CN101336878A - Extraction method of common turmeric powder and use thereof in cosmetics - Google Patents
Extraction method of common turmeric powder and use thereof in cosmetics Download PDFInfo
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- CN101336878A CN101336878A CNA2008100634745A CN200810063474A CN101336878A CN 101336878 A CN101336878 A CN 101336878A CN A2008100634745 A CNA2008100634745 A CN A2008100634745A CN 200810063474 A CN200810063474 A CN 200810063474A CN 101336878 A CN101336878 A CN 101336878A
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Abstract
The present invention relates to a white powdery substance extracted from traditional Chinese medicine of common turmeric, which has good antiphlogistic effect and non-toxicity. The present invention comprises extracting technique of common turmeric, application thereof in cosmetic especially in face pack and skin-care products, and cosmetic composition added with the powder of common turmeric.
Description
One. technical field
The present invention relates to a kind of from RADIX CURCUMAE, extract, white powder common turmeric powder, comprise the extracting method of common turmeric powder and the purposes in cosmetics with certain antiinflammatory action.
Two. technical background
RADIX CURCUMAE (warm Rhizoma Curcumae) is China's Chinese medicine material, mainly originates in Wenzhou City, Zhejiang Province and surrounding area thereof, and its medicinal record can be traced back to the Tang Dynasty the earliest.RADIX CURCUMAE (warm Rhizoma Curcumae) has removing blood stasis eliminating stagnation, promoting the circulation of blood analgesic effect, gathers the medicine commonly used of note of the ancient Chinese abdominal mass for removing blood stasis circulation of qi promoting treatment, also is one of China recent years Chinese medicine medicine for preventing of excavating out.Contain active ingredients such as curcumenol, curzerenone, elemene, curcumin in the RADIX CURCUMAE (warm Rhizoma Curcumae).The Oleum Curcumae that extracts from RADIX CURCUMAE has pharmacologically actives such as antiinflammatory, antitumor, antibiotic and antiviral, has been developed to Oleum Curcumae injection, is to be used for antitumor and antiviral drug clinically.The content of this volatile oil in warm Rhizoma Curcumae is about 3%-5%.Oleum Curcumae is used for the treatment of cervical cancer, has taken in Chinese Pharmacopoeia (the 463rd page) in 1977.Oleum Curcumae can not only directly suppress, destroy tumor cell and inactivating pathogens, but also can enhancing body self immunologic function, thereby promote the immunoreation of body to tumor and virus.
Through research, we extract a kind of white powder material from RADIX CURCUMAE, common turmeric powder by name, and it quality inspection and active testing have been carried out, find that its inside also has the active component in some Oleum Curcumae, have good anti-inflammatory activity, its antiinflammatory action is synthetic with inhibition PGE2 and lipid peroxidation is relevant.Add the Powdered character that its white is fine and smooth, we think that it will have wide prospect at cosmetic field.Through experiment and test, we find that this common turmeric powder can be used as the substrate of additive or facial film class cosmetics in cosmetics, have the effect of good antiinflammatory, skin care, elimination acne and speckle dispelling, and can improve.
In order to make skin can in all environment, bring into play its physiological function, need regularly it to be cleaned and nurses.The cleaning of skin is used to remove spot, sweat stain and residual dead bark granule, and they are all kinds pathogen and parasitic desirable hotbed.Usually carry out skin clean by means of surfactant (preparation of soap, surfactant, rare alcohol), they produce foamy gel with meeting or solid (soap-cake) form exists, and after on spreading upon skin, water washes out again.
Skin nursing products generally are skin lotion, ointment or washing liquid, and they are mainly used in preserving moisture of skin and lubricated.Often they are added active substance, these active substances should make skin regeneration and prevention and avoid for example aging (for example the forming little wrinkle, wrinkle) in advance of skin.
So, task of the present invention is, develop common turmeric powder and it is made an addition to cosmetics, eliminate the inflammatory reaction of skin on the one hand, improve skin condition, do not having too much under the condition of skin absorbs large quantity of moisture, to reduce skin brightness efficiently and for a long time constantly on the other hand, particularly oily skin brightness, and bring (subjective) exsiccant dermal sensation.
Three. summary of the invention:
1: a kind of white powder common turmeric powder and extracting method thereof that obtains that from RADIX CURCUMAE, extract, extraction process is: the fresh RADIX CURCUMAE of getting constant weight, remove fibrous root, directly pulverize powdered after clean, add the water purification of 3～20 times of weight (being preferably 5～11 times), stir 2～20 minutes (being preferably 8～15 minutes); After removing by filter disintegrating slag with 60 orders or 80 mesh sieves, place precipitation, go supernatant to get white thickness slurry, 20～60 ℃ of (being preferably 45～55 ℃) dryings are removed moisture wherein, obtain the white powder material again after smashing to pieces, are common turmeric powder.Productive rate is 3%～9%.
2: this common turmeric powder has good antiphlogistic effects, and its antiinflammatory action is with to suppress prostaglandin 2 synthetic and lipid peroxidation is relevant.
3: common turmeric powder is made an addition in the cosmetic composition as active additive, and the weight of common turmeric powder in cosmetic composition is 0.01%～80%, is preferably 0.05%～20% weight, more preferably 0.1%～10% weight.These cosmetics can be used for maintenance, speckle dispelling of facial film, face and hand skin etc.In addition, common turmeric powder is being used to reduce skin brightness, particularly oily skin brightness.Common turmeric powder is in the application of the cosmetic formulations that contains the lipid phase that is used for reducing skin brightness, and the polarity of lipid phase has the interfacial tension of 5-30mN/m to the middle polarity component.
4: the purposes of common turmeric powder according to the present invention in cosmetics, common turmeric powder can exist with multi-form.So it can be the microemulsion of for example solution, anhydrous preparation, emulsion or Water-In-Oil (W/O) type or oil-in-water (O/W) type, such as multiple emulsion, gel, solid block, ointment or the aerosol of water-oil-water cladded type (W/O/W).Preferable use of the present invention is characterised in that preparation exists with emulsion or ointment situation.
Correspondingly, when preparation with multiple emulsion, microemulsion, choose emulsion (Pickering-Emulsion), when the forms such as emulsion or ointment of can spraying exist, make up or respiratory viral infections in purposes also be content of the present invention.Emulsion of the present invention contains for example above-mentioned fat, oil, wax and other fat-bodies, and water and emulsifying agent, the emulsifying agent in the preparation type as being used in usually.
Four. specific embodiment
Listed examples is only for being described more specifically the present invention herein, and and unrestricted the present invention.
A. the extraction of common turmeric powder:
1. get 10 kilograms fresh RADIX CURCUMAE, remove fibrous root, directly pulverize after clean powderedly, add 60 kilograms water purification, with electric blender vigorous stirring 10 minutes; After removing by filter disintegrating slag with 80 mesh sieves, place precipitation, go supernatant to get white thickness slurry, 50 ℃ of dryings are removed moisture wherein, obtain the white powder material again after smashing to pieces, are common turmeric powder 872 grams, and productive rate is 8.72%.
2. get 35 kilograms fresh RADIX CURCUMAE, remove fibrous root, directly pulverize after clean powderedly, add 217 kilograms water purification, with electric blender vigorous stirring 13 minutes; After removing by filter disintegrating slag with 80 mesh sieves, place precipitation, go supernatant to get white thickness slurry, moisture is wherein removed in 51 ℃ of aeration-drying, obtains the white powder material again after smashing to pieces, is 2.52 kilograms of common turmeric powders, and productive rate is 7.2%.
3. get 70 kilograms fresh RADIX CURCUMAE, remove fibrous root, directly pulverize after clean powderedly, add 688 kilograms water purification, with electric blender vigorous stirring 15 minutes; After removing by filter disintegrating slag with 80 mesh sieves, place precipitation, go supernatant to get white thickness slurry, moisture is wherein removed in 55 ℃ of aeration-drying, obtains the white powder material again after smashing to pieces, is 4.41 kilograms of common turmeric powders, and productive rate is 6.3%.
B. the analytical control of common turmeric powder:
Inspection item comprise: moisture; Acidity; Ash; Protein (in butt); Sulfur dioxide; Arsenic; Plumbous; Copper; Cadmium; Hydrargyrum; Gamma Hexaochlorocyclohexane; Clofenotane; Bayer 71628.
Reference standard: GB/T50009.3-2003; GB/T5009.4-2003; GB/T5009.5-2003; GB/T5009.19-2003.
Main testing equipment and model thereof: inductive coupling plasma emission spectrograph (IRIS Intrepid II XSP, Thermo Jnrrell Ash Co., USA); Gas chromatograph (GC-14C, Shimudzu, Japan); Gamma Hexaochlorocyclohexane, clofenotane, Bayer 71628 detection limit are respectively: 1.0 μ g/kg, 1.0 μ g/kg, 0.02mg/kg.
Result: moisture: 15.7%; Acidity: 2.79T; Ash: 1.10%; Protein (in butt): 1.20%; Sulfur dioxide: 0.01g/Kg; Arsenic: 0.07mg/Kg; Plumbous: 0.07mg/Kg; Copper:＜0.5mg/Kg; Cadmium:＜0.5mg/Kg; Hydrargyrum: 0.005mg/Kg; Gamma Hexaochlorocyclohexane (α-HCH, β-HCH, γ-HCH, δ-HCH): do not detect; Clofenotane (ρ, ρ '-DDE, o, ρ '-DDT, ρ, ρ ' DDD, ρ, ρ '-DDT): do not detect; Bayer 71628 (C
2H
8O
2SPN): do not detect.
C. the anti-inflammatory activity of common turmeric powder check
Observe the antiinflammatory action of common turmeric powder by experimental models such as mice ear, rat carrageenan pedal swelling, rat granuloma are swollen, and measure the content of PGE2 (PGE2), malonaldehyde (MDA) in the rat foot claw.Result of study discovery common turmeric powder can obviously suppress the mice ear due to the dimethylbenzene, and the suppression ratio of 240mg/kg, 120mg/kg, three dosage of 60mg/kg is respectively 31.4%, 21.8% and 18.1%.Common turmeric powder can obviously suppress rat paw edema due to the carrageenin, and two dosage of 240mg/kg, 120mg/kg 4h suppression ratio after medication is respectively 51.0% and 31.4%.Common turmeric powder can obviously suppress the hypertrophy of rat granulation tissue, and the suppression ratio of 240mg/kg, two dosage of 120mg/kg is respectively 24.0% and 19.1%.The antiinflammatory action of common turmeric powder may have nothing to do with mice hypophysis, adrenal cortex function.Prostaglandin is the very strong inflammatory mediator of a class activity in the inflammatory reaction, experimental result shows, common turmeric powder can obviously reduce PGE2 content in the rat foot local inflammation tissue, and one of anti-inflammatory mechanisms of prompting common turmeric powder may be synthetic relevant with PGE2 in the minimizing inflammation tissue.During prostaglandin is synthetic with the generation of oxygen-derived free radicals.Studies show that free radical participates in inflammatory reaction, the free radical scavenger superoxide dismutase also has stronger antiinflammatory action.Experiment shows that common turmeric powder can obviously reduce MDA content in the rat foot local inflammation tissue, and this shows that iso propylidene shikimic acid can suppress lipid peroxidation product formation in the tissue inflammation.
In addition, common turmeric powder avirulence, skin irritation and sensitization are found in the check of the toxicity of common turmeric powder and skin irritation.
D. contain the preparation of the cosmetic composition of common turmeric powder
I. the W/O-emulsion that contains common turmeric powder
| 1 | 2 | 3 | 4 | 5 | |
| Two isostearic acid triglyceride | 1.2 | 0.5 | 0.25 | 2.0 | 3.0 |
| Two glycerol dimerization hydroxy stearic acid esters | 1.0 | 1.5 | 1.75 | 3.0 | 2.0 |
| Paraffin oil | 13.5 | 10.0 | 8.0 | 5.0 | 17.5 |
| Vaseline | 7.0 | 6.0 | 5.0 | 12.0 | 2.5 |
| Hydrogenation cocoa glyceride | 2.4 | 1.0 | 2.5 | 5.0 | 0.25 |
| Decyl oleate | 0.4 | 0.75 | 1.0 | 2.0 | 0.25 |
| Octyldodecanol | 0.4 | 1.0 | 0.75 | 3.0 | 0.25 |
| Aluminium stearate | 0.6 | 0.3 | 0.6 | 1.0 | 0.05 |
| Two caprylyl carbonic esters | 0.1 | 0.05 | 0.15 | 0.5 | 1.0 |
| Castor oil hydrogenated | 0.6 | 0.75 | 1.0 | 2.5 | 5.0 |
| Microcrystalline Cellulose | 0.5 | 1.0 | - | 0.25 | 0.1 |
| Magnesium sulfate | 0.5 | 0.6 | 0.5 | 0.7 | 1.0 |
| Glycerol | 3.0 | 5.0 | 10.0 | 15.0 | 1.5 |
| Citric acid | 0.2 | 0.1 | 0.2 | 0.3 | 1.0 |
| Sodium citrate | 0.2 | 0.05 | 0.4 | 0.3 | 2.0 |
| Spice | In right amount | In right amount | In right amount | In right amount | In right amount |
| Ethanol | 2.0 | - | 5.0 | - | - |
| Sad-/the capric acid triglyceride | 2.0 | 2.5 | 3.0 | 5.0 | 0.5 |
| Potassium sorbate | 0.04 | 0.15 | 0.05 | 0.03 | 0.4 |
| Benzyl alcohol | 0.3 | 0.4 | 0.25 | 0.15 | - |
| Common turmeric powder | 1.8 | 0.3 | 0.5 | 1.0 | 5.0 |
| Water | Surplus to 100 | Surplus to 100 | Surplus to 100 | Surplus to 100 | Surplus to 100 |
II. the W/S-emulsion that contains common turmeric powder
| 6 | 7 | 8 | 9 | 10 | |
| Cetyl PEG/PPG-10/1 dimethyl siloxane | 1.0 | - | - | 3.0 | 5.0 |
| Cyclohexyl methyl siloxanes+PEG/PPG-18/18 dimethyl siloxane (90: 10) | 10.0 | 12.5 | 25 | - | - |
| The cyclohexyl methyl siloxanes | 12.5 | 15 | 28.0 | 25.0 | 17.5 |
| Dimethyl siloxane | 5.0 | 13.0 | 5.0 | 12.0 | 15.0 |
| Parleam | 0.5 | 0.75 | 1.0 | 2.0 | 0.25 |
| Octyldodecanol | 0.5 | 1.0 | 0.75 | 3.0 | 0.25 |
| Panthenol | 0.5 | 1.0 | 0.75 | 0.25 | 0.1 |
| Sodium chloride | 2.0 | 0.6 | 2.5 | 0.7 | 1.0 |
| Glycerol | 3.0 | 5.0 | 10.0 | 15.0 | 1.5 |
| Lactic acid | 0.2 | 0.1 | 0.2 | - | - |
| Sodium lactate | 0.2 | 1.0 | 0.05 | - | - |
| Spice | In right amount | In right amount | In right amount | In right amount | In right amount |
| Common turmeric powder | 1.0 | 3.5 | 1.5 | 2.5 | 0.1 |
| The stearoyl dimethyl siloxane | 0.5 | - | 0.7 | - | - |
| Dehydroactic acid | - | - | 0.05 | - | 0.1 |
| Water | Surplus to 100 | Surplus to 100 | Surplus to 100 | Surplus to 100 | Surplus to 100 |
III. the facial film and the using method thereof that contain common turmeric powder
| 11 | 12 | 13 | 14 | 15 | |
| Common turmeric powder | 85 | 75 | 70 | 65 | 90 |
| The Growth of Biologic Cell factor | In right amount | In right amount | In right amount | In right amount | In right amount |
| Spice | In right amount | In right amount | In right amount | In right amount | In right amount |
| Sodium lactate | 0.2 | 0.35 | 0.5 | 0.7 | 0.8 |
| Collagen protein | In right amount | In right amount | In right amount | In right amount | In right amount |
| Starch | Surplus to 100 | Surplus to 100 | Surplus to 100 | Surplus to 100 | Surplus to 100 |
Using method: the film powder is poured in the container, added proper amount of clear water and be stirred to pasty state, exerting pressure slightly during stirring makes it water-soluble even, is applied to face then, keeps about 30 minutes.Promptly can film powder integral body be peeled off from face.
Claims (5)
1: a kind of white powder common turmeric powder and extracting method thereof that obtains that from RADIX CURCUMAE, extract, extraction process is as follows:
Get the fresh RADIX CURCUMAE of constant weight, remove fibrous root, directly pulverize after clean powderedly, add the water purification of 3～20 times of weight, stirred 2～20 minutes; After removing by filter disintegrating slag with 60 orders or 80 mesh sieves, place precipitation, go supernatant to get white thickness slurry, 20～60 ℃ of dryings are removed moisture wherein, obtain the white powder material again after smashing to pieces, are common turmeric powder.Productive rate is 3%～9%.
2: a kind of cosmetic composition, contain the described common turmeric powder of claim 1 in the cosmetics acceptable medium.
3: the described cosmetic composition of claim 2, it is characterized in that the weight of the described common turmeric powder of claim 1 in compositions is 0.01%～80%, be preferably 0.05%～20% weight, more preferably 0.1%～10% weight.
4: the cosmetic composition of the described adding common turmeric powder of claim 2, its purposes comprises facial film, facial film substrate, especially the maintenance of face and hand skin and speckle dispelling also comprise being used for antiinflammatory, defying age, antioxidation and antimicrobial cosmetics or the cosmetics additive that contains common turmeric powder.
5: a kind of method of skin care is characterized in that it is to the cosmetic composition that contains common turmeric powder described in the dermal administration claim 2～5 that needs maintenance.
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| CNA2008100634745A CN101336878A (en) | 2008-08-14 | 2008-08-14 | Extraction method of common turmeric powder and use thereof in cosmetics |
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| CNA2008100634745A CN101336878A (en) | 2008-08-14 | 2008-08-14 | Extraction method of common turmeric powder and use thereof in cosmetics |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239380A (en) * | 2013-05-20 | 2013-08-14 | 刘小青 | Application of traditional Chinese medicine, screening method and anti-ageing drug thereof |
| CN103893040A (en) * | 2012-12-27 | 2014-07-02 | 杨雪 | Novel medicinal beauty mask |
-
2008
- 2008-08-14 CN CNA2008100634745A patent/CN101336878A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893040A (en) * | 2012-12-27 | 2014-07-02 | 杨雪 | Novel medicinal beauty mask |
| CN103239380A (en) * | 2013-05-20 | 2013-08-14 | 刘小青 | Application of traditional Chinese medicine, screening method and anti-ageing drug thereof |
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Open date: 20090107 |