CN104824011A - Insecticidal composition containing pyridine quinazoline and guadipyr - Google Patents
Insecticidal composition containing pyridine quinazoline and guadipyr Download PDFInfo
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- CN104824011A CN104824011A CN201510208021.7A CN201510208021A CN104824011A CN 104824011 A CN104824011 A CN 104824011A CN 201510208021 A CN201510208021 A CN 201510208021A CN 104824011 A CN104824011 A CN 104824011A
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- pyridine quinazoline
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- penta pyrrole
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Abstract
The invention discloses an insecticidal composition containing pyridine quinazoline and guadipyr. The composition comprises a first effective component (pyridine quinazoline), a second effective component (guadipyr), and usual auxiliary components; wherein the weight ratio of pyridine quinazoline to guadipyr is 40:1 to 1:40. The results of a great number of indoor and outdoor experiments show that the provided insecticidal composition has a prominent synergetic effect, and the controlling effect on a plurality of injurious insects is better than that of single component. The using amount of pesticide is reduced at the same time, thus the residual pesticide on the agricultural products is reduced, the pollution to the environment is relieved, and the generation of drug resistance becomes more difficult.
Description
Technical field
The present invention relates to agricultural insecticide composition and application thereof, specifically a kind of with pyridine quinazoline and penta pyrrole worm guanidine for the composite binary complex of active ingredient, be mainly used in the control of insect on crops.
Background technology
Pyridine quinazoline (Pyrifluquinazon), belong to novel quinazoline quinoline insecticides, the mechanism of action stops insect feed, until insect is slowly died of hunger, to be mainly used on the crop such as control vegetables, fruit tree and tealeaves the sucking mouthpart insects such as Phytophthira, aleyrodid class, shell insects, leafhopper class, thrips class, significantly can reduce the propagation of viral vectors, this compound can penetrate blade face completely, also can reach the object of effective prevention and control to the insect of predation and perch below blade face.
Penta pyrrole worm guanidine (Guadipyr), belong to nitro contracting aminoguanidine compounds, it is a kind of brand-new insecticide of efficient, low toxicity, low-residual, have the architectural feature of anabasine insecticide and sodium-ion channel inhibitor insecticides concurrently, there is insecticidal spectrum wide, the features such as action target site is many, have good preventive effect to lepidoptera pests such as the homoptera pests such as aphid, plant hopper, aleyrodid, leafhopper and cotton bollworm, diamond-back moth, beet armyworms.
The resistance problems of pest is global problems, is the emphasis problem that agricultural science and technology worker pays close attention to always.Along with the continuity year in year out of Chemical Control of Harmful Insects, the increase of Pesticide use amount and the not factor such as scientifical use agricultural chemicals, cause pest resistance day by day serious, the pest species producing resistance is on the increase.Meanwhile, the use agricultural chemicals of high strength, result in that Practice for Pesticide Residue in Agricultural Products exceeds standard, the series of problems such as contaminated environment and the increase of peasant's drug cost, is unfavorable for the sustainable development of agricultural.
Therefore, development is efficient, low toxicity, low-residual, the different mechanism of action, have again the complex preparation of synergistic function simultaneously, not only contribute to the generation delaying pest resistance to insecticide, but also the service life of pesticide species can be extended, reduce using dosage, cost-saving, reduce the pollution to environment.
The compounded formula screening of the present inventor to pyridine quinazoline and penta pyrrole worm guanidine conducts in-depth research, surprisingly pyridine quinazoline and penta pyrrole worm guanidine carry out composite, within the scope of certain compound proportion, there is significant synergistic function, in actual use, outstanding control efficiency is all had to the various pests on crops, after further study, the present invention is completed.
Not yet find pyridine quinazoline and the composite report for preventing and treating agriculturally insect of penta pyrrole worm guanidine at present.
Summary of the invention
The object of the invention is to overcome the problems referred to above and a kind of Pesticidal combination containing pyridine quinazoline and penta pyrrole worm guanidine is provided, this complex composition has significant synergistic function, expand insecticidal spectrum, be mainly used in the control of the Thysanoptera such as homoptera pest and thrips such as the lepidoptera pests such as the striped rice borer on crops, paddy stem borer, rice leaf roller, diamond-back moth, cabbage caterpillar, prodenia litura, beet armyworm, lima bean pod borer, leaf roller, cotton bollworm, scale insect, trialeurodes vaporariorum, pear sucker, Bemisia tabaci, rice fulgorid, aphid, tea lesser leafhopper.
Technical scheme: a kind of Pesticidal combination containing pyridine quinazoline and penta pyrrole worm guanidine, active ingredient is pyridine quinazoline and penta pyrrole worm guanidine, the weight ratio of pyridine quinazoline and penta pyrrole worm guanidine is 40:1 ~ 1:40, preferred weight ratio is 10:1 ~ 1:10, pyridine quinazoline and penta pyrrole worm guanidine weight summation percentage by weight are in the composition 1 ~ 85%, and all the other are allow in agricultural chemicals to use and acceptable auxiliary element.
Described auxiliary element is one or more the combination in solvent, emulsifier, wetting agent, dispersant, stabilizing agent, antifreezing agent, thickener, disintegrant, binding agent, defoamer, bleeding agent, synergist, fire retardant, density adjuster and filler, above material is known substance conventional in pesticidal preparations, change to some extent according to being prepared into the different formulations of pesticide, but be not particularly limited.
Pesticidal combination of the present invention can be prepared into any one formulation that applicable agricultural production uses by known method, reasonable formulation has micro-capsule suspension, suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wetting powder, thermal fog and ultra low volume liquids.
The production technology of the various application forms of described Pesticidal combination all belongs to existing known technology, does not repeat them here.
The frequency of administration of Pesticidal combination of the present invention and amount of application change with crops, insect, weather condition and have small variations, can by the object using suitable dosage reach effectively control.
Compared with prior art, the invention has the advantages that:
The present invention in use can reduce dosage, reduces the residual quantity of agricultural chemicals on crops, delay the generation of pest resistance to insecticide, it can also be made to be used alone to compare than single dose to the control efficiency of various insect and to significantly improve, laborsaving, economical, reduce farmer's burdens.
1, pyridine quinazoline and penta pyrrole worm guanidine binary built use and have significant synergistic function, the control efficiency significantly improved insect is used alone than single dose, expand insecticidal spectrum simultaneously, solve the defect to some pest controling effect difference when single dose is used alone.
2, pyridine quinazoline and penta pyrrole worm guanidine binary built use, and the mechanism of action is different, and action site increases, and can delay the generation of pest resistance to insecticide.
3, pyridine quinazoline and penta pyrrole worm guanidine binary built use, and decrease Pesticide use amount, reduce use cost, alleviate the pollution to environment.
Embodiment
In order to understand essence of the present invention better; below in conjunction with embodiment, content of the present invention is described further; but can not limitation of the present invention be considered as; the following stated is only for explaining the present invention; for not departing from amendment that the present invention's spirit and principle make, replacement or improvement, all belong to the scope of protection of present invention.
(1) Formulation Example
In following each embodiment, each component percentages is weight percentage.
Embodiment 1:12% pyridine quinazoline penta pyrrole worm guanidine ultra low volume liquids
Pyridine quinazoline 7%, penta pyrrole worm guanidine 5%, methyl naphthalene 20%, loose base oil 10%, phenethyl phenol polyethenoxy ether phosphate 5%, calcium dodecyl benzene sulfonate 5%, gibberellic acid 0.02%, azone 2%, methyl oleate complements to 100%.After above-mentioned active ingredient stirring solvent being dissolved, then add other auxiliary agent, be fully uniformly mixed, 12% pyridine quinazoline penta pyrrole worm guanidine ultra low volume liquids can be obtained.
Embodiment 2:15% pyridine quinazoline penta pyrrole worm guanidine ultra low volume liquids
Pyridine quinazoline 10%, penta pyrrole worm guanidine 5%, trimethylbenzene 20%, 1-METHYLPYRROLIDONE 10%, phenethyl phenol polyethenoxy ether phosphate 5%, DBSA ammonium 5%, brassin lactones 0.02%, isophorone 2%, corn oil complements to 100%.After above-mentioned active ingredient stirring solvent being dissolved, then add other auxiliary agent, be fully uniformly mixed, 15% pyridine quinazoline penta pyrrole worm guanidine ultra low volume liquids can be obtained.
Embodiment 3:20% pyridine quinazoline penta pyrrole worm guanidine micro-capsule suspension
Pyridine quinazoline 8%, penta pyrrole worm guanidine 12%, toluene di-isocyanate(TDI) 20%, ethyl acetate 10%, dimethyl carbonate 10%, castor oil polyoxyethylene ether 5%, sodium methylene bis-naphthalene sulfonate 3%, deionized water complements to 100%.By above-mentioned active ingredient, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, dispersant, add citric acid adjust ph to 6.5 again, surplus deionized water is supplied, and bi-material reacts at oil-water interfaces, form macromolecule cyst wall, 20% pyridine quinazoline penta pyrrole worm guanidine micro-capsule suspension can be obtained.
Embodiment 4:10% pyridine quinazoline penta pyrrole worm guanidine micro-capsule suspension
Pyridine quinazoline 4%, penta pyrrole worm guanidine 6%, diethylenetriamine 20%, solvent naphtha S-20010%, dimethyl carbonate 10%, castor oil polyoxyethylene ether 5%, polycarboxylate 3%, deionized water complements to 100%.By above-mentioned active ingredient, macromolecule cyst material, solvent, make to be dissolved into homogeneous oil phase, in a shear condition, oil phase is joined in the aqueous phase solution containing emulsifier, dispersant, add mannitol adjust ph to 6.5 again, surplus deionized water is supplied, and bi-material reacts at oil-water interfaces, form macromolecule cyst wall, 10% pyridine quinazoline penta pyrrole worm guanidine micro-capsule suspension can be obtained.
Embodiment 5:30% pyridine quinazoline penta pyrrole worm guanidine suspending agent
Pyridine quinazoline 20%, penta pyrrole worm guanidine 10%, alkylphenol-polyethenoxy base ether phosphate 10%, acrylate homopolymer sodium salt 5%, naphthalene sulfonic acid condensate sodium salt 5%, polyethylene glycol 3%, xanthans 1%, polyethers emulsion 0.1%, azone 1%, Kathon CG KF88 1%, deionized water supplies 100%.By above-mentioned active ingredient, wetting agent, dispersant, antifreezing agent, thickener, defoamer, synergist and preservative sand milling in high speed shear dispersion, sand mill, the high dispersive formed in water-medium, stable suspension system, can obtain 30% pyridine quinazoline penta pyrrole worm guanidine suspending agent.
Embodiment 6:25% pyridine quinazoline penta pyrrole worm guanidine suspending agent
Pyridine quinazoline 12.5%, penta pyrrole worm guanidine 12.5%, lauryl sodium sulfate 10%, rosin segmented APEO polyoxypropylene ether sulfonate 5%, naphthalene sulfonic acid condensate sodium salt 5%, polyethylene glycol 3%, bentonite 1%, isooctanol 0.1%, vegetable oil 1%, sorb sodium alkoxide 0.1%, deionized water supplies 100%.By above-mentioned active ingredient, wetting agent, dispersant, antifreezing agent, thickener, defoamer, synergist and preservative sand milling in high speed shear dispersion, sand mill, the high dispersive formed in water-medium, stable suspension system, can obtain 25% pyridine quinazoline penta pyrrole worm guanidine suspending agent.
Embodiment 7:35% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion
Pyridine quinazoline 15%, penta pyrrole worm guanidine 20%, durene 10%, dibasic ester 10%, terminal hydroxy group polyoxyethylene poly-oxygen propylene aether 10%, polycarboxylate 5%, the formaldehyde condensation products 5% of methyl naphthalene sulfonic acid sodium, epoxidized soybean oil 1%, glycerine 1%, deionized water supplies 100%.Above-mentioned active ingredient, solvent, emulsifier, dispersant and stabilizing agent are mixed to form oil phase, antifreezing agent dissolves and forms aqueous phase in water, slowly oil phase is added in aqueous phase under clipper effect, and continue to shear about 30 minutes, the pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion of obtained 35%.
Embodiment 8:20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion
Pyridine quinazoline 10%, penta pyrrole worm guanidine 10%, methyl naphthalene 10%, dibasic ester 10%, terminal hydroxy group polyoxyethylene poly-oxygen propylene aether 10%, polycarboxylate 5%, the formaldehyde condensation products 5% of methyl naphthalene sulfonic acid sodium, pentaerythrite 1%, glycerine 1%, deionized water supplies 100%.Above-mentioned active ingredient, solvent, emulsifier, dispersant and stabilizing agent are mixed to form oil phase, antifreezing agent dissolves and forms aqueous phase in water, slowly oil phase is added in aqueous phase under clipper effect, and continue to shear about 30 minutes, the pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion of obtained 20%.
Embodiment 9:40% pyridine quinazoline penta pyrrole worm guanidine microemulsion
Pyridine quinazoline 30%, penta pyrrole worm guanidine 10%, trimethylbenzene 5%, dimethyl carbonate 15%, triphen ethyl phenol polyoxyethylene groups ether phosphate 10%, pyrogallic acid 2%, organosilicon 1%, azone 2%, deionized water supplies 100%.Active ingredient solvent is dissolved completely, and then add emulsifier, stabilizing agent, bleeding agent, synergist mix, finally add deionized water, after fully stirring, the pyridine quinazoline penta pyrrole worm guanidine microemulsion of 40% can be obtained.
Embodiment 10:45% pyridine quinazoline penta pyrrole worm guanidine microemulsion
Pyridine quinazoline 5%, penta pyrrole worm guanidine 40%, ethanol 5%, dibasic ester 15%, alkylphenol polyoxyethylene sulfosuccinate 10%, epoxychloropropane 2%, organosilicon 1%, thiophene ketone 2%, deionized water supplies 100%.Active ingredient solvent is dissolved completely, and then add emulsifier, stabilizing agent, bleeding agent, synergist mix, finally add deionized water, after fully stirring, the pyridine quinazoline penta pyrrole worm guanidine microemulsion of 45% can be obtained.
Embodiment 11:50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules
Pyridine quinazoline 25%, penta pyrrole worm guanidine 25%, alkyl phenol resin polyoxyethylene ether sulfate 10%, the formaldehyde condensation products 10% of methyl naphthalene sulfonic acid sodium, polycarboxylate 10%, sodium hexametaphosphate 5%, kaolin supplies 100%.Above-mentioned active ingredient, wetting agent, dispersant, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then adding in fluidized-bed granulation dryer and carrying out granulation, drying, screening, 50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules can be obtained.
Embodiment 12:70% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules
Pyridine quinazoline 50%, penta pyrrole worm guanidine 20%, alkyl phenol resin polyoxyethylene ether sulfate 10%, the formaldehyde condensation products 5% of methyl naphthalene sulfonic acid sodium, acrylate homopolymer sodium salt 5%, mineral salt 5%, diatomite supplies 100%.Above-mentioned active ingredient, wetting agent, dispersant, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then adding in fluidized-bed granulation dryer and carrying out granulation, drying, screening, 70% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules can be obtained.
Embodiment 13:80% pyridine quinazoline penta pyrrole worm guanidine wetting powder
Pyridine quinazoline 20%, penta pyrrole worm guanidine 60%, butyl naphthalene sulfonate 5%, aerosol-OT salt 5%, rosin segmented APEO polyoxypropylene ether sulfonate 5%, potter's clay supplies 100%.By above-mentioned, active ingredient, wetting agent, dispersant and filler are mixed, again through air-flow crushing after mechanical crushing, mix, 80% pyridine quinazoline penta pyrrole worm guanidine wetting powder can be obtained.
Embodiment 14:75% pyridine quinazoline penta pyrrole worm guanidine wetting powder
Pyridine quinazoline 50%, penta pyrrole worm guanidine 25%, lauryl sodium sulfate 5%, aerosol-OT salt 5%, rosin segmented APEO polyoxypropylene ether sulfonate 5%, fine particle calcium carbonate supplies 100%.By above-mentioned, active ingredient, wetting agent, dispersant and filler are mixed, again through air-flow crushing after mechanical crushing, mix, 75% pyridine quinazoline penta pyrrole worm guanidine wetting powder can be obtained.
Embodiment 15:8% pyridine quinazoline penta pyrrole worm guanidine thermal fog
Pyridine quinazoline 5%, penta pyrrole worm guanidine 3%, 2-butyl acetate 5%, 1-METHYLPYRROLIDONE 15%, phenol derivatives APEO 10%, paracide 2%, glycerine 1%, sodium carboxymethylcellulose 1%, polyethylene glycol diglycidyl ether 3%, azone 2%, soybean oil complements to 100%.Above-mentioned active ingredient and solvent are dropped in the reaction vessel of band stirring, after active ingredient is fully dissolved, add again emulsifier, anti-elegant dose, antifreezing agent, thickener, stabilizing agent and synergist, abundant stir about 60 minutes, make it mix, 8% pyridine quinazoline penta pyrrole worm guanidine thermal fog can be obtained.
Embodiment 16:10% pyridine quinazoline penta pyrrole worm guanidine thermal fog
Pyridine quinazoline 1%, penta pyrrole worm guanidine 9%, isooctanol 5%, 2-butyl acetate 15%, phenol derivatives APEO 10%, paracide 2%, glycerine 1%, bentonite 1%, epoxidized linseed 3%, azone 2%, soybean oil complements to 100%.Above-mentioned active ingredient and solvent are dropped in the reaction vessel of band stirring, after active ingredient is fully dissolved, add again emulsifier, anti-elegant dose, antifreezing agent, thickener, stabilizing agent and synergist, abundant stir about 60 minutes, make it mix, 10% pyridine quinazoline penta pyrrole worm guanidine thermal fog can be obtained.
(2) the indoor biological determination of activity of the present composition and field efficacy checking
Embodiment 17: pyridine quinazoline and penta pyrrole worm guanidine are to the indoor joint toxicity measuring test of rice hoppers
For examination worm: indoor rice fulgorid 3 nymph in age for many generations raising health.
Reagent agent: the former medicine of 98.4% pyridine quinazoline and the 90% penta former medicines of pyrrole worm guanidine.
Test method: adopt rice-stem dipping method to measure, specific as follows.
First choose 2 leaf 1 heart rice seedling 15 strains, within 30 seconds, take out nature afterwards supplying dipping in reagent liquid and dry, encase root moisturizing with wet absorbent cotton, outsourcing preservative film, be placed in teat glass (200 × 30mm), every concentration repeats for 4 times.Then with rice fulgorid 3 nymph in age of writing brush access ether light anesthesia, often pipe 20, the white gauze of the mouth of pipe is tightened, and is placed in indoor observation.After process, 72h investigation examination worm death condition (gently stinging examination worm without autonomic response for judging the standard of examination worm death with pin), records dead borer population and total borer population.
Carry out statistical analysis with DPS statistical analysis software, calculate the LC of each medicament
50, and the co-toxicity coefficient (CTC value) of mixture is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent LC
50/ reagent agent LC
50) × 100.
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
As can be seen from Table 1, pyridine quinazoline and penta pyrrole worm guanidine composite in the scope of 40:1 ~ 1:40 (by weight) time, co-toxicity coefficient (CTC) is all greater than 120, shows synergistic function to rice hoppers; In the scope of 10:1 ~ 1:10 (by quality), synergistic function is more remarkable, and co-toxicity coefficient (CTC) is all more than 300; Especially composite with 1:1 (by quality), synergistic function is the most remarkable, and co-toxicity coefficient (CTC) is 362.20.Visible pyridine quinazoline and penta pyrrole worm guanidine is composite has reasonability and feasibility.
Table 1, pyridine quinazoline and penta pyrrole worm guanidine are to the indoor joint toxicity measuring result of rice hoppers
| Medicament title and proportioning (weight ratio) | LC 50(mg/L) | ATI | TTI | CTC |
| Pyridine quinazoline | 6.41 | 100.00 | - | - |
| Penta pyrrole worm guanidine | 17.49 | 36.65 | - | - |
| Pyridine quinazoline: penta pyrrole worm guanidine (40:1) | 4.16 | 154.09 | 98.45 | 156.52 |
| Pyridine quinazoline: penta pyrrole worm guanidine (30:1) | 3.31 | 193.66 | 97.96 | 197.69 |
| Pyridine quinazoline: penta pyrrole worm guanidine (20:1) | 2.66 | 240.98 | 96.98 | 248.48 |
| Pyridine quinazoline: penta pyrrole worm guanidine (10:1) | 2.25 | 284.89 | 94.24 | 302.30 |
| Pyridine quinazoline: penta pyrrole worm guanidine (5:1) | 2.13 | 300.94 | 89.44 | 336.47 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:1) | 2.59 | 247.49 | 68.33 | 362.20 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:5) | 3.78 | 169.58 | 47.21 | 359.20 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:10) | 4.55 | 140.88 | 42.41 | 332.19 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:20) | 6.02 | 106.48 | 39.67 | 268.41 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:30) | 8.21 | 78.08 | 38.69 | 201.81 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:40) | 10.42 | 61.52 | 38.20 | 161.05 |
Embodiment 18: pyridine quinazoline and the indoor joint toxicity measuring test of penta pyrrole worm guanidine to wild cabbage diamond-back moth supply examination worm: diamond-back moth 3 instar larvae that indoor for many generations raising Individual Size is consistent with physiological status.
Reagent agent: the former medicine of 98.4% pyridine quinazoline and the 90% penta former medicines of pyrrole worm guanidine.
Test method: adopt the malicious blade method of folder, concrete grammar is as follows.
First beat with the card punch of diameter 1cm and get leaf butterfly, put into culture dish, moisturizing.Then with capillary dropper by each treatment agent from low concentration, every leaf butterfly drop 1 μ L liquid, after solvent volatilization and another sheet scribble that the leaf butterfly of gelatinized corn starch is involutory makes the malicious leaf butterfly of folder, make in the complete hole being put in 12 hole tissue culturing plates.Connect 1 examination worm in each hole of last tissue culturing plate, be placed in temperature 26 ± 1 DEG C, relative moisture is in the intelligent insectary of 70%.Connect worm after 2 ~ 4 hours, after examination worm has taken food pastille leaf butterfly, in cultivation plate hole, added clean feeds continue to raise to investigation, eliminate the examination worm not eaten a complete leaf butterfly.Often 4 repetition are established in process, often repeat to be no less than 12 malicious leaf butterflies of folder, and the process of establishing the corresponding organic solvent not containing medicament in contrast.After process, 72h investigation examination worm death condition, records total borer population and dead borer population.
Carry out statistical analysis with DPS statistical analysis software, calculate the LC of each medicament
50, and the co-toxicity coefficient (CTC value) of mixture is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent LC
50/ reagent agent LC
50) × 100.
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
As can be seen from Table 2, pyridine quinazoline and penta pyrrole worm guanidine composite in the scope of 40:1 ~ 1:40 (by weight) time, co-toxicity coefficient (CTC) is all greater than 120, shows synergistic function to wild cabbage diamond-back moth; In the scope of 10:1 ~ 1:10 (by quality), synergistic function is more remarkable, and co-toxicity coefficient (CTC) is all more than 300; Especially composite with 1:1 (by quality), synergistic function is the most remarkable, and co-toxicity coefficient (CTC) is 394.84.Visible pyridine quinazoline and penta pyrrole worm guanidine is composite has reasonability and feasibility.
Table 2, pyridine quinazoline and penta pyrrole worm guanidine are to the indoor joint toxicity measuring result of wild cabbage diamond-back moth
| Medicament title and proportioning (weight ratio) | LC 50(mg/L) | ATI | TTI | CTC |
| Pyridine quinazoline | 27.42 | 100.00 | - | - |
| Penta pyrrole worm guanidine | 21.35 | 128.43 | - | - |
| Pyridine quinazoline: penta pyrrole worm guanidine (40:1) | 17.21 | 159.33 | 100.69 | 158.24 |
| Pyridine quinazoline: penta pyrrole worm guanidine (30:1) | 15.16 | 180.87 | 100.92 | 179.22 |
| Pyridine quinazoline: penta pyrrole worm guanidine (20:1) | 11.39 | 240.74 | 101.35 | 237.53 |
| Pyridine quinazoline: penta pyrrole worm guanidine (10:1) | 8.43 | 325.27 | 102.58 | 317.09 |
| Pyridine quinazoline: penta pyrrole worm guanidine (5:1) | 7.54 | 363.66 | 104.74 | 347.20 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:1) | 6.08 | 450.99 | 114.22 | 394.84 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:5) | 6.32 | 433.86 | 123.69 | 350.76 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:10) | 6.95 | 394.53 | 125.85 | 313.49 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:20) | 7.47 | 367.07 | 127.08 | 288.85 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:30) | 9.36 | 292.95 | 127.51 | 229.75 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:40) | 11.89 | 230.61 | 127.74 | 180.53 |
Embodiment 19: pyridine quinazoline and the indoor joint toxicity measuring test of penta pyrrole worm guanidine to eggplant thrips supply examination worm: eggplant thrips 2 nymph in age of indoor feeding.
Reagent agent: the former medicine of 98.4% pyridine quinazoline and the 90% penta former medicines of pyrrole worm guanidine.
Test method: adopt dip method to measure, specific as follows.
Choose healthy and strong eggplant thrips nymph, provoking with writing brush and being carried on the back to be bonded at posts on the slide of double faced adhesive tape, every agreement that contracts a film or TV play to an actor or actress 35, be placed in culture dish, moisturizing after 2h, often only tries worm with 6 times of stereoscope inspections under temperature (25 ± 1) DEG C condition, removes the individuality that oneself is dead and very not active, make in every slide, have 25 to try worm, often process 2 slides; Immerse with the slide one end being stained with examination worm and to be measured shake slide gently in reagent liquid, take out after leaching 5s, suck unnecessary liquid with blotting paper, put into culture dish, be placed in incubator moisturizing and cultivate.Often process arranges 4 repetitions, and using the water containing DMF solvent and 0.1%Tween80 emulsifier as blank.Examination worm death condition is checked, line item of going forward side by side after 24h.
Carry out statistical analysis with DPS statistical analysis software, calculate the LC of each medicament
50, and the co-toxicity coefficient (CTC value) of mixture is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent LC
50/ reagent agent LC
50) × 100.
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index × mixture in the percentage composition of B.
Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
According to the NY/T11547.7-2006 insecticide combination effect criteria for classifying: co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.
Table 3, pyridine quinazoline and penta pyrrole worm guanidine are to the indoor joint toxicity measuring result of eggplant thrips
| Medicament title and proportioning (weight ratio) | LC 50(mg/L) | ATI | TTI | CTC |
| Pyridine quinazoline | 9.58 | 100.00 | - | - |
| Penta pyrrole worm guanidine | 16.81 | 56.99 | - | - |
| Pyridine quinazoline: penta pyrrole worm guanidine (40:1) | 5.37 | 178.40 | 98.95 | 180.29 |
| Pyridine quinazoline: penta pyrrole worm guanidine (30:1) | 4.25 | 225.41 | 98.61 | 228.59 |
| Pyridine quinazoline: penta pyrrole worm guanidine (20:1) | 3.37 | 284.27 | 97.95 | 290.22 |
| Pyridine quinazoline: penta pyrrole worm guanidine (10:1) | 2.89 | 331.49 | 96.09 | 344.98 |
| Pyridine quinazoline: penta pyrrole worm guanidine (5:1) | 2.72 | 352.21 | 92.83 | 379.41 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:1) | 3.05 | 314.10 | 78.50 | 400.13 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:5) | 4.16 | 230.29 | 64.16 | 358.93 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:10) | 5.13 | 186.74 | 60.90 | 306.63 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:20) | 6.27 | 152.79 | 59.04 | 258.79 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:30) | 7.85 | 122.04 | 58.38 | 209.04 |
| Pyridine quinazoline: penta pyrrole worm guanidine (1:40) | 9.29 | 103.12 | 58.04 | 177.67 |
As can be seen from Table 3, pyridine quinazoline and penta pyrrole worm guanidine composite in the scope of 40:1 ~ 1:40 (by weight) time, co-toxicity coefficient (CTC) is all greater than 120, shows synergistic function to eggplant thrips; In the scope of 10:1 ~ 1:10 (by quality), synergistic function is more remarkable, and co-toxicity coefficient (CTC) is all more than 300; Especially composite with 1:1 (by quality), synergistic function is the most remarkable, and co-toxicity coefficient (CTC) is 400.13.Visible pyridine quinazoline and penta pyrrole worm guanidine is composite has reasonability and feasibility.
Embodiment 20: the field control effectiveness test of control paddy rice rice leaf roller
Adopt the embodiment of the present invention 11 (50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules), embodiment 6 (25% pyridine quinazoline penta pyrrole worm guanidine suspending agent), embodiment 8 (20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion) for preventing and treating paddy rice rice leaf roller, investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d investigate residual borer population of living respectively, investigation Shi Mei community adopts parallel great-jump-forward random sampling 15 point, 2 clumps often, totally 30 clumps of paddy rice, borer population alive in statistics leaf roll, calculates control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100.
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine.
As can be seen from Table 4,50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules, 25% pyridine quinazoline penta pyrrole worm guanidine suspending agent, 20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion respectively process and will be used alone apparently higher than 20% pyridine quinazoline suspending agent and 20% penta pyrrole worm guanidine suspending agent single doses the control efficiency of paddy rice rice leaf roller, after medicine, 14d preventive effect all still reaches more than 90% simultaneously, illustrate that compound drug has good lasting effect, in pilot survey process, do not find that compound drug produces poisoning to paddy rice.
The result of the test of table 4, each process chemical control paddy rice rice leaf roller
Embodiment 21: the field control effectiveness test of control wheat aphid
Adopt the embodiment of the present invention 11 (50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules), embodiment 6 (25% pyridine quinazoline penta pyrrole worm guanidine suspending agent), embodiment 8 (20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion) for preventing and treating wheat aphid, investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d investigate residual borer population of living respectively, investigation Shi Mei community is undertaken by five point samplings, fix 10 strains at often and have aphid strain (fringe), investigate the aphid head number determined in strain (fringe), calculate control efficiency.Control efficiency computational methods are as follows:
Control efficiency (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100.
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine.
The result of the test of table 5, each process chemical control wheat aphid
As can be seen from Table 5,50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules, 25% pyridine quinazoline penta pyrrole worm guanidine suspending agent, 20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion respectively process and will be used alone apparently higher than 20% pyridine quinazoline suspending agent and 20% penta pyrrole worm guanidine suspending agent single doses the control efficiency of wheat aphid, after medicine, 14d preventive effect all still reaches more than 90% simultaneously, illustrate that compound drug has good lasting effect, in pilot survey process, do not find that compound drug produces poisoning to wheat.
Embodiment 22: the field control effectiveness test of control oranges and tangerines scale insect
Adopt the embodiment of the present invention 11 (50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules), embodiment 6 (25% pyridine quinazoline penta pyrrole worm guanidine suspending agent), embodiment 8 (20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion) for preventing and treating oranges and tangerines scale insect, investigation insect population radix before dispenser, after medicine, 3d, 7d, 14d investigate residual borer population of living respectively, 2 strains are looked in investigation Shi Mei community, every strain looks into 5 blades respectively by orientation, 4, the four corners of the world, each community looks into 40 blades altogether, record borer population of living, calculate control efficiency.Control efficiency computational methods are as follows:
Preventive effect (%)=(1-CK
1× Pt
1/ CK
2× Pt
2) × 100.
Wherein: CK
1represent insect population number before the medicine of check plot; Pt
1represent insect population number after treatment region medicine;
CK
2represent insect population number after the medicine of check plot; Pt
2represent insect population number before treatment region medicine.
The result of the test of table 6, each process chemical control oranges and tangerines scale insect
As can be seen from Table 6,50% pyridine quinazoline penta pyrrole worm guanidine water dispersible granules, 25% pyridine quinazoline penta pyrrole worm guanidine suspending agent, 20% pyridine quinazoline penta pyrrole worm guanidine aqueous emulsion respectively process and will be used alone apparently higher than 20% pyridine quinazoline suspending agent and 20% penta pyrrole worm guanidine suspending agent single doses the control efficiency of oranges and tangerines scale insect, after medicine, 14d preventive effect all still reaches more than 90% simultaneously, illustrate that compound drug has good lasting effect, in pilot survey process, do not find that compound drug produces poisoning to oranges and tangerines.
In sum, the present invention adopts two kinds of active components to be the composite Pesticidal combination of pyridine quinazoline and penta pyrrole worm guanidine, obvious synergy, compared with existing unitary agent, insecticidal effect significantly improves, and the lasting period is long, to crop safety, be worth applying in agricultural production.
Claims (5)
1. contain a Pesticidal combination for pyridine quinazoline and penta pyrrole worm guanidine, it is characterized in that: active ingredient is pyridine quinazoline and penta pyrrole worm guanidine, and the weight ratio of pyridine quinazoline and penta pyrrole worm guanidine is 40:1 ~ 1:40.
2. the Pesticidal combination containing pyridine quinazoline and penta pyrrole worm guanidine according to claim 1, is characterized in that: the weight ratio of described pyridine quinazoline and penta pyrrole worm guanidine is 10:1 ~ 1:10.
3. the Pesticidal combination containing pyridine quinazoline and penta pyrrole worm guanidine according to claim 1 and 2, it is characterized in that: described pyridine quinazoline and penta pyrrole worm guanidine weight summation percentage by weight are in the composition 1 ~ 85%, all the other are allow in agricultural chemicals to use and acceptable auxiliary element.
4. the Pesticidal combination containing pyridine quinazoline and penta pyrrole worm guanidine according to claim 1 and 2, is characterized in that: the formulation of described Pesticidal combination when practical application is the one in micro-capsule suspension, suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wetting powder, thermal fog and ultra low volume liquids.
5. the Pesticidal combination containing pyridine quinazoline and penta pyrrole worm guanidine according to claim 1 is preventing and treating the application in the striped rice borer on crops, paddy stem borer, rice leaf roller, diamond-back moth, cabbage caterpillar, prodenia litura, beet armyworm, lima bean pod borer, leaf roller, cotton bollworm lepidoptera pest, scale insect, trialeurodes vaporariorum, pear sucker, Bemisia tabaci, rice fulgorid, aphid, tea lesser leafhopper homoptera pest and thrips Thysanoptera.
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|---|---|---|---|---|
| CN107736371A (en) * | 2017-10-17 | 2018-02-27 | 邓杵娇 | Containing the composition pesticide for killing white butterfly element and guadipyr |
| CN107751205A (en) * | 2016-08-16 | 2018-03-06 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination and its method for controlling agricultural pest |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006106798A1 (en) * | 2005-03-30 | 2006-10-12 | Nihon Nohyaku Co., Ltd. | Pest control agent and method of using the same |
| CN102858161A (en) * | 2010-04-27 | 2013-01-02 | 先正达参股股份有限公司 | Methods of controlling neonicotinoid resistant aphids |
| JP2014024770A (en) * | 2012-07-25 | 2014-02-06 | Nippon Nohyaku Co Ltd | Animal ectoparasite-controlling agent |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006106798A1 (en) * | 2005-03-30 | 2006-10-12 | Nihon Nohyaku Co., Ltd. | Pest control agent and method of using the same |
| CN102858161A (en) * | 2010-04-27 | 2013-01-02 | 先正达参股股份有限公司 | Methods of controlling neonicotinoid resistant aphids |
| JP2014024770A (en) * | 2012-07-25 | 2014-02-06 | Nippon Nohyaku Co Ltd | Animal ectoparasite-controlling agent |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107751205A (en) * | 2016-08-16 | 2018-03-06 | 江苏龙灯化学有限公司 | A kind of Pesticidal combination and its method for controlling agricultural pest |
| CN107736371A (en) * | 2017-10-17 | 2018-02-27 | 邓杵娇 | Containing the composition pesticide for killing white butterfly element and guadipyr |
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