CN101365494A - 治疗自身免疫性疾病的组合物和方法 - Google Patents

治疗自身免疫性疾病的组合物和方法 Download PDF

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Publication number
CN101365494A
CN101365494A CNA2006800456906A CN200680045690A CN101365494A CN 101365494 A CN101365494 A CN 101365494A CN A2006800456906 A CNA2006800456906 A CN A2006800456906A CN 200680045690 A CN200680045690 A CN 200680045690A CN 101365494 A CN101365494 A CN 101365494A
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CN
China
Prior art keywords
self
vector
polypeptide
secreted
intron
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800456906A
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English (en)
Chinese (zh)
Inventor
内尼特·苏瓦山
迈克尔·勒维腾
海德基·葛元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayhill Therapeutics Inc
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Bayhill Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayhill Therapeutics Inc filed Critical Bayhill Therapeutics Inc
Publication of CN101365494A publication Critical patent/CN101365494A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2006800456906A 2005-10-05 2006-10-04 治疗自身免疫性疾病的组合物和方法 Pending CN101365494A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72420305P 2005-10-05 2005-10-05
US60/724,203 2005-10-05

Publications (1)

Publication Number Publication Date
CN101365494A true CN101365494A (zh) 2009-02-11

Family

ID=37943343

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800456906A Pending CN101365494A (zh) 2005-10-05 2006-10-04 治疗自身免疫性疾病的组合物和方法

Country Status (9)

Country Link
US (1) US20100160415A1 (https=)
EP (1) EP1931390B1 (https=)
JP (1) JP2009511014A (https=)
CN (1) CN101365494A (https=)
AU (1) AU2006302477A1 (https=)
CA (1) CA2624615A1 (https=)
IL (1) IL190520A0 (https=)
NZ (1) NZ567150A (https=)
WO (1) WO2007044394A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1668105T3 (pl) * 2003-09-29 2019-03-29 Deb Ip Limited Kompozycje żelopodobne i pieniące o dużej zawartości alkoholu
DE102004062775A1 (de) 2004-12-21 2006-06-29 Stockhausen Gmbh Alkoholischer Pumpschaum
BRPI0608347A2 (pt) 2005-03-07 2009-12-08 Deb Worldwide Healthcare Inc composição alcoólica espumável, concentrado de composição, composição alcoólica desinfetante espumável, métodos para formar, produzir e dispensar uma espuma, dispensador não pressurizado, e, métodos para usar uma composição alcoólica de espuma para desinfecção pessoal e para produzir e aplicar a uma pele de indivìduo uma composição alcoólica de espuma desinfetante de pele
WO2010151420A1 (en) * 2009-06-05 2010-12-29 Bayhill Therapeutics, Inc. Compositions and methods for treatment of insulin-dependent diabetes mellitus
EP2525825A1 (en) * 2010-01-20 2012-11-28 Bayhill Therapeutics, Inc. Combination therapy to treat autoimmune diseases
EP2716756B1 (en) * 2011-05-25 2021-12-08 National University Corporation Okayama University Reic-expressing adenovirus vector for use in treating cancer
KR101466875B1 (ko) * 2012-05-11 2014-12-03 가톨릭대학교 산학협력단 항종양괴사인자 수용체 2를 발현하도록 설계된 미니서클 벡터를 이용한 자가면역질환 치료
KR101466874B1 (ko) * 2012-05-11 2014-12-03 가톨릭대학교 산학협력단 자가면역 질환의 예방과 치료를 위한 ｉｌ-６ 수용체에 대한 항체를 발현하는 미니서클
US20160287685A1 (en) 2013-11-22 2016-10-06 Amarna Holding B.V. Method for restoring immune tolerance in vivo
EP3090263A4 (en) * 2013-12-31 2017-08-23 Yeda Research and Development Co., Ltd. Methods for assaying immunological competence
US10545144B2 (en) 2013-12-31 2020-01-28 Yeda Research And Development Co., Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
CN106535926B (zh) * 2014-06-04 2022-02-01 戴尔米德医疗公司 用于基于抗原的疗法的新型组合物
US12605432B2 (en) 2014-06-04 2026-04-21 Diamyd Medical Ab Combinations for antigen based therapy
EP3265814B1 (en) 2015-03-01 2020-11-18 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
WO2017222911A1 (en) * 2016-06-20 2017-12-28 The Board Of Trustees Of The Leland Stanford Junior University Circular rnas and their use in immunomodulation
CA3042321A1 (en) 2016-11-01 2018-05-11 Novo Nordisk A/S Tolerogenic dna vaccine
US20210277417A1 (en) * 2018-06-25 2021-09-09 Akouos, Inc. Methods of treating clrn1-associated hearing loss and/or vision loss
US11279745B2 (en) 2019-04-26 2022-03-22 Novo Nordisk A/S Tolerogenic DNA vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274136B1 (en) * 1996-05-29 2001-08-14 University Of Southern California Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
WO2000002591A1 (en) * 1998-07-09 2000-01-20 Merck & Co., Inc. Polynucleotide vaccine formulations
WO2000046147A2 (en) * 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
US7030098B2 (en) * 1999-03-12 2006-04-18 The Board Of Trustees Of The Leland Stanford Junior University DNA vaccination for treatment of autoimmune disease
US6479474B2 (en) * 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
EP1421104A4 (en) * 2001-08-02 2005-08-24 Trinity Biomedical Technology HUMANE ZONA PELLUCIDA PROTEINS AND METHOD FOR THEIR USE IN THE DIAGNOSIS OF MALE INFERENCE
CN101670119A (zh) * 2001-11-21 2010-03-17 利兰·斯坦福青年大学托管委员会 多核苷酸
WO2003082269A1 (en) * 2002-03-29 2003-10-09 The Board Of Trustees Of The Leland Stanford Junior University Use of statins and other immunomodulatory agents in the treatment of autoimmune disease
PT1685251E (pt) * 2003-10-10 2014-04-15 Powderject Vaccines Inc Construções de ácido nucleico

Also Published As

Publication number Publication date
IL190520A0 (en) 2008-11-03
EP1931390A4 (en) 2009-04-15
US20100160415A1 (en) 2010-06-24
WO2007044394A2 (en) 2007-04-19
CA2624615A1 (en) 2007-04-19
WO2007044394A3 (en) 2007-07-12
JP2009511014A (ja) 2009-03-19
EP1931390B1 (en) 2012-07-25
NZ567150A (en) 2011-12-22
AU2006302477A1 (en) 2007-04-19
EP1931390A2 (en) 2008-06-18

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20090211