CN101884758A - Food therapy preparation for preventing and treating cerebrovascular diseases based on theories of preventive treatment of disease and medicine food homology - Google Patents

Food therapy preparation for preventing and treating cerebrovascular diseases based on theories of preventive treatment of disease and medicine food homology Download PDF

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CN101884758A
CN101884758A CN2009100688720A CN200910068872A CN101884758A CN 101884758 A CN101884758 A CN 101884758A CN 2009100688720 A CN2009100688720 A CN 2009100688720A CN 200910068872 A CN200910068872 A CN 200910068872A CN 101884758 A CN101884758 A CN 101884758A
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food therapy
therapy preparation
food
disease
medicine
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CN101884758B (en
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石学敏
胡国强
冯红
王爱明
颜艳
倪天庆
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Tianjin Pacific Pharmaceutical Co Ltd
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Abstract

The invention relates to a food therapy preparation for preventing and treating cerebrovascular diseases based on the theories of preventive treatment of disease and medicine food homology, which is characterized by comprising the effective ingredients of the following raw materials in weight ratio: 9-11 peach seeds, 4-6 kudzu-vine roots, 4-6 barbary wolfberry fruits, 4-6 fructus alpiniae oxyphyllae, 4-6 cassia seeds and 4-6 hawthorn. The prescription of the food therapy preparation is based on the theory of preventive treatment of disease, and the food therapy preparation is prepared from a sufficient amount of effective ingredients. Although the food therapy preparation is not a medicine, the actions of the medicine can be exerted. The food therapy preparation not only can greatly limit the occurrence and the development of the cerebrovascular diseases, but also can save a great amount of medical resources and investments for China simultaneously. People can conveniently and correctly select the food therapy preparation in a pertinence way according to early symptoms per se, and thus, the purposes of disease prevention and body building are achieved. The food therapy preparation can be directly taken according to a certain amount.

Description

Food therapy preparation based on the control cerebrovascular of preventive treatment of disease and integration of edible and medicinal herbs theory
Technical field
The invention belongs to food therapy preparation, particularly relate to a kind of food therapy preparation of the control cerebrovascular based on preventive treatment of disease and integration of edible and medicinal herbs theory.
Background technology
Come from Chinese medicine " preventive treatment of disease " thought of Huangdi's Internal Classics, be subjected to elucidating of Han dynasty Zhang Zhongjing " Treatise on Febrile and Miscellaneous Disease " and " Medical Treasures of the Golden Chamber ", after ancient Chinese medicine doctor is enriched constantly and is developed, to the bright clear comparatively complete theory and practice system that begun to take shape, may be summarized to be with health is core, comprises (1) anosis health preserving, takes preventive measures;
(2) the desire disease is rescued and is sprouted, checks erroneous ideas at the outset; (3) control, prevent its change of disease sick morning; (4) take good care of oneself, prevent to recur the substance of four aspects after being ill.The sub-health state that people often mention both belonged to the scope of " preventive treatment of disease " " anosis health preserving, take preventive measures ".Chinese medicine for the common measure of " preventive treatment of disease " take good care of oneself that feelings will, dietetic therapy rationally, daily life often have, strike a proper balance between work and rest, Traditional health care, acupuncture and tuina-massage and herbal treatment.
" integration of edible and medicinal herbs " be the Chinese nation over 10000000 year with the experience crystallization of the Nature and disease long-term struggle, the dietetic therapy that grows up thus also has distinct characteristic, is one of the common measure of " preventive treatment of disease ".China's Ministry of Public Health in 2002 announced be food be again the article list of medicine, totally 87 kinds of article.
In the prior art, use at cerebrovascular be food be that the prescription of medicine article is more common in and some Chinese medicine mixed configuration, the for example application for a patent for invention of publication number CN1415360 " Chinese medicine and the manufacture method thereof of treatment apoplectic hemiplegia ", this medicine is made up of following raw materials by weight percent: Hirudo 12.5~17.5, Rhizoma Chuanxiong 10~14, Semen Persicae 4~6, Radix Puerariae 6.5~9, Pheretima 12.5~17.5, Agkistrodon 10~14, Flos Carthami 4~6, Radix Cyathulae 4~6, Radix Notoginseng 6.5~9, the Radix Astragali 10~14, Radix Paeoniae Rubra 4~6.The Chinese invention patent of notification number CN1406609 " a kind of Chinese medicinal capsule agent and method for making thereof that can be used for treating the apoplexy and the thoracic obstruction " for another example is to be basic prescription with raw materials such as the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicaes.
In the actual life, people have certain cognition and application level for dietetic therapy, for example people to common, commonly used be food be again the article of medicine such as Rhizoma Dioscoreae, Semen Persicae, Arillus Longan, Bulbus Lilii, Fructus Lycii ... or the like often eat it with the form of medicated wine, medicated porridge, medicated diet, medicine drink, medicated tea.
But people are not remarkable at the food therapy effect of cerebrovascular in generally reflecting reality and living, and according to applicant's investigation, its reason has three, one, because bioactive ingredients content is lower in the integration of edible and medicinal herbs article, is not enough to manifest the prevention effect to certain disease; The 2nd, eating method is improper, causes the loss of active component; The 3rd, can not strictness follow Chinese medicine and pharmacy determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle and select " food " because of the people suits the medicine to the illness.
Summary of the invention
The objective of the invention is in order to solve the inapparent technical problem of food therapy effect in the actual life, and a kind of food therapy preparation of the control cerebrovascular based on preventive treatment of disease and integration of edible and medicinal herbs theory is disclosed, said preparation has the outstanding feature that Chinese medicine and pharmacy determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle is followed in strictness.
The food therapy preparation of control cerebrovascular of the present invention is made up of the effective ingredient of following weight ratio raw material components: Semen Persicae 9-11, Radix Puerariae 4-6, Fructus Lycii 4-6, Fructus Alpiniae Oxyphyllae 4-6, Semen Cassiae 6-8, Fructus Crataegi 4-6.
The weight ratio of described each dietetic therapy raw material components is Semen Persicae 7, Radix Puerariae 5, Fructus Lycii 5, Fructus Alpiniae Oxyphyllae 5, Semen Cassiae 7, Fructus Crataegi 5.
Described food therapy preparation is powder, granule, capsule or tablet.
The basic effective constituents of above-mentioned each dietetic therapy raw material components and main effect thereof are:
Semen Persicae: contain amygdalin, have the effect of blood circulation promoting and blood stasis dispelling.
Radix Puerariae: containing puerarin, is a kind of isoflavonoid, has the expansion cardiovascular and cerebrovascular vessel, reduces myocardium keto consumption, improves the effect of myocardium shrinkage function and promotion blood microcirculation.
Fructus Lycii: contain the necessary nutritional labelings of multiple human body such as protein, fat, crude fibre, vitamin and copper, ferrum, zinc, manganese, magnesium, chromium, have kidney-tonifying health-care, an effect of disappear tired refreshment, blood lipid-reducing blood sugar-decreasing, hepatoprotective.
Fructus Alpiniae Oxyphyllae: contain Fructus Alpiniae Oxyphyllae and contain volatile oil, Fructus Alpiniae Oxyphyllae ketone, vitamin B1, vitamin B2, vitamin C, vitamin E and several amino acids, fatty acid etc., have the effect of kidney tonifying the kidney invigorating.
Semen Cassiae: contain emodin etc., have treatment of vascular sclerosis and hypertensive effect.
Fructus Crataegi: contain citric acid etc., have the effect of blood fat reducing, spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.
Cerebrovascular is a kind of commonly encountered diseases, frequently-occurring disease in China, belongs to the traditional Chinese medical science " apoplexy " categories such as " hemiplegia ", and diseases such as dyskinesia will appear in the patient behind the cerebral infarction, have a strong impact on patient's life quality, brings serious burden for family and society.The traditional Chinese medical science thinks that cerebral infarction sequela is mainly due to the hepatic and renal YIN deficiency, and the brain mistake is moistened foster, blood stasis due to qi deficiency, and the stasis of blood hinders venation and sends out.
The applicant has concluded the early symptom of cerebrovascular according to the evidence-based medicine EBM theory: 1 unexpected take place dizzy; 2 haltingly, the skelasthenia of walking; 3 yawns are continuous; 4 dysarteriotonies; 5 unexpected one or of short duration blackout of eyes or blurred vision; The 6 unexpected tongues of speaking are sent out benzene, babble; 7 unexpected side handss, foot or facial numb (wood) or with limb adynamia; 8 without any the premonition tumbling down suddenly, or with of short duration obnubilation; 9 is tired, drowsiness; 10 sialorrhea; 11 liang of dryness and uneasy feeling of the eye, food back are tried out.Especially the people who meets following situation more answers the generation of prevention of brain angiopathy, and 1 age is greater than 45 years old male, greater than 55 years old women; 2 smokers; 3 hyperpietics; 4 diabeticss; 5 hypercholesterolemiapatients patients; 6 have Inheritance medical history person; 7 overweight peoples; 8 lack motion or work strain person.
The present invention is according to the early symptom of cerebrovascular, theory with preventive treatment of disease is guidance, take promoting blood circulation to remove obstruction in the collateral, the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs general plan of brain-strengthening kidney tonifying makes the Semen Persicae of blood circulation promoting and blood stasis dispelling be monarch, Radix Puerariae goes wind and removing obstruction in channels to think minister, Fructus Lycii, Fructus Alpiniae Oxyphyllae nourishing the liver and kidney are thought assistant, and Semen Cassiae removing heat from the liver, Fructus Crataegi blood circulation promoting and blood stasis dispelling make for assistant altogether, the side of closing share plays promoting blood circulation to remove obstruction in the collateral, the effect of brain-strengthening kidney tonifying altogether.
This food therapy preparation is according to the theoretical prescription of " preventive treatment of disease ", and form with the effective ingredient of q.s, though be not the effect that medicine but can play medicine, in the generation development that reduces cerebrovascular greatly, can also save a large amount of medical resources and investment for country.
This food therapy preparation is convenient to people and may be caused cerebrovascular to take place according to self early symptom and accurately select, sit in the right seat, and reaches the purpose of anti-treating diseases and making health-care.
This food therapy preparation can directly be taken according to quantity, and the additive and food, the beverage that also can be used as food, beverage merge edible.
Its beneficial effect of food therapy preparation of the present invention can access proof by following test.
1 test material:
Kunming mouse, body weight 20 ± 2 grams, male and female half and half, totally 48.By this food therapy preparation that Semen Persicae, Radix Puerariae, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Semen Cassiae, Fructus Crataegi effective ingredient are formed, paste-forming rate 15.66%.Be subjected to reagent liquid concentration 1.42g/ml.Sodica calx, vaseline, stopwatch, 250ml wide mouthed bottle.
2 methods and result:
2.1 influence to the ligation bilateral common carotid arteries time-to-live
Get 24 male and female half and half of mice, be divided into 2 groups at random, 12 every group.The blank group is irritated stomach and is given distilled water, and the medicine group is irritated stomach and is subjected to reagent liquid 11.33g/kg, 20ml/kg.Once a day, successive administration 5 days, the last administration with the separation of mice bilateral common carotid arteries and together with the vagus nerve ligation, was observed its death time after 1 hour.The results are shown in Table 1, visible medicinal liquid can obviously prolong the time-to-live of mice ligation bilateral common carotid arteries.
The table 1 mice ligation bilateral common carotid arteries time-to-live
Annotate: compare with matched group *P<0.05
2.2 influence to the normal pressure anoxia enduring
The mice group administration is all with 2.1.After the last administration 1 hour, put into the 250ml wide mouthed bottle that fills the 5g sodica calx, bottleneck is coated with vaseline to increase sealing.The observed and recorded mice dying time.The results are shown in Table 2, visible medicinal liquid can obviously prolong the anoxybiotic time-to-live under the mice normal pressure.
The table 2 mice normal pressure anoxia enduring time-to-live
Annotate: compare * P<0.05 with matched group
3 conclusions:
Experimental result shows, is subjected to reagent liquid can increase the cerebral blood flow of mice, improves cerebral ischemia, improves hypoxia-bearing capability, helps to improve the symptom of patients with cerebrovascular disease.
The acute toxicity testing of this food therapy preparation:
1 experiment material
1.1 laboratory animal ICR mice SPF level, available from Institute of Radiation Medicine, Chinese Academy of Medical Sciences's Experimental Animal Center, credit number: SCXK Tianjin 2005-0001.Totally 40, male and female half and half, body weight 20 ± 1 grams.
1.2 this food therapy preparation that medicine is made up of Semen Persicae, Radix Puerariae, Fructus Lycii, Fructus Alpiniae Oxyphyllae, Semen Cassiae, Fructus Crataegi effective ingredient, it is 0.57g/ml that adjusting is subjected to reagent liquid concentration, make it can pass through the mouse stomach device, do not receive to try concentration most greatly, matching while using but do not produce to stop up to it.
This food therapy preparation paste-forming rate is 15.66g%, and the clinical application amount is 0.567g/kg.
1.3 experimental condition: 20 ℃-25 ℃ of room temperatures, relative humidity 45-60%RH, exhaust fan ventilates, and the air-conditioning attemperation was swept the Mus house one time in 3 days, kept clean, and light/dark time is 12/12 hour.
2 methods
Fasting be can't help water 12 hours before the test, was divided into 2 groups according to the sex body weight, normal control group and administration group.The disposable filling stomach of administration group is given every 0.8ml of Cmax medicinal liquid, and matched group gives the co-content distilled water.Outward appearance, behavioral activity, ergasia, breathing, appetite, defecation and color thereof, the muzzle chamber of observing mice subsequently have or not abnormal secretion thing, body weight change and death condition.Dead animal in time performs an autopsy on sb, and the discovery diseased organ is done the pathology histological examination, observes continuously 7 days.
Observation index sees table 1 for details.
Table 1 animal acute toxicity test is observed table
Figure G2009100688720D00051
Animal was observed 7 after the 3 experimental result administrations, muscular movement atremia, tic, ataxia, paralysis as a result, the muscular tension reaction is normal, neuro-vegetative response, breathing, skin color are normal, diet is no abnormal, the mice activity freely, do not have cry unusual, tremble, convulsions, movement disorder, sialorrhea, shed tears, phenomenons such as rhinorrhea, dyspnea, diarrhoea, constipation, intestinal tympanites take place.Animal skin gloss compares weight increase before none death of animal in 7 days after the administration, animal and administration, compare the weight of animals there was no significant difference (seeing table 2 for details) with matched group, does not also have other abnormal phenomenas.Animal on the 8th all takes off cervical vertebra and puts to death, by only doing postmortem, each internal organs of perusal rat, organs and tissues positions such as the heart, liver, spleen, lung, kidney, adrenal gland, thymus, stomach, intestinal, bladder, testis, prostate, uterus, ovary, thoracic cavity, abdominal cavity there is no unusually as a result.
The influence of table 2 pair mice body weight
Figure G2009100688720D00052
This experiment maximum dosage-feeding is 40ml/kg * 0.57g/ml=22.80g/kg, is equivalent to crude drug in whole 22.80g/kg ÷ 0.1566g/g=145.59g/kg, is equivalent to 145.59g/kg ÷ 0.567g/kg=257 times of Coming-of-Age Day consumption 0.567g/kg.
Conclusion:
This food therapy preparation is irritated stomach and is given ICR mice, and the maximum possible dosage is 145.59g/kg, and death does not appear in animal, and the maximum possible dosage is equivalent to 257 times of 60kg Coming-of-Age Day consumption, does not have the acute toxicity effect so this food therapy preparation filling stomach gives mice.
The specific embodiment
Further specify the present invention below in conjunction with embodiment.
Embodiment 1
Get Semen Persicae 11 weight portions, Radix Puerariae 6 weight portions, Fructus Lycii 4 weight portions, Fructus Alpiniae Oxyphyllae 4 weight portions, Semen Cassiae 8 weight portions, Fructus Crataegi 6 weight portions.
Above Six-element, wherein Fructus Lycii adds 10 times of water gagings decoctions 2 times, and each 1 hour, filter, merging filtrate, standby; Radix Puerariae, Semen Cassiae add 8 times of amount 70% ethanol extractions 2 times, and each 1 hour, filter, merge ethanol extract, reclaim ethanol to there not being the alcohol flavor, medicinal liquid is standby; Semen Persicae, Fructus Alpiniae Oxyphyllae, Fructus Crataegi add 10 times of water gagings and decoct 2 times, each 1 hour, filter, collecting decoction is concentrated into 1g/ml, puts to room temperature, add ethanol to containing alcohol amount 80%, stir evenly, left standstill 24 hours, supernatant is reclaimed ethanol to there not being the alcohol flavor, and merge with Fructus Lycii extracting solution, Radix Puerariae, Semen Cassiae extracting solution, concentrate, 15.66%, promptly per 100 gram medical materials get extract 15.66 grams.
The spray-dried one-tenth powder of paste medicinal liquid, damp-prrof packing, weight depends on the needs.
The powder of embodiment 1 can add in beverage, the food edible, all can in the addition 1-5% scope.Also can make aqueous solution by above addition and spray in the Folium Camelliae sinensis surface, back to be dried comes into the market with Folium Camelliae sinensis by the tea packaging form.
Embodiment 2
Get Semen Persicae 7 weight portions, Radix Puerariae 5 weight portions, Fructus Lycii 5 weight portions, Fructus Alpiniae Oxyphyllae 5 weight portions, Semen Cassiae 7 weight portions, Fructus Crataegi 5 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 15.66%, the powder after the spray drying add an amount of excipient and become granule, bag distribution packaging, and every bag of 1g can be directly oral, becomes 1 bag of human oral one time, every day three times.
Embodiment 3
Get Semen Persicae 9 weight portions, Radix Puerariae 4 weight portions, Fructus Lycii 6 weight portions, Fructus Alpiniae Oxyphyllae 6 weight portions, Semen Cassiae 6 weight portions, Fructus Crataegi 4 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 15.66%, powdered after the spray drying, capsulation, every capsules contains effective composition 280mg.Become 4 of human oral one time, every day three times.
Embodiment 4,
Get Semen Persicae 7 weight portions, Radix Puerariae 5 weight portions, Fructus Lycii 5 weight portions, Fructus Alpiniae Oxyphyllae 5 weight portions, Semen Cassiae 7 weight portions, Fructus Crataegi 5 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 15.66%, powdered after the spray drying adds an amount of excipient compacting in flakes, and sugar coating is promptly.
Every in the tablet of embodiment 4 contains effective composition 450mg, becomes 4 of human oral one time, every day three times, takes after ante cibum and does not limit.

Claims (3)

1. the food therapy preparation based on the control cerebrovascular of preventive treatment of disease and integration of edible and medicinal herbs theory is characterized in that being made up of the effective ingredient of following weight ratio raw material components: Semen Persicae 9-11, Radix Puerariae 4-6, Fructus Lycii 4-6, Fructus Alpiniae Oxyphyllae 4-6, Semen Cassiae 6-8, Fructus Crataegi 4-6.
2. the food therapy preparation of control cerebrovascular according to claim 1 is characterized in that: the weight ratio of described each dietetic therapy raw material components is Semen Persicae 10, Radix Puerariae 5, Fructus Lycii 5, Fructus Alpiniae Oxyphyllae 5, Semen Cassiae 7, Fructus Crataegi 5.
3. the food therapy preparation of control cerebrovascular according to claim 1 is characterized in that: described food therapy preparation is powder, granule, capsule or tablet.
CN2009100688720A 2009-05-15 2009-05-15 Food therapy preparation for preventing and treating cerebrovascular diseases based on theories of preventive treatment of disease and medicine food homology Expired - Fee Related CN101884758B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108125091A (en) * 2018-01-22 2018-06-08 斯汏克(北京)生物科技有限公司 A kind of preparation method for improving cardiovascular and cerebrovascular Chinese herbal medicine composite enzyme drink
CN111567704A (en) * 2020-06-15 2020-08-25 广州市脑力皇贸易有限公司 Brain-strengthening and nerve-soothing plant beverage and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1049351C (en) * 1997-04-03 2000-02-16 黄肇源 Chinese patent medicine for curing cerebrovascular disease
CN101234171A (en) * 2008-03-06 2008-08-06 杨青华 Health product with blood fat lowering and preventing and treating cardio-cerebralvascular disease function and preparation thereof
CN101513505A (en) * 2009-03-15 2009-08-26 威海博力生物工程有限公司 A capsule for treating cardiovascular and cerebrovascular diseases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108125091A (en) * 2018-01-22 2018-06-08 斯汏克(北京)生物科技有限公司 A kind of preparation method for improving cardiovascular and cerebrovascular Chinese herbal medicine composite enzyme drink
CN111567704A (en) * 2020-06-15 2020-08-25 广州市脑力皇贸易有限公司 Brain-strengthening and nerve-soothing plant beverage and preparation method and application thereof

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