CN1879626A - Compound Vitamin B injection and preparation method thereof - Google Patents
Compound Vitamin B injection and preparation method thereof Download PDFInfo
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- CN1879626A CN1879626A CN 200610013752 CN200610013752A CN1879626A CN 1879626 A CN1879626 A CN 1879626A CN 200610013752 CN200610013752 CN 200610013752 CN 200610013752 A CN200610013752 A CN 200610013752A CN 1879626 A CN1879626 A CN 1879626A
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Abstract
The invention relates to a composite vitamin B injection and relative preparation, wherein the preparation comprises: (1) adding vitamin B1 into the injection water to be mixed; (2) dissolving vitamin B6 into injection water, to be mixed with the solution of step (1), and adding carbachol to be dissolved; (3) dissolving niacinamide into injection water, and adding non-water vitamin B2-5'-sodium phosphate to be mixed and dissolved; (4) dissolving the panthoject and complexon into injection water to be mixed with the solution in step (3); (5) dissolving tween-80 into injection water to be mixed with the solutions of steps (2, 4), and adjusting pH, adding water to 1000ml. The invention uses several B vitamins to be reacted with the carbachol to obtain high efficiency, and it can improve the immunity.
Description
Technical field
The present invention relates to a kind of vitamin B complex injection and preparation method.
Background technology
Anorexia and dyspepsia are one of modal diseases in the livestock and poultry cultivation, are seriously restricting the development of aquaculture.In decades all over the world vitamin B group as prophylactic treatment anorexia and dyspeptic choice drug, owing to use vitamin B group to take effect slowly separately, also have vitamin B group is made compound preparation, but, can find and a kind ofly make vitamin B group produce curative effect rapidly and keep the composite B vitamin preparation of long period, a problem that still needs to be resolved hurrily.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of quick-acting long lasting vitamin B complex injection is provided.
Second purpose of the present invention provides a kind of preparation method of vitamin B complex injection.
Technical scheme of the present invention is summarized as follows:
A kind of vitamin B complex injection, make with following method:
(1) with the vitamin B of 5g-15g
1Be added in 40～50 ℃ of waters for injection of 350ml-450ml, stir and make dissolving;
(2) with the vitamin B of 0.5g-2g
6Be dissolved in the water for injection of 40ml-60ml,, add the carbamylcholine chloride of 1g-3g, make it dissolving with the prepared solution mixing of step (1);
(3) the 10g-20g nicotiamide is dissolved in the water for injection of 150ml-250ml, adds the anhydrous vitamin B of 1g-2g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 0.1g-1g sodium dextropantothenate, 0.1g-0.3g disodiumedetate are dissolved in the water for injection of 40ml-60ml, mixing, the solution mixing that makes with step (3);
(5) the 1g-2g tween 80 is dissolved in the water for injection of 40ml-60ml,, adds the injection water, regulate pH value to 3.5～5.5, add water to 1000ml to 850ml-950ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 1g-2g, stirring and adsorbing 15～20min;
(7) coarse filtration decarburization, clear and bright through 0.2 μ m mixed cellulose ester membrane fine straining again to medicinal liquid, promptly make a kind of vitamin B complex injection.
Preferably: described vitamin is B
110g, anhydrous vitamin B
2-5 '-sodium phosphate is 1.37g, vitamin B
6For 1g, carbamylcholine chloride are that 2.5g, nicotiamide are that 15g, sodium dextropantothenate are that 0.5g, tween 80 are that 1.8g, disodiumedetate are 0.2g.
A kind of preparation method of vitamin B complex injection comprises the steps:
(1) with the vitamin B of 5g-15g
1Be added in 40～50 ℃ of waters for injection of 350ml-450ml, stir and make dissolving;
(2) with the vitamin B of 0.5g-2g
6Be dissolved in the water for injection of 40ml-60ml,, add the carbamylcholine chloride of 1g-3g, make it dissolving with the prepared solution mixing of step (1);
(3) the 10g-20g nicotiamide is dissolved in the water for injection of 150ml-250ml, adds the anhydrous vitamin B of 1g-2g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 0.1g-1g sodium dextropantothenate, 0.1g-0.3g disodiumedetate are dissolved in the water for injection of 40ml-60ml, mixing, the solution mixing that makes with step (3);
(5) the 1g-2g tween 80 is dissolved in the water for injection of 40ml-60ml,, adds the injection water, regulate pH value to 3.5～5.5, add water to 1000ml to 850ml-950ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 1g-2g, stirring and adsorbing 15～20min;
(7) coarse filtration decarburization, clear and bright through 0.2 μ m mixed cellulose ester membrane fine straining again to medicinal liquid, promptly make a kind of vitamin B complex injection.
Preferably: described vitamin is B
110g, anhydrous vitamin B
2-5 '-sodium phosphate is 1.37g, vitamin B
6For 1g, carbamylcholine chloride are that 2.5g, nicotiamide are that 15g, sodium dextropantothenate are that 0.5g, tween 80 are that 1.8g, disodiumedetate are 0.2g.
Advantage of the present invention is: owing to adopt multiple vitamin B group and carbamylcholine chloride (bethanechol chloride) compatibility to use, make this product reach quick-acting effects efficiently aspect treatment poultry anorexia and the dyspepsia disease; The function that has enhancing immunity simultaneously can increase body's immunological function after the medication, for growth of animals or poultry provides healthy internal milieu.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of preparation method of vitamin B complex injection comprises the steps:
(1) with the vitamin B of 10g
1Be added in 50 ℃ of waters for injection of 400ml, stir and make dissolving;
(2) with the vitamin B of 1g
6Be dissolved in the water for injection of 50ml,, add the carbamylcholine chloride of 2.5g, make it dissolving with the prepared solution mixing of step (1);
(3) the 15g nicotiamide is dissolved in the water for injection of 200ml, adds the anhydrous vitamin B of 1.37g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 0.5g sodium dextropantothenate, 0.2g disodiumedetate are dissolved in the water for injection of 50ml, mixing, the solution mixing that makes with step (3);
(5) the 1.8g tween 80 is dissolved in the water for injection of 50ml,, adds the injection water, regulate pH value to 4.5, add water to 1000ml to 900ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 1g-2g, stirring and adsorbing 15～20min;
(7) coarse filtration decarburization is sent embedding through 0.2 μ m mixed cellulose ester membrane fine straining to medicinal liquid is clear and bright again; 100 ℃ of constant temperature sterilizations of semi-finished product injection and flowing steam 20min promptly makes a kind of vitamin B complex injection after the embedding.
The preparation method of 2 one kinds of vitamin B complex injections of embodiment comprises the steps:
(1) with the vitamin B of 15g
1Be added in 45 ℃ of waters for injection of 450ml, stir and make dissolving;
(2) with the vitamin B of 0.5g
6Be dissolved in the water for injection of 40ml,, add the carbamylcholine chloride of 1g, make it dissolving with the prepared solution mixing of step (1);
(3) the 10g nicotiamide is dissolved in the water for injection of 150ml, adds the anhydrous vitamin B of 1g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 1g sodium dextropantothenate, 0.1g disodiumedetate are dissolved in the water for injection of 60ml, mixing, the solution mixing that makes with step (3);
(5) the 1g tween 80 is dissolved in the water for injection of 40ml,, adds the injection water, regulate pH value to 3.5, add water to 1000ml to 850ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 2g, stirring and adsorbing 15min;
(7) coarse filtration decarburization is sent embedding through 0.2 μ m mixed cellulose ester membrane fine straining to medicinal liquid is clear and bright again; 100 ℃ of constant temperature sterilizations of semi-finished product injection and flowing steam 20min promptly makes a kind of vitamin B complex injection after the embedding.
The preparation method of 3 one kinds of vitamin B complex injections of embodiment comprises the steps:
(1) with the vitamin B of 5g
1Be added in 40 ℃ of waters for injection of 350ml, stir and make dissolving;
(2) with the vitamin B of 2g
6Be dissolved in the water for injection of 60ml,, add the carbamylcholine chloride of 3g, make it dissolving with the prepared solution mixing of step (1);
(3) the 20g nicotiamide is dissolved in the water for injection of 250ml, adds the anhydrous vitamin B of 2g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 0.1g sodium dextropantothenate, 0.3g disodiumedetate are dissolved in the water for injection of 40ml, mixing, the solution mixing that makes with step (3);
(5) the 2g tween 80 is dissolved in the water for injection of 60ml,, adds the injection water, regulate pH value to 5.5, add water to 1000ml to 950ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 1g, stirring and adsorbing 20min;
(7) coarse filtration decarburization is sent embedding through 0.2 μ m mixed cellulose ester membrane fine straining to medicinal liquid is clear and bright again; 100 ℃ of constant temperature sterilizations of semi-finished product injection and flowing steam 20min promptly makes a kind of vitamin B complex injection after the embedding.
Clinical trial:
Picked at random does not have other bacteriovirus infections and stress situation, but only 20 of the pigs of anorexia and indigestion symptom are arranged, and according to body condition, term, close situation was divided into three groups,
| Numbering | Group | Mortality rate % | Inefficiency % | Effective percentage % | Cure rate % | The symptom pig's head is arranged during end | The relative weight gain rate % |
| A | Do not treat (matched group) | 2 | - | - | - | - | - |
| B | Vitamin B group treatment (0.01mg/kg) | 1 | 5.3 | 73.3 | 68.3 | 3 | 69.2 |
| C | Compound vitamin B treatment (0.01mg/kg) | 0 | 3.6 | 96.4 | 95.4 | 0 | 96.5 |
This result of the test is analyzed by statistics, and compound vitamin B treatment group and vitamin B group treatment matched group difference is (P＜0.01) extremely significantly, treatment group and matched group significant difference (P＜0.05).
Claims (4)
1. vitamin B complex injection is characterized in that making with following method:
(1) with the vitamin B of 5g-15g
1Be added in 40～50 ℃ of waters for injection of 350ml-450ml, stir and make dissolving;
(2) with the vitamin B of 0.5g-2g
6Be dissolved in the water for injection of 40ml-60ml,, add the carbamylcholine chloride of 1g-3g, make it dissolving with the prepared solution mixing of step (1);
(3) the 10g-20g nicotiamide is dissolved in the water for injection of 150ml-250ml, adds the anhydrous vitamin B of 1g-2g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 0.1g-1g sodium dextropantothenate, 0.1g-0.3g disodiumedetate are dissolved in the water for injection of 40ml-60ml, mixing, the solution mixing that makes with step (3);
(5) the 1g-2g tween 80 is dissolved in the water for injection of 40ml-60ml,, adds the injection water, regulate pH value to 3.5～5.5, add water to 1000ml to 850ml-950ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 1g-2g, stirring and adsorbing 15～20min;
(7) coarse filtration decarburization, clear and bright through 0.2 μ m mixed cellulose ester membrane fine straining again to medicinal liquid, promptly make a kind of vitamin B complex injection.
2. a kind of vitamin B complex injection according to claim 1 is characterized in that described vitamin is B
110g, anhydrous vitamin B
2-5 '-sodium phosphate is 1.37g, vitamin B
6For 1g, carbamylcholine chloride are that 2.5g, nicotiamide are that 15g, sodium dextropantothenate are that 0.5g, tween 80 are that 1.8g, disodiumedetate are 0.2g.
3. the preparation method of a vitamin B complex injection is characterized in that comprising the steps:
(1) with the vitamin B of 5g-15g
1Be added in 40～50 ℃ of waters for injection of 350ml-450ml, stir and make dissolving;
(2) with the vitamin B of 0.5g-2g
6Be dissolved in the water for injection of 40ml-60ml,, add the carbamylcholine chloride of 1g-3g, make it dissolving with the prepared solution mixing of step (1);
(3) the 10g-20g nicotiamide is dissolved in the water for injection of 150ml-250ml, adds the anhydrous vitamin B of 1g-2g
2-5 '-sodium phosphate stirs and to make it dissolving;
(4) 0.1g-1g sodium dextropantothenate, 0.1g-0.3g disodiumedetate are dissolved in the water for injection of 40ml-60ml, mixing, the solution mixing that makes with step (3);
(5) the 1g-2g tween 80 is dissolved in the water for injection of 40ml-60ml,, adds the injection water, regulate pH value to 3.5～5.5, add water to 1000ml to 850ml-950ml with the solution mixing that step (2), step (4) make;
(6) add medical injection charcoal 1g-2g, stirring and adsorbing 15～20min;
(7) coarse filtration decarburization, clear and bright through 0.2 μ m mixed cellulose ester membrane fine straining again to medicinal liquid, promptly make a kind of vitamin B complex injection.
4. the preparation method of a kind of vitamin B complex injection according to claim 4 is characterized in that described vitamin is B
110g, anhydrous vitamin B
2-5 '-sodium phosphate is 1.37g, vitamin B
6For 1g, carbamylcholine chloride are that 2.5g, nicotiamide are that 15g, sodium dextropantothenate are that 0.5g, tween 80 are that 1.8g, disodiumedetate are 0.2g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610013752 CN1879626A (en) | 2006-05-18 | 2006-05-18 | Compound Vitamin B injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610013752 CN1879626A (en) | 2006-05-18 | 2006-05-18 | Compound Vitamin B injection and preparation method thereof |
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|---|---|
| CN1879626A true CN1879626A (en) | 2006-12-20 |
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| CN 200610013752 Pending CN1879626A (en) | 2006-05-18 | 2006-05-18 | Compound Vitamin B injection and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322722B (en) * | 2008-07-18 | 2011-01-05 | 天津生机集团股份有限公司 | Compound carbamylcholine chloride injection for animals and preparation method thereof |
| CN103239461A (en) * | 2012-02-13 | 2013-08-14 | 瑞阳制药有限公司 | Vitamin B complex injection and preparation method thereof |
| CN104147587A (en) * | 2014-08-05 | 2014-11-19 | 河北科恒生物科技有限公司 | Preparation method for bird-used immunopotentiator VB peptide |
| CN104398521A (en) * | 2014-12-08 | 2015-03-11 | 重庆综艺制药有限公司 | Preparation method of veterinary compound levofloxacin injection |
| CN107115354A (en) * | 2017-07-03 | 2017-09-01 | 山东中牧兽药有限公司 | A kind of vitamin B complex injection and preparation method |
| CN110251461A (en) * | 2019-07-16 | 2019-09-20 | 河南益华动物药业有限公司 | Vitamin B complex injection and preparation method thereof |
| CN114306345A (en) * | 2021-12-28 | 2022-04-12 | 天津市中升挑战生物科技有限公司 | Raw material composition of vitamin B complex preparation, vitamin B complex preparation and preparation method and application thereof |
-
2006
- 2006-05-18 CN CN 200610013752 patent/CN1879626A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322722B (en) * | 2008-07-18 | 2011-01-05 | 天津生机集团股份有限公司 | Compound carbamylcholine chloride injection for animals and preparation method thereof |
| CN103239461A (en) * | 2012-02-13 | 2013-08-14 | 瑞阳制药有限公司 | Vitamin B complex injection and preparation method thereof |
| CN104147587A (en) * | 2014-08-05 | 2014-11-19 | 河北科恒生物科技有限公司 | Preparation method for bird-used immunopotentiator VB peptide |
| CN104398521A (en) * | 2014-12-08 | 2015-03-11 | 重庆综艺制药有限公司 | Preparation method of veterinary compound levofloxacin injection |
| CN104398521B (en) * | 2014-12-08 | 2017-01-04 | 重庆综艺制药有限公司 | The preparation method of animal compound levofloxacin |
| CN107115354A (en) * | 2017-07-03 | 2017-09-01 | 山东中牧兽药有限公司 | A kind of vitamin B complex injection and preparation method |
| CN110251461A (en) * | 2019-07-16 | 2019-09-20 | 河南益华动物药业有限公司 | Vitamin B complex injection and preparation method thereof |
| CN110251461B (en) * | 2019-07-16 | 2021-07-13 | 河南益华动物药业有限公司 | Vitamin B complex injection and preparation method thereof |
| CN114306345A (en) * | 2021-12-28 | 2022-04-12 | 天津市中升挑战生物科技有限公司 | Raw material composition of vitamin B complex preparation, vitamin B complex preparation and preparation method and application thereof |
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