CN101380025B - Acaricide composition containing tebufenpyrad and azocyclotin with synergistic action - Google Patents
Acaricide composition containing tebufenpyrad and azocyclotin with synergistic action Download PDFInfo
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- CN101380025B CN101380025B CN2008101325876A CN200810132587A CN101380025B CN 101380025 B CN101380025 B CN 101380025B CN 2008101325876 A CN2008101325876 A CN 2008101325876A CN 200810132587 A CN200810132587 A CN 200810132587A CN 101380025 B CN101380025 B CN 101380025B
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- tebufenpyrad
- azacyclotin
- azocyclotin
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- mite
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Abstract
The invention relates to a tebufenpyrad and azocyclotin miticide composite provided with synergy, which consists of effective active ingredients, auxiliaries and solvent or stuffing, and is characterized in that the effective active ingredients are tebufenpyrad and azocyclotin; the mixture ratio of tebufenpyrad and azocyclotin is 1:50-70:1. The advantages of the invention lie in that obvious synergy and continuous prevention and curing effect are possessed after tebufenpyrad and azocyclotin are combined; desinsection ectrum is enlarged, thus common fruit tree and cotton pests like red mites, tetranychus urticae koch and tetranychus cinnabarinus and so on can be killed; the composite has a plurality of functions of high efficiency, low mammalian toxicity, low pollution and low residue, and the like; besides, usage amount and frequencies of drugs are prominently lowered; cost is decreased; resistance to drugs of pests is retarded.
Description
Technical field
The invention belongs to the agricultural chemicals of control pest, the Compositional acaricide that to relate to a kind of effective active composition be tebufenpyrad and azacyclotin.
Background technology
Along with the fast development of Chinese national economy and improving constantly of living standards of the people, more and more higher requirement has been proposed for quantity, quality and the safety thereof of agricultural product.But, over past ten years, because high-quality, high yield and the variation of fruit tree crops such as oranges and tangerines, apple, and climate warming and the invasion of external pest, the generation prestige evil of fruit tree diseases and pests totally is the situation that rises significantly.
Mite pest, be commonly called as two spotted spider mite, it is one of main insect pest of crops such as fruit tree, cotton, vegetables, not only have a strong impact on the growing way of fruit tree and crops, because the generation algebraically of mite class is many, breeding spreads fast again, and alternately growth of many generations, thereby prevent quite difficulty, again because mite class and general farmland insect pest physiological mechanism different, general efficient pesticides does not almost have preventive and therapeutic effect to the mite class.In the past, it is less that China is used to prevent and treat the specialized acaricide of mite class, generally is to use dicofol, tetradiphon, isocarbophos, mixture of azacyclotin and they and diesel oil etc. etc., and control efficiency is undesirable.All need to use a large amount of agricultural chemicals and carry out pest control every year, retrieves crop yield loss as far as possible.But the agricultural chemicals abuse makes insect produce more and more serious resistance to agricultural chemicals, causes the pest control effect to reduce year by year.Many chemical pesticides residue in environment, and environment is polluted, and therefore, urgent need is more novel, more efficient, safer, the Pesticidal products of environmental protection more.
Tebufenpyrad belongs to the amide-type miticide, and its effect is to suppress the electronics transmission.The evil mite based on action of contace poison, is had permeability to plant tissue, but absorption in not having.All effective each breeding time to the mite class, can be used for fruit tree, tea tree, cotton, vegetables control tetranychid, rust mite, tarsonemid, palpus mite, aphid, aleyrodid also there are certain effect.Lasting period can reach more than 40 days.
In China, because tebufenpyrad import price height, usable floor area is confined on the high part fruit and vegetables of economic value added, and it is less to use area, can not use on agricultural insect pests control widely.
Azacyclotin: be the stronger broad spectrum activity miticide of action of contace poison.Can kill if mite, one-tenth mite and summer egg are invalid to winter egg.Light and rainwater are had stability preferably, and the longevity of residure is longer.Under typical concentrations to crop safety.
The synergistic complex of agricultural chemicals is expanding prevention spectrum and the effective measures that improve preventive effect, still finds no up to now and closes tebufenpyrad and the acaricidal composition of azacyclotin.
Summary of the invention
The objective of the invention is to: at using tebufenpyrad and azacyclotin control evil mite at present separately, dosage is bigger, and cost is higher, reuses the practical problem that insect easily produces resistance, has proposed a kind of composite tebufenpyrad azacyclotin acaricide composition.Because tebufenpyrad is different fully to the mechanism of action of target evil mite with azacyclotin, both composite uses can fully improve drug effect, raising insecticidal effect, minimizing dosage, reduce cost, delay the generation of evil mite resistance.
The object of the present invention is achieved like this: a kind of tebufenpyrad and azacyclotin have the acaricide composition of synergistic effect, comprise effective active component, auxiliary agent and solvent or filler, it is characterized in that: the effective active composition is tebufenpyrad and azacyclotin, and the weight proportion of tebufenpyrad and azacyclotin is 1: 50～70: 1.
In the Compositional acaricide that the present invention relates to, the shared percentage by weight of each effective active composition, auxiliary agent and solvent or inserts is: tebufenpyrad 1～50%; Azacyclotin 1～70%; Auxiliary agent 5～30%; Solvent or filling auxiliary material 20～75%.
The formulation that Compositional acaricide of the present invention relates to comprises missible oil, microemulsion, suspending agent, aqueous emulsion, wetting powder, water dispersible granules.
The invention has the advantages that: after tebufenpyrad and azacyclotin are composite, have notable synergistic and hold the effect control efficiency; Enlarged insecticidal spectrum, mandarin tree, apple tree, common Panonychus citri, Tetranychus urticae, the Tetranychus cinnabarinus of cotton have been had greater activity; Reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution; Person poultry safety, good, the harmful mite of Environmental compatibility are difficult for developing immunity to drugs.
Embodiment
Embodiment 1
The preparation of 30% tebufenpyrad azacyclotin wetting powder (active drug composition 5: 25):,
Auxiliary agent is selected: sodium lignin sulfonate, penetrant t.
Filler is selected: precipitated calcium carbonate.
Each component is got the raw materials ready according to percentage by weight:
Tebufenpyrad: 5%; Azacyclotin: 25%; Sodium lignin sulfonate one calcium 14 grams, penetrant t 3 grams, surplus precipitated calcium carbonate add to 100 grams.
Preparation process: tebufenpyrad, azacyclotin, sodium lignin sulfonate one calcium, penetrant t, surplus precipitated calcium carbonate are added to 100 grams.The method that above raw material is prepared wetting powder routinely drops in the mixing kettle mixes, and forms the system wetting powder.
Embodiment 2
The configuration of 55% tebufenpyrad azacyclotin suspension emulsion (active drug composition 5: 50):
Auxiliary agent is selected: sodium lignin sulfonate, OP-10; CMC; Organic silicone; Ethylene glycol.
Solvent is selected: water.
Each component is got the raw materials ready according to percentage by weight:
Tebufenpyrad: 5%; Azacyclotin: 50%; Sodium lignin sulfonate: 10%; OP-10:5%; Thickener CMC:1%; Defoamer organic silicone: 0.01%; Antifreeze glycol: 8%; Water: surplus.
Preparation process: with tebufenpyrad, azacyclotin, sodium lignin sulfonate, OP-10, thickener CMC, defoamer organic silicone, antifreeze glycol places reactor according to the above ratio, water adds to 100% and mixes, and mixture being introduced be milled to the material fineness in the skin grinder again is 1-5um; Mix integrated suspension emulsion after milling.
Embodiment 3
The configuration of 18% tebufenpyrad azacyclotin missible oil (active drug composition 10: 8):
Auxiliary agent is selected: basic sulfoacid calcium of dodecane and phenethyl phenol polyethenoxy ether mixture
The filling auxiliary material is selected: dimethylbenzene.
Tebufenpyrad: 10%; Azacyclotin: 8%; Basic sulfoacid calcium of dodecane and phenethyl phenol polyethenoxy ether mixture: 8%; Dimethylbenzene: an amount of.
Tebufenpyrad, azacyclotin, the basic sulfoacid calcium of dodecane and phenethyl phenol polyethenoxy ether mixture are placed blender according to the above ratio, be filled to 100% with dimethylbenzene; Above raw material is prepared missible oil and the mixing of method input mixing kettle high speed routinely, form missible oil.
Embodiment 4
The configuration of 20% tebufenpyrad azacyclotin microemulsion (active drug composition 10: 10):
Auxiliary agent is selected: the compound of calcium dodecyl benzene sulfonate and cyclohexanone
The filling auxiliary material is selected: water.
Each component is got the raw materials ready according to percentage by weight:
Tebufenpyrad: 10%; Azacyclotin: 10%; Calcium dodecyl benzene sulfonate and cyclohexanone: 8%; Water: an amount of.
Tebufenpyrad, azacyclotin, calcium dodecyl benzene sulfonate and cyclohexanone mixture are placed blender according to the above ratio, and water is filled to 100%; Above raw material is prepared microemulsion and the mixing of method input mixing kettle high speed routinely, form the agent of micro emulsion emulsion.
Embodiment 5
Composition such as tebufenpyrad, Avermectin has carried out mutual composite synergy research experiment:
Experimental condition
1, for the examination target
Tangerine Panonychus citri (Panonychus citri) becomes mite, for the worm kind is raised in this experiment on the greenhouse pot culture citrus.
2, condition of culture
In temperature is 25 ± 1 ℃, cultivates in the biochemical incubator about RH=85%.
3, instrument and equipment
Ten thousand/balance, binocular, illumination box, liquid-transfering gun, graduated cylinder, tweezers, tag board etc., marking pen, writing brush, slide, double faced adhesive tape, beaker, volumetric flask, pallet, sponge etc.
Experimental scheme
1, test medicine
The former medicine of azacyclotin (azocyclotin), content 90% (Shaanxi Welch Crop Protection Co., Ltd. provides).
The former medicine of tebufenpyrad (diafenthiuron), content 90% (Shaanxi Welch Crop Protection Co., Ltd. provides).
2, compounding method for medicament
Earlier azacyclotin is mixed with 1% water suspension emulsion mother liquor before the test, prescription is: former medicine 1.11g, dense newborn 500#1.00g, emulsifier 600 #1.00g, xanthans 0.20g, deionized water 96.69g; Tebufenpyrad is mixed with 1% water suspension emulsion mother liquor, and prescription is: former medicine 1.09g, and dense newborn 500#1.00g, emulsifier 600 #1.00g, xanthans 0.20g, deionized water 96.71g, other establishes no medicine blank.
3, dosage setting
Earlier azacyclotin, tebufenpyrad two single agent and different proportioning mixture thereof are carried out preliminary experiment, determine each medicament active ingredient concentration range, design 5 concentration respectively by active constituent content then and handle, concrete concentration is handled as follows:
Tebufenpyrad 5,10,15,20,25 μ g/ml
Azacyclotin 10,20,30,40,50 μ g/ml
Tebufenpyrad: azacyclotin (50: 10) 5,10,15,20,25 μ g/ml
Tebufenpyrad: azacyclotin (40: 25) 5,10,15,20,25 μ g/ml
Tebufenpyrad: azacyclotin (30: 40) 5,10,15,20,25 μ g/ml
Tebufenpyrad: azacyclotin (20: 55) 5,10,15,20,25 μ g/ml
Tebufenpyrad: azacyclotin (10: 70) 5,10,15,20,25 μ g/ml
Blank
4, test repeats
Each concentration is handled and is repeated 4 times, and each repeats used examination borer population is 30.
5, processing method
The slide infusion process.
Test method
This test is carried out with reference to " agricultural chemicals indoor bioassay test rule insecticide ".Adopt the slide infusion process.Double faced adhesive tape is cut into 2～3cm length, be attached to an end of microslide, throw off the scraps of paper on the adhesive tape with tweezers, select the citrus red mite that size is consistent, body colour is bright-coloured, action is active with No. zero writing brush and become mite, its back is bonded at (mite foot, mite palpus and mouthpart are not clung in attention) on the two-sided tape, every sticking 3 row.In temperature is 25 ± 1 ℃, behind the placement 4h, uses binocular vision in the biochemical incubator about RH=85%, rejects the torpescence individuality, and reaching 10 of every row is that every slide has 30 active one-tenth mites.End that will band mite slide immerses in the soup, takes out after shaking 5s gently, inhales with blotting paper rapidly and removes unnecessary soup.Slide is put into the pallet that is covered with moistening sponge, place the biochemical incubator of above-mentioned condition.
Data survey and statistical analysis
1, investigation method
Try the worm death condition with the binocular inspection after 48 hours.Touch the mite body with writing brush, motionless person is death with the mite foot.
2, defeated analysis according to statistics
Calculate each medicament lethality and corrected mortality according to following formula.
Corrected mortality is converted into probit value (y), and drug concentration (μ g/ml) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the LC of every kind of medicament thus
50Value and 95% confidence limit.Calculate co-toxicity coefficient (CTC) according to Sun Yun Liubang's formula, co-toxicity coefficient is an antagonism less than 80, and 80～120 is summation action, is synergistic effect more than or equal to 120.Computing formula following (with the tebufenpyrad is the standard medicament, and its toxicity index is 100):
The TI*P tebufenpyrad of theoretical toxicity index (TTI)=tebufenpyrad of M+azacyclotin TI*P azacyclotin
Wherein: M is the mixture of tebufenpyrad and the different proportionings of azacyclotin
P
TebufenpyradBe tebufenpyrad proportion in combination
P
AzacyclotinBe azacyclotin shared ratio in combination
Test results and analysis
Tebufenpyrad the results are shown in Table 1 to 48 hours toxicity test of tangerine Panonychus citri, medicament virulence regression equation formula, LC with azacyclotin two single agent and the mixing of different proportioning thereof
50Value (μ g/ml) sees Table 2 with the co-toxicity coefficient of 95% confidence limit and tebufenpyrad and the different proportionings of azacyclotin.
Table 2 tebufenpyrad and azacyclotin two single agent and different proportioning thereof are used the virulence to the tangerine Panonychus citri with
| For the gesture medicament | Toxicity regression formula (y=a+bx) | LC50 (μ g/ml) (95% writes limit) | Single agent toxicity index (TI) | The actual toxicity index of mixture (ATI) | The theoretical toxicity index (TTI) of mixture | Co-toxicity coefficient (CTC) |
| Azacyclotin | y＝3.04921+1.616 04x | 16.11(7.69～72.34) | 100.00 | - | - | - |
| Tebufenpyrad | y＝2.91205+1.419 05x | 29.61(19.02～53.53) | 54.41 | - | - | - |
| Tebufenpyrad: azacyclotin (10: 70) | y＝2.98162+1.740 46x | 14.44(6.69～79.18) | - | 121.58 | 89.60 | 254.72 |
| Tebufenpyrad: azacyclotin (20: 55) | y＝3.24147+1.548 12x | 13.67(5.69～150.69) | - | 137.85 | 90.76 | 273.52 |
| Tebufenpyrad: azacyclotin (30: 40) | y＝2.64378+1.955 66x | 16.03(7.90～63.50) | - | 142.53 | 92.30 | 294.27 |
| Tebufenpyrad: azacyclotin (40: 25) | y＝2.83485+1.716 86x | 18.24(7.93～115.29) | - | 150.33 | 95.55 | 309.47 |
| Tebufenpyrad: azacyclotin (50: 10) | y＝2.76574+1.684 16x | 21.21(8.33～203.85) | - | 155.95 | 96.50 | 310.32 |
As can be seen from Table 2, tebufenpyrad and azacyclotin are respectively the LC50 of tangerine Panonychus citri
16.11 μ g/ml and 29.61 μ g/ml, tebufenpyrad and abamectin compounded in the scope of 1: 70～50: 1 (by quality), has very high synergistic effect to Panonychus citri.
Claims (3)
1. the Compositional acaricide of tebufenpyrad and azacyclotin comprises effective active component, auxiliary agent and solvent or inserts, and it is characterized in that: the effective active composition is tebufenpyrad and azacyclotin, and the weight proportion of tebufenpyrad and azacyclotin is 10: 70～50: 10.
2. the Compositional acaricide of tebufenpyrad according to claim 1 and azacyclotin is characterized in that: each effective active composition, auxiliary agent and solvent or the percentage by weight of inserts in Compositional acaricide are: tebufenpyrad 10%～50%; Azacyclotin 10%～70%; Auxiliary agent 5%～30%; Solvent or inserts 20%～75%, the content summation of said components is 100%.
3. the Compositional acaricide of tebufenpyrad according to claim 1 and 2 and azacyclotin is characterized in that: the formulation of Compositional acaricide is missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder, water dispersible granules.
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| CN2008101325876A CN101380025B (en) | 2008-07-17 | 2008-07-17 | Acaricide composition containing tebufenpyrad and azocyclotin with synergistic action |
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| CN2008101325876A CN101380025B (en) | 2008-07-17 | 2008-07-17 | Acaricide composition containing tebufenpyrad and azocyclotin with synergistic action |
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| CN101380025B true CN101380025B (en) | 2011-07-20 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305713A (en) * | 2000-01-14 | 2001-08-01 | 山东华阳农药化工集团有限公司 | Broad-spectrum mixture of agirculture insecticide and miticide |
| CN1943343A (en) * | 2006-11-07 | 2007-04-11 | 深圳诺普信农化股份有限公司 | Miticide with synergistic function containing tebufenpyrad and pyridaben |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305713A (en) * | 2000-01-14 | 2001-08-01 | 山东华阳农药化工集团有限公司 | Broad-spectrum mixture of agirculture insecticide and miticide |
| CN1943343A (en) * | 2006-11-07 | 2007-04-11 | 深圳诺普信农化股份有限公司 | Miticide with synergistic function containing tebufenpyrad and pyridaben |
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| Title |
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| JP特开2006-213664A 2006.08.17 |
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Effective date of registration: 20161216 Address after: 715500 Shaanxi Pucheng County agricultural base industrial park Patentee after: Shaanxi Meibang Pesticides Co., Ltd. Address before: 715500 Pucheng province Shaanxi County Chengguan Town Food City Street No. 23 Patentee before: Zhang Shaowu |
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