CN1879633A - Compound sulfamethoxazole injection for animal, its preparation method and use - Google Patents
Compound sulfamethoxazole injection for animal, its preparation method and use Download PDFInfo
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- CN1879633A CN1879633A CNA2006100137512A CN200610013751A CN1879633A CN 1879633 A CN1879633 A CN 1879633A CN A2006100137512 A CNA2006100137512 A CN A2006100137512A CN 200610013751 A CN200610013751 A CN 200610013751A CN 1879633 A CN1879633 A CN 1879633A
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Abstract
The invention relates to an animal composite lianhuang injection, relative preparation and application, wherein the preparation comprises: (1) heating methyl glycol and adding trimethoprim, to be mixed and cooled, adding alcohol, anhydrous sodium sulfite, anhydrous sodium sulfite, and aristebon to be dissolved; (2) adding water into aminoethyl alcohol to be diluted, and adding gantanol; (3), combining the solutions of steps (1, 2), adding water to 1000 deals, to obtain the final injection. The invention can expand the antibiogram, improve the cure effect and expand clinical application, to cure high temperature and cold, etc.
Description
Technical field
The present invention relates to a kind of chemical drug composition, Preparation method and use, particularly relate to a kind of compound recipe connection sulphur injection and the application in preparation treatment toxoplasmosis medicine.
Background technology
The pig toxoplasmosis is one of modal disease of swinery, is seriously restricting the development of pig industry.Oxytetracycline is listed the choice drug of treatment pig toxoplasmosis in such as in various places in decades, because prolonged and repeated use antibiotic causes toxoplasma that medicine has been produced drug resistance, and reduced curative effect.
Summary of the invention
The purpose of this invention is to provide a kind of compound sulfamethoxazole injection for animal of avoiding toxoplasma to develop immunity to drugs.
Second purpose of the present invention provides a kind of preparation method of compound sulfamethoxazole injection for animal.
The 3rd purpose of the present invention provides the application of a kind of compound sulfamethoxazole injection for animal in preparation treatment toxoplasmosis medicine.
Technical scheme of the present invention is summarized as follows:
A kind of compound sulfamethoxazole injection for animal is to make with following method:
(1) gets propylene glycol 20-50 weight portion and be heated to 60-90 ℃, add trimethoprim 1-5 weight portion, stirring and dissolving, after being cooled to 15-30 ℃, the adding concentration of volume percent is 95% ethanol 1-10 weight portion, stir, add anhydrous sodium sulfite 0.1-0.3 weight portion, disodiumedetate 0.01-0.05 weight portion, sulfanilamide again a Sulfamonomethoxine sodium 5-12 weight portion stirring and dissolving;
(2), add the dissolving of sulfamethoxazole 5-15 weight portion with behind ethanolamine 1-5 weight portion thin up to 12 weight portion;
(3) solution that makes of combining step (1) and step (2) adds water to 1000 weight portions, promptly makes a kind of compound sulfamethoxazole injection for animal.
Preferably: described sulfanilamide is 8 weight portions to a Sulfamonomethoxine sodium, and described sulfamethoxazole is 9 weight portions.
Described trimethoprim is 1 weight portion, described concentration of volume percent is that 95% ethanol is 6 weight portions, and described anhydrous sodium sulfite is 0.15 weight portion, and described propylene glycol is 35 weight portions, described ethanolamine is 2 weight portions, and described disodiumedetate is 0.01 weight portion.
A kind of preparation method of compound sulfamethoxazole injection for animal comprises the steps:
(1) gets propylene glycol 20-50 weight portion and be heated to 60-90 ℃, add trimethoprim 1-5 weight portion, stirring and dissolving, after being cooled to 15-30 ℃, the adding concentration of volume percent is 95% ethanol 1-10 weight portion, stir, add anhydrous sodium sulfite 0.1-0.3 weight portion, disodiumedetate 0.01-0.05 weight portion, sulfanilamide again a Sulfamonomethoxine sodium 5-12 weight portion stirring and dissolving;
(2), add the dissolving of sulfamethoxazole 5-15 weight portion with behind ethanolamine 1-5 weight portion thin up to 12 weight portion;
(3) solution that makes of combining step (1) and step (2) adds water to 1000 weight portions, promptly makes a kind of compound sulfamethoxazole injection for animal.
Preferably: described sulfanilamide is 8 weight portions to a Sulfamonomethoxine sodium, and described sulfamethoxazole is 9 weight portions.
Described trimethoprim is 1 weight portion, described concentration of volume percent is that 95% ethanol is 6 weight portions, and described anhydrous sodium sulfite is 0.15 weight portion, and described propylene glycol is 35 weight portions, described ethanolamine is 2 weight portions, and described disodiumedetate is 0.01 weight portion.
The compound sulfamethoxazole injection for animal made from said method is preparing the application for the treatment of in the toxoplasmosis medicine.
The present invention is owing to adopt compound preparation, enlarge antimicrobial spectrum, heighten the effect of a treatment, clinical practice is extensive, except that can using bacterial infection, the application of the medicine that the heating that can also cause at preparation treatment toxoplasmosis, hyperpyrexia, dyspnea, loss of appetite even useless exhausted, diarrhoea etc. are sick.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
A kind of compound sulfamethoxazole injection for animal is to make with following method:
(1) gets propylene glycol 35 grams and be heated to 70 ℃, add trimethoprim 1 gram, stirring and dissolving, after being cooled to 15 ℃, the adding concentration of volume percent is 95% ethanol 6 grams, stir, add anhydrous sodium sulfite 0.15 gram, disodiumedetate 0.01 gram, sulfanilamide again a Sulfamonomethoxine sodium 8 gram stirring and dissolving;
(2) with behind ethanolamine 2 gram thin up to 12 grams, add sulfamethoxazole 13 gram dissolvings;
(3) solution that makes of combining step (1) and step (2) adds water in to 1000 grams, promptly makes a kind of compound sulfamethoxazole injection for animal.
Embodiment 2
A kind of compound sulfamethoxazole injection for animal is to make with following method:
(1) gets propylene glycol 20 grams and be heated to 60 ℃, add trimethoprim 3 grams, stirring and dissolving, after being cooled to 30 ℃, the adding concentration of volume percent is 95% ethanol 1 gram, stir, add anhydrous sodium sulfite 0.3 gram, disodiumedetate 0.05 gram, sulfanilamide again a Sulfamonomethoxine sodium 5 gram stirring and dissolving;
(2) with behind ethanolamine 5 gram thin up to 12 grams, add sulfamethoxazole 15 gram dissolvings;
(3) solution that makes of combining step (1) and step (2) adds water in to 1000 grams, promptly makes a kind of compound sulfamethoxazole injection for animal.
Embodiment 3
A kind of compound sulfamethoxazole injection for animal is to make with following method:
(1) gets propylene glycol 50 grams and be heated to 90 ℃, add trimethoprim 5 grams, stirring and dissolving, after being cooled to 20 ℃, the adding concentration of volume percent is 95% ethanol 10 grams, stir, add anhydrous sodium sulfite 0.1 gram, disodiumedetate 0.01 gram, sulfanilamide again a Sulfamonomethoxine sodium 12 gram stirring and dissolving;
(2) with behind ethanolamine 1 gram thin up to 12 gram, add sulfamethoxazole 5 gram dissolvings;
(3) solution that makes of combining step (1) and step (2) adds water in to 1000 grams, promptly makes a kind of compound sulfamethoxazole injection for animal.
Embodiment 4
Clinical trial:
Picked at random does not have other bacteriovirus infections and piglet that stress situation, but only 100 of the pigs of arc disease symptoms are arranged, and according to body condition, term, close situation was divided into three groups.Medication three days, every day secondary.
| Numbering | Group | Mortality rate % | Inefficiency % | Effective percentage % | Cure rate % | Symptom pig's head number is arranged during end | The relative weight gain rate % |
| A | Do not treat (matched group) | 2 | - | - | - | - | - |
| B | Sulfanilamide is to a Sulfamonomethoxine sodium treatment (18mg/Kg) | 1 | 5.6 | 74.6 | 73.5 | 3 | 73.2 |
| C | Sulfamethoxazole treatment (25mg/Kg) | 1 | 3.5 | 72.3 | 70.2 | 5 | 69.2 |
| D | Compound sulfamethoxazole injection for animal connection sulphur treatment (embodiment 1 preparation (8mg/Kg)) | 0 | 1.2 | 98.3 | 90.8 | 1 | 89.0 |
This result of the test is analyzed by statistics, and compound sulfamethoxazole injection for animal group and sulfanilamide are to a Sulfamonomethoxine sodium matched group difference extremely significantly (P＜0.01), treatment group and matched group significant difference (P＜0.05).
Claims (7)
1. compound sulfamethoxazole injection for animal is characterized in that making with following method:
(1) gets propylene glycol 20-50 weight portion and be heated to 60-90 ℃, add trimethoprim 1-5 weight portion, stirring and dissolving, after being cooled to 15-30 ℃, the adding concentration of volume percent is 95% ethanol 1-10 weight portion, stir, add anhydrous sodium sulfite 0.1-0.3 weight portion, disodiumedetate 0.01-0.05 weight portion, sulfanilamide again a Sulfamonomethoxine sodium 5-12 weight portion stirring and dissolving;
(2), add the dissolving of sulfamethoxazole 5-15 weight portion with behind ethanolamine 1-5 weight portion thin up to 12 weight portion;
(3) solution that makes of combining step (1) and step (2) adds water to 1000 weight portions, promptly makes a kind of compound sulfamethoxazole injection for animal.
2. a kind of compound sulfamethoxazole injection for animal according to claim 1 is characterized in that described sulfanilamide is 8 weight portions to a Sulfamonomethoxine sodium, and described sulfamethoxazole is 9 weight portions.
3. a kind of compound sulfamethoxazole injection for animal according to claim 1 and 2, it is characterized in that described trimethoprim is 1 weight portion, described concentration of volume percent is that 95% ethanol is 6 weight portions, described anhydrous sodium sulfite is 0.15 weight portion, described propylene glycol is 35 weight portions, described ethanolamine is 2 weight portions, and described disodiumedetate is 0.01 weight portion.
4. the preparation method of a compound sulfamethoxazole injection for animal, its feature comprises the steps:
(1) gets propylene glycol 20-50 weight portion and be heated to 60-90 ℃, add trimethoprim 1-5 weight portion, stirring and dissolving, after being cooled to 15-30 ℃, the adding concentration of volume percent is 95% ethanol 1-10 weight portion, stir, add anhydrous sodium sulfite 0.1-0.3 weight portion, disodiumedetate 0.01-0.05 weight portion, sulfanilamide again a Sulfamonomethoxine sodium 5-12 weight portion stirring and dissolving;
(2), add the dissolving of sulfamethoxazole 5-15 weight portion with behind ethanolamine 1-5 weight portion thin up to 12 weight portion;
(3) solution that makes of combining step (1) and step (2) adds water to 1000 weight portions, promptly makes a kind of compound sulfamethoxazole injection for animal.
5. the preparation method of a kind of compound sulfamethoxazole injection for animal according to claim 4 is characterized in that described sulfanilamide is 8 weight portions to a Sulfamonomethoxine sodium, and described sulfamethoxazole is 9 weight portions.
6. according to the preparation method of claim 4 or 5 described a kind of compound sulfamethoxazole injection for animal, it is characterized in that described trimethoprim is 1 weight portion, described concentration of volume percent is that 95% ethanol is 6 weight portions, described anhydrous sodium sulfite is 0.15 weight portion, described propylene glycol is 35 weight portions, described ethanolamine is 2 weight portions, and described disodiumedetate is 0.01 weight portion.
7. the application of the described compound sulfamethoxazole injection for animal of one of claim 1-3 in preparation treatment toxoplasmosis medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100137512A CN1879633A (en) | 2006-05-18 | 2006-05-18 | Compound sulfamethoxazole injection for animal, its preparation method and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100137512A CN1879633A (en) | 2006-05-18 | 2006-05-18 | Compound sulfamethoxazole injection for animal, its preparation method and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1879633A true CN1879633A (en) | 2006-12-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006100137512A Pending CN1879633A (en) | 2006-05-18 | 2006-05-18 | Compound sulfamethoxazole injection for animal, its preparation method and use |
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| Country | Link |
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| CN (1) | CN1879633A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416935B (en) * | 2007-10-22 | 2010-12-01 | 洛阳普莱柯生物工程有限公司 | Preparation method of composite sulfamethoxydiazine suspension |
| CN103417552A (en) * | 2012-12-17 | 2013-12-04 | 华中农业大学 | Veterinary aditoprim (ADP)-sulfamethoxazole (SMZ) compound injection and preparation method thereof |
-
2006
- 2006-05-18 CN CNA2006100137512A patent/CN1879633A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416935B (en) * | 2007-10-22 | 2010-12-01 | 洛阳普莱柯生物工程有限公司 | Preparation method of composite sulfamethoxydiazine suspension |
| CN103417552A (en) * | 2012-12-17 | 2013-12-04 | 华中农业大学 | Veterinary aditoprim (ADP)-sulfamethoxazole (SMZ) compound injection and preparation method thereof |
| CN103417552B (en) * | 2012-12-17 | 2016-11-23 | 华中农业大学 | General quinoline-sulfamethoxazole compound injection and the preparation method of ending for animals |
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