CN100450519C - Chinese medicine preparation for changing diabetes II insulin resistance and sugar, fat metabolic disorder - Google Patents

Abstract

The present invention belongs to the field of Chinese medicine technology, and is especially one kind of Chinese medicine preparation capable of changing the insulin resistance and sugar and fat metabolic disorder of type II diabetics. The Chinese medicine preparation is prepared with bupleurum root, skullcap root, rehmannia root, dogwood, Chinese yam and other ten kinds of Chinese medicinal materials. It has functions of reducing blood sugar, regulating blood fat, lowering blood viscosity, improving insulin secreting level, eliminating secreting fault, and raising insulin sensitivity index.

Description

A kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine preparation

Technical field

The invention belongs to the Chinese medicine technical field, specifically be a kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine preparation.

Background technology

At type 2 diabetes mellitus medically is metabolic disease, is the disease of multiple metabolism disorders such as glucose, fat.Insulin resistant and defect of insulin secretion or the combined effect of the two are the bases that this metabolism disorder takes place.So the metabolism disorder problem of research treatment type 2 diabetes mellitus with regard to studying insulin resistant and be caused.At present doctor trained in Western medicine, the combination of Chinese and Western medicine and in medical circles begun to pay close attention to this problem, western medical treatment insulin resistant and the metabolism disorder that is caused thereof or from blood sugar lowering, or from transferring fat, or start with, but do not have a kind of active drug to emerge so far as yet from strengthening insulin sensitivity.Traditional Chinese medical science research is treated or is started with from the expectorant stasis of blood, or starts with from deficiency of both QI and YIN, or starts with from insufficiency of the spleen, suffer from a deficiency of the kidney etc., though emphasize all to some extent, gives priority to, and dislikes unilateral slightly, dislikes basic inadequately slightly.The present inventor thinks that insulin resistant and the metabolism disorder that is caused thereof should be gone understanding from the pathomechanism of the traditional Chinese medical science " liver-heat is suffered from a deficiency of the kidney, the retardance of the expectorant stasis of blood ", go research.This is according to the understanding of ancient medicines such as treatise on Febrile Diseases, " Medicine Comprehended ", Huangdi's Internal Classics, " medical secrets of official " to " quench one's thirst belong to heat syndrome of JUE YIN ", " quench one's thirst and belong to kidney ", and the new feature that occurs in conjunction with modern diabetes is many liver-heat, suffer from a deficiency of the kidney more, the excessive phlegm stasis of blood and the understanding viewpoint of establishing.

Summary of the invention

The present invention overcomes doctor trained in Western medicine, the defective of Chinese and western medicine aspect the treatment primary disease, think that from the mechanism angle of curing the disease of the traditional Chinese medical science primary disease insulin resistant and sugar, disorders of lipid metabolism are by due to Liver and kidney imbalance and the retardance of the expectorant stasis of blood, so the nourishing kidney of a kind of accent liver is provided, regulating YIN and YANG, dissipating phlegm and removing blood stasis can change type 2 diabetes mellitus insulin resistant and Chinese medicine preparation sugared, disorders of lipid metabolism.

The present invention realizes by following scheme, and a kind of Chinese medicine preparation that can change type 2 diabetes mellitus insulin resistant and sugar, disorders of lipid metabolism is to be made by following weight ratio (part) effective ingredient raw material of Chinese medicine:

6～30 parts of 6～40 parts of mountain cornels of 5～15 parts of Radix Rehmanniae of 6～18 parts of Radix Scutellariaes of Radix Bupleuri

6～15 parts of 6～33 portions of Rhizoma Alismatis of 8～33 parts of Radix Pseudostellariaes of 6～40 parts of Radix Trichosanthis of Rhizoma Dioscoreae

2～9 parts of 2～12 portions of Cortex Cinnamomis of 6～33 portions of Rhizoma Coptidis of 9～30 parts of Radix Salviae Miltiorrhizaes of Rhizoma Atractylodis

6～20 parts of 2～15 portions of Semen Plantaginiss of 6～30 portions of Radix Gentianaes of Herba Epimedii

Of the present invention a kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine, be to make by following weight ratio effective ingredient raw material of Chinese medicine;

10～20 parts of 10～20 parts of mountain cornels of 8～10 parts of Radix Rehmanniae of 8～15 parts of Radix Scutellariaes of Radix Bupleuri,

9～14 parts of 10～30 portions of Rhizoma Alismatis of 9～30 parts of Radix Pseudostellariaes of 12～30 parts of Radix Trichosanthis of Rhizoma Dioscoreae

3～8 parts of 3～9 portions of Cortex Cinnamomis of 10～30 portions of Rhizoma Coptidis of 12～24 parts of Radix Salviae Miltiorrhizaes of Rhizoma Atractylodis

8～16 parts of 4～12 portions of Semen Plantaginiss of 10～24 portions of Radix Gentianaes of Herba Epimedii

Of the present invention a kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine, be to make by following weight ratio effective ingredient raw material of Chinese medicine:

20 parts of 20 portions of Rhizoma Dioscoreaes of 30 parts of mountain cornels of 6 parts of Radix Rehmanniae of 12 parts of Radix Scutellariaes of Radix Bupleuri

30 parts of 18 parts of Radix Salviae Miltiorrhizaes of 12 parts of Rhizoma Atractylodis of 20 portions of Rhizoma Alismatis of 20 parts of Radix Pseudostellariaes of Radix Trichosanthis

9 parts of 6 portions of Semen Plantaginiss of 18 portions of Radix Gentianaes of 4 parts of Herba Epimedii of 6 portions of Cortex Cinnamomis of Rhizoma Coptidis

Radix Bupleuri is bitter flat in the side, goes into the liver and gall warp, the heresy of the few sun of expelling heat from the exterior and removing summer-heat, the stasis of catharsis liver and gall mechanism of qi; The Radix Scutellariae bitter cold, the heat of clearing away the heat in SHAO YANG; Radix Rehmanniae heat clearing away, yin nourishing, the also nourishing kidney of promoting the production of body fluid; Fructus Corni, Rhizoma Dioscoreae nourishing kidney-yin and astringent or styptic treatment for spontaneous sweating kidney essense, kidney qi are principal agent altogether.The Radix Trichosanthis clearing away heat and promoting production of body fluid is with the Radix Rehmanniae mutually 5, to eliminate the thirsty of the cloudy Tianjin of hepatocholic depression thermal burn; The Radix Pseudostellariae supplementing QI and nourishing YIN, also at insufficiency of primordial QI, cloudy Tianjin can not on the thirsty polydipsia that holds, again can spleen invigorating, be accessory drugs altogether; Rhizoma Alismatis, Rhizoma Atractylodis spleen invigorating, damp eliminating, reduce phlegm, also antimagnetic greasy; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, again can with the wet medicine that eliminates the phlegm mutually 5 with the expectorant stasis of blood and control, be adjuvant altogether.Play altogether and transfer liver (soothing the liver, liver heat removing, let out gallbladder) nourishing kidney, regulating YIN and YANG, the merit of dissipating phlegm and removing blood stasis full side.

Manufacture method: 1. clean; 2. dry naturally or the electrical heating oven dry; 3. pulverize: be ground into superfine end with 120 purpose Chinese medicine grinder; 4. pack: with the medicamental pulverata disposable paper filter bag of packing into, every bag heavy 10g; 5. seal: earlier with paper filter bag heat sealing, again it is inserted in plastic bag heat sealing again with the plastic sheeting sealing machine.The medicine that the present invention makes can be called after diseases due to endogenous heat of ZANG FU organs decoction formulation (teabag), down together.

Usage: one time 1 bag, 2-3 time on the one, blister is worked as tea-drinking, is a course of treatment bimester of serveing on.

Medicine of the present invention is called " diseases due to endogenous heat of ZANG FU organs soup ".Its technical scheme is new reasonable, and effect is remarkable, embodies the thought of controlling, controlling from expectorant stasis of blood opinion from the Liver and kidney opinion.In blood sugar lowering, have concurrently and transfer fat, reduce blood viscosity, improve the effect of insulin resistant.The variation by observing clinical symptoms and the variation of related experiment number of chambers certificate, prove the present invention to the type 2 diabetes mellitus insulin resistant and due to sugar, disorders of lipid metabolism have good improvement and regulating action, thereby can treat type 2 diabetes mellitus effectively.

Clinical trial and observation:

1 selects case: select case 118 examples altogether, be divided into treatment group and matched group at random.68 examples are organized in treatment, matched group 50 examples.Wherein treatment group male 30 examples, women's 38 examples; Age: 35～74 years old, average 50.38 ± 7.1 years old; The course of disease: 1～20 year, average 8.60 ± 2.4 years.Matched group: male's 21 examples, women's 29 examples; Age: 36～75 years old, average 50.36 ± 7.2 years old; The course of disease: 1～18 year, average 8.41 ± 2.34 years.Two groups of sexes, age and courses of disease all do not have the statistics difference.

2 diagnostic criterias: Western medicine diagnose standard: according to WHO expert consulting report in 1999, with reference to " the new Chinese medicine clinical research guideline " of new revision in 2002, the diabetes diagnosis standard was as follows: fasting glucose (FPG) 〉=7.0mmol/L; Or back two hours blood glucose (2hPG) 〉=11.1mmol/L of clothes sugar in the carbohydrate tolerance test (OGTT); Or symptom+random blood sugar 〉=11.1mmol/L and get rid of the temporary hyperglycemia that actute infection, wound and other case of emergency cause.Tcm syndrome diagnostic criteria: with reference to " the new Chinese medicine clinical research guideline " of new revision in 2002 relevant diabetes Syndrome in TCM marquis diagnostic criteria, on based on the basis of intense heat due to deficiency of YIN type, type of deficiency of both QI and YIN pattern of syndrome in conjunction with the understanding viewpoint of the expectorant stasis of blood and the viewpoint of controlling from the Liver and kidney opinion, formulated basic pattern of syndrome, promptly liver-heat suffer from a deficiency of the kidney, imbalance of YIN and YANG, expectorant stasis of blood retardance card.Specific as follows: the performance of (1) cardinal symptom: dry mouth and throat is accompanied or is not accompanied polydipsia, has a dizzy spell, and nocturia increases, and fatigue and weakness or heavy sensation of the body are weak; (2) minor symptom performance: vexed fear heat, soreness of the waist and knees, polyphagia or easily hungry, bitter taste.The tongue arteries and veins: red tongue is dim, or red tongue margin is dim, yellow fur or greasy, stringy and rolling pulse or stringy and thready pulse number.Cardinal symptom possesses more than 3, minor symptom possess 1～2 promptly diagnosable.

Insulin resistant (IRS) diagnostic criteria: diagnose according to the suggestion that World Health Organization (WHO) proposed the IRS research work in 1999.(1) primary symptom: 1. insulin resistant (IR): patient's insulin sensitivity sex index (ISI) significantly is lower than the average with crowd healthy people.2. carbohydrate tolerance goes down (IGT): back two hours blood glucose of clothes sugar is 7.84 ~ 11.2mmol/L.3. diabetes (DM): random blood sugar 〉=11.1mmol/L or fasting glucose (FPG) 〉=inferior disease of 7.80mmol/L (2): 1. hypertension: arteriotony 〉=140/90mmHg.2. hypertriglyceridemia: serum levels of triglyceride (TG) 〉=1.70mmol/L.3. HDL-C (HDL-C) reduces, man＜0.9mmol/L, woman＜1.0mmol/L.4. central obesity: Body Mass Index (BMI)＞25; Or waist-to-hipratio man＞0.90, woman＞0.85.5. Microalbuminuria: urine protein＞20 μ g; Or albumin/creatinine ratio＞30mg/g.See 1 of above-mentioned primary symptom, and see 2 of time diseases, can make the diagnosis of IRS.

3 exclusion standards: be associated with other serious disease persons,, or in selected preceding 3 months the myocardial infarction person taken place as the cerebrovascular acute stage, or other severe complications persons; Merge the severe infections person; Suffers from malignant tumor person; Other gastroenteropathys person who suffers from serious dyspepsia and maybe can influence drug absorption does not make selected scope.

4 treatment and observational techniques:

4.1 Therapeutic Method: two groups of patients all carry out the Primary Care of diabetes routine, comprise diabetes health education, quantitatively diet control and basic antidiabetic drug treatment, promptly select diformin tablet 0.25g for use, 3 times on the one, gliclazide sheet 40～80mg, 2 times on the one treatments.The treatment group adds in above-mentioned Primary Care uses diseases due to endogenous heat of ZANG FU organs soup.Usage: one time 1 bag, 2～3 times on the one, blister is worked as tea-drinking, is a course of treatment bimester of serveing on.Matched group is only used above-mentioned Primary Care scheme.

4.2 observation index and score:

4.3 clinical symptoms: mainly observe dry mouth and throat, have a dizzy spell, nocturia increases, fatigue and weakness, the dim red yellow fur of tongue etc.Light according to clinical syndrome, in, counted 1,2,3 fen heavily respectively.That is, 1 minute: clinical syndrome did not often occur, and degree is lighter; 2 minutes: clinical syndrome often occurred, and degree is medium; 3 minutes: clinical syndrome frequently occurred, and degree is serious.All clinical syndrome score additions are drawn total mark, add up.

4.4 lab index: (1) blood glucose: comprise fasting glucose and 2h blood glucose after the meal.Each is surveyed once respectively at before the treatment and treatment back, and middle per two weeks survey once, with the monitoring state of an illness.(2) glycolated hemoglobin: respectively at each is surveyed once with the treatment back before the treatment.(3) blood fat: respectively at each is surveyed once with the treatment back before the treatment.(4) hemorheology: preceding with treatment respectively, treatment back is respectively surveyed once.(5) insulin secretion level, insulin sensitivity index: respectively at each is surveyed once before and after the treatment.Insulin sensitivity index, the method that employing Guangwei LI etc. is introduced, i.e. IAI=-log (FINS*FPG).(6) check routinely: 1. physical examination; 2. respectively at respectively survey routine blood test, routine urinalysis before and after the treatment, just routine, liver function, renal function, electrocardiogram etc. are once.4.5 statistical method: measurement data is checked with t, enumeration data x ²Check, the expression of all enumeration datas is represented with x ± S.

5 therapeutic outcomes

5.1 efficacy assessment standard: with reference to the diabetes guideline in " the new Chinese medicine clinical research guideline " of the new revision of National Drug Administration in 2002.Produce effects: tcm clinical practice symptom, sign are obviously improved, the syndrome integration reduces 〉=70%, fasting glucose reaches after the meal, and 2h blood glucose drops to normal range, or fasting glucose reaches blood glucose value decline in 2 hours after the meal above 40% before treating, the glycolated hemoglobin value drops to below 6.2%, or descends above 30% before the treatment; Effectively: tcm clinical practice symptom, sign all take a favorable turn, the syndrome integration reduces 〉=30%, and fasting glucose reaches 2h blood glucose decline after the meal above 20% before treating, but does not reach the produce effects standard, the glycolated hemoglobin value descends above 10% before the treatment, but does not reach the produce effects standard; Invalid: tcm clinical practice symptom, sign all do not have obvious improvement, and the syndrome integration reduces＜30%, and fasting glucose and 2 hours after the meal blood glucose do not have to descend or descend and do not reach effective standard, and the glycolated hemoglobin value does not have decline, or descend and do not reach effective standard.

5.2 two groups of curative effects relatively: treatment is organized in 68 examples, produce effects 33 examples (48.5%), effective 30 examples (44.1%), invalid 5 examples (7.4%), obvious effective rate 48.5%, total effective rate 92.6%.Effective 24 examples of matched group (48.00%), invalid 11 examples (22.00%), obvious effective rate 30.00%, total effective rate 78.00%.Two groups relatively: the treatment group obviously is better than matched group, and learning processing difference by statistics has significance (P＜0.01).

5.3 cardinal symptom improvement situations relatively before and after two groups of treatments: table 1 shows, relatively all there is significance (P＜0.01) two groups of treatment backs to the group difference that improves of listed symptom, and the treatment group obviously is better than matched group to the improvement effect of symptom.

5.4 cardinal symptom integration situation relatively before and after two groups of treatments: table 2 shows that the symptom integral after the treatment of treatment group obviously descends, and difference has significance (P＜0.01), matched group integration decline then not obvious (P＞0.05)

5.5 blood glucose, glycolated hemoglobin values change relatively before and after two groups of treatments: table 3 shows, the fasting glucose of treatment group and all obvious reductions before the treatment of 2h blood glucose and glycolated hemoglobin after the meal, and comparing difference with matched group has significance (P＜0.01).

5.6 Blood Lipid relatively before and after two groups of treatments: table 4 shows, the treatment group all has tangible reduction effect to T-CHOL (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), (HDL-C) has the rising effect to HDL-C, and difference all has significance (P＜0.01).Matched group does not have obvious reduction effect to TC, TG, LDL-C, and HDL-C is not had obvious rising effect (P＞0.05).Compare two groups of treatment backs, and the treatment group is better than matched group to the regulating action of blood fat.

5.7 hemorheology index changes relatively before and after two groups of treatments: table 5 shows that the whole blood specific viscosity after the treatment of treatment group, blood plasma specific viscosity, Fibrinogen all obviously reduce, and curative effect obviously is better than matched group, and comparing difference for two groups has significance (P＜0.01).

5.8 two groups of comparisons for the treatment of front and back fasting insulin level, insulin sensitivity index: table 6 shows that the fasting plasma insulin level after the treatment of treatment group descends, and promptly the hyperinsulinemia level descends, and the insulin sensitivity index rising.Contrast all has significant difference (P all＜0.05) between self cross-reference and group.

Cardinal symptom improvement situation comparison before and after the table 1 liang group treatment (x ± S) ^-

With comparison after the treatment of control group, * P＜0.05, * △ P＜0.01

Cardinal symptom integration situation comparison before and after the table 2 liang group treatment (integration x ± s) ^-

Relatively preceding with the treatment of this group, * P＜0.01,

Fasting glucose before and after the treatment of table 3 liang group, 2h blood glucose, glycolated hemoglobin (x ± s) relatively after the meal ^-

Relatively preceding with the treatment of this group, * P＜0.01; With comparison after the treatment of control group, * △ P＜0.01

Blood Lipid comparison before and after the table 4 liang group treatment (mmol/L, x ± s) ^-

Relatively preceding with the treatment of this group, * P＜0.01; With comparison after the treatment of control group, * △ P＜0.01

A hemorheology index changes relatively (x ± S) before and after the treatment of table 5 liang group ^-

Relatively preceding with the treatment of this group, * P＜0.01; With comparison after the treatment of control group, * △ P＜0.01

The comparison of fasting insulin level, insulin sensitivity index before and after the table 6 liang group treatment (x ± s) ^-

Relatively preceding with the treatment of this group, * P＜0.05; With comparison after the treatment of control group, * △ P＜0.05

Model case

Case 1

Guo, the man, 38 years old, the thirsty polydipsia of main cause, polyuria is lost weight, in first visit in November, 2003.The patient has a liking for tobacco and wine, surfeit delicious food, disorder of emotion more.Thirsty polydipsia occurs in the year before, polyuria is lost weight, and To Be Protected from Heat, perspiration, the tired power of body, soreness of the waist and knees, and disease such as abundant expectoration, dream are many is examined then.The patient has the family history of hypertension, cerebral infarction.

Check: blood glucose is 16.3mmol/L on an empty stomach, 2h24.24mmol/L after the meal, glycolated hemoglobin 11.92%.Blood fat: T-CHOL 6.7mmol/L, triglyceride 2.79mmol/L, low density cholesterol 3.9mmol/L, high density cholesterol 0.9mmol/L.Hemorheology: whole blood contrast viscosity: height is cut 6.31mpa.s, the low 16.16mpa.s that cuts, and the reduction height is cut 9.92mpa.s, the low 27.21mpa.s that cuts of reduction.Blood plasma specific viscosity 1.61mpa.s, Fibrinogen 4.92g/L.Fasting plasma insulin concentration 10.03 μ U/ml, insulin sensitivity index-4.79.

Tcm syndrome finding: tired mind, dim complexion, emaciated physique.The excessive thirst polydipsia, polyuria, To Be Protected from Heat, perspire, bitter taste in the mouth and dry throat, abundant expectoration, dream are many, soreness of the waist and knees.Body of the tongue is dim, red tip of the tongue, yellow and greasy fur, stringy and rolling pulse.

Tcm diagnosis: diabetes; Western medicine diagnose: type 2 diabetes mellitus

Dialectical: liver and gall are hot and suffocating, deficiency of kidney-YIN, the retardance of the expectorant stasis of blood.The rule of treatment: transfer the liver nourishing kidney, dissipating phlegm and removing blood stasis, regulating YIN and YANG.

Prescription: diseases due to endogenous heat of ZANG FU organs soup.Usage: 1 bag of every clothes (10g), every day 2 times, blister is worked as tea-drinking.

Successively through 5 diagnosis and treatment, take 8 weeks of diseases due to endogenous heat of ZANG FU organs soup altogether, the above-mentioned all diseases of patient are eliminated, and spiritual complexion takes a turn for the better, the tongue normal pulse.Check: fasting glucose 6.92mmol/L, 2h blood glucose 7.9mmol/L after the meal, glycolated hemoglobin 7.12%.Blood fat: T-CHOL 5.69mmol/L, triglyceride 1.70mmol/L, HDL1 .23mmol/L, low density lipoprotein, LDL 3.14mmol/L.Hemorheology: whole blood contrast viscosity: height is cut 4.31mpa.s, the low 9.11mpa.s that cuts; The reduction height is cut 9.54mpa.s, the low 23.71mpa.s that cuts of reduction; Blood plasma specific viscosity 1.21mpa.s, Fibrinogen 2.36g/L.Fasting plasma insulin concentration 8.10 μ U/ml, insulin sensitivity index-3.89.

Press: the assertive evidence patient is early sent out diabetes by eating and drinking without temperance (comprise and have a liking for tobacco and wine and surfeit delicious food) and disorder of emotion.As " element ask strange sick opinion " cloud: " this fertile institute is sent out also, and its people must count and eat sweet and refreshing and many fertilizer also, the overeating greasy food bringing about internal heat, and the over-eating the food with sweet flavor bringing about abdominal distension is so its gas overflow transfers to and quenching one's thirst." " Ling Shu Miraculous Pivot or Divine Axis. five become " piece of writing says: " rage causing upward adverse flow of liver-QI is contrary, accumulates the vim and vigour adverse current in the heart ... then being heat, the heat skin that then disappears is so be diseases due to endogenous heat of ZANG FU organs." eating and drinking without temperance can cause expectorant Re Neisheng, the expectorant stasis of blood can cause mutual knot again mutually; Disorder of emotion is that the catharsis of liver is not normal, the hot and suffocating generation of liver, and the moon of the hot and suffocating the five internal organs of burning, the moon of the kidney of especially burning is smart, causes the whole body imbalance of YIN and YANG, forms the card of quenching one's thirst.The pathogenesis of making a general survey of this case is: liver-heat is suffered from a deficiency of the kidney, the retardance of the expectorant stasis of blood, imbalance of YIN and YANG.The pathogenesis that meets diseases due to endogenous heat of ZANG FU organs soup is so can obtain significant curative effect.

Case 2

The Wang, the woman, 42 years old, main cause is ictal had a dizzy spell, and accompanied thirsty polydipsia, became thin, in first visit on March 19 in 1999.The back occur dizzy, dizzy and feel sick, bitter taste, hypochondriac pain, be ictal, above-mentioned symptom increases the weight of, more double thirsty polydipsia, polyuria, appetite increases slightly, it is weak to become thin, and soreness of the waist and knees, being irritable and getting angry easily, card such as dreaming often and waking easily marquis.

Check: blood glucose: empty stomach 14.4mmol/L, two hours after the meal 18.6mmol/L, glycolated hemoglobin 12.34%; Blood fat: T-CHOL 5.7mmol/L, triglyceride 2.05mmol/L, low-density lipoprotein cholesterol 4.1mmol/L, HDL-C 1.0mmol/L.Hemorheology: whole blood contrast viscosity: height is cut 6.15mpa.s, the low 15.16mpa.s that cuts, and the reduction height is cut 9.90mpa.s, the low 27.72mpa.s that cuts of reduction.Blood plasma specific viscosity 1.61mpa.s, Fibrinogen 4.94g/L.Fasting plasma insulin concentration 12.09 μ U/ml, insulin sensitivity index-4.82.Liver function is normal.X line cervical vertebra is taken the photograph the sheet no abnormality seen, and neck cranium doppler ultrasound is normal.

Tcm diagnosis: diabetes; Western medicine diagnose: type 2 diabetes mellitus.Dialectical: the hot kidney of liver (gallbladder) (the moon) void, the retardance of the expectorant stasis of blood.The rule of treatment: the catharsis liver and gall, nourish kidney yin, dissipating phlegm and removing blood stasis.

Prescription: diseases due to endogenous heat of ZANG FU organs soup.Usage: 1 bag of every clothes (10g), every day 2 times, blister is worked as tea-drinking.

Serve on January, all diseases disappear substantially, and spiritual complexion is clearly better, and body of the tongue is light red, and are little dim, and white and thin fur, stringy and thready pulse are slightly sliding.Blood pressure 149/91mmHg.Blood glucose: 7.2mmol/L on an empty stomach, 2h8.9mmol/L after the meal.Know that pathogenic heat go, turbid firstization of expectorant, few sun beginning and, and temper is empty slightly, controls up the basis and goes up the amount that strengthens Radix Pseudostellariae, and add Radix Astragali with invigorating the spleen and replenishing QI, one course of treatment of clothes of continuing.The all diseases in back disappear, and spiritual complexion is good greatly.Blood pressure is reduced to 138/89mmHg.Lab testing: fasting glucose 6.0mmol/L, 2h blood glucose 7.8mmol/L after the meal, glycolated hemoglobin 7.13%.Blood fat: T-CHOL 4.7mmol/L, triglyceride 1.69mmol/L, low-density lipoprotein cholesterol 3.15mmol/L, HDL-C 1.36mmol/L.Hemorheology: whole blood contrast viscosity: height is cut 4.31mpa.s, the low 8.70mpa.s that cuts, and the reduction height is cut 8.22mpa.s, the low 20.01mpa.s, blood plasma specific viscosity 1.29mpa.s, Fibrinogen 2.92g/L of cutting of reduction.Fasting plasma insulin concentration 7.13 μ U/ml, insulin sensitivity index-4.03.From the clinical symptoms to the lab index, all be significantly improved.Followed up a case by regular visits to 1 year, all diseases are not sent out, and blood glucose is still in normal range.

This routine patient with ictally have a dizzy spell, thirsty polydipsia, becoming thin is chief complaint, with being irritable and getting angry easily, dreaming often and waking easily, red tongue margin, diseases such as yellow and greasy fur, one pathogenic fire derived from stagnation of liver-QI, the sign that liver and gall are hot and suffocating.Double again resembling of suffering from a deficiency of the kidney is as diseases such as soreness of the waist and knees.So belong to the liver and gall intenseness of heat, deficiency of kidney-YIN, the card of expectorant stasis of blood retardance.Control to dredge the eliminating pathogen in the liver gallbladder, nourish kidney yin, dissipating phlegm and removing blood stasis.The side controls it with diseases due to endogenous heat of ZANG FU organs soup, pathogenesis with cube justice conform to, the side with demonstrate,prove congenial, so can obtain significant curative effect.

Case 3

Tall certain, woman, 43 years old.The thirsty polydipsia of main cause, polyuria, polyorexia, companion's external genital pruritus, blurred vision etc. 1 year increase the weight of and progressive emaciation half a year and examining.

Check: blood glucose: 12.42mmol/L on an empty stomach, 2h16.53mmol/L after the meal, glycolated hemoglobin 12.42%.Blood fat: T-CHOL 5.92mmol/L, triglyceride 4.01mmol/L, HDL-C 0.87mmol/L, low-density lipoprotein cholesterol 4.10mmol/L.Hemorheology: whole blood contrast viscosity: height is cut 6.21mpa.s, the low 15.18mpa.s that cuts, and the reduction height is cut 9.95mpa.s, the low 23.01mpa.s that cuts of reduction.Blood plasma specific viscosity 1.65mpa.s, Fibrinogen 4.87g/L.Fasting plasma insulin concentration 13.12 μ U/ml, insulin sensitivity index-5.04.

The tcm syndrome finding: depressed emotions, tired mind, dim complexion looks emaciated.The excessive thirst polydipsia, polyuria, polyorexia, it is weak to become thin, pruritus vulvae, soreness of the waist and knees.Body of the tongue is dim, tongue tip side of red.Yellowish fur, stringy and rolling pulse.Tcm diagnosis: diabetes.Western medicine diagnose: 1, type 2 diabetes mellitus, 2, hypertension I level, middle danger.Dialectical: liver and gall are hot and suffocating, deficiency of kidney-YIN, and the retardance of the expectorant stasis of blood, the rule of treatment: the catharsis liver and gall, nourish kidney yin, dissipating phlegm and removing blood stasis.

Prescription: diseases due to endogenous heat of ZANG FU organs soup.Usage: 1 bag of every clothes (10g), every day 2 times, blister is worked as tea-drinking.

Successively, take 6 weeks of diseases due to endogenous heat of ZANG FU organs soup altogether, check: fasting glucose 6.92mmol/L, 2h blood glucose 10.48mmol/L after the meal through four diagnosis and treatment.Glycolated hemoglobin 6.92%.Blood fat: T-CHOL 5.1mmol/L, triglyceride 1.62mmol/L, low-density lipoprotein cholesterol 3.13mmol/L, HDL-C 1.16mmol/L.Hemorheology: whole blood viscosity: height cuts 4.29, hangs down and cuts 8.58, and the reduction height cuts 7.98, and reduction is low cuts 21.01, blood plasma specific viscosity 1.30, Fibrinogen 2.91.Fasting plasma insulin concentration 6.92 μ U/ml, insulin sensitivity index-4.11.Obtain clinical produce effects.Follow up a case by regular visits to after the drug withdrawal and do not recur half a year.

This case is with thirsty polydipsia, polyuria, polyorexia, and companion's external genital pruritus, blurred vision are primary symptom, doublely sees diseases such as soreness of the waist and knees, hyperhidrosis that To Be Protected from Heat.So thirsty polydipsia, polyphagia is become thin; Liver channel of foot-Jueyin supports few abdomen, so the external genital pruritus around external genitals; Liver opening at eye, the Liver Channel intenseness of heat, so deficiecny of liver-YIN is blurred vision.Card belongs to the liver and gall intenseness of heat, and damp invasion of lower energizer is main, the deficiency of the kidney yin interior-heat of holding concurrently, the card of stagnation of blood stasis.Control suitable catharsis dampness-heat in the liver and gallbladder, nourish kidney yin, dissipating phlegm and removing blood stasis.Side's diseases due to endogenous heat of ZANG FU organs soup.Side's card is in step with, so can obtain effect.

The specific embodiment

Embodiment 1

Get Radix Bupleuri 12 grams, Radix Scutellariae 6 grams, the Radix Rehmanniae 30 grams, mountain cornel 20 grams, Rhizoma Dioscoreae 20 grams, Radix Trichosanthis 20 grams, Radix Pseudostellariae 20 grams, Rhizoma Alismatis 12 grams, Rhizoma Atractylodis 18 grams, Radix Salviae Miltiorrhizae 30 grams, Rhizoma Coptidis 6 grams, Cortex Cinnamomi 4 grams, Herba Epimedii 18 grams, Radix Gentianae 6 grams, Semen Plantaginis 9 grams, manufacture method: 1. clean; 2. dry naturally or the electrical heating oven dry; 3. pulverize: be ground into superfine end with 120 purpose Chinese medicine grinder; 4. pack: with the medicamental pulverata disposable paper filter bag of packing into, every bag heavy 10g; 5. seal: earlier with paper filter bag heat sealing, again it is inserted in plastic bag heat sealing again with the plastic sheeting sealing machine.

Usage: one time 1 bag, 2-3 time on the one, blister is worked as tea-drinking, is a course of treatment bimester of serveing on.

Embodiment 2,

Get Radix Bupleuri 6 grams, Radix Scutellariae 14 grams, the Radix Rehmanniae 25 grams, mountain cornel 28 grams, Rhizoma Dioscoreae 40 grams, Radix Trichosanthis 15 grams, Radix Pseudostellariae 30 grams, Rhizoma Alismatis 6 grams, Rhizoma Atractylodis 10 grams, Radix Salviae Miltiorrhizae 15 grams, Rhizoma Coptidis 4 grams, Cortex Cinnamomi 8 grams, Herba Epimedii 25 grams, Radix Gentianae 10 grams, Semen Plantaginis 15 grams, manufacture method is identical with embodiment 1 with usage and dosage.

Embodiment 3, and every part 5 gram calculates.

Get 18 parts of Radix Bupleuri, 6 parts of Radix Scutellariaes, 40 parts in the Radix Rehmanniae, 25 parts of mountain cornels, 40 parts of Rhizoma Dioscoreaes, 15 parts of Radix Trichosanthis, 30 parts of Radix Pseudostellariaes, 15 parts of Rhizoma Alismatis, 29 parts of Rhizoma Atractylodis, 20 parts of Radix Salviae Miltiorrhizaes, 2 parts of Rhizoma Coptidis, 3 parts of Cortex Cinnamomis, 30 parts of Herba Epimedii, 15 parts of Radix Gentianaes, 20 parts of Semen Plantaginiss, manufacture method is identical with embodiment 1 with usage and dosage.

Embodiment 4, and every part 1 gram calculates and takes by weighing,

6 parts of Radix Bupleuri, 5 parts of Radix Scutellariaes, 6 parts in the Radix Rehmanniae, 6 parts of mountain cornels, 6 parts of Rhizoma Dioscoreaes, 8 parts of Radix Trichosanthis, 6 parts of Radix Pseudostellariaes, 6 parts of Rhizoma Alismatis, 9 parts of Rhizoma Atractylodis, 6 parts of Radix Salviae Miltiorrhizaes, 2 parts of Rhizoma Coptidis, 2 parts of Cortex Cinnamomis, 6 parts of Herba Epimedii, 2 parts of Radix Gentianaes, 6 parts of Semen Plantaginiss.Method is with embodiment 1

Embodiment 5, and every part 10 gram calculates and takes by weighing,

18 parts of Radix Bupleuri, 15 parts of Radix Scutellariaes, 40 parts in the Radix Rehmanniae, 30 parts of mountain cornels, 40 parts of Rhizoma Dioscoreaes, 33 parts of Radix Trichosanthis, 33 parts of Radix Pseudostellariaes, 15 parts of Rhizoma Alismatis, 30 parts of Rhizoma Atractylodis, 33 parts of Radix Salviae Miltiorrhizaes, 12 parts of Rhizoma Coptidis, 9 parts of Cortex Cinnamomis, 30 parts of Herba Epimedii, 15 parts of Radix Gentianaes, 20 parts of Semen Plantaginiss.Method is with embodiment 1.

Claims (3)

1, a kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine preparation, be to make by following weight ratio effective ingredient raw material of Chinese medicine,

6～30 parts of 6～40 parts of mountain cornels of 5～15 parts of Radix Rehmanniae of 6～18 parts of Radix Scutellariaes of Radix Bupleuri

6～15 parts of 6～33 portions of Rhizoma Alismatis of 8～33 parts of Radix Pseudostellariaes of 6～40 parts of Radix Trichosanthis of Rhizoma Dioscoreae

2～9 parts of 2～12 portions of Cortex Cinnamomis of 6～33 portions of Rhizoma Coptidis of 9～30 parts of Radix Salviae Miltiorrhizaes of Rhizoma Atractylodis

6～20 parts of 2～15 portions of Semen Plantaginiss of 6～30 portions of Radix Gentianaes of Herba Epimedii.

2, according to claim 1 a kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine preparation, be to make by following weight ratio effective ingredient raw material of Chinese medicine,

10～20 parts of 10～20 parts of mountain cornels of 8～10 parts of Radix Rehmanniae of 8～15 parts of Radix Scutellariaes of Radix Bupleuri

9～14 parts of 10～30 portions of Rhizoma Alismatis of 9～30 parts of Radix Pseudostellariaes of 12～30 parts of Radix Trichosanthis of Rhizoma Dioscoreae

3～8 parts of 3～9 portions of Cortex Cinnamomis of 10～30 portions of Rhizoma Coptidis of 12～24 parts of Radix Salviae Miltiorrhizaes of Rhizoma Atractylodis

8～16 parts of 4～12 portions of Semen Plantaginiss of 10～24 portions of Radix Gentianaes of Herba Epimedii.

3, according to claim 1 a kind of can change the type 2 diabetes mellitus insulin resistant with sugar, disorders of lipid metabolism Chinese medicine preparation, be to make by following weight ratio effective ingredient raw material of Chinese medicine,

20 parts of 20 portions of Rhizoma Dioscoreaes of 30 parts of mountain cornels of 6 parts of Radix Rehmanniae of 12 parts of Radix Scutellariaes of Radix Bupleuri

30 parts of 18 parts of Radix Salviae Miltiorrhizaes of 12 parts of Rhizoma Atractylodis of 20 portions of Rhizoma Alismatis of 20 parts of Radix Pseudostellariaes of Radix Trichosanthis

9 parts of 6 portions of Semen Plantaginiss of 18 portions of Radix Gentianaes of 4 parts of Herba Epimedii of 6 portions of Cortex Cinnamomis of Rhizoma Coptidis.