CN101884675B - Food therapy preparation for preventing and treating hyperlipidemia based on theories of preventive treatment of disease and medicine food homology - Google Patents
Food therapy preparation for preventing and treating hyperlipidemia based on theories of preventive treatment of disease and medicine food homology Download PDFInfo
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Abstract
The invention relates to a food therapy preparation for preventing and treating hyperlipidemia based on the theories of preventive treatment of disease and medicine food homology, which is characterized by comprising the effective ingredients of the following raw materials in weight ratio: 4-6 kelp, 6-8 peach seeds, 6-8 cassia seeds, 14-16 oyster and 4-6 of lotus leaves. The prescription of the food therapy preparation is based on the theory of preventive treatment of disease, and the food therapy preparation is prepared from a sufficient amount of effective ingredients. Although the food therapy preparation is not a medicine, the actions of the medicine can be exerted. The food therapy preparation not only can greatly limit the occurrence and the development of the hyperlipidemia, but also can save a great amount of medical resources and investments for China simultaneously. People can conveniently and correctly select the food therapy preparation in a pertinence way according to early symptoms per se to prevent the possible occurrence of the hyperlipidemia, and thus, the purposes of disease prevention and body building are achieved. The food therapy preparation can be directly taken according to a certain amount, and can also be eaten together with foods and drinks as an additive of the foods and the drinks.
Description
Technical field
The invention belongs to food therapy preparation, particularly relate to a kind of food therapy preparation of the anti-curing hyperlipemia based on preventive treatment of disease and integration of edible and medicinal herbs theory.
Background technology
Come from Chinese medicine " preventive treatment of disease " thought of Huangdi's Internal Classics, be subjected to elucidating of Han dynasty Zhang Zhongjing " Treatise on Febrile and Miscellaneous Disease " and " Medical Treasures of the Golden Chamber ", enrich constantly and develop by ancient Chinese medicine doctor, to the bright clear comparatively complete theory and practice system that begun to take shape, may be summarized to be take health as core, comprise (1) anosis health preserving, take preventive measures; (2) the wish disease is rescued and is sprouted, checks erroneous ideas at the outset; (3) control, prevent its change of disease sick morning; (4) take good care of oneself after being ill, prevent from recurring the substance of four aspects.The sub-health state that people often mention both belonged to the scope of " preventive treatment of disease " " anosis health preserving, take preventive measures ".Chinese medicine for the common measure of " preventive treatment of disease " have that regulating emotions, rationally dietetic therapy, daily life often have, strike a proper balance between work and rest, Traditional health care, acupuncture and tuina-massage and herbal treatment.
" integration of edible and medicinal herbs " be the Chinese nation over 10000000 year with the experience crystallization of the Nature and disease long-term struggle, the dietetic therapy that grows up thus also has distinct characteristic, is one of the common measure of " preventive treatment of disease ".China's Ministry of Public Health in 2002 announced be food be again the article list of medicine, totally 87 kinds of article.
In the prior art, use for anti-curing hyperlipemia be food be that the prescription of medicine article is more common in and some Chinese medicine mixed configuration, Fructus Crataegi powder by the Herb Gynostemmae Pentaphylli powder after extracting, after extracting of the patent of invention of notification number CN1686442 " a kind of Chinese medicinal capsule for blood fat reducing, preparation method and its usage " for example, its Chinese medicinal capsule, the Radix Salviae Miltiorrhizae powder after extracting, the astragalus membranaceus powder after extracting are made; Weight ratio is Herb Gynostemmae Pentaphylli powder 3-12 part, the Fructus Crataegi powder 3-12 part after extracting, the Radix Salviae Miltiorrhizae powder 2-8 part after extracting after extracting, the astragalus membranaceus powder 2-8 part after extracting.
Application number is 200510046692.4 application for a patent for invention " health food of blood sugar lowering, blood fat reducing and method for making thereof " for another example, is comprised of the component of following weight part ratio: Rhizoma amorphophalli 85-115, Fructus Momordicae charantiae 68-92, Fructus Lycii 51-69, Radix Astragali 34-46, Radix Ginseng 17-23.
Application number is 200710092622.1 application for a patent for invention " ganoderma lucidum cordyceps sinensis powder of Radix Puerariae and preparation method thereof " for another example, can treat hyperlipidaemic conditions by this powder that Ganoderma, Cordyceps, Folium Stevlae Rebaudianae, milk powder and Radix Puerariae form.
In the actual life, people have certain cognition and application level for the Dietotherapy method of anti-curing hyperlipemia, and still, people generally believe that the food therapy effect of relevant anti-curing hyperlipemia in the actual life is not remarkable.According to applicant's investigation, its reason has three, one, because bioactive ingredients content is lower in the integration of edible and medicinal herbs article, is not enough to manifest the prevention effect to certain disease; The 2nd, eating method is improper, causes active ingredient loss; The 3rd, can not strictly follow Chinese medicine and pharmacy determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle and because of people's choosing " food " of suiting the medicine to the illness.
Summary of the invention
The objective of the invention is in order to solve in the actual life for the food therapy effect of preventing curing hyperlipemia and inapparent technical problem, and a kind of food therapy preparation of the anti-curing hyperlipemia based on preventive treatment of disease and integration of edible and medicinal herbs theory is disclosed, said preparation has the outstanding feature of strictly following Chinese medicine and pharmacy determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle.
The food therapy preparation of anti-curing hyperlipemia of the present invention is comprised of the effective ingredient of following weight ratio raw material components: Thallus Laminariae (Thallus Eckloniae) 4-6, Semen Persicae 6-8, Semen Cassiae 6-8, Concha Ostreae 14-16, Folium Nelumbinis 4-6.
The weight ratio of described each dietetic therapy raw material components is Thallus Laminariae (Thallus Eckloniae) 5, Semen Persicae 7, Semen Cassiae 7, Concha Ostreae 15, Folium Nelumbinis 5.
Described food therapy preparation is powder, granule, capsule or tablet.
The basic effective constituents of above-mentioned each dietetic therapy raw material components and main effect thereof are:
Thallus Laminariae (Thallus Eckloniae): i.e. Thallus Laminariae (Thallus Eckloniae), contain the elements such as gas chromatography and iodine, potassium, calcium, ferrum, also contain protein, fatty acid, saccharide, multivitamin and nicotinic acid etc.Significantly cholesterol reducing has certain prevention and auxiliary therapeutic action to hyperlipidemia, coronary heart disease, arteriosclerosis and lipomatosis.
Semen Persicae: contain amygdalin, have the effect of blood circulation promoting and blood stasis dispelling.
Semen Cassiae: contain the anthraglycosides material, produce emodin, physcione, chrysophanic acid, chrysophanol and glucose etc. after decomposing.Have blood fat reducing, blood pressure lowering, the effect such as antibiotic.
Concha Ostreae: contain the nutritions such as rich in protein, fat, calcium, phosphorus, ferrum.Effect with QI invigorating, nourshing blood and promoting blood circulation in the hard masses softening and resolving accent.
Folium Nelumbinis: contain nuciferine, physiologically active is remarkable, has obvious blood fat reducing, antivirus action
Hyperlipidemia is higher at the sickness rate of China, and the serious threat people's is healthy.How by eating and drinking without temperance, impairing the spleen and stomach causes spleen insufficiency, and endogenous damp formation stops day of year of a specified duration, then blocks QI-blood circulation, causes due to blood stasis increases the weight of, should be with the dehumidifying of being amusing, and blood circulation promoting and blood stasis dispelling is ruled it by law.
The applicant has concluded the early symptom of hyperlipidemia according to the evidence-based medicine EBM theory: 1 often occurs feeling dizzy or easily sleeping with the people gap of talking.2 xanthelasma palpebrarums are signals of middle aged and aged women Lipid increase.3 calfs often knot, and often tingle.In 4 short time at facial, hand more black speck (speckle is bigger than senile plaque, and color is darker) appears.5 see thing, and a burst of is fuzzy.6 adults T-CHOL 5.20mmol/L～5.72mmol/L on an empty stomach; Low-density lipoprotein cholesterol (LDL-C) 3.12mmol/L～3.64mmol/L; HDL-C (HDL-C) 1.04mmol/L～0.91mmol/L; Triglyceride is marginality rising person near 1.70mmol/L.Especially the people who meets following situation more should prevent the generation of hyperlipidemia: 1 has hyperlipidemia family history person; 2 build overweight peoples; 3 middle-aged and elderly people; 4 long-term high-carbonhydrate diet persons; 5 postmenopausal women; 6 long-term smokings, alcoholic; 7 people that get used to sitting quietly; 8 lives are irregular, emotion is emotional, spiritual in tension person; The patients such as 9 hepatorenal disease, diabetes, hypertension.
The present invention is according to the early symptom of hyperlipidemia, take the theory of preventive treatment of disease as guidance, take the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs general plan of hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, make Thallus Laminariae (Thallus Eckloniae) hard masses softening and resolving, the Semen Persicae blood circulation promoting and blood stasis dispelling is monarch drug altogether, and Semen Cassiae, Concha Ostreae liver heat removing YANG hyperactivity suppressing are that ministerial drug is to remove stasis of blood heat-transformation of a specified duration, the disease of disturbing on the liver-wind, Folium Nelumbinis is removed the wet heart and is thought that assistant makes, and full side plays hard masses softening and resolving, blood circulation promoting and blood stasis dispelling altogether, the power of the dehumidifying of being amusing.
This food therapy preparation is according to the theoretical prescription of " preventive treatment of disease ", and form with the effective ingredient of q.s, although be not the effect that medicine but can play medicine, in the genesis that greatly reduces hyperlipidemia, can also save a large amount of medical resources and investment for country.
This food therapy preparation is convenient to people and may be caused hyperlipidemia to occur according to self early symptom and accurately select, sit in the right seat, and reaches the purpose of anti-treating diseases and making health-care.
Its beneficial effect of food therapy preparation of the present invention can be proven by following test.
Test name: the experimentation of this food therapy preparation effect for reducing blood fat
1 test material:
The Wistar rat, body weight 220 ± 20 grams, male and female half and half, totally 30.By this food therapy preparation that Thallus Laminariae (Thallus Eckloniae), Semen Persicae, Semen Cassiae, Concha Ostreae, Folium Nelumbinis effective ingredient form, paste-forming rate 5.85%.Tested liquor strength is 0.27g/ml.Cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, LDL test kit all build up bio-engineering research institute available from Nanjing.
2 methods and result:
2.1 the preparation of high lipid food
The high lipid food composition is cholesterol 1%, Adeps Sus domestica 10%, methylthiouracil 0.2%, and all the other add normal feedstuff.
2.2 the nursing of rat adaptability after 3 days, is divided into 3 groups by body weight, 10 every group at random.Blank group feeding normal feedstuff, model, medicine group feeding high lipid food.Medicine group gavage gives tested medicinal liquid 13mg/kg simultaneously, volume 20ml/kg, and contrast gives distilled water with model group, and once a day, gavage is 30 days continuously.After time administration, fasting not can't help water after 16 hours, abdominal aortic blood, and separation of serum is measured TC, TG, HDL-c, LDL-c, and cuts open and get liver and weigh.The results are shown in Table 1, table 2, visible model group rat compared with normal rat body weight increases, liver coefficient, serum TC, TG, HDL, LDL level increase and significant difference are arranged, and show the modeling success.The medicine group than model group relatively, serum TC, TG level reduce and significant difference are arranged.
Table 1 is on the impact of high fat rat weight
Annotate: compare with matched group
*P＜0.05
Table 2 is on the impact of high fat rat fat
Annotate: compare #P＜0.05, ##P＜0.01 with matched group; Compare with model group
*P＜0.05
3 conclusions:
Experimental result shows, tested medicinal liquid can significantly reduce high blood lipid model rat blood serum cholesterol, triglyceride levels, helps to regulate patient's hyperlipidemia state.
The acute toxicity testing of this food therapy preparation:
1 test material
1.1 laboratory animal ICR mice SPF level, available from Institute of Radiation Medicine, Chinese Academy of Medical Sciences's Experimental Animal Center, credit number: SCXK Tianjin 2005-0001.Totally 40, male and female half and half, body weight 20 ± 1 grams.
1.2 medicine is by this food therapy preparation that Thallus Laminariae (Thallus Eckloniae), Semen Persicae, Semen Cassiae, Concha Ostreae, Folium Nelumbinis effective ingredient form, regulating tested liquor strength is 0.27g/ml, makes it can pass through the mouse stomach device, is not its maximum tested concentration, matching while using but do not produce to stop up.
This food therapy preparation paste-forming rate 5.85%.The clinical application amount is 0.65g/kg.
1.3 experimental condition: 20 ℃-25 ℃ of room temperatures, relative humidity 45-60%RH, exhaust fan ventilates, and air-conditioning is regulated temperature, sweeps the Mus house one time in 3 days, keeps clean, and light/dark time is 12/12 hour.
2 methods
Fasting be can't help water 12 hours before the test, was divided into 2 groups according to the sex body weight, Normal group and administration group.The disposable gavage of administration group is given every 0.8ml of Cmax medicinal liquid, and matched group gives the co-content distilled water.Outward appearance, behavioral activity, ergasia, breathing, appetite, defecation and color thereof, the muzzle chamber of observing subsequently mice have or not abnormal secretion thing, body weight change and death condition.Dead animal in time performs an autopsy on sb．, and the discovery diseased organ is done the pathology histological examination, Continuous Observation 7 days.
Observation index sees table 1 for details.
Table 1 animal acute toxicity test is observed table
Animal was observed 7 after the 3 experimental result administrations, as a result muscular movement atremia, tic, ataxia, paralysis, the muscular tension reaction is normal, neuro-vegetative response, breathing, skin color are normal, diet is without unusually, the mice activity freely, unusual without cry, tremble, convulsions, movement disorder, sialorrhea, shed tears, the phenomenons such as rhinorrhea, dyspnea, diarrhoea, constipation, intestinal tympanites occur.Animal skin gloss, relatively body weight increase before none death of animal in 7 days after the administration, animal and administration is compared the weight of animals there was no significant difference (seeing table 2 for details) with matched group, also without other abnormal phenomenas.Animal on the 8th all takes off cervical vertebra and puts to death, by only doing postmortem, each internal organs of perusal rat, the organs and tissues positions such as the heart, liver, spleen, lung, kidney, adrenal gland, thymus, stomach, intestinal, bladder, testis, prostate, uterus, ovary, thoracic cavity, abdominal cavity are showed no unusually as a result.
Table 2 is on the impact of Mouse Weight
This test maximum dosage-feeding is 40ml/kg * 0.27g/ml=10.80g/kg, is equivalent to crude drug in whole 10.80g/kg ÷ 0.0585g/g=184.62g/kg, is equivalent to the 184.62g/kg ÷ 0.65g/kg=284 of Coming-of-Age Day consumption 0.65g/kg doubly.
Conclusion:
This food therapy preparation gavage gives the ICR mice, and the maximum possible dosage is 184.62g/kg, and death does not appear in animal, and this test maximum dosage-feeding is equivalent to 284 times of 60kg Coming-of-Age Day consumption, therefore this food therapy preparation gavage gives mice without Acute Toxicity.
The specific embodiment
Further specify the present invention below in conjunction with embodiment.
Embodiment 1
Get Thallus Laminariae (Thallus Eckloniae) 6 weight portions, Semen Persicae 8 weight portions, Semen Cassiae 6 weight portions, Concha Ostreae 14 weight portions, Folium Nelumbinis 6 weight portions.
The above five tastes, Semen Cassiae add 8 times of amount 70% ethanol extractions 2 times, and each 1 hour, filter, merge ethanol extract, Recycled ethanol is to nothing alcohol flavor, and medicinal liquid is for subsequent use; Thallus Laminariae (Thallus Eckloniae), Semen Persicae, Concha Ostreae, Folium Nelumbinis add 10 times of water gagings and decoct 2 times, each 1 hour, filter, collecting decoction is concentrated into 1g/ml, and leaving standstill concentrated solution is room temperature, add ethanol to containing alcohol amount 80%, stir evenly, left standstill 24 hours, supernatant Recycled ethanol to nothing alcohol is distinguished the flavor of, merge with the Semen Cassiae extracting solution, concentrated, spray drying, paste-forming rate 5.85%, namely per 100 gram medical materials get extract 5.85 grams.
The spray-dried one-tenth powder of paste medicinal liquid, damp-prrof packing, weight depends on the needs.
The powder of embodiment 1 can add in beverage, the food edible, all can in the addition 1-5% scope.Also can make aqueous solution by above addition and spray in Folium Camelliae sinensis surface, come into the market with Folium Camelliae sinensis by the tea packaging form after to be dried.
Embodiment 2
Get Thallus Laminariae (Thallus Eckloniae) 5 weight portions, Semen Persicae 7 weight portions, Semen Cassiae 7 weight portions, Concha Ostreae 15 weight portions, Folium Nelumbinis 5 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 5.85%, the powder after the spray drying add an amount of excipient and become granule, bag distribution packaging, and every bag of 2g becomes 1 bag of human oral one time, every day three times.
Embodiment 3
Get Thallus Laminariae (Thallus Eckloniae) 4 weight portions, Semen Persicae 6 weight portions, Semen Cassiae 8 weight portions, Concha Ostreae 16 weight portions, Folium Nelumbinis 4 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 5.85%, powdered after the spray drying, capsulation, every capsules 280mg.Become 4 of human oral one time, every day three times.
Embodiment 4
Get Thallus Laminariae (Thallus Eckloniae) 5 weight portions, Semen Persicae 7 weight portions, Semen Cassiae 7 weight portions, Concha Ostreae 15 weight portions, Folium Nelumbinis 5 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 5.85%, powdered after the spray drying adds the compacting of an amount of excipient in flakes, sugar coating and get final product.
Every in the tablet tablet of embodiment 4 contains effective composition 380mg, becomes 2 of human oral one time, every day three times, does not limit after ante cibum.
Claims (3)
1. the food therapy preparation based on the anti-curing hyperlipemia of preventive treatment of disease and integration of edible and medicinal herbs theory is characterized in that being comprised of the contained effective ingredient of the raw material of following weight ratio: Thallus Laminariae (Thallus Eckloniae) 4-6, Semen Persicae 6-8, Semen Cassiae 6-8, Concha Ostreae 14-16, Folium Nelumbinis 4-6.
2. the food therapy preparation of anti-curing hyperlipemia according to claim 1 is characterized in that being comprised of the contained effective ingredient of the raw material of following weight ratio: Thallus Laminariae (Thallus Eckloniae) 5, Semen Persicae 7, Semen Cassiae 7, Concha Ostreae 15, Folium Nelumbinis 5.
3. the food therapy preparation of anti-curing hyperlipemia according to claim 1, it is characterized in that: described food therapy preparation can be made powder, granule, capsule or tablet.
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| CN200910068867XA CN101884675B (en) | 2009-05-15 | 2009-05-15 | Food therapy preparation for preventing and treating hyperlipidemia based on theories of preventive treatment of disease and medicine food homology |
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| CN101884675B true CN101884675B (en) | 2013-03-06 |
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| CN103416669B (en) * | 2013-08-05 | 2014-08-20 | 赵杏珍 | Medicinal and edible noodles suitable for people suffering from high blood pressure, high blood lipid and high blood sugar |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179893A (en) * | 1996-09-20 | 1998-04-29 | 张士舜 | Method for producing fetid cassia tea |
| CN101167904A (en) * | 2007-11-09 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for treating hyperlipemia and its preparing process |
| CN101390547A (en) * | 2008-07-31 | 2009-03-25 | 李国柱 | Lipid-lowering tea and production method thereof |
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2009
- 2009-05-15 CN CN200910068867XA patent/CN101884675B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179893A (en) * | 1996-09-20 | 1998-04-29 | 张士舜 | Method for producing fetid cassia tea |
| CN101167904A (en) * | 2007-11-09 | 2008-04-30 | 北京中科雍和医药技术有限公司 | Medicinal composition for treating hyperlipemia and its preparing process |
| CN101390547A (en) * | 2008-07-31 | 2009-03-25 | 李国柱 | Lipid-lowering tea and production method thereof |
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