CN101322722A - Compound carbamylcholine chloride injection for animals and preparation method thereof - Google Patents
Compound carbamylcholine chloride injection for animals and preparation method thereof Download PDFInfo
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- CN101322722A CN101322722A CNA2008100538803A CN200810053880A CN101322722A CN 101322722 A CN101322722 A CN 101322722A CN A2008100538803 A CNA2008100538803 A CN A2008100538803A CN 200810053880 A CN200810053880 A CN 200810053880A CN 101322722 A CN101322722 A CN 101322722A
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Abstract
The invention discloses an veterinary compound bethanechol chloride injection and a preparation method thereof and aims at providing a compound bethanechol chloride injection which can quickly take effect on treating constipation of livestock, relieve the stress reaction of the bodies of the ill livestock, and treat constipation both from the superficiality and origin; the invention also provides a preparation method with simple process and easy realization. Every 100L of the injection is composed of the following components: 0.05-0.4kg of bethanechol chloride, 10-50kg of bile, 20-100kg of 95% ethanol, 0.5kg of Tween 80, 2kg of talc powder, 0.2kg of sodium bisulphite, 0.01kg of EDTA-2 Na, and sufficient water for injection. The invention is a compound preparation of bethanechol chloride for stimulating the intestinal motion of the livestock and the bile with the function of removing heat and toxic materials, which has double efficacies, reasonable formula and reasonable determination of contents of components, quickly takes effect on treating constipation of livestock, and treats constipation both from the superficiality and origin. The injection has the advantages of preventing the abnormal fermentation of the gastrointestinal feed chyme, and improving the curative ratio.
Description
Technical field
The present invention relates to a kind of compound carbamylcholine chloride injection for animals and preparation method thereof.
Background technology
Constipation is one of domestic animal commonly encountered diseases, mainly by the intestinal movement disorder, food reason etc. causes, show as the animal waste drying, what have presents spherical or can not discharge fully, and ill domestic animal performance inappetence is often exerted duty, but can not arrange feces, what have shows as symptoms such as intestinal obstruction, stomachache, the intestinal sound weakens or stop.
At present, the method for oral purgative is adopted in the constipation of treatment domestic animal more, concerning domestic animal, uses inconvenience, and because animal is a group support, and the constipation situation does not appear in the individuality that has in a group, adopts whole dispensing, can cause other individuality diarrhoea.And, for animal individual because constipation, be reluctant oral, gavage use inconvenient.And, not good with single medication effect, normal, and cause the enterogenous endotoxin accumulation because of timely defecation, food abnormal fermentation and cause the generation of other diseases.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, a kind of treatment domestic animal constipation instant effect to be provided, can treating at ill domestic animal individuality, and is easy to use, the compound carbamylcholine chloride injection for animals for the treatment of both the principal and secondary aspects of a disease.
It is simple that another object of the present invention provides a kind of technology, easily the preparation method of the above-mentioned compound carbamylcholine chloride injection for animals of realizing.
The present invention is achieved through the following technical solutions:
A kind of compound carbamylcholine chloride injection for animals, it is characterized in that, every 100L injection is made by following component: carbamylcholine chloride 0.05～0.4kg, bile 10～50kg, ethanol 20～100kg of 95%, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
A kind of preparation method of above-mentioned compound carbamylcholine chloride injection for animals is characterized in that, comprises the steps:
(1) gets bile 10～50kg, heated and boiled 10 minutes.Heated and boiled can be removed unnecessary proteins matter, fat and sterilization.Remove oil slick after the heated and boiled again.Because oil slick is a fat, and is mixed with fragment of tissue, removal can be so that follow-up work disposal.Afterwards, add 95% ethanol 20～100kg and Pulvis Talci 2kg again and stir, leave standstill 24 hours after-filtration.Again with filtrate recycling ethanol to do not have the alcohol flavor, cross filter to remove separate out be dissolved in ethanol but standby behind the water-fast material.
(2) take by weighing carbamylcholine chloride 0.05～0.4kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirs 2 all dissolvings, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
The preferable content of each component is in wherein every 100L injection: carbamylcholine chloride 0.1～0.3kg, bile 20～40kg, ethanol 40～80kg of 95%, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na0.01kg, the water for injection of surplus.
The optimum content of each component is in every 100L injection: carbamylcholine chloride 0.25kg, bile 30kg, 95% ethanol 60kg, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
Bile can adopt Fel Sus domestica, Fel Bovis seu Bubali etc.
The present invention has following technique effect:
The compound preparation of the present invention for adopting carbamylcholine chloride that can stimulate intestinal peristalsis promoting and bile to share with effects for removing toxic heat, carbamylcholine chloride and biliaryly unite use, adopt double effects, carbamylcholine chloride stimulates intestinal peristalsis promoting, promote feces to discharge, the bile heat-clearing and toxic substances removing, have certain bowel relaxing functions and rush down function down, both pass through reasonable formula, and to rationally the determining of each constituent content, to domestic animal constipation therapy instant effect, effectively and efficient, can alleviate and suffer from poultry health stress, and treating both the principal and secondary aspects of a disease.Can prevent the abnormal fermentation of gastrointestinal feedstuff chyme, improve cure rate.And the present invention is an injection, can treat at ill domestic animal individuality, avoids other individualities are exerted an influence, and is easy to use, instant effect.
The preparation method technology of compound carbamylcholine chloride injection for animals of the present invention is simple, realizes easily.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
(1) get Fel Sus domestica 10kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 20kg and Pulvis Talci 2kg again and stirs, and leaves standstill 24 hours after-filtration.Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby.
(2) take by weighing carbamylcholine chloride 0.4kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirring and dissolving.Add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
Embodiment 2
(1) get Fel Sus domestica 50kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 100kg and Pulvis Talci 2kg again and stirs, and leaves standstill 24 hours after-filtration.Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby.
(2) take by weighing carbamylcholine chloride 0.05kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirring and dissolving.Add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
Embodiment 3
(1) get Fel Sus domestica 20kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 40kg and Pulvis Talci 2kg again and stirs, and leaves standstill 24 hours after-filtration.Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby.
(2) take by weighing carbamylcholine chloride 0.3kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirring and dissolving.Add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
Embodiment 4
(1) get Fel Bovis seu Bubali 40kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 80kg and Pulvis Talci 2kg again and stirs, and leaves standstill 24 hours after-filtration.Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby.
(2) take by weighing carbamylcholine chloride 0.01kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirring and dissolving.Add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
Embodiment 5
(1) get Fel Bovis seu Bubali 25kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 50kg and Pulvis Talci 2kg again and stirs, and leaves standstill 24 hours after-filtration.Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby.
(2) take by weighing carbamylcholine chloride 0.2kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirring and dissolving.Add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
Embodiment 6
(1) get Fel Bovis seu Bubali 30kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 60kg and Pulvis Talci 2kg again and stirs, and leaves standstill 24 hours after-filtration.Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby.
(2) take by weighing carbamylcholine chloride 0.25kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings.
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, stirring and dissolving.Add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
Compound carbamylcholine chloride injection for animals of the present invention is applicable to domestic animals such as pig, cattle, sheep.
Be that example is tested compound carbamylcholine chloride injection for animals of the present invention with ill one-tenth pig below.
Clinical trial:
1. laboratory animal:
75 of the ill one-tenth of picked at random pigs.
2. experiment medicine:
Compound carbamylcholine chloride injection for animals unit's development of the embodiment of the invention 6 preparations;
Magnesium sulfate is bought on the market
3. experimental technique:
Suffer from pig with 75 and be divided into three groups at random by body weight, 25 every group.
The A group does not give Drug therapy for the blank group.
The B group is treated usage with magnesium sulfate: oral, once measure, and oral, every 1kg body weight 0.3g is with 1 time
The C group is treated usage with the compound carbamylcholine chloride injection for animals of the embodiment of the invention 6 preparations: intramuscular injection, every 1kg body weight 0.1ml is with 1 time.
After the treatment beginning, every day, record trouble poultry health situation of change distributed, and treat after the 3rd day and add up therapeutic effect, wherein:
Invalid: as after referring to 2 days, to suffer from the poultry symptom and do not have obvious change, still keep the preceding symptom of treatment.
Effectively: after referring to 2 days, suffer from the poultry symptom and change, the effect before symptom is better than treating.
Cure: after referring to 2 days, transference cure is suffered from poultry and is got well.Its numeral is included in the significant digits.
Symptom is arranged during end: after referring to 2 days, suffer from poultry and still have certain symptom, its symptom performance is better than before the treatment or does not have change, suffers from poultry and does not cure.Its numeral has been included in the numeral of invalid number and effective number.
Result of the test is as shown in table 1.
4. conclusion:
Analyze by statistics from the result of the test of table 1, compound carbamylcholine chloride injection for animals treatment group, magnesium sulfate and the matched group difference of the embodiment of the invention 6 is (P＜0.01) extremely significantly.Curative effect of the present invention is better than existing medicine.And it is more convenient to adopt the Therapeutic Method ratio of injecting to orally use, and can avoid other individualities are exerted an influence.
Table 1
| Numbering | Group | Invalid number | Effective number | Cure a number | A symptom number is arranged during end |
| A | Matched group | 25 | 0 | 0 | 25 |
| B | The magnesium sulfate treatment | 7 | 18 | 13 | 12 |
| D | The compound carbamylcholine chloride injection treatment of embodiment 6 | 3 | 22 | 21 | 4 |
Claims (6)
1, a kind of compound carbamylcholine chloride injection for animals, it is characterized in that, every 100L injection is made by following component: carbamylcholine chloride 0.05～0.4kg, bile 10～50kg, ethanol 20～100kg of 95%, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
2, compound carbamylcholine chloride injection for animals according to claim 1, it is characterized in that, every 100L injection is made by following component: carbamylcholine chloride 0.1～0.3kg, bile 20～40kg, ethanol 40～80kg of 95%, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
3, compound carbamylcholine chloride injection for animals according to claim 1, it is characterized in that, every 100L injection is made by following component: carbamylcholine chloride 0.25kg, bile 30kg, 95% ethanol 60kg, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
4, the preparation method of the described compound carbamylcholine chloride injection for animals of a kind of claim 1 is characterized in that, comprises the steps:
(1) get bile 10～50kg, heated and boiled 10 minutes is removed oil slick, adds 95% ethanol 20～100kg and Pulvis Talci 2kg again, stirs, and leaves standstill 24 hours after-filtration; Again filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, filter standby;
(2) take by weighing carbamylcholine chloride 0.05～0.4kg and put into water for injection 10L, after the stirring and dissolving, add sodium sulfite 0.2kg, EDTA-2Na 0.01kg again, be stirred to whole dissolvings;
(3) the prepared solution of combining step 1 and step 2 adds tween 80 0.5kg, is stirred to whole dissolvings, add water for injection again to 100L, stir, keep 15-20min, treat that medicinal liquid promptly makes compound carbamylcholine chloride injection for animals of the present invention after clear and bright.
5, the preparation method of compound carbamylcholine chloride injection for animals according to claim 4, it is characterized in that, contain carbamylcholine chloride 0.1～0.3kg in every 100L injection, bile 20～40kg, ethanol 40～80kg of 95%, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
6, the preparation method of compound carbamylcholine chloride injection for animals according to claim 4, it is characterized in that, contain carbamylcholine chloride 0.25kg in every 100L injection, bile 30kg, 95% ethanol 60kg, tween 80 0.5kg, Pulvis Talci 2kg, sodium sulfite 0.2kg, EDTA-2Na 0.01kg, the water for injection of surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100538803A CN101322722B (en) | 2008-07-18 | 2008-07-18 | Compound carbamylcholine chloride injection for animals and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100538803A CN101322722B (en) | 2008-07-18 | 2008-07-18 | Compound carbamylcholine chloride injection for animals and preparation method thereof |
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| CN101322722A true CN101322722A (en) | 2008-12-17 |
| CN101322722B CN101322722B (en) | 2011-01-05 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398521A (en) * | 2014-12-08 | 2015-03-11 | 重庆综艺制药有限公司 | Preparation method of veterinary compound levofloxacin injection |
| CN113368065A (en) * | 2021-06-29 | 2021-09-10 | 上海轩耘生物医药科技有限公司 | Formulation of freeze-dried powder of methacholine chloride for inhalation and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879626A (en) * | 2006-05-18 | 2006-12-20 | 天津生机集团有限公司 | Compound Vitamin B injection and preparation method thereof |
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2008
- 2008-07-18 CN CN2008100538803A patent/CN101322722B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398521A (en) * | 2014-12-08 | 2015-03-11 | 重庆综艺制药有限公司 | Preparation method of veterinary compound levofloxacin injection |
| CN104398521B (en) * | 2014-12-08 | 2017-01-04 | 重庆综艺制药有限公司 | The preparation method of animal compound levofloxacin |
| CN113368065A (en) * | 2021-06-29 | 2021-09-10 | 上海轩耘生物医药科技有限公司 | Formulation of freeze-dried powder of methacholine chloride for inhalation and preparation method thereof |
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| CN101322722B (en) | 2011-01-05 |
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Owner name: TIANJIN TIANHELI PHARMACEUTICAL R + D CO., LTD. Free format text: FORMER OWNER: TIANJIN SHENGJI GROUP CO., LTD. Effective date: 20131128 |
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Effective date of registration: 20131128 Address after: 316, room 9, science and Technology Park, Nankai Science Park, No. 300000 Yibin Road, Tianjin, Nankai District Patentee after: Tianjin Tianheli Pharmaceutical R & D Co.,Ltd. Address before: 301609. 2, Tianyu Science Park, Jinghai, Tianjin Patentee before: Tianjin Shengji Group Co., Ltd. |