CN101392026B - 用于预防和治疗纤维化类疾病以及肝癌的多肽 - Google Patents

用于预防和治疗纤维化类疾病以及肝癌的多肽 Download PDF

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Publication number
CN101392026B
CN101392026B CN2008102009378A CN200810200937A CN101392026B CN 101392026 B CN101392026 B CN 101392026B CN 2008102009378 A CN2008102009378 A CN 2008102009378A CN 200810200937 A CN200810200937 A CN 200810200937A CN 101392026 B CN101392026 B CN 101392026B
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polypeptide
liver
cell
sequence
pdgf
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Expired - Fee Related
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CN2008102009378A
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English (en)
Chinese (zh)
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CN101392026A (zh
Inventor
黄岚
袁胜涛
周华
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Wuxi MTLH Biotechnology Co Ltd
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Priority to CN2008102009378A priority Critical patent/CN101392026B/zh
Publication of CN101392026A publication Critical patent/CN101392026A/zh
Priority to US13/123,424 priority patent/US8637467B2/en
Priority to PCT/CN2009/074048 priority patent/WO2010040305A1/en
Priority to EP09818769.3A priority patent/EP2344528B1/en
Priority to JP2011530354A priority patent/JP5734856B2/ja
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Publication of CN101392026B publication Critical patent/CN101392026B/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/49Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2008102009378A 2008-10-09 2008-10-09 用于预防和治疗纤维化类疾病以及肝癌的多肽 Expired - Fee Related CN101392026B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2008102009378A CN101392026B (zh) 2008-10-09 2008-10-09 用于预防和治疗纤维化类疾病以及肝癌的多肽
US13/123,424 US8637467B2 (en) 2008-10-09 2009-09-21 Pharmaceutical being used for treating cancer and fibrosis disease and the composition and uses thereof
PCT/CN2009/074048 WO2010040305A1 (en) 2008-10-09 2009-09-21 Pharmaceutical being used for treating cancer and fibrosis disease and the composition and uses thereof
EP09818769.3A EP2344528B1 (en) 2008-10-09 2009-09-21 Pharmaceutical being used for treating cancer and fibrosis disease and the composition and uses thereof
JP2011530354A JP5734856B2 (ja) 2008-10-09 2009-09-21 癌及び線維症疾患の治療に使用される医薬及び組成物ならびにその使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2008102009378A CN101392026B (zh) 2008-10-09 2008-10-09 用于预防和治疗纤维化类疾病以及肝癌的多肽

Publications (2)

Publication Number Publication Date
CN101392026A CN101392026A (zh) 2009-03-25
CN101392026B true CN101392026B (zh) 2011-11-09

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CN2008102009378A Expired - Fee Related CN101392026B (zh) 2008-10-09 2008-10-09 用于预防和治疗纤维化类疾病以及肝癌的多肽

Country Status (5)

Country Link
US (1) US8637467B2 (enExample)
EP (1) EP2344528B1 (enExample)
JP (1) JP5734856B2 (enExample)
CN (1) CN101392026B (enExample)
WO (1) WO2010040305A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101392026B (zh) 2008-10-09 2011-11-09 黄岚 用于预防和治疗纤维化类疾病以及肝癌的多肽
CN111701020A (zh) * 2020-06-08 2020-09-25 南通大学 一种治疗pdgf诱导的肝纤维化的分子靶点

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355209A (zh) * 2000-11-24 2002-06-26 复旦大学 一种新的多肽——钙依赖性氯离子通道16.72和编码这种多肽的多核苷酸
CN1671734A (zh) * 2002-05-31 2005-09-21 儿童医院医疗中心 用于治疗囊性纤维化的cftr修饰基因和表达的多肽以及检测和/或鉴定它们的方法和产品

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
CN1330664A (zh) 1998-09-30 2002-01-09 路德维格癌症研究所 血小板衍生生长因子c、其编码dna及其应用
US20030211994A1 (en) * 1998-09-30 2003-11-13 Ludwig Institute For Cancer Research Composition and method for modulating vasculogenesis or angiogenesis
DE69936733T2 (de) 1998-12-22 2008-06-05 Janssen Pharmaceutica N.V. Vaskulärer endothelialer wachstumsfaktor x
AU2004209668A1 (en) * 2003-02-04 2004-08-19 Flanders Interuniversity Institute For Biotechnology VEGF-B and PDGF modulation of stem cells
WO2007022287A2 (en) 2005-08-15 2007-02-22 Vegenics Limited Modified vegf and pdgf with improved angiogenic properties
CN101392026B (zh) 2008-10-09 2011-11-09 黄岚 用于预防和治疗纤维化类疾病以及肝癌的多肽

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1355209A (zh) * 2000-11-24 2002-06-26 复旦大学 一种新的多肽——钙依赖性氯离子通道16.72和编码这种多肽的多核苷酸
CN1671734A (zh) * 2002-05-31 2005-09-21 儿童医院医疗中心 用于治疗囊性纤维化的cftr修饰基因和表达的多肽以及检测和/或鉴定它们的方法和产品

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙丽文等.β淀粉样肽在阿尔茨海默症发病中的分子机制.《生物化学与生物物理进展》.2007,第34卷(第1期),18-24. *
陈志伟等.慢性乙型肝炎和肝炎肝硬化患者血浆内皮素1水平与血清肝纤维化指标和门静脉宽度的关系.《实用肝脏杂志》.2007,第10卷(第2期),89-91. *

Also Published As

Publication number Publication date
CN101392026A (zh) 2009-03-25
US20110263513A1 (en) 2011-10-27
EP2344528A4 (en) 2012-03-28
EP2344528A1 (en) 2011-07-20
JP2012504941A (ja) 2012-03-01
WO2010040305A1 (en) 2010-04-15
EP2344528B1 (en) 2013-12-18
US8637467B2 (en) 2014-01-28
JP5734856B2 (ja) 2015-06-17

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