CN101346129A - 制备维生素e吸附物的方法 - Google Patents
制备维生素e吸附物的方法 Download PDFInfo
- Publication number
- CN101346129A CN101346129A CNA2006800488485A CN200680048848A CN101346129A CN 101346129 A CN101346129 A CN 101346129A CN A2006800488485 A CNA2006800488485 A CN A2006800488485A CN 200680048848 A CN200680048848 A CN 200680048848A CN 101346129 A CN101346129 A CN 101346129A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- chemical compound
- adsorbate
- silica carrier
- silica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002156 adsorbate Substances 0.000 title claims abstract description 41
- 229940088594 vitamin Drugs 0.000 title abstract description 10
- 229930003231 vitamin Natural products 0.000 title abstract description 10
- 235000013343 vitamin Nutrition 0.000 title abstract description 10
- 239000011782 vitamin Substances 0.000 title abstract description 10
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract description 10
- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 238000000034 method Methods 0.000 claims abstract description 50
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 119
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 69
- 235000019165 vitamin E Nutrition 0.000 claims description 58
- 239000011709 vitamin E Substances 0.000 claims description 58
- 239000000377 silicon dioxide Substances 0.000 claims description 57
- 229930003427 Vitamin E Natural products 0.000 claims description 56
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 56
- 229940046009 vitamin E Drugs 0.000 claims description 56
- -1 vitamin E chemical compound Chemical class 0.000 claims description 44
- 239000000203 mixture Substances 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 20
- 229940042585 tocopherol acetate Drugs 0.000 claims description 15
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 14
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 238000009423 ventilation Methods 0.000 claims description 2
- 235000012239 silicon dioxide Nutrition 0.000 abstract description 3
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 7
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 5
- 239000000654 additive Substances 0.000 description 5
- 230000000996 additive effect Effects 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- 239000010703 silicon Substances 0.000 description 5
- 238000005507 spraying Methods 0.000 description 5
- 239000004575 stone Substances 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000002349 favourable effect Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000000889 atomisation Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920002261 Corn starch Polymers 0.000 description 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 239000013590 bulk material Substances 0.000 description 2
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000010458 rotten stone Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005062009.4 | 2005-12-22 | ||
| DE102005062009 | 2005-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101346129A true CN101346129A (zh) | 2009-01-14 |
Family
ID=37709682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800488485A Pending CN101346129A (zh) | 2005-12-22 | 2006-12-11 | 制备维生素e吸附物的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080293955A1 (und) |
| EP (1) | EP1965766A1 (und) |
| JP (1) | JP2010512142A (und) |
| KR (1) | KR20080098586A (und) |
| CN (1) | CN101346129A (und) |
| BR (1) | BRPI0620102A2 (und) |
| RU (1) | RU2008129544A (und) |
| TW (1) | TW200731935A (und) |
| WO (1) | WO2007074043A1 (und) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380908A (zh) * | 2015-12-09 | 2016-03-09 | 河北大学 | 一种丁苯酞药物复合物及其制备方法和缓释制剂 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11052029B2 (en) | 2009-06-16 | 2021-07-06 | W. R. Grace & Co.-Conn. | Cation compatible metal oxides and oral care compositions containing the metal oxides |
| AR079182A1 (es) * | 2009-06-16 | 2012-01-04 | Grace W R & Co | Oxidos metalicos cationico - compatibles y composiciones para cuidado bucodental que contienen los oxidos metalicos |
| JP6460791B2 (ja) * | 2011-07-08 | 2019-01-30 | ピュラック バイオケム ビー． ブイ． | 飼料製品における使用の為の活性組成物 |
| CN109718206B (zh) * | 2017-10-31 | 2022-02-18 | 大丰海嘉诺药业有限公司 | 一种生产维生素e粉的方法 |
| WO2020011961A1 (en) * | 2018-07-12 | 2020-01-16 | Dsm Ip Assets B.V. | Continuous production of an adsorption product of a vitamin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603143A (en) * | 1983-05-02 | 1986-07-29 | Basf Corporation | Free-flowing, high density, fat soluble vitamin powders with improved stability |
| US4711894A (en) * | 1986-01-16 | 1987-12-08 | Henkel Corporation | Stabilized tocopherol in dry, particulate, free-flowing form |
| DE19860441A1 (de) * | 1998-12-28 | 2000-07-06 | Degussa | Wirkstoffadsorbate auf Basis von Kieselsäure |
| DE10029079B4 (de) * | 2000-06-13 | 2006-04-20 | Mars Inc. | Probiotische Mikroorganismen enthaltendes Nahrungsmittelerzeugnis |
| EP1476137A1 (en) * | 2002-01-28 | 2004-11-17 | Phares Pharmaceutical Research N.V. | Composition comprising low water soluble compounds within porous carriers |
| DE10311585A1 (de) * | 2003-03-14 | 2004-09-23 | Basf Ag | Wirkstoffhaltige Adsorbate |
-
2006
- 2006-12-11 EP EP06830498A patent/EP1965766A1/de not_active Withdrawn
- 2006-12-11 JP JP2008546367A patent/JP2010512142A/ja not_active Withdrawn
- 2006-12-11 WO PCT/EP2006/069524 patent/WO2007074043A1/de active Application Filing
- 2006-12-11 BR BRPI0620102A patent/BRPI0620102A2/pt not_active IP Right Cessation
- 2006-12-11 CN CNA2006800488485A patent/CN101346129A/zh active Pending
- 2006-12-11 KR KR1020087017777A patent/KR20080098586A/ko not_active Application Discontinuation
- 2006-12-11 RU RU2008129544/15A patent/RU2008129544A/ru not_active Application Discontinuation
- 2006-12-11 US US12/158,495 patent/US20080293955A1/en not_active Abandoned
- 2006-12-22 TW TW095148609A patent/TW200731935A/zh unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380908A (zh) * | 2015-12-09 | 2016-03-09 | 河北大学 | 一种丁苯酞药物复合物及其制备方法和缓释制剂 |
| CN105380908B (zh) * | 2015-12-09 | 2018-08-10 | 河北大学 | 一种丁苯酞药物复合物及其制备方法和缓释制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008129544A (ru) | 2010-01-27 |
| TW200731935A (en) | 2007-09-01 |
| KR20080098586A (ko) | 2008-11-11 |
| EP1965766A1 (de) | 2008-09-10 |
| WO2007074043A1 (de) | 2007-07-05 |
| BRPI0620102A2 (pt) | 2017-11-21 |
| JP2010512142A (ja) | 2010-04-22 |
| US20080293955A1 (en) | 2008-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090114 |