CN101322800B - Chinese medicinal composition for increasing skin moisture and preparation thereof - Google Patents
Chinese medicinal composition for increasing skin moisture and preparation thereof Download PDFInfo
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- CN101322800B CN101322800B CN2008100295500A CN200810029550A CN101322800B CN 101322800 B CN101322800 B CN 101322800B CN 2008100295500 A CN2008100295500 A CN 2008100295500A CN 200810029550 A CN200810029550 A CN 200810029550A CN 101322800 B CN101322800 B CN 101322800B
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Abstract
The invention provides a traditional Chinese medicine composition for increasing the moisture of skin. The composition consists of an effective component and a auxiliary material which can be accepted in medicine, wherein, the effective component is made from the following crude drugs with the weight proportion by parts: 20-80 parts of asparagus root, 20-80 parts of white fungus and 1-40 parts ofsafflower. The composition of the invention nourishes the lung yin and kidney yin, regulates the moisture of skin by nourishing yin, and lays stress on the general regulation, has the efficacies of nourishing the lung and the kidney, nourishing yin and regulating and tonifying the blood, and moistening and lustering skin, can improve the moisture of skin, effectively relieve the symptoms of dry skin, postpone senility, has marked effect in treating dry skin, and is used for the symptoms of deficiency of pulmonary and renal yin, little moisture and dryness of skin, darkish and lusterless complexion, and the like, caused by pressure, poor sleep, improper diet or long-term stay in the air-conditioned environment. The composition of the invention is also mild in temperament, has the nature ofhomologous source of food and drug and has no side and toxic effect, which is suitable for regulating function of human body for a long term.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of medical configuration product.
Background technology
No matter season, age, skin matter, nearly all skin problem all reduces relevant with xerosis cutis hydropenia, skin self-protection and maintenance mechanism.We can say, increase moisture of skin and be the basis of beauty and skin care and basic.After skin dries out, dry, the desquamation of epidermis cell meeting; Exsiccant skin loses protective capability, is subjected to the immersion of antibacterial and harmful substance easily and dermatitis takes place to cause pruritus; The skin that dries out is can be dry coarse, form microgroove, pigmentation, causes many skin problems.
Modern's rhythm of life is fast, and pressure is big, and poor sleep lacks maintenance, adds and live in for a long time in the air conditioner surroundings that cause the moisture of skin disequilibrium, the hydropenia dry situation is very general; Because environmental pollution is on the rise, dust, ultraviolet have more increased the weight of the aging of skin to the injury of skin again.At present, there is not highly effective method for improving xerosis cutis.Have researcher to advise that drinking 8 glasss of water every day improves the xerosis cutis problem, but clinical many patients think that this method effect is also not obvious, the external moisture-keeping cosmetics is then cured the symptoms, not the disease.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of Chinese medicine composition that fundamentally improves the xerosis cutis problem.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of Chinese medicine composition that increases moisture of skin, said composition is made up of active ingredient and medically acceptable adjuvant, and the following bulk drugs of wherein said active ingredient is made: Radix Asparagi 20～80, Tremella 20～80 and Flos Carthami 1～40.
Compositions of the present invention, 40～50 parts of the proportion optimization Radix Asparagis of the crude drug of wherein said active ingredient, 10～20 parts of 40～50 parts of and Flos Carthami of Tremella, the best is 40 parts of Radix Asparagis, 20 parts of 40 parts of and Flos Carthami of Tremella.
The preparation method of the active ingredient of compositions of the present invention is:
Getting Radix Asparagi, Tremella and Flos Carthami decocted 1 hour after 1 hour with the water logging bubble of 8～12 times of crude drug amounts, leach decocting liquid, the decocting that adds 6～8 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 decocting liquids and the ratio that is evaporated to dosage is 5: 1, left standstill 1～2 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1～2g in every milliliter of concentrated solution.
Compositions of the present invention can be common peroral dosage form, as oral liquid, granule, capsule etc.
The traditional Chinese medical science thinks that xerosis cutis is due to the deficiency of YIN-blood." element asks that the five internal organs generate ": " the tissue connected with the lung being skin, its flourish hair also." the cloudy blood consumption of lung meridian hinders, pachylosis then, hair is withered easily to fall; Kidney master water is regulated the defeated cloth of human body body fluid, and deficiency of the kidney yin then is difficult skin care, and complexion is black dull withered and matt; So nourishing YIN is especially when the moon of paying attention to nourishing lung and kidney.So according to above-mentioned etiology and pathogenesis, the principle of medicine is selected in selected the kidney invigorating lung moistening for the present invention: the moon of nourishing lung and kidney is selected Radix Asparagi, and as monarch drug of the present invention, Zhang Xichun says: " cool in nature, body fluid is dense lubricious for Radix Asparagi, the little suffering of sweet in the mouth, kind promoting the production of body fluid to quench thirst.The property of Tianjin dope cunning, can tonneau two just, the circulation blood vessels, fluent meridians, though be the product of YIN nourishing, the real energy tonification edema caused by disorder of QI of holding concurrently." so the moon of the clear and rich lung kidney of Radix Asparagi, YIN nourishing and the production of body fluid promoting is moisturized, and it contains the gas of giving birth to life, and the body fluid of holding dense cunning under the arm is popular in all over the body, moist skin; Tremella nourishing is promoted the production of body fluid, and the lung moistening nourishing the stomach helps the power of Radix Asparagi skin moistening, is ministerial drug; Assistant is warm in nature with Flos Carthami, goes the cold of yin-nourishing drug, and nourishes blood and blood, reaches the whole body, the ruddy gloss of the skin moisturizing and the colour of skin to help the cloudy liquid profit of skin.The difference of two flavor yin-nourishing drugs and other yin nourishing Chinese medicines is to mend and oiliness in the present composition, and property is gentle and not cold and cool, takes for a long time and can not suppress yang-energy in the body; And slightly with blood medicine Flos Carthami with Yin Yang balancing, promote the cloudy liquid skin of moistening, many medicine compatibilities play the effect of YIN nourishing and the production of body fluid promoting, skin care.
Modern pharmacology studies have shown that the Radix Asparagi tuber contains multiple Zi body Saponin, fructose and aminoacid, can activate Skin Cell, keep skin wet, smooth and elasticity; Tremella contains multiple polysaccharide, fatty acid and phospholipid, and the collagen protein of activation corium strengthens the water-retaining property of skin, and slow down aging is arranged, and promotes biosynthesiss such as protein and nucleic acid, promotes effects such as hemopoietic function; Flos Carthami can distend the blood vessels, and microcirculation improvement makes the nutrient mass-energy in the blood pass through the tiny and narrow timely skin nutrition of blood vessel, strengthens the anoxia enduring and the anti-damage ability of skin.
The moon of present composition nourishing lung and kidney, support outer and the adjusting moisture of skin with interior, pay attention to integrally-regulated, effect with nourishing lung and kidney, yin nourishing and blood, moist skin, moisture of skin be can improve, effectively dryness skin symptom, slow down aging alleviated, cure mainly the dryness skin, be used for because of pressure, poor, the eating and drinking without temperance of sleep etc., or YIN-deficiency of the lung and kidney, skin hydropenia drying, dim complexion do not have diseases such as pool due to being in the air conditioner surroundings for a long time.And the present composition property of medicine is gentle, and the product of " integration of edible and medicinal herbs " are arranged, and has no side effect, and is fit to the long-time conditioning function of human body.
In order to understand the present invention better, will prove the technique effect that the present invention has by clinical trial below.
1 clinical data
1.1 physical data is observed case totally 50 examples, is attached Nanfang Hospital of Nanfang Medical Univ (former No.1 Military Medical Univ.) surgery of Chinese medicine outpatient service in June, 2007～2008 case in year May.Be divided into 2 groups at random, 30 examples are organized in treatment, wherein male 8 examples, women 22 examples; 25～42 years old age, average 36.3 years old; Matched group 20 examples, wherein male 3 examples, women 17 examples, 25～44 years old age, 34.9 years old mean age.2 groups of data are learned processing by statistics, and difference there are no significant meaning (p＞0.05) has comparability.
1.2 include Standard Selection in 25 years old～45 years old dryness skin patient, male or female often has dry and astringent tight sense after washing one's face at ordinary times, and skin often has desquamation when dry weather.
1.3 skin of face illness such as the concurrent dermatitis of exclusion standard, acne; Gestation or women breast-feeding their children; Be associated with liver, cardiovascular disease person; Malignant tumor patient; Once systematic treating mistake in 4 weeks; End treatment during the treatment or change medicine, method person; Can't judge not umbra sound curative effect judgement person of curative effect or data.
2 Therapeutic Method
2.1 the treatment group gives Chinese medicine composition of the present invention, promptly presses embodiment 1 described method and produces oral liquid.Each 10ml, every day 3 times, oral.Observed result after 4 weeks of treatment.
2.2 matched group oral vitamin E soft gelatin capsule (natural type, Qingdao Double Whale Pharmaceutical Co., Ltd.), each 0.1g, every day 2 times.
2.3 statistical method adopts the T check.
3 efficacy analysis
3.1 test instrunment KF-833 moisture of skin oil content elastic force monitor (Kang Futong Electronics Co., Ltd.)
3.2 all tests of method of testing are all carried out in the room of constant temperature, constant humidity, temperature (22 ± 1) ℃, humidity (50 ± 5) %.The person of being observed under quiescent condition, detects skin of forehead moisture, oil content and elastic force before treatment, after 4 weeks of treatment.At period in a medicine, all objects of observation are not all taken other medicine or health product of increasing moisture of skin.
3.3 therapeutic outcome 30 routine patients see Table 1 through 4 all traditional Chinese medicine composition for treating rear face skin properties result of variations statistics.The skin moisture content meansigma methods is 24.4 ± 4.7 before the treatment of treatment group, and the skin moisture content meansigma methods is 23.5 ± 5.2, two groups of relatively no difference of science of statistics (p＞0.05) before the treatment of control group; Treatment back treatment group skin moisture content meansigma methods is 57.5 ± 6.8, and matched group skin moisture content meansigma methods is 26.6 ± 7.3, and both relatively have significant difference (p＜0.05); The pairing T value is 21.5 before and after the treatment of treatment group, shows that taking the treatment by Chinese herbs group has significant difference (p＜0.01).Treatment is simultaneously organized the secretion of 18 routine patients (60%) sensation facial oil and is reduced relatively, relatively has significance meaning (P＜0.05) with matched group, and its pairing T check shows significant difference (p＜0.05) before and after the treatment of treatment group; After the course of treatment, the skin elasticity test is relatively preceding with treatment, there was no significant difference (P＞0.05).Treatment group and matched group do not have any untoward reaction during the treatment, all can adhere to treatment.
Facial skin properties situation before and after table 1 treatment group and the treatment of control group
Compare with matched group,
*P＜0.01,
*P＜0.05
4 conclusions
This Chinese medicine composition is through clinical observation, and proving obviously to increase moisture of skin, and can suitably reduce the skin oil and fat secretion, meets the viewpoint of skin " water oil balance ".Cause the more oils and fats of smegma to protect skin after the skin hydropenia, and after replenishing moisture of skin, can suitably reduce the secretion of sebaceous gland.The elasticity of skin does not have significant change after treating 1 course of treatment, this may be relevant inadequately with the course of treatment.
The specific embodiment
Example 1:
Get Radix Asparagi 400g, Tremella 400g, Flos Carthami 200g by best proportioning, steeped 1 hour, decocted 1 hour with the water logging of 8 times of crude drug amounts, leach decocting liquid, the decocting that adds 8 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, be evaporated to 5000ml then, left standstill 1 hour, filter; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1g in every milliliter of concentrated solution.
Instructions of taking: oral, every day dosage: 30ml, divide and take for three times, each 10ml.
Example 2:
Get Radix Asparagi 800g, Tremella 800g, Flos Carthami 100g, steeped 1 hour, decocted 1 hour with the water logging of 12 times of crude drug amounts, leach decocting liquid, the decocting that adds 6 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, be evaporated to 8500ml then, left standstill 1 hour, filter; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1g in every milliliter of concentrated solution.
Instructions of taking: oral, every day dosage: 30ml, divide and take for three times, each 10ml.
Example 3:
Get Radix Asparagi 200g, Tremella 800g, Flos Carthami 400g, steeped 1 hour, decocted 1 hour with the water logging of 10 times of crude drug amounts, leach decocting liquid, the decocting that adds 7 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, be evaporated to 7000ml then, left standstill 2 hours, filter; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1g in every milliliter of concentrated solution.
Instructions of taking: oral, every day dosage: 30ml, divide and take for three times, each 10ml.
Example 4:
Get Radix Asparagi 800g, Tremella 200g, Flos Carthami 100g, with the water logging of 8 times of crude drug amounts bubble 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 8 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, was evaporated to 5500ml then, left standstill filtration 2 hours; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1: 3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Employing aluminum-plastic composite membrane packing, every packing has the 10g content.
Instructions of taking: warm boiled water, dosage 30g divided and took for three times every day, each 10g.
Example 5:
Get Radix Asparagi 500g, Tremella 500g, Flos Carthami 200g, steeped 1 hour, decocted 1 hour with the water logging of 12 times of crude drug amounts, leach decocting liquid, the decocting that adds 6 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, be evaporated to 6000ml then, left standstill 2 hours, filter; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1: 3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Employing aluminum-plastic composite membrane packing, every packing has the 10g content.
Instructions of taking: warm boiled water, dosage 30g divided and took for three times every day, each 10g.
Example 6:
Get Radix Asparagi 400g, Tremella 800g, Flos Carthami 200g, with the water logging of 8 times of crude drug amounts bubble 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 6 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, was evaporated to 7000ml then, left standstill filtration 1 hour; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1: 3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Fill content 0.6g in every capsule with No. 0 capsulae vacuus.
Instructions of taking: oral, dosage 10g divided and took for three times, each 6 every day.
Example 7:
Get Radix Asparagi 400g, Tremella 800g, Flos Carthami 10g, with the water logging of 8 times of crude drug amounts bubble 1 hour, decocted 1 hour, leach decocting liquid, the decocting that adds 6 times of crude drug amounts again in the filtering residue boiled 1 hour, merged 2 times decocting liquid, was evaporated to 6050ml then, left standstill filtration 1 hour; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 2g in every milliliter of concentrated solution.In Chinese medical concrete in extractum: the ratio of excipient=1: 3.5 (weight ratio) adds excipient, makes granule by conventional method.Wherein, each 1/3rd forms described excipient by soluble starch, dextrin, lactose.Fill content 0.6g in every capsule with No. 0 capsulae vacuus.
Instructions of taking: oral, dosage 10g divided and took for three times, each 6 every day.
Claims (3)
1. Chinese medicine composition that increases moisture of skin, said composition is made up of active ingredient and medically acceptable adjuvant, it is characterized in that described active ingredient made by following bulk drugs: 40～50 parts of Radix Asparagis, 10～20 parts of 40～50 parts of and Flos Carthami of Tremella.
2. the described compositions of claim 1 is characterized in that the proportioning of the crude drug of described active ingredient is: 40 parts of Radix Asparagis, 20 parts of 40 parts of and Flos Carthami of Tremella.
3. the preparation method of the active ingredient of claim 1 or 2 described compositionss, this method is: get Radix Asparagi, Tremella and Flos Carthami and decocted 1 hour after 1 hour with the water logging bubble of 8～12 times of crude drug amounts, leach decocting liquid, the decocting that adds 6～8 times of crude drug amounts in the filtering residue boiled 1 hour again, the ratio that merges 2 decocting liquids and be evaporated to dosage is 5: 1, left standstill 1～2 hour, and filtered; Getting filtrate is concentrated into and contains the crude drug amount that is equivalent to 1～2g in every milliliter of concentrated solution.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1709494A (en) * | 2005-06-20 | 2005-12-21 | 余内逊 | Method for preparing micron suganr ginseng white fungus granule and capsule for moistening face and lungs, and lowering blood-sugar |
| CN1827145A (en) * | 2005-03-01 | 2006-09-06 | 重庆大易科技投资有限公司 | Chinese medicinal composition with beautifying function and method for preparing the same |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827145A (en) * | 2005-03-01 | 2006-09-06 | 重庆大易科技投资有限公司 | Chinese medicinal composition with beautifying function and method for preparing the same |
| CN1709494A (en) * | 2005-06-20 | 2005-12-21 | 余内逊 | Method for preparing micron suganr ginseng white fungus granule and capsule for moistening face and lungs, and lowering blood-sugar |
Non-Patent Citations (2)
| Title |
|---|
| 曾秀池.中药抗衰老机理浅识.实用中医药杂志.2006,第22卷(第11期),712-713. * |
| 权信哲等.抗皮肤衰老的中医疗法.中医药学刊.2006,第24卷(第5期),867-868. * |
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