CN101389652B - 特异性结合vygfvracl-hla-a24的t细胞受体 - Google Patents

特异性结合vygfvracl-hla-a24的t细胞受体 Download PDF

Info

Publication number
CN101389652B
CN101389652B CN2006800182554A CN200680018255A CN101389652B CN 101389652 B CN101389652 B CN 101389652B CN 2006800182554 A CN2006800182554 A CN 2006800182554A CN 200680018255 A CN200680018255 A CN 200680018255A CN 101389652 B CN101389652 B CN 101389652B
Authority
CN
China
Prior art keywords
tcr
cell
chain
human
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800182554A
Other languages
English (en)
Chinese (zh)
Other versions
CN101389652A (zh
Inventor
B·K·雅各布森
李懿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avidex Ltd
Adaptimmune Ltd
Original Assignee
Immunocore Ltd
Medigene Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2005/002078 external-priority patent/WO2005116646A1/en
Application filed by Immunocore Ltd, Medigene Ltd filed Critical Immunocore Ltd
Priority claimed from PCT/GB2006/001857 external-priority patent/WO2006125962A2/en
Publication of CN101389652A publication Critical patent/CN101389652A/zh
Application granted granted Critical
Publication of CN101389652B publication Critical patent/CN101389652B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN2006800182554A 2005-05-25 2006-05-19 特异性结合vygfvracl-hla-a24的t细胞受体 Expired - Fee Related CN101389652B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBPCT/GB2005/002078 2005-05-25
PCT/GB2005/002078 WO2005116646A1 (en) 2004-05-26 2005-05-25 Method for the identification of a polypeptide which binds to a given pmhc complex
GB0524477.7 2005-11-30
GBGB0524477.7A GB0524477D0 (en) 2005-11-30 2005-11-30 Isolated T cell receptors which specifically bind to vygfvracl-hla-24
PCT/GB2006/001857 WO2006125962A2 (en) 2005-05-25 2006-05-19 T cell receptors which specifically bind to vygfvracl-hla-a24

Publications (2)

Publication Number Publication Date
CN101389652A CN101389652A (zh) 2009-03-18
CN101389652B true CN101389652B (zh) 2013-05-29

Family

ID=35685841

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800182554A Expired - Fee Related CN101389652B (zh) 2005-05-25 2006-05-19 特异性结合vygfvracl-hla-a24的t细胞受体

Country Status (8)

Country Link
US (1) US8017730B2 (enExample)
EP (1) EP1885754B1 (enExample)
JP (1) JP5149789B2 (enExample)
CN (1) CN101389652B (enExample)
AT (1) ATE497976T1 (enExample)
DE (1) DE602006020037D1 (enExample)
ES (1) ES2360598T3 (enExample)
GB (1) GB0524477D0 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105899530A (zh) * 2013-11-22 2016-08-24 伊利诺伊州大学理事会 工程化的高亲和力人类t细胞受体

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
ES2719495T5 (en) 2012-05-07 2025-09-10 Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
EP2877489A4 (en) 2012-07-27 2016-04-13 Univ Illinois MANIPULATION OF T-CELL RECEPTORS
EP2971045B1 (en) * 2013-03-13 2019-06-19 Health Research, Inc. Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
GB201516277D0 (en) * 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
WO2017076308A1 (zh) * 2015-11-04 2017-05-11 广州市香雪制药股份有限公司 识别ny-eso-1抗原短肽的tcr
CN107987155A (zh) * 2016-10-27 2018-05-04 中国科学院广州生物医药与健康研究院 识别sage1抗原短肽的t细胞受体
CN109251243B (zh) * 2017-07-13 2021-10-19 中国科学院广州生物医药与健康研究院 一种识别sage1抗原的t细胞受体及编码该受体的核酸
KR20200063215A (ko) 2017-10-06 2020-06-04 오슬로 유니버시테시케후스 에이치에프 키메라 항원 수용체

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044004A2 (en) * 2002-11-09 2004-05-27 Avidex Limited T cell receptor display

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
MXPA04001974A (es) * 2001-08-31 2004-07-16 Avidex Ltd Receptor de celula t soluble.
US20100068186A1 (en) * 2004-05-26 2010-03-18 Avidex Limited High affinity telomerase t cell receptors
GB0427585D0 (en) 2004-12-16 2005-01-19 Avidex Ltd Assay

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004044004A2 (en) * 2002-11-09 2004-05-27 Avidex Limited T cell receptor display

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Junko Arai, et al..Identification of human telomerase reverse transcriptase–derived peptides that induce HLA-A24–restricted antileukemia cytotoxic T lymphocytes.《BLOOD》.2001,第97卷(第9期),2903-2907. *
Yi Li, et al..Directed evolution of human T-cell receptors with picomolar affinities by phage display.《NATURE BIOTECHNOLOGY》.2005,第23卷(第3期),349-354. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105899530A (zh) * 2013-11-22 2016-08-24 伊利诺伊州大学理事会 工程化的高亲和力人类t细胞受体
US10344075B2 (en) 2013-11-22 2019-07-09 The Board Of Trustees Of The University Of Illinois Engineered high-affinity human t cell receptors
CN105899530B (zh) * 2013-11-22 2020-05-08 伊利诺伊州大学理事会 工程化的高亲和力人类t细胞受体

Also Published As

Publication number Publication date
US8017730B2 (en) 2011-09-13
CN101389652A (zh) 2009-03-18
ES2360598T3 (es) 2011-06-07
ATE497976T1 (de) 2011-02-15
EP1885754A2 (en) 2008-02-13
GB0524477D0 (en) 2006-01-11
US20080292602A1 (en) 2008-11-27
DE602006020037D1 (de) 2011-03-24
EP1885754B1 (en) 2011-02-09
JP5149789B2 (ja) 2013-02-20
JP2009506753A (ja) 2009-02-19

Similar Documents

Publication Publication Date Title
CN101189261B (zh) 高亲和力Melan-A T细胞受体
JP4773434B2 (ja) 高親和性ｎｙ−ｅｓｏｔ細胞受容体
WO2006125962A2 (en) T cell receptors which specifically bind to vygfvracl-hla-a24
JP2008514685A (ja) 治療剤に連結した、非天然型ジスルフィド鎖間結合を含有するｔ細胞レセプター
JP2006523437A (ja) レセプター複合体
JP5149789B2 (ja) Ｖｙｇｆｖｒａｃｌ−ｈｌａ−ａ２４に特異的に結合するｔ細胞レセプター
CN106632660A (zh) 识别ny‑eso‑1抗原短肽的tcr
JP2008520227A (ja) 可溶性二官能性タンパク質
JP2008520223A (ja) ガンマ−デルタｔ細胞レセプター
CN1989153B (zh) 高亲和力ny-eso t细胞受体
JP5186209B2 (ja) テロメラーゼ高親和性ｔ細胞受容体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: AMERICAN RUO BRANCH CO., LTD.

Free format text: FORMER OWNER: MEDIGENE LTD.

Effective date: 20100728

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20100728

Address after: Oxfordshire

Applicant after: Avidex Ltd.

Address before: Oxfordshire

Applicant before: Medigene Ltd.

C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: ADAPTIMMUNE LTD.

Effective date: 20140813

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20140813

Address after: Oxfordshire

Patentee after: Avidex Ltd.

Patentee after: ADAPTIMMUNE LTD

Address before: Oxfordshire

Patentee before: Avidex Ltd.

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130529

Termination date: 20160519

CF01 Termination of patent right due to non-payment of annual fee