CN101386873B - 使用改进量的氯和钾在微藻类中产生高水平的dha - Google Patents

使用改进量的氯和钾在微藻类中产生高水平的dha Download PDF

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Publication number
CN101386873B
CN101386873B CN200810166137.9A CN200810166137A CN101386873B CN 101386873 B CN101386873 B CN 101386873B CN 200810166137 A CN200810166137 A CN 200810166137A CN 101386873 B CN101386873 B CN 101386873B
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dha
sodium
substratum
potassium
concentration
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CN101386873A (zh
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保罗·W·贝伦斯
约翰·M·汤普森
柯克·阿普特
约瑟夫·W·法伊弗第三
詹姆斯·P·温
詹姆斯·C·利普迈耶
贾奥亚德·菲克塔里
乔恩·汉森
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Dsmip Asset Co
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DSM IP Assets BV
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium

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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200810166137.9A 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha Expired - Lifetime CN101386873B (zh)

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US50850503P 2003-10-02 2003-10-02
US60/508,505 2003-10-02

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CN101386873A CN101386873A (zh) 2009-03-18
CN101386873B true CN101386873B (zh) 2014-05-07

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CN200810166137.9A Expired - Lifetime CN101386873B (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha
CN201410126418.7A Pending CN103834699A (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha
CN2004800356858A Expired - Lifetime CN1890376B (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha

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CN2004800356858A Expired - Lifetime CN1890376B (zh) 2003-10-02 2004-10-01 使用改进量的氯和钾在微藻类中产生高水平的dha

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US (17) US7163811B2 (https=)
EP (2) EP2759599A3 (https=)
JP (4) JP4733043B2 (https=)
KR (6) KR20140119198A (https=)
CN (3) CN101386873B (https=)
AU (2) AU2004280575B8 (https=)
CA (2) CA2801065C (https=)
DK (1) DK1702073T3 (https=)
ES (1) ES2454196T3 (https=)
HK (1) HK1199289A1 (https=)
MX (4) MX271416B (https=)
NO (1) NO20061916L (https=)
WO (1) WO2005035775A1 (https=)

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HK1089482A1 (en) 2006-12-01
CN1890376B (zh) 2012-06-13
AU2004280575B2 (en) 2010-04-22
WO2005035775A1 (en) 2005-04-21
AU2004280575B8 (en) 2010-05-13
US20130150604A1 (en) 2013-06-13
JP4733043B2 (ja) 2011-07-27
US7824892B2 (en) 2010-11-02
US7745183B2 (en) 2010-06-29
US20060100279A1 (en) 2006-05-11
JP2015130886A (ja) 2015-07-23
EP1702073A4 (en) 2011-08-24
JP2013212126A (ja) 2013-10-17
NO20061916L (no) 2006-06-12
CN101386873A (zh) 2009-03-18
JP5813061B2 (ja) 2015-11-17
US20080032353A1 (en) 2008-02-07
CN103834699A (zh) 2014-06-04
CA2540617A1 (en) 2005-04-21
MX338455B (es) 2016-04-18
KR20140006109A (ko) 2014-01-15
US7252979B2 (en) 2007-08-07
EP2759599A2 (en) 2014-07-30
AU2004280575A1 (en) 2005-04-21
KR101180594B1 (ko) 2012-09-06
US8008050B2 (en) 2011-08-30
US9834799B2 (en) 2017-12-05
US20160108443A1 (en) 2016-04-21
US20130158280A1 (en) 2013-06-20
CA2801065A1 (en) 2005-04-21
EP1702073A1 (en) 2006-09-20
US20080032358A1 (en) 2008-02-07
US20120071677A1 (en) 2012-03-22
EP2759599A3 (en) 2014-12-10
US20080032354A1 (en) 2008-02-07
HK1199289A1 (en) 2015-06-26
KR20110033283A (ko) 2011-03-30
US8663953B2 (en) 2014-03-04
US7163811B2 (en) 2007-01-16
US20080032352A1 (en) 2008-02-07
US9249434B2 (en) 2016-02-02
JP5940194B2 (ja) 2016-06-29
JP2007527233A (ja) 2007-09-27
US7871809B2 (en) 2011-01-18
ES2454196T3 (es) 2014-04-09
EP1702073B1 (en) 2014-01-01
JP2011036261A (ja) 2011-02-24
JP5466120B2 (ja) 2014-04-09
US20080032359A1 (en) 2008-02-07
CA2801065C (en) 2020-04-28
KR20060097009A (ko) 2006-09-13
US20080032355A1 (en) 2008-02-07
MX304474B (https=) 2012-10-22
KR101761164B1 (ko) 2017-07-25
KR20130041366A (ko) 2013-04-24
AU2010202691B2 (en) 2013-09-12
MX351381B (es) 2017-10-12
US8669090B2 (en) 2014-03-11
US20140142331A1 (en) 2014-05-22
US20050112736A1 (en) 2005-05-26
US20080032357A1 (en) 2008-02-07
US20080044865A1 (en) 2008-02-21
CN1890376A (zh) 2007-01-03
AU2010202691A1 (en) 2010-07-15
KR20150125731A (ko) 2015-11-09
KR101295390B1 (ko) 2013-09-17
US20080032356A1 (en) 2008-02-07
DK1702073T3 (da) 2014-04-07
US20080044866A1 (en) 2008-02-21
MXPA06003467A (es) 2006-06-20
KR20140119198A (ko) 2014-10-08
US7829129B2 (en) 2010-11-09
MX271416B (es) 2009-10-30

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