CN200780009233 A CN 200780009233A CN 101405278 A CN101405278 A CN 101405278A
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CN
China
Prior art keywords
alkyl
halo
hydroxy alkylene
amino
group
Prior art date
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Pending
Application number
CNA2007800092336A
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English (en)
Chinese (zh)
Inventor
约翰·莱班
哈拉尔德·施米特
克里斯蒂娜·沃尔夫
斯蒂凡诺·彼格拉罗
安德烈亚斯·伍兹克
罗尔夫·卡尔尤斯
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4SC AG
Original Assignee
4SC AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/375,259 external-priority patent/US7601745B2/en
Priority claimed from PCT/EP2006/002396 external-priority patent/WO2007016979A2/fr
Application filed by 4SC AG filed Critical 4SC AG
Publication of CN101405278A publication Critical patent/CN101405278A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800092336A 2006-03-15 2007-03-14 新颖的杂环NF-κB抑制剂 Pending CN101405278A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EPPCT/EP2006/002396 2006-03-15
US11/375,259 US7601745B2 (en) 2004-09-27 2006-03-15 Heterocyclic NF-kB inhibitors
PCT/EP2006/002396 WO2007016979A2 (fr) 2005-07-29 2006-03-15 Nouveaux inhibiteurs heterocycliques de nf-kb
US11/375,259 2006-03-15

Publications (1)

Publication Number Publication Date
CN101405278A true CN101405278A (zh) 2009-04-08

Family

ID=38461965

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800092336A Pending CN101405278A (zh) 2006-03-15 2007-03-14 新颖的杂环NF-κB抑制剂

Country Status (3)

Country Link
EP (1) EP1994017A2 (fr)
CN (1) CN101405278A (fr)
WO (1) WO2007104557A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104356127A (zh) * 2014-11-13 2015-02-18 重庆理工大学 含n双杂环酰胺类化合物及其作为免疫抑制剂的应用
CN109988121A (zh) * 2019-04-28 2019-07-09 梯尔希（南京）药物研发有限公司 一种阿考替胺衍生物的制备方法
WO2023056897A1 (fr) * 2021-10-09 2023-04-13 浙江大学 Utilisation d'un inhibiteur de la c-abl dans la préparation d'un médicament pour la prévention et/ou le traitement de la sclérose latérale amyotrophique

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007115805A2 (fr) * 2006-04-05 2007-10-18 European Molecular Biology Laboratory (Embl) Inhibiteurs de la kinase aurora
CA2682050A1 (fr) * 2007-03-27 2008-10-02 4Sc Ag Composition pharmaceutique comprenant une cytokine
WO2009037357A1 (fr) * 2007-09-19 2009-03-26 4Sc Ag Inhibiteurs de nf-kappab du type benzimidazole
DE102007047735A1 (de) * 2007-10-05 2009-04-09 Merck Patent Gmbh Thiazolderivate
RU2461551C2 (ru) * 2007-10-24 2012-09-20 Астеллас Фарма Инк. Азолкарбоксамидное соединение или его фармацевтически приемлемая соль
CN102007101A (zh) * 2007-11-30 2011-04-06 生物区科学管理控股有限公司 作为抗菌剂的四氢-异喹啉ppat抑制剂
WO2009073534A2 (fr) 2007-11-30 2009-06-11 Maxthera Inc. Inhibiteurs de ppat bicycliques utilisés en tant qu'agents antibactériens
EP2237774B1 (fr) * 2007-12-21 2016-06-22 Merial Limited Utilisation de composés 6-halogéno-(1,2,4)-triazolo-(1,5-a)-pyrimidine dans la lutte contre les nuisibles chez l'animal
ES2432383T3 (es) * 2008-05-05 2013-12-03 Merck Patent Gmbh Derivados de nip-tiazol como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa
AU2009316786A1 (en) * 2008-11-19 2010-05-27 Merck Sharp & Dohme Corp. Inhibitors of diacylglycerol acyltransferase
KR101051077B1 (ko) * 2008-12-05 2011-07-21 한국화학연구원 2-피페라지노-4,5-이중치환-1,3-티아졸 유도체, 그의 제조방법 및 그를 유효성분으로 함유하는 ｓｐｃ 수용체 활성으로 유발되는 염증관련질환 치료제
WO2010071885A1 (fr) 2008-12-19 2010-06-24 Cephalon, Inc. Pyrrolotriazines en tant qu'inhibiteurs d'alk et de jak2
FR2969611B1 (fr) * 2010-12-28 2013-02-08 Sanofi Aventis Nouveaux derives de thiazoles, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
GB201401886D0 (en) 2014-02-04 2014-03-19 Lytix Biopharma As Neurodegenerative therapies
JP2023551474A (ja) * 2020-11-25 2023-12-08 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の処置および予防のための芳香族架橋環アミド誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90337A0 (en) * 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
GB0230162D0 (en) * 2002-12-24 2003-02-05 Metris Therapeutics Ltd Compounds useful in inhibiting angiogenesis
WO2005079791A1 (fr) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Derives d'acide thiophene-2-carboxylique (1h-benzimidazol-2 yl)-amide et composes associes utilises comme inhibiteurs de la tec kinase itk (kinase des lymphocites inductibles par l'interleukine -2) pour traiter une inflammation et des troubles immunologiques et allergiques
CA2580725A1 (fr) * 2004-09-20 2006-03-30 4Sc Ag Nouveaux inhibiteurs heterocycliques du nf-?b

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104356127A (zh) * 2014-11-13 2015-02-18 重庆理工大学 含n双杂环酰胺类化合物及其作为免疫抑制剂的应用
CN109988121A (zh) * 2019-04-28 2019-07-09 梯尔希（南京）药物研发有限公司 一种阿考替胺衍生物的制备方法
CN109988121B (zh) * 2019-04-28 2023-01-03 梯尔希（南京）药物研发有限公司 一种阿考替胺衍生物的制备方法
WO2023056897A1 (fr) * 2021-10-09 2023-04-13 浙江大学 Utilisation d'un inhibiteur de la c-abl dans la préparation d'un médicament pour la prévention et/ou le traitement de la sclérose latérale amyotrophique

Also Published As

Publication number Publication date
WO2007104557A3 (fr) 2008-05-22
EP1994017A2 (fr) 2008-11-26
WO2007104557A2 (fr) 2007-09-20

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