CN101361909A - Anti-senility traditional Chinese medicine composition for increasing skin oil and preparation method thereof - Google Patents
Anti-senility traditional Chinese medicine composition for increasing skin oil and preparation method thereof Download PDFInfo
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Abstract
The invention provides an anti-aging Chinese medicine compound used for increasing skin oil, which is composed of effective components and medically acceptable excipients, wherein, the effective ingredients are made from the raw medicines with the following weight portion: 1 portion to 20 portions of Ginseng, 10 portions to 40 portions of Rhizoma Polygonatum, 10 portions to 50 portions of sweet Almond and 1 portion to 20 portions of Safflower. The compound can not only obviously increase the skin oil, but also increase the skin moisture with the increasing of the treatment time, thus realizing the functions of wholly regulating function of a human body, improving skin elasticity, decreasing fine wrinkle and preventing aging.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of medicinal preparation of plant extract preparation.
Background technology
The dryness skin of oil starvation is more common in crowd above middle age, causes the reason of the dryness skin of oil starvation mostly to be coarse etc. by skin aging, the unhealthy or abnormal skin nursing method of diet body, cosmetics.Oils and fats, the sweat gland secretion of the dry skin of oil starvation are few, thin and transparent.The people of this skin is owing to lack the nature oils and fats and moisten, and it is dry and astringent unglazed that facial skin seems, easily produces broken stricture of vagina, even desquamation and seem coarse, and it is loose that eye, cervical region occur, and aging increasingly sharpens.
Still there is not at present the dry skin that safe and effective medicine is treated oil starvation, depend merely on the additional oil content of the moist cosmetics of external and can not solve root problem, vitamin A commonly used clinically or E increase skin oil and defying age, but short run effect is also not obvious, can cause poisoning and take in a large number for a long time.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of medicine that increases skin oil.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of delay aging drug compositions that increases skin oil, said composition is made up of active ingredient and medically acceptable adjuvant, wherein said active ingredient is made by following bulk drugs: Radix Ginseng 1～20, Rhizoma Polygonati 10～40, Semen pruni armeniacae 10～50 and Flos Carthami 1～20.Described Radix Ginseng is a Radix Ginseng.
Compositions of the present invention, 10～20 parts of the proportion optimization Radix Ginsengs of the crude drug of wherein said active ingredient, 20～30 parts of Rhizoma Polygonatis, 1～10 part of 30～40 parts of and Flos Carthami of Semen pruni armeniacae, the best is 10 parts of Radix Ginsengs, 20 parts of Rhizoma Polygonatis, 10 parts of 30 parts of and Flos Carthami of Semen pruni armeniacae.
The preparation method of the active ingredient of compositions of the present invention is:
Getting Radix Ginseng, Rhizoma Polygonati, Semen Armeniacae Amarum and Flos Carthami decocted 1 hour after 1 hour with the water logging bubble of 8～12 times of crude drug amounts, leach decocting liquid, the decocting that adds 6～8 times of crude drug amounts in the filtering residue boiled 1 hour again, merge 2 times decocting liquid, be evaporated to water extract volume with the dispensing quality ratio be 5:1, left standstill 1～2 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1～2g in every milliliter of concentrated solution.
Compositions of the present invention can be common peroral dosage form, as oral liquid, granule, capsule etc.
Huangdi's Internal Classics is said: " ... five or eight, kidney qi declines, the trichomadesis withering of teeth; Six or eight, yang-energy depletion is in last, and wrinkly face is sent out temples and issued white; Seven or eight, irritability declines, the tendon being unable to move, and exhaustion of kidney-essence with promoting reproductive function, oligospermia, kidney are hidden and are declined physique and configuration of the body being very feeble and atrophied; Eight or eight, then tooth and hair goes.The kidney dominating water metabolism is subjected to five to hide essence at six mansions and hide it, so five Tibetan Shengs are to write.Debility of the bone and muscle, using up kidney-essence with promoting reproductive function are all declined in modern five Tibetan." five hide and all to decline, so be difficult to nourish skin, scaly dry skin shrinkage, debility of the bone and muscle.In view of the above, the present invention selects the QI invigorating replenishing essence, grows product treatment oil starvation dryness, the aging skin of marrow skin moistening, wherein, Radix Ginseng is a monarch drug, strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind, Shennong's Herbal is called this medicine " the main life of supporting is with Ying Tian; nontoxic, obeys clothes of a specified duration more and does not hurt sb.'s feelings, and the QI invigorating of desiring to make light of one's life by commiting suicide is not prolonged life always "; Rhizoma Polygonati is a ministerial drug, principal drug assistance boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying; Adjuvant drug Semen Armeniacae Amarum lung moistening YIN nourishing helps monarch, ministerial drug to nourish the power of five Tibetan; Flos Carthami then is a messenger drug, not only invigorate blood circulation helping the defeated cloth of the cloudy liquid whole body, and it is greasy to keep away tonic.Four Chinese medicine cooperates the shape that declines that can reverse five Tibetan, and the marrow skin moistening is grown in the QI invigorating replenishing essence.Modern medicine study also shows and contains the Saponin and the protein synthesis factor in the Radix Ginseng, and the Radix Ginseng total saponins hydroxyproline content in the skin that can significantly raise makes the delicate gloss of skin, the control wrinkle; The protein synthesis factor can promote DNA, RNA and protein synthesis, and human body protein content is increased, and helps healthy and strong skin, fleshiness and increase skin elasticity.Rhizoma Polygonati is the obvious slow down aging of tool, enhancing immunity then, effects such as antioxidation.Nutritional labelings such as Semen Armeniacae Amarum rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum, and beauty functions is arranged, can promote skin microcirculation, make the ruddy gloss of skin.Flos Carthami can distend the blood vessels, and microcirculation improvement makes the nutrient mass-energy in the blood pass through the tiny and narrow timely skin nutrition of blood vessel, strengthens the anoxia enduring and the anti-damage ability of skin.
The present composition by the QI invigorating replenishing essence, is grown the marrow skin moistening, supports outer and the increase skin oil with interior; Pay attention to integrally-regulatedly, having increases skin oil, reverses old and feeble effect, can improve symptom, the slow down aging of oil starvation dryness and aging skin; Cure mainly oil starvation dryness skin, be used for, or skin loses due to the conditioning five and hides that all skin oil starvation drying, the dim complexion of void do not have diseases such as pool because of naturally-aged, five hides that deficient, pressure, sleep are poor, eating and drinking without temperance etc.The present composition has no side effect, and is fit to the long-time conditioning function of human body.
In order to understand the present invention better, will prove the technique effect of the present composition by experiment below.
1 clinical data
1.1 physical data is observed case totally 40 examples, is attached Nanfang Hospital of Nanfang Medical Univ (former No.1 Military Medical Univ.) surgery of Chinese medicine outpatient service in December, 2006～2007 year December case.Be divided into 2 groups at random, 20 examples are organized in treatment, wherein male 2 examples, women 18 examples; 35～48 years old age, average 43.5 years old; Matched group 20 examples, wherein male 3 examples, women 17 examples, 37～50 years old age, 44.9 years old mean age.2 groups of data are learned processing by statistics, and difference there are no significant meaning (p〉0.05), have comparability.
1.2 include Standard Selection in 35 years old～50 years old oil starvation dryness skin patient, male or female, the xerosis cutis desquamation has wrinkle, is the aging skin.
1.3 skin of face illness such as the concurrent dermatitis of exclusion standard, acne; Gestation or women breast-feeding their children; Be associated with liver, cardiovascular disease person; Malignant tumor patient; Once systematic treating mistake in 4 weeks; End treatment during the treatment or change medicine, method person; Can't judge not umbra sound curative effect judgement person of curative effect or data.
2 Therapeutic Method
2.1 the treatment group gives the herbal mixture compositions, promptly produce capsule: Radix Ginseng (Radix Ginseng) 100g, Rhizoma Polygonati 200g, Semen pruni armeniacae by best proportioning) 300g, Flos Carthami 100g, water logging with 8 times of crude drug amounts was steeped 1 hour, decocted 1 hour, and leached decocting liquid, the decocting that adds 8 times of crude drug amounts again in the filtering residue boiled 1 hour, merge 2 times decocting liquid, the water extract is 5:1 with the ratio of dosage, leaves standstill 1 hour, filters; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1:3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Employing aluminum-plastic composite membrane packing, every packing has the 10g content.Instructions of taking: warm water delivery service, dosage 30g divided and took for three times every day, each 10g.
2.2 matched group oral vitamin E soft gelatin capsule (natural type, Qingdao Double Whale Pharmaceutical Co., Ltd.), each 0.1g, every day 2 times.
2.3 statistical method adopts the T check.
3 efficacy analysis
3.1 test instrunment KF-833 moisture of skin oil content elastic force monitor (Kang Futong Electronics Co., Ltd.)
3.2 all tests of method of testing are all carried out in the room of constant temperature, constant humidity, temperature (25 ± 1) ℃, humidity (50 ± 5) %.The person of being observed under quiescent condition, detects skin of forehead oil content moisture and elastic force before treatment, after 4 weeks of treatment, 8 weeks of treatment.At period in a medicine, all objects of observation are not all taken other medicine or health product of increasing skin oil.
3.3 therapeutic outcome 20 routine patients see Table 1 through 4 all traditional Chinese medicine composition for treating rear face skin properties result of variations statistics.Skin oil content meansigma methods is 19.8 ± 6.2 before the treatment group treatment, and skin oil content meansigma methods is 20.1 ± 2.5, two groups of relatively no difference of science of statistics (p〉0.05) before the treatment of control group; Treatment 4 week back treatment group skin oil content meansigma methods is 35.8 ± 4.0, and matched group skin oil content meansigma methods is 27.5 ± 5.6, and both relatively have significant difference (p＜0.05); After treating for 8 weeks, treatment group skin oil content meansigma methods is 41.2 ± 3.8, and matched group skin moisture content meansigma methods is 26.8 ± 7.5, and both relatively have significant difference (p＜0.05), shows that taking present composition treatment group curative effect is better than matched group.After treating for 4 weeks, treatment group and matched group moisture of skin test comparison there was no significant difference (p〉0.05), relatively have significant difference (p＜0.05) but treat 8 all back treatment group moistures and matched group, the prompting long time course of treatment, this Chinese drug-treated group can increase moisture of skin.15 routine patients (75%) sensation skin of face elasticity is organized in treatment simultaneously to be increased, the microgroove minimizing, but after treating a course of treatment, compare before skin elasticity test and the treatment, there was no significant difference (P〉0.05); But after treating two courses of treatment, treatment group flexibility test and matched group be tool significant difference (p＜0.05) relatively, and prompting improves skin elasticity need increase treatment time.Other treatment is organized 11 routine patients (55%) and is felt that spirit takes a turn for the better in the daytime, and nighttime sleep is preferable.Treatment group and matched group do not have any untoward reaction during the treatment, all can adhere to treatment.
Facial skin properties situation before and after table 1 treatment group and the treatment of control group
Compare with matched group,
*P＜0.05
4 conclusions
This herbal mixture compositions is through clinical observation, and proving obviously to increase skin oil, and increasing with treatment time to increase moisture of skin, improves skin elasticity, reduces microgroove; And the quality of making the life better, opposing is old and feeble.Illustrate that this Chinese medicine composition has integrally-regulated function of human body, with the effect outside interior the supporting, from the situation of basic solution skin oil starvation, aging.
The specific embodiment
Example 1
Get Radix Ginseng 100g, Rhizoma Polygonati 200g, Semen pruni armeniacae 300g, Flos Carthami 100g, water logging with 8 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 8 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 1 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1g in every milliliter of concentrated solution.
Instructions of taking: oral, every day dosage: 30ml, divide and take for three times, each 10ml.
Example 2:
Get Radix Ginseng 200g, Rhizoma Polygonati 400g, Semen pruni armeniacae 500g, Flos Carthami 100g, water logging with 12 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 6 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 1 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1g in every milliliter of concentrated solution.
Instructions of taking: oral, every day dosage: 30ml, divide and take for three times, each 10ml.
Example 3:
Get Radix Ginseng 100g, Rhizoma Polygonati 100g, Semen pruni armeniacae 500g, Flos Carthami 100g, water logging with 10 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 7 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 2 hours, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1g in every milliliter of concentrated solution.
Instructions of taking: oral, every day dosage: 30ml, divide and take for three times, each 10ml.
Example 4:
Get Radix Ginseng 200g, Rhizoma Polygonati 100g, Semen pruni armeniacae 200g, Flos Carthami 10g, water logging with 8 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 8 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 2 hours, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1:3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Employing aluminum-plastic composite membrane packing, every packing has the 10g content.
Instructions of taking: warm boiled water, dosage 30g divided and took for three times every day, each 10g.
Example 5:
Get Radix Ginseng 10g, Rhizoma Polygonati 100g, Semen pruni armeniacae 500g, Flos Carthami 100g, water logging with 12 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 6 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 2 hours, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1:3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Employing aluminum-plastic composite membrane packing, every packing has the 10g content.
Instructions of taking: warm boiled water, dosage 30g divided and took for three times every day, each 10g.
Example 6:
Get Radix Ginseng 200g, Rhizoma Polygonati 400g, Semen pruni armeniacae 500g, Flos Carthami 10g, water logging with 8 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 6 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 1 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1:3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Fill content 0.6g in every capsule with No. 0 capsulae vacuus.
Instructions of taking: oral, dosage 10g divided and took for three times, each 6 every day.
Example 7:
Get Radix Ginseng 100g, Rhizoma Polygonati 200g, Semen pruni armeniacae 300g, Flos Carthami 10g, water logging with 8 times of crude drug amounts was steeped 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 6 times of crude drug amounts in the filtering residue boiled 1 hour again, merged 2 times decocting liquid, and the ratio that is evaporated to water extract volume and dispensing quality is 5:1, left standstill 1 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1:3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Fill content 0.6g in every capsule with No. 0 capsulae vacuus.
Instructions of taking: oral, dosage 10g divided and took for three times, each 6 every day.
Claims (4)
1, a kind of delay aging drug compositions that increases skin oil, said composition is made up of active ingredient and medically acceptable adjuvant, wherein said active ingredient is made by following bulk drugs: Radix Ginseng 1～20, Rhizoma Polygonati 10～40, Semen pruni armeniacae 10～50 and Flos Carthami 1～20.
2, the described compositions of claim 1, the proportioning that it is characterized in that the crude drug of described active ingredient are 10～20 parts of Radix Ginsengs, 20～30 parts of Rhizoma Polygonatis, 1～10 part of 30～40 parts of and Flos Carthami of Semen pruni armeniacae.
3, the described compositions of claim 1, the proportioning that it is characterized in that the crude drug of described active ingredient are 10 parts of Radix Ginsengs, 20 parts of Rhizoma Polygonatis, 10 parts of 30 parts of and Flos Carthami of Semen pruni armeniacae.
4, the preparation method of the active ingredient of claim 1,2 or 3 described compositionss, this method is: get Radix Ginseng, Rhizoma Polygonati, Semen Armeniacae Amarum and Flos Carthami and decocted 1 hour after 1 hour with the water logging bubble of 8～12 times of crude drug amounts, leach decocting liquid, the decocting that adds 6～8 times of crude drug amounts in the filtering residue boiled 1 hour again, merge 2 times decocting liquid, the ratio that is evaporated to water extract volume and dispensing quality is 5:1, leaves standstill 1～2 hour, filters; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1～2g in every milliliter of concentrated solution.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055102A (en) * | 2013-03-22 | 2014-09-24 | 何咸稳 | Anti-aging dietotherapy composition |
| CN106620295A (en) * | 2015-07-21 | 2017-05-10 | 上海家化联合股份有限公司 | Chinese herbal medicine composition |
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2008
- 2008-09-12 CN CN2008101985081A patent/CN101361909B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055102A (en) * | 2013-03-22 | 2014-09-24 | 何咸稳 | Anti-aging dietotherapy composition |
| CN106620295A (en) * | 2015-07-21 | 2017-05-10 | 上海家化联合股份有限公司 | Chinese herbal medicine composition |
| CN106620295B (en) * | 2015-07-21 | 2020-05-22 | 上海家化联合股份有限公司 | Chinese herbal medicine composition |
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| CN101361909B (en) | 2010-11-17 |
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