CN114869949B - A pharmaceutical composition for treating puerperal diseases, and its preparation method - Google Patents

Abstract

The invention discloses a pharmaceutical composition for treating female postpartum diseases, which is prepared from the following traditional Chinese medicines or traditional Chinese medicine extracts in parts by weight: 8-16 parts of roasted astragalus root, 8-16 parts of dangshen, 8-16 parts of eucommia bark charcoal, 8-16 parts of wine baical skullcap root, 16-24 parts of prepared rehmannia root, 16-24 parts of himalayan teasel root, 8-16 parts of ground roasted largehead atractylodes rhizome, 8-16 parts of vinegar turtle shell, 20-30 parts of calcined oyster, 5-10 parts of jujube and 3-6 parts of sanchi. The pharmaceutical composition for treating female postpartum diseases and the preparation method thereof have the effects of tonifying qi and blood, promoting blood circulation and relieving pain, tonifying liver and kidney, nourishing yin and clearing heat, stopping bleeding and suppressing sweating.

Description

A pharmaceutical composition for treating puerperal diseases, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a pharmaceutical composition for treating postpartum diseases of women and a preparation method thereof.

Background

Puerperal disorders, also known as puerperal disorders, refer to childbirth or puerperal related disorders that occur during puerperal periods after production (including small) of pregnant women. The puerperal women need 6-8 weeks to recover substantially to normal state after production, which period is called "puerperal", the so-called "sitting month". Various postpartum diseases can be caused by postpartum blood loss, internal resistance of blood stasis, damaged primordial qi, viscera movement, deficiency of hundred knots, loose striae, loose defensive exterior and slightly inadequate nursing. Common puerperal diseases include poor uterine recovery, postpartum hemorrhage, postpartum fever, postpartum night sweat, puerperal infection, postpartum headache, body pain, postpartum arthralgia, postpartum frequent urination, urinary incontinence, postpartum milk stasis, acute mastitis, lactation lack, postpartum depression and the like. These diseases not only seriously affect the physical and mental health of the parturient, but also prevent the parturient from being able to breast-feed normally. Therefore, the method has important significance for early prevention, early discovery and early treatment of postpartum diseases and ensuring the health of puerperal women and newborns.

The traditional Chinese medicine has long history of postpartum diseases, and the traditional Chinese medicine considers that postpartum diseases are deficiency and excess, deficiency symptoms are most, and the puerperal diseases related to delivery and puerperal diseases occur in the period from delivery to puerperal period, namely postpartum diseases, and the puerperal primordial qi is damaged and vital qi is weakened due to the trauma and bleeding during delivery, the temporary sudden qi burst and the like, so that the puerperal diseases have the theory of 'postpartum hundred-section deficiency'. Namely the deficiency of qi and blood which is commonly known in traditional Chinese medicine. Qi is yang and blood is yin, so it is said that qi is mainly warming and blood is mainly soft in the theory of difficult menstruation and twenty-two difficult menstruation. However, there is a close relationship between qi and blood, i.e., qi is the general meaning of blood and blood is the mother meaning of qi.

The pathogenesis of various postpartum diseases is considered to have four points:

(1) blood loss and body fluid loss:

the sudden death of yin and blood, the floating of deficient yang, that is to say blood deficiency, occurs due to labor, sweating, birth and hemorrhage. Excessive blood loss, insufficient new blood generation and supplementation, and weak spleen and stomach, insufficient dietary nutrition, reduced function of raw blood or insufficient source of raw blood generation, and blood deficiency can be caused by blood liquefaction and disorder, and the symptoms of pale complexion, pale and lusterless lips and tongue nails, dizziness, palpitation, listlessness, poor body, dry eyes, blurred vision and the like can occur. Is prone to postpartum anemic fainting, postpartum convulsive disease, postpartum fever, postpartum difficult urination, stranguria and postpartum blood strain, etc.

(2) Impaired primordial qi:

delivery is a long lasting physical exertion. If the labor is too long, the labor is consumed during the labor, the postpartum fatigue is too early, qi is consumed along with blood, so that qi deficiency is not controlled, and the thoroughfare and conception vessels are not caused, so that postpartum urination is not easy, postpartum lochia is not absolute, postpartum milk is self-discharged, postpartum sweat is caused, postpartum fever is caused, postpartum blood is caused, and the like.

(3) Internal resistance to blood stasis:

blood stasis is mainly the unsmooth blood circulation. Stagnation of qi movement can cause stasis. The traumatic, damaged and bleeding vessels can cause blood stasis when leaving the channels. The postpartum hundred-node deficiency and qi deficiency can promote blood circulation to cause blood stasis. If the living is careless, cold and heat are felt, and cold accumulation and heat burning can cause stasis; or residual placenta and placenta, blood stasis, postpartum abdominal pain, postpartum fever, postpartum lochia, postpartum depression, etc.

(4) Exogenous six-pathogenic factors or impairment of the eating house:

the postpartum primordial qi and body fluid and blood are damaged, the striae and striae are loose, so-called 'postpartum hundred-section void deficiency', the life is slightly careless or improper in regulation and control, qi and blood are not regulated, nutrient and defensive qi are disregulated, viscera function is abnormal, and thoroughfare and conception vessel are damaged, so that various diseases are produced.

In short, postpartum diseases are mainly marked by 'deficiency' and 'stasis', so the theory of 'postpartum excessive deficiency and excessive stasis' is that deficiency and stasis are sometimes mixed. The pathogenesis of "deficiency and stasis" formed by postpartum blood loss, body fluid loss, primordial qi damage and blood stasis internal resistance is the basis and internal cause of postpartum disease.

At present, the traditional Chinese medicine has definite curative effect, safety and few side effects in treating postpartum diseases, has little stimulation to gastrointestinal tract and no damage, and is proved by clinic. The treatment of postpartum diseases should be based on the characteristics of blood loss, body fluid impairment, blood stasis, deficiency and stasis, and it is indicated for qi and blood to be regulated regardless of deficiency and excess. Based on the principle of "don't restrict to postpartum and don't forget to postpartum", syndrome differentiation and treatment are performed in combination with the disease condition. "Jingyue full book" say: the three are treated by usual methods when the disease is followed by the person, and the disease is not treated with the heart, the general nourishment is performed, so that the pathogenic factors are assisted. "the postpartum deficiency should be mainly marked by the large tonifying qi and blood, but the medicine must be used for preventing the stagnation and helping the evil; after delivery, the method of activating blood and removing stasis is used for treating postpartum excessive blood stasis, and blood nourishing is also needed to be assisted, so that pathogenic factors are eliminated without hurting the body resistance, and blood stasis is eliminated without hurting the blood. The recipe is selected for taking care of qi and blood. The depression is not excessively dissipated, the spleen is supported by both the digestion-promoting and spleen-strengthening functions, the cold is not excessively warm and dry, and the heat is not excessively bitter and cold. Meanwhile, should master the postpartum drug. Ban, namely ban the big sweat, in order to prevent the yang from dying; prevent yin death by inhibiting the severity; forbidden to induce urination to prevent body fluid loss.

For postpartum disease, the prescription should be taken with the effects of both qi and blood, promoting qi circulation without excessive dissipation, eliminating the need for spleen and spleen support, and the cold syndrome should not be used excessively for warm dryness, the heat syndrome should not be used excessively for cold and cool, so that the medicine is supplemented without stagnation and diarrhea without injury.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for treating female postpartum diseases and a preparation method thereof, and the pharmaceutical composition has the effects of tonifying qi and blood, promoting blood circulation and relieving pain, tonifying liver and kidney, nourishing yin and clearing heat, stopping bleeding and suppressing sweating.

In order to achieve the above purpose, the invention provides a pharmaceutical composition for treating female postpartum diseases, which is prepared from the following traditional Chinese medicines or traditional Chinese medicine extracts in parts by weight: 8-16 parts of roasted astragalus root, 8-16 parts of dangshen, 8-16 parts of eucommia bark charcoal, 8-16 parts of wine baical skullcap root, 16-24 parts of prepared rehmannia root, 16-24 parts of himalayan teasel root, 8-16 parts of ground roasted largehead atractylodes rhizome, 8-16 parts of vinegar turtle shell, 20-30 parts of calcined oyster, 5-10 parts of jujube and 3-6 parts of sanchi.

Preferably, the pharmaceutical composition is prepared from the following traditional Chinese medicines in parts by weight: 8 parts of roasted astragalus root, 9 parts of dangshen, 12 parts of eucommia bark charcoal, 10 parts of wine baical skullcap root, 18 parts of prepared rehmannia root, 16 parts of himalayan teasel root, 12 parts of earth-fried largehead atractylodes rhizome, 10 parts of vinegar turtle shell, 28 parts of calcined oyster, 10 parts of jujube and 4 parts of sanchi.

Preferably, the pharmaceutical composition is prepared from the following traditional Chinese medicines in parts by weight: 15 parts of roasted astragalus root, 12 parts of dangshen, 14 parts of eucommia bark charcoal, 15 parts of wine baical skullcap root, 16 parts of prepared rehmannia root, 24 parts of himalayan teasel root, 8 parts of earth-fried largehead atractylodes rhizome, 8 parts of vinegar turtle shell, 22 parts of calcined oyster, 6 parts of jujube and 5 parts of pseudo-ginseng.

Preferably, the pharmaceutical composition is prepared from the following traditional Chinese medicines in parts by weight: 15 parts of roasted astragalus root, 10 parts of dangshen, 10 parts of eucommia bark charcoal, 6 parts of wine baical skullcap root, 10 parts of prepared rehmannia root, 10 parts of himalayan teasel root, 8 parts of earth-fried largehead atractylodes rhizome, 12 parts of vinegar turtle shell, 20 parts of calcined oyster, 5 parts of jujube and 3 parts of sanchi.

Preferably, the composition further comprises pharmaceutically acceptable auxiliary materials.

Preferably, the pharmaceutical composition is any one of pharmaceutical oral preparations, and the oral preparations are granules, tablets, capsules, powder or pills.

A preparation method of a pharmaceutical composition for treating puerperal diseases of women comprises the following steps:

s1, extracting traditional Chinese medicine raw materials with a certain weight portion for 2-4 times by water according to a proportion, adding 10-15 times of water each time, and decocting for 0.5-2 hours;

s2, filtering, combining the filtrates obtained in the step S1, concentrating to obtain an extract with the relative density of 1.00-1.50, drying and crushing to obtain the product.

Therefore, the pharmaceutical composition for treating female postpartum diseases and the preparation method thereof have the effects of tonifying qi and blood, promoting blood circulation, relieving pain, tonifying liver and kidney, nourishing yin, clearing heat, stopping bleeding and suppressing sweating. Can be used for treating puerperal deficiency of qi and yin, heat disturbance of thoroughfare and conception vessels, blood stasis, and internal resistance, manifested by pale complexion, dizziness, debilitation, soreness of waist and knees, vexation, dry mouth, pain in lower abdomen, dribbling weight, lochia, sweating, qi deficiency, constipation, suppuration, and puerperal blood strain.

The astragalus root in the pharmaceutical composition is good at tonifying qi, especially for invigorating yang, and can tonify qi and blood, and qi and foot can smooth blood, so that the pharmaceutical composition is a monarch. The earth-fried bighead atractylodes rhizome can invigorate the spleen and replenish qi, and the earth-fried bighead atractylodes rhizome can be combined with the astragalus root to enhance the effect of invigorating qi; radix codonopsis pilosulae invigorates spleen and lung qi, strengthens body resistance and eliminates evil; malnutrition of heart and liver is caused by blood deficiency, prepared rehmannia root is sweet Wen Zirun, blood is enriched, yin is nourished, essence is filled, marrow is benefited, prepared rehmannia root property mainly belongs to yin, codonopsis pilosula and stir-fried atractylodes macrocephala are actively belongs to yang, and the three medicines are combined together to form astragalus root, qi and blood are both supplemented, yin and yang are both compatible, and dynamic and static combination is achieved. Qi and foot can generate blood, promote blood circulation and blood and foot can promote qi and transform qi, and the qi and foot can assist each other and serve as ministerial drugs.

Wine Baical skullcap root relieves cold nature and clears the fire of upper energizer. Eucommia ulmoides charcoal nourishes liver and kidney and strengthens tendons and bones. Fried radix dipsaci, and has effects of tonifying liver and kidney, strengthening tendons and bones, and treating metrorrhagia, metrostaxis and blood. Vinegar turtle shell has effects of nourishing yin, suppressing yang, and relieving fever and removing steaming. Calcined oyster has effects of suppressing yang, nourishing yin, astringing and inducing astringency. Notoginseng radix has effects of stopping bleeding, removing blood stasis, and not hurting body resistance. Auxiliary and ministerial drugs, strengthening body resistance and tonifying deficiency, nourishing yin and suppressing yang, activating blood and stopping bleeding, and removing steaming and sweating.

Jujube is used as a guiding drug, and is added with other drugs to regulate the action of the drugs, so that the drug is used as a guiding drug. The medicines are matched to play roles in tonifying qi and blood, tonifying liver and kidney, strengthening tendons and bones, removing blood stasis and stopping sweat, so that qi and blood are sufficient, spleen and stomach are qi-transformed to generate, yin and yang are self-flattened, and body functions are quickly recovered.

The technical scheme of the invention is further described in detail through examples.

Detailed Description

The technical scheme of the invention is further described below by examples.

Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art. Such other embodiments are also within the scope of the present invention.

It should also be understood that the above-mentioned embodiments are only for explaining the present invention, the protection scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the protection scope of the present invention by equally replacing or changing the technical scheme and the inventive concept thereof within the scope of the present invention.

The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances. The term "about" as used herein has a meaning well known to those skilled in the art, and preferably means that the term is modified by a value within the range of + -50%, + -40%, + -30%, + -20%, + -10%, + -5% or + -1%.

All terms (including technical or scientific terms) used in this disclosure have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs, unless specifically defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

Techniques, methods, and apparatus known to one of ordinary skill in the relevant art may not be discussed in detail, but are intended to be considered part of the specification where appropriate.

The disclosures of the prior art documents cited in the present specification are incorporated by reference in their entirety into the present invention and are therefore part of the present disclosure.

Example 1

The pharmaceutical composition is prepared from the following traditional Chinese medicines in parts by weight: 8 parts of roasted astragalus root, 9 parts of dangshen, 12 parts of eucommia bark charcoal, 10 parts of wine baical skullcap root, 18 parts of prepared rehmannia root, 16 parts of himalayan teasel root, 12 parts of earth-fried largehead atractylodes rhizome, 10 parts of vinegar turtle shell, 28 parts of calcined oyster, 10 parts of jujube and 4 parts of sanchi.

Weighing the components according to the parts by weight, adding water, decocting for 3 times, wherein the water consumption of each time is 10 times of the mass of the traditional Chinese medicine mixture, and decocting for 1h. Mixing the filtrates, concentrating to obtain extract with relative density of 1.15-1.20 (room temperature), drying under reduced pressure, and pulverizing into fine powder. Granulating by wet method, drying, and making into granule.

Example two

The pharmaceutical composition is prepared from the following traditional Chinese medicines in parts by weight: 15g of roasted astragalus root, 10g of dangshen, 10g of eucommia bark charcoal, 6g of wine baical skullcap root, 10g of prepared rehmannia root, 10g of himalayan teasel root, 8g of earth-fried largehead atractylodes rhizome, 12g of vinegar turtle shell, 20g of calcined oyster, 5g of Chinese date and 3g of sanchi.

A preparation method of a pharmaceutical composition for treating puerperal diseases of women comprises the following steps:

s1, extracting traditional Chinese medicine raw materials with a certain weight portion with water for 3 times according to a proportion, adding 10 times of water each time, and decocting for 1h;

s2, filtering and combining the filtrate obtained in the step S1, concentrating to obtain an extract with the relative density of 1.15-1.20 (room temperature), drying and crushing to obtain the product.

Example III

1. Case analysis

100 women post-partum patients with clinically definite diagnosis are randomly selected, one of the main symptoms and the secondary symptoms is included in the clinical diagnosis standard, and the tongue pulse is met, so that the analysis data can be included.

Main symptoms are as follows: (1) the postpartum lower abdomen is hidden and pain is treated, and the treatment of the postpartum lower abdomen is carried out with the advantages of being favored by kneading and pressing, little lochia, pale color, dizziness, palpitation, constipation, pale red tongue, thin and white coating and weak pulse. (2) At first sight, postpartum cold and first sight, lochia is not caused, or the lower part is too little, the color purple is dark and has blocks, the lower abdomen pain is refused to be pressed, the tongue is dark, or the blood stasis spots are present, and the pulse is wiry and forceful.

Secondary symptoms: (1) soreness and weakness of waist and knees; (2) weakness of limbs; (3) poor appetite; (4) aversion to wind and sweating.

Tongue pulse: a dark tongue with thin and white coating and a deep, wiry or slow pulse.

2. Experimental method

100 patients diagnosed take the powder prepared in example two 3 times a day, 1 bag each time, with 10g of the powder prepared in example two in each bag. The condition of the patient was followed after 2 weeks.

Wherein, efficacy assessment criteria: (1) and (3) curing: the clinical symptoms disappear, (2) the effect is displayed: the main symptoms are basically eliminated, and the physical function is recovered, so that the labor and the work can be participated; (3) the method is effective: the main symptoms are relieved, and long-term conditioning is required. (4) Invalidation: the original symptoms and physical signs are not relieved.

As a result, 83 cases (83%) were cured, 17 cases were effective (17% of effective rate), and 0 cases were ineffective (0% of ineffective rate).

Example IV

20 post-partum KM mice were randomly divided into 2 groups, and the test group was administered 4.55g/kg (equivalent to 1 time of the clinical dose of normal human) by gavage, 1 time per day. The blank control group is infused with the same amount of physiological saline, and the test group and the control group are killed after taking for 7 days, so that the uterus condition is observed.

The pregnant mice of the test group had a uterine hyperemia area of 1/3, uterine edema+, and a smooth placenta-adhering surface. The pregnant mice of the control group have a uterine hyperemia area of 2/3, a uterine edema degree++, and a rough placenta adhesion surface.

Therefore, the pharmaceutical composition for treating the postpartum diseases of women and the preparation method thereof have the effects of tonifying qi and blood, promoting blood circulation to relieve pain, tonifying liver and kidney, nourishing yin, clearing heat, stopping bleeding and suppressing sweating, and are used for treating the postpartum diseases of women such as deficiency of qi and yin, heat disturbing thoroughfare and conception vessels, blood stasis internal resistance and the like.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention and not for limiting it, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that: the technical scheme of the invention can be modified or replaced by the same, and the modified technical scheme cannot deviate from the spirit and scope of the technical scheme of the invention.

Claims (7)

1. A Chinese medicinal composition for treating female postpartum diseases is characterized by being prepared from the following raw materials: 8-16 parts of roasted astragalus root, 8-16 parts of dangshen, 8-16 parts of eucommia bark charcoal, 8-16 parts of wine baical skullcap root, 16-24 parts of prepared rehmannia root, 16-24 parts of himalayan teasel root, 8-16 parts of ground roasted largehead atractylodes rhizome, 8-16 parts of vinegar turtle shell, 20-30 parts of calcined oyster, 5-10 parts of jujube and 3-6 parts of sanchi.

2. The traditional Chinese medicine composition for treating postpartum diseases of women according to claim 1, which is characterized by being prepared from the following raw materials: 8 parts of roasted astragalus root, 9 parts of dangshen, 12 parts of eucommia bark charcoal, 10 parts of wine baical skullcap root, 18 parts of prepared rehmannia root, 16 parts of himalayan teasel root, 12 parts of earth-fried largehead atractylodes rhizome, 10 parts of vinegar turtle shell, 28 parts of calcined oyster, 10 parts of jujube and 4 parts of sanchi.

3. The traditional Chinese medicine composition for treating postpartum diseases of women according to claim 1, which is characterized by being prepared from the following raw materials: 15 parts of roasted astragalus root, 12 parts of dangshen, 14 parts of eucommia bark charcoal, 15 parts of wine baical skullcap root, 16 parts of prepared rehmannia root, 24 parts of himalayan teasel root, 8 parts of earth-fried largehead atractylodes rhizome, 8 parts of vinegar turtle shell, 22 parts of calcined oyster, 6 parts of jujube and 5 parts of pseudo-ginseng.

4. The traditional Chinese medicine composition for treating postpartum diseases of women according to claim 1, which is characterized by being prepared from the following raw materials: 15 parts of roasted astragalus root, 10 parts of dangshen, 10 parts of eucommia bark charcoal, 6 parts of wine baical skullcap root, 10 parts of prepared rehmannia root, 10 parts of himalayan teasel root, 8 parts of earth-fried largehead atractylodes rhizome, 12 parts of vinegar turtle shell, 20 parts of calcined oyster, 5 parts of jujube and 3 parts of sanchi.

5. A medicament for treating post-partum diseases in women, characterized in that: is prepared from the traditional Chinese medicine composition as claimed in any one of claims 1 to 4.

6. A medicament according to claim 5, characterized in that: the medicine is an oral preparation, and the oral preparation is selected from granules, tablets, capsules, powder or pills.

7. The method for preparing a Chinese medicinal composition for treating post-partum diseases of women according to any one of claims 1 to 4, which comprises the following steps:

s1, extracting traditional Chinese medicine raw materials with a certain weight portion for 2-4 times by water according to a proportion, adding 10-15 times of water each time, and decocting for 0.5-2 hours;

s2, filtering, combining the filtrates obtained in the step S1, concentrating to obtain an extract with the relative density of 1.00-1.50, drying and crushing to obtain the product.