CN101376121B - 具有磁体的微板支架 - Google Patents
具有磁体的微板支架 Download PDFInfo
- Publication number
- CN101376121B CN101376121B CN200810214692.4A CN200810214692A CN101376121B CN 101376121 B CN101376121 B CN 101376121B CN 200810214692 A CN200810214692 A CN 200810214692A CN 101376121 B CN101376121 B CN 101376121B
- Authority
- CN
- China
- Prior art keywords
- microplate
- well
- particle
- magnetic
- permanent magnet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000006249 magnetic particle Substances 0.000 claims abstract description 64
- 239000007788 liquid Substances 0.000 claims abstract description 47
- 238000000034 method Methods 0.000 claims abstract description 21
- 239000002245 particle Substances 0.000 claims description 19
- 238000005406 washing Methods 0.000 claims description 16
- 238000010828 elution Methods 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 5
- 238000005086 pumping Methods 0.000 claims description 3
- 238000007667 floating Methods 0.000 description 4
- 238000003491 array Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 229910001172 neodymium magnet Inorganic materials 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 229920006324 polyoxymethylene Polymers 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000012447 hatching Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000006148 magnetic separator Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- QJVKUMXDEUEQLH-UHFFFAOYSA-N [B].[Fe].[Nd] Chemical compound [B].[Fe].[Nd] QJVKUMXDEUEQLH-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000005408 paramagnetism Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- -1 polyoxymethylenes Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
- B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01360/07 | 2007-08-31 | ||
| CH13602007 | 2007-08-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101376121A CN101376121A (zh) | 2009-03-04 |
| CN101376121B true CN101376121B (zh) | 2014-02-19 |
Family
ID=39111812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810214692.4A Active CN101376121B (zh) | 2007-08-31 | 2008-08-29 | 具有磁体的微板支架 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8658042B2 (enExample) |
| EP (1) | EP2030689B1 (enExample) |
| JP (1) | JP5399023B2 (enExample) |
| CN (1) | CN101376121B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10407660B2 (en) * | 2010-08-10 | 2019-09-10 | Greiner Bio-One North America, Inc. | Hardware for magnetic 3D culture |
| US20160137974A1 (en) * | 2008-09-25 | 2016-05-19 | Nano3D Biosciences, Inc | Microplates for magnetic 3d culture |
| WO2011080068A1 (en) * | 2009-12-21 | 2011-07-07 | Pea Genetics Ab | Method for polynucleotide hybridization |
| CN102445376B (zh) * | 2010-09-30 | 2015-05-06 | 广州阳普医疗科技股份有限公司 | 滑道式加样皿装置 |
| US9952237B2 (en) | 2011-01-28 | 2018-04-24 | Quanterix Corporation | Systems, devices, and methods for ultra-sensitive detection of molecules or particles |
| US20120220045A1 (en) * | 2011-02-25 | 2012-08-30 | Colin Bozarth | Double Trench Well for Assay Procedures |
| US8920751B2 (en) | 2011-07-08 | 2014-12-30 | Life Technologies Corporation | Automated enrichment for nucleic acid sequencing |
| US20150233932A1 (en) * | 2013-02-19 | 2015-08-20 | Ching-Ping Tseng | Methods, Systems, and Compositions for Enrichment of Rare Cells |
| TWI529402B (zh) * | 2013-07-26 | 2016-04-11 | 財團法人工業技術研究院 | 磁性液滴控制裝置及磁性液滴的控制方法 |
| US10151672B2 (en) * | 2014-02-11 | 2018-12-11 | Wallac Oy | Device and a method for managing a sample to be analyzed and a solid sample carrier and liquid sample carrier |
| US9663780B2 (en) | 2014-10-15 | 2017-05-30 | Alpaqua Engineering, LLC | Solid-core ring-magnet |
| AU2016200047A1 (en) * | 2015-01-07 | 2016-07-21 | Personal Genomics, Inc. | Oriented Loading Systems And Method For Orienting A Particle Loaded In A Well |
| US9656267B2 (en) * | 2015-09-17 | 2017-05-23 | Nvigen, Inc. | Magnetic rack |
| CN105543089A (zh) * | 2016-03-08 | 2016-05-04 | 湖南圣湘生物科技有限公司 | 一种磁珠法核酸提取装置及方法 |
| RU2643385C1 (ru) * | 2016-11-11 | 2018-02-01 | Общество с ограниченной ответственностью "ДРД" | Устройство для разделения магнитных частиц из реакционных жидкостей |
| US11433402B2 (en) * | 2017-07-19 | 2022-09-06 | Amgen Inc. | Magnetic assisted separation apparatuses and related methods |
| NL2020773B1 (en) * | 2018-04-16 | 2019-10-23 | Meyn Food Processing Tech Bv | Processing apparatus for poultry comprising one or more transfer units |
| US11242519B2 (en) | 2018-08-23 | 2022-02-08 | Alpaqua Engineering, LLC | Discontinuous wall hollow core magnet |
| MA53439A (fr) | 2018-08-23 | 2021-06-30 | Alpaqua Eng Llc | Aimant à noyau solide |
| CN109609344A (zh) * | 2019-01-14 | 2019-04-12 | 宁波美晶医疗技术有限公司 | 一种微磁体细胞捕获装置及其制作方法 |
| US12372497B2 (en) | 2021-08-18 | 2025-07-29 | Alpaqua Engineering, LLC | Plate cushion device having a compression gap lock |
| EP4252907A1 (en) * | 2022-03-30 | 2023-10-04 | Blink AG | A method for arranging microspheres in a non-aqueous liquid phase |
| CN115405823A (zh) * | 2022-09-09 | 2022-11-29 | 深圳鸣基医疗科技有限公司 | 微板支架及微板组件 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297380A (zh) * | 1998-02-20 | 2001-05-30 | 佛罗里达卅立大学 | 混合物成分的连续磁性分离 |
| US20060081539A1 (en) * | 2002-04-26 | 2006-04-20 | Abbott Laboratories | Structure and method for handling magnetic particles in biological assays |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2045757A (en) * | 1934-07-09 | 1936-06-30 | Fuller Co | Screw conveyer |
| US2352749A (en) * | 1942-09-09 | 1944-07-04 | Lock Joint Pipe Co | Apparatus for applying plastic coatings |
| US2404884A (en) * | 1945-03-12 | 1946-07-30 | American Dyewood Company | Apparatus for handling powdered materials |
| US3093271A (en) * | 1959-04-10 | 1963-06-11 | H L Stoker Company | Material-handling device |
| US3464539A (en) * | 1968-01-30 | 1969-09-02 | Fred Kelly & Sons Proprietary | Screw conveyors |
| US3580384A (en) * | 1969-01-27 | 1971-05-25 | Ameron Inc | Material feeding apparatus |
| US3702128A (en) * | 1971-03-26 | 1972-11-07 | Celanese Corp | Solids feeder apparatus |
| US4272510A (en) * | 1976-04-26 | 1981-06-09 | Smith Kendall O | Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods |
| DE3070333D1 (en) * | 1979-11-13 | 1985-04-25 | Technicon Instr | Test-tube assembly, kit for making it and method of manual immunoassay |
| JP2701891B2 (ja) * | 1987-11-16 | 1998-01-21 | ジーン−トラック・システムス | 磁気的分離デバイスおよび不均質検定における使用法 |
| US4988618A (en) * | 1987-11-16 | 1991-01-29 | Gene-Trak Systems | Magnetic separation device and methods for use in heterogeneous assays |
| DE3942561C1 (enExample) * | 1989-08-22 | 1991-01-10 | Hans-Georg Dipl.-Ing. 8434 Berching De Huber | |
| WO1992005443A1 (en) * | 1990-09-15 | 1992-04-02 | Medical Research Council | Reagent separation |
| US5541072A (en) * | 1994-04-18 | 1996-07-30 | Immunivest Corporation | Method for magnetic separation featuring magnetic particles in a multi-phase system |
| FR2679660B1 (fr) * | 1991-07-22 | 1993-11-12 | Pasteur Diagnostics | Procede et dispositif magnetique d'analyse immunologique sur phase solide. |
| US5290521A (en) * | 1992-09-04 | 1994-03-01 | Destefano Jr Albert M | Lab-top work station |
| DE69329135T2 (de) * | 1992-09-24 | 2001-01-11 | Amersham Pharmacia Biotech Uk Ltd., Little Chalfont | Verfahren und Vorrichtung zur magnetischen Abscheidung |
| EP0589636B1 (en) | 1992-09-24 | 2000-08-02 | Amersham Pharmacia Biotech UK Limited | Magnetic separation method and apparatus therefor |
| US5609826A (en) * | 1995-04-17 | 1997-03-11 | Ontogen Corporation | Methods and apparatus for the generation of chemical libraries |
| GB2300258A (en) | 1995-04-28 | 1996-10-30 | Philip John Jewess | A separation device for magnetisable particles |
| US5779907A (en) * | 1996-12-06 | 1998-07-14 | Systems Research Laboratories, Inc. | Magnetic microplate separator |
| US6776174B2 (en) * | 1998-08-21 | 2004-08-17 | Paul E. Nisson | Apparatus for washing magnetic particles |
| JP2000121511A (ja) * | 1998-10-13 | 2000-04-28 | Hitachi Koki Co Ltd | 自動分離抽出装置及びその制御方法 |
| US6406671B1 (en) * | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
| JP2000292426A (ja) | 1999-04-08 | 2000-10-20 | Tdk Corp | マイクロタイタープレートを用いる免疫学的測定方法 |
| US6485690B1 (en) * | 1999-05-27 | 2002-11-26 | Orchid Biosciences, Inc. | Multiple fluid sample processor and system |
| US6514415B2 (en) * | 2000-01-31 | 2003-02-04 | Dexter Magnetic Technologies, Inc. | Method and apparatus for magnetic separation of particles |
| WO2002040159A2 (en) * | 2000-11-16 | 2002-05-23 | Prolinx Incorporated | Device for applying a magnetic field to a microtiter plate for biological separations |
| US20020070173A1 (en) | 2000-12-08 | 2002-06-13 | Promega Corporation, Madison, Wisconsin | Apparatus and method for use in magnetic separation of magnetically attractable particles in a liquid |
| US6645431B2 (en) * | 2001-01-22 | 2003-11-11 | Thomas W. Astle | Apparatus for automated magnetic separation of materials in laboratory trays |
| US6514416B1 (en) * | 2001-05-07 | 2003-02-04 | Dexter Magnetic Technologies, Inc. | Method and apparatus for magnetic separation of particles |
| US7169578B2 (en) * | 2001-07-27 | 2007-01-30 | Surface Logix, Inc. | Cell isolation and screening device and method of using same |
| JP4129864B2 (ja) | 2003-03-24 | 2008-08-06 | 農工大ティー・エル・オー株式会社 | 磁気微粒子の磁気分離装置 |
| JP4552185B2 (ja) | 2004-01-19 | 2010-09-29 | 日立金属株式会社 | 磁気分離装置 |
-
2008
- 2008-08-22 EP EP08162810A patent/EP2030689B1/de active Active
- 2008-08-26 US US12/198,210 patent/US8658042B2/en active Active
- 2008-08-29 CN CN200810214692.4A patent/CN101376121B/zh active Active
- 2008-09-01 JP JP2008223156A patent/JP5399023B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297380A (zh) * | 1998-02-20 | 2001-05-30 | 佛罗里达卅立大学 | 混合物成分的连续磁性分离 |
| US20060081539A1 (en) * | 2002-04-26 | 2006-04-20 | Abbott Laboratories | Structure and method for handling magnetic particles in biological assays |
Also Published As
| Publication number | Publication date |
|---|---|
| US20090064800A1 (en) | 2009-03-12 |
| EP2030689A1 (de) | 2009-03-04 |
| JP2009072774A (ja) | 2009-04-09 |
| JP5399023B2 (ja) | 2014-01-29 |
| CN101376121A (zh) | 2009-03-04 |
| EP2030689B1 (de) | 2013-02-13 |
| US8658042B2 (en) | 2014-02-25 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |