CN1214909A - Complex anti-parasite medicine for animal use - Google Patents
Complex anti-parasite medicine for animal use Download PDFInfo
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- CN1214909A CN1214909A CN 98108347 CN98108347A CN1214909A CN 1214909 A CN1214909 A CN 1214909A CN 98108347 CN98108347 CN 98108347 CN 98108347 A CN98108347 A CN 98108347A CN 1214909 A CN1214909 A CN 1214909A
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- albendazole
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Abstract
The present invention relates to a compound antiparasitic medicine for animals. It is characterized by that said compound antiparasitic preparation for animals is made up by using avermectin or evermectin and albendazole through a certain preparation process, and can be made into oral powder, oral capsule, oral tablet, oral paste, oral suspension, oral, and injection emulsion and oil injection. Said invention possesses strong repelling and killing actions not only for animal internal nema and external parasite, but also for tenia and fluke, and its cost is low.
Description
The present invention relates to anti-parasite medicine for animal use, more specifically say so by the compound anti-parasitic preparation of avilamycin (AVM) or ivermectin (IVM) and the composite oral powder that forms of Albendazole (ABDZ), capsule, tablet, paste (or unguentum), suspending agent, Emulsion, injectable emulsion and oily injection.
U.S. Merck company successfully is developed as anti-parasite medicine for animal use with avilamycin and two kinds of materials of Yi Cui rhzomorph at the beginning of 80 generations, for nematicide and vermin in the body that extensively parasitizes animal (demodicid mite, Ticks, louse, fly larvae etc.) the stronger effect of killing is arranged, but they do not have the effect of killing interior cestode of body and trematodiasis.(William?C.Campbell,Ivermectin?and?Abamectin,1989,Springer-Verlag,New?York?Inc·,P215-229)。
The most of infection simultaneously of domestic animals and fowls such as pig, cattle, sheep, chicken has nematicide, trematodiasis, cestode and epizoa, therefore, between feeding period, in order to guarantee the livestock birds health normal growth, must adopt anthelmintic and drive the repeatedly anthelmintic of epizoa medicine.Up to now, still there is not a kind of folk prescription anti-parasite medicine can kill nematicide, trematodiasis, cestode and epizoa simultaneously.
Order of the present invention is to overcome the problem that prior art exists, and provides a kind of a drug can kill nematicide, trematodiasis, cestode and ectozoic compound anti-parasitic medicine in the animal body simultaneously.
Main technical schemes of the present invention: be re-dubbed by AVM or IVM and Albendazole (Albendazole) and comprise oral powder, capsule, tablet, paste, suspending agent, Emulsion, injectable emulsion and oily injection dosage form.
The present invention is 1 by the ratio of AVM or IVM in AVM or IVM and the composite antiparasitic compound preparation that makes of Albendazole and Albendazole: 10-100, and with 1: 40-60 the best.The concrete composition of various preparations and content (is 100% in various amount of formulation) are as follows:
One. oral powder
The composition of oral powder of the present invention and content: AVM or IVM0.01-2%, Albendazole 0.5-99%, antioxidant 0.01-0.1%, all the other are filler.
Described AVM is the tunning of A Foman mycin (Streptonyces avermitilis), by the mixture that eight closely similar homologues of structure are formed, generally uses B more
1a, B
1bMixture, it can adopt prior art to separate; Described IVM be avilamycin the oxygenation reduzate (William C, Campball, " Ivermectin and Abamectin ", Springer-Verlag, New York Inc., 1989, P287-310).
Described Albendazole is the commercially available prod, it is a kind of anthelmintic medicine of extensive use, the entozoic nematicide of animal body, trematodiasis and cestode are all killed effect, but epizoa (demodicid mite, Ticks, louse, fly larvae etc.) and larva invalid (the Yan Ji owner volume thereof extensively parasitic to animal, " poultry Arzneibucs ", second edition, 1997, Golden Shield publishing house).
Described antioxidant comprises dibenzylatiooluene (BHT), butylated hydroxyarisol, and they all are the commercially available prod.Described filler comprises CaCO
3, soybean cake powder.
Two. oral capsule
Oral capsule constituent content of the present invention: contain AVM or IVM0.5-10mg, Albendazole 10-500mg in every, all the other are implant.
Described implant comprises starch, CaCO
3
Three. oral tablet
The constituent content of oral tablet of the present invention: contain AVM or IVM0.5-20mg, Albendazole 10-750mg in every, all the other are excipient.
Described excipient comprises starch, dextrin, magnesium stearate.
Four. oral paste
The constituent content of oral paste of the present invention: AVM or IVM0.01-2.5%, Albendazole 0.25-80%, calcium hydrogen phosphate 0-30%, CaCO
30-20%, glycerol 10-30%, water 10-20%, sodium carboxymethyl cellulose 0.5-1.5%.
Five. the oral suspension agent
The constituent content of oral suspension agent of the present invention: AVM or IVM0.01-2%, Albendazole 0.5-60%, stabilizing agent 0.1-3%, antiseptic 0.5-2%, all the other are water.
Described stabilizing agent comprises sodium carboxymethyl cellulose, xanthan gum.
Described antiseptic comprises benzyl alcohol.
Six. Orally taken emulsion
The constituent content of Orally taken emulsion of the present invention: AVM or IVM0.01-1.5%, Albendazole 0.5-30%, glacial acetic acid 2-30%, triethanolamine are an amount of, surfactant 0.5-10%, glycerol 5-20%, ethanol 5-20%, stabilizing agent 0.1-20%, antiseptic 0.5-2%, and all the other are water.
Described surfactant comprises tween 80.
Described stabilizing agent comprises carmethose, xanthan gum.
Described antiseptic comprises benzyl alcohol.
Described triethanolamine is used to regulate the pH value of Emulsion.
Seven. injectable emulsion
The constituent content of injectable emulsion of the present invention: AVM or IVM0.05-1.5%, Albendazole 2-25%, glacial acetic acid 2-20%, triethanolamine are an amount of, surfactant 0.5-10%, glycerol 5-50%, ethanol 5-50%, and all the other are water.
Described surfactant comprises tween 80.
Described triethanolamine is used to regulate the pH value of Emulsion.
Eight. injection oil injection
Oily injection constituent content of the present invention: AVM or IVM0.05-1.0%, Albendazole 2-10%, ethyl oleate 0-10%, all the other are Oleum sesami.
Eight kinds of preparations of the present invention are method preparations routinely and use.
Major advantage of the present invention and effect:
The compound preparation that the present invention adopts AVM or IVM and Albendazole to be mixed with can be killed nematicide, trematodiasis, cestode and vermin simultaneously, thereby reduced the medication number of times, reduce production costs and drug cost, greatly make things convenient for peasant and veterinary work person in the use, be that at present existing other anthelmintic medicine and antibody epizoa medicine have vast market prospect can't be obtained.
Further specify characteristics of the present invention below by example.
Example 1
This examples preparation contains the oral administered compound powder of avilamycin 0.02% and Albendazole 0.6% (W/W).
Take by weighing 0.022kg purity and be 90% avilamycin, dibenzylatiooluene (BHT) 0.1kg, place dissolving tank, after adding the dissolving of 500ml medicinal alcohol, spray on the Albendazole (purity 95%) in 0.63kg, further mix thoroughly, add again that 100kg corn starch stirring and evenly mixing in material-compound tank gets promptly that avilamycin content is 0.02%, Albendazole content is 0.6% oral administered compound powder.
Purposes and consumption: kill cattle, sheep parasitic worm and epizoa, every 1kg body weight is taken this powder 1g, kills the epizoa of pig, and every 1kg body weight is taken this powder 1.5g.
Example 2
This examples preparation contains the oral administered compound powder of ivermectin 1.9%, Albendazole 95%.
Take by weighing 2.11kg purity and be 90% ivermectin, butylated hydroxyarisol 0.02kg, place dissolving tank, add the dissolving of 500ml medicinal alcohol after, spray afterwards on the Albendazole (purity is 95%) in 97.9kg, further mix thoroughly, add CaCO again
3To 100kg, promptly to get ivermectin content be that 1.9% Albendazole content is 95% oral administered compound powder to stirring and evenly mixing in material-compound tank.
Purposes and consumption: kill cattle, sheep parasitic worm and epizoa, every 95kg body weight is taken this product 1g, kills the epizoa of pig, and every 95kg body weight is taken this product 1.5g.
Example 3
This example is that every of preparation contains avilamycin 0.5mg, the oral capsule of Albendazole 50mg.Take by weighing purity and be 90% avilamycin 0.55kg, place dissolving tank, add 10 liters of ethyl ester ethyl esters dissolvings, with 50kg Albendazole mixing, add CaCO more afterwards
3To 200kg, mixing, the vacuum drying packing, every loading amount is 200mg.
Purposes and consumption: kill cattle, sheep parasitic worm and epizoa, every 2.5kg body weight is taken 1 of this capsule, kills the pig endoparasite and ectoparasite, and every 5kg body weight is taken 3 of this capsules.
Example 4
This example is every oral capsule that contains IVM9mg, Albendazole 480mg of preparation.
Take by weighing purity and be 90% ivermectin 9.9kg, in dissolving tank, add 10 liters of acetic acid ethyl dissolutions, with 480kg Albendazole mixing, add starch more afterwards to 500kg, mixing, vacuum drying, packing, every loading amount is 500mg.
Purposes and consumption: kill cattle, sheep parasitic worm and epizoa, every 45kg body weight is taken 1 of this capsule, kills the pig endoparasite and ectoparasite, and every 90kg body weight is taken 3 of this capsules.
Example 5
This example is that every of preparation contains ivermectin 1mg, the oral tablet of Albendazole 30mg.
Take by weighing purity and be 92% ivermectin 0.11kg, place dissolving tank, add 5 liters of dissolvings of ethanol, spray afterwards on the 20kg starch, in agitator tank, stir, add 3kg Albendazole, 10kg dextrin, 2kg magnesium stearate afterwards, stirring and evenly mixing, pelletize, tabletting, every heavy 350mg (containing ivermectin 1mg, Albendazole 30mg).
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, the 5kg body weight is with 1.
Example 6
This example is every oral tablet that contains IVM15mg, Albendazole 700mg of preparation.
Take by weighing purity and be 92% ivermectin 15.6kg, place dissolving tank, add 20 liters of dissolvings of ethanol, spray afterwards on the 70kg starch, in agitator tank, stir, add 700kg Albendazole, 20kg dextrin, 10kg magnesium stearate afterwards, stirring and evenly mixing, pelletize, tabletting, every heavy 800mg (containing ivermectin 15mg, Albendazole 750mg)
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, the 75kg body weight is with 1.
Example 7
This example is that preparation contains avilamycin 0.1%, the oral paste of Albendazole 5.0%.
The avilamycin that takes by weighing 0.11kg92% adds 1 liter of ethanol, heating for dissolving, add 30 liters of glycerol, mixing, add the 5.3kg Albendazole, add 30kg calcium hydrogen phosphate and 20kg calcium carbonate again, add 100 liters of aqueous solutions that contain the 1.5kg carboxymethyl cellulose, stir, promptly get oral paste after grinding with colloid mill.
Purposes and consumption: kill sheep endoparasitism anthelmintic and vermin, the 5kg body weight is taken 1g.
Example 8
This example is that preparation contains ivermectin 2.5%, the oral paste of Albendazole 75%.
3 liters of ethanol are gone into by the ivermectin state of getting 2.7kg92%, and heating for dissolving adds 10 liters of glycerol, mixing adds the 75kg Albendazole, adds 2kg phosphoric acid again, add the aqueous solution to 100 liter contain the 0.5kg carboxymethyl cellulose, stir, promptly get oral paste after grinding with colloid mill.
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, 25kg body weight 0.2g.
Example 9
This example is that preparation contains avilamycin 0.02%, the oral suspension agent of Albendazole 1%.
Take by weighing 0.022kg avilamycin (purity 90%) and add 0.5 liter of dissolve with ethanol, add 20 liter 1, the 2-propylene glycol, 0.05 liter of benzyl alcohol, the 1kg Albendazole adds 0.3% xanthan glue and mends to 100 liters, and stirring and evenly mixing gets final product.
Purposes and consumption: kill sheep endoparasitism anthelmintic and vermin, the 1kg body weight is taken 1ml.
Example 10
This example is the oral suspension agent that preparation contains IVM1.8%, Albendazole 60%.
Get 2.0kg ivermectin (purity 90%) and add 1 liter of dissolve with ethanol, add 20 liter 1, the 2-propylene glycol, 1 liter of benzyl alcohol, the 60kg Albendazole adds 2.5% sodium carboxymethyl cellulose liquid and mends to 100 liters, and stirring and evenly mixing gets final product.
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, 90kg body weight 1ml.
Example 11
This example is the Orally taken emulsion that preparation contains avilamycin 0.05%, Albendazole 2.5%.
Get 0.055 kilogram of ivermectin (purity is 90%) in dissolving tank, add the dissolvings of 2 liters of alcohol, must solution A.Other get 2.55 kilograms of Albendazoles with the dissolving of 28 liters of glacial acetic acids after, add triethanolamine PH transferred to 4-5, add tween 80 2kg afterwards, mixing adds 7kg glycerol and 2kg benzyl alcohol again, get solution B, mend to 100 liters with 0.3% xanthan glue after A liquid is mixed with B liquid.
Purposes and consumption: kill sheep endoparasitism anthelmintic and vermin, the 10kg body weight is taken 4ml.
Example 12
This example is the Orally taken emulsion that preparation contains ivermectin 1.5%, Albendazole 30%.
Get 1.66 kilograms of ivermectins (purity is 90%) in dissolving tank, add 18 liters of dissolve with ethanols it, solution A.The Albendazole that other gets 31.5 kilograms (purity is 95%) with 5 liters of glacial acetic acids dissolvings after, add three ethanol wrists pH is transferred to 4-5, add 8 kilograms of tween 80s afterwards, mixing, add 18kg glycerol and 0.5kg benzyl alcohol again, get solution B, mend to 100 liters with 2% sodium carboxymethyl cellulose liquid after A liquid is mixed with B liquid.
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, 75kg body weight 1ml.
Example 13
This example is the injectable emulsion that preparation contains avilamycin 0.1%, Albendazole 5.0%.
Get 0.11 kilogram of avilamycin (purity is 90%) in dissolving tank, add 5 liters of dissolve with ethanols it, solution A.Other get 5.5 kilograms of Albendazoles with the dissolving of 18 liters of glacial acetic acids after, add triethanolamine PH be transferred to 4-5, add 8 kilograms of tween 80s afterwards, mixing adds the 45kg glycerol again and gets solution B, and A liquid is mixed with B liquid afterwards with 0.3% xanthan glue benefit to 100 liters.
Purposes and consumption: kill sheep endoparasitism anthelmintic and vermin, this Emulsion of 10kg body weight injection 2ml.
Example 14
This example is the injectable emulsion that preparation contains ivermectin 1.2%, Albendazole 24%.
Get 1.33 kilograms of ivermectins (purity is 90%) in dissolving tank, add 48 liters of dissolve with ethanols it, solution A.Other get 25.3 kilograms of (purity is 95%) Albendazoles with the dissolving of 4 liters of glacial acetic acids after, add triethanolamine pH be transferred to 4-5, add 2 kilograms of tween 80s afterwards, mixing, add the 8kg glycerol again, get solution B, mend to 100 liters with 2% sodium carboxymethyl cellulose liquid after A liquid is mixed with B liquid.
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, 60kg body weight 1ml.
Example 15
This example is the injection oil injection of preparation avilamycin 0.1%, Albendazole 5%.
Getting 5.5 kilograms of Albendazoles adds 40 liters of Oleum sesami and is ground to the Albendazole granule gets the Albendazole oil suspension less than 5 μ m in sand mill.Other gets 0.11 kilogram of avilamycin (purity is 90%) and dissolves with 2 liters of ethyl oleate, adds 30 liters of Oleum sesami mixings afterwards, and this oil solution is mixed with the Albendazole oil suspension, adds Oleum sesami to 100 again and liter gets final product.
Purposes and consumption: kill sheep endoparasitism anthelmintic and vermin, 5kg body weight injection 1ml.
Example 16
This example is the injection oil injection that preparation contains ivermectin 1.0%, Albendazole 10%.
Getting 10.5 kilograms of Albendazoles (purity is 95%) adds 40 liters of Oleum sesami and is ground to the Albendazole granule gets the Albendazole oil suspension less than 5 μ m in sand mill.Other gets 1.11 kilograms of ivermectins (purity is 90%) and dissolves with 10 liters of ethyl oleate, adds 30 liters of Oleum sesami mixings afterwards, and this oil solution is mixed with the Albendazole oil suspension, adds Oleum sesami to 100 liter more promptly.
Purposes and consumption: kill sheep entozoa (anthelmintic) and vermin, 50kg body weight 1ml.
Example 17
This example is done the comparison of drug effect aspect to the complex preparation among the present invention and avilamycin, ivermectin and the agent of Albendazole list.Choose healthy laboratory animal, after the random packet respectively by the conventional method of nematicide, cestode and trematodiasis counting and calculate deworming rates respectively.
Each preparation of table 1. is to the effect of anthelmintic and external acarid in the sheep body
| Dosage form | Dosage (mg/kg) | Deworming rates (%) | ||||||
| AVM/ IVM | ?ABDZ | Haemonchus contortus | Trichostrongylus colubriformis | The first nematicide of sheep's wool | The Moritz cestode | Distoma hepaticum | Psoroptes communis | |
| Oral powder in the example 1 | 0.2 | ?10 | ?100 | ?100 | ?91.5 | ?100 | ?100 | ?95.1 |
| The A Fuding powder | 0.2 | ?100 | ?100 | ?92.0 | ?0 | ?0 | ?94.2 | |
| Capsule in the example 3 | 0.2 | ?10 | ?100 | ?100 | ?90.5 | ?100 | ?100 | ?93.6 |
| The Yi Fuding capsule | 0.2 | ?100 | ?100 | ?90.2 | ?0 | ?0 | ?93.5 | |
| Tablet in the example 5 | 0.2 | ?10 | ?100 | ?100 | ?92.1 | ?100 | ?100 | ?94.1 |
| The Albendazole tablet | ?- | ?15 | 100 | ?100 | ?89.7 | ?100 | ?100 | ?0 |
| Paste in the example 7 | 0.2 | ?10 | ?100 | ?100 | ?90.7 | ?100 | ?100 | ?94.4 |
| Suspending agent in the example 9 | 0.2 | ?10 | ?100 | ?100 | ?89.9 | ?100 | ?100 | ?95.2 |
| Orally taken emulsion in the example 11 | 0.2 | ?10 | ?100 | ?100 | ?90.5 | ?100 | ?100 | ?95.0 |
| Injectable emulsion in the example 13 | 0.2 | ?10 | ?100 | ?100 | ?92.6 | ?100 | ?100 | ?94.3 |
| Oily injection in the example 15 | 0.2 | ?10 | ?100 | ?100 | ?94.2 | ?100 | ?100 | ?96.2 |
Annotate: the A Fuding powder is commercially available avilamycin powder (New Tech. Development General Co., Beijing Agriculture Univ.'s production).The Yi Fuding capsule is commercially available avilamycin capsule (New Tech. Development General Co., Beijing Agriculture Univ.'s production).The Albendazole tablet is commercially available prod (the military Mantidis in Gansu pharmaceutical factory produces).
By the result of this example as seen, after avilamycin or ivermectin and Albendazole are re-dubbed compound preparation, can kill nematicide, trematodiasis, cestode and external acarid in the body simultaneously, and avilamycin, the agent of ivermectin list are invalid to cestode, trematodiasis, Albendazole is invalid to external demodicid mite, illustrate to have enlarged insecticidal spectrum after composite, so just reduce the medication number of times, reduce production costs and use cost.
Claims (9)
1. anti-parasite medicine for animal use that contains avilamycin or ivermectin, it is characterized in that it being by containing the preparation that avilamycin or ivermectin and Albendazole component are re-dubbed oral powder, oral capsule, oral tablet, oral paste, oral suspension agent, Orally taken emulsion, injectable emulsion and oily injection, avilamycin in the preparation or ivermectin and Albendazole weight ratio are 1: 10-100.
2. according to the described antiparasitic of claim 1, the component and the content (is 100 in powder weight) that it is characterized in that described oral powder: all the other are filler for avilamycin or ivermectin 0.01-2%, Albendazole 0.5-99%, antioxidant 0.01-0.1%, described antioxidant comprises dibenzylatiooluene, and described filler comprises CaCO
3, starch, soybean cake powder.
3. according to the described antiparasitic of claim 1, the component and the content that it is characterized in that described oral capsule: every capsules contains avilamycin or ivermectin 0.5-10mg, Albendazole 10-500mg, all the other are implant, and described implant comprises starch, caco
3
4. according to the described antiparasitic of claim 1, the component and the content that it is characterized in that described oral tablet: every middle avilamycin or ivermectin 0.5-20mg, Albendazole 10-750mg, all the other are excipient, and described excipient comprises starch, dextrin, magnesium stearate.
5. according to the described antiparasitic of claim 1, it is characterized in that the component and the content (is 100 in paste weight) of described oral paste: avilamycin or ivermectin 0.01-2.5%, Albendazole 0.25-80%, calcium hydrogen phosphate 0-30%, caco
30-20%, glycerol 10-30%, sodium carboxymethyl cellulose 0.5-1.5%, water 10-20%.
6. according to the described antiparasitic of claim 1, the component and the content (is 100 in suspending agent weight) that it is characterized in that described oral suspension agent: avilamycin or ivermectin 0.01-2%, Albendazole 0.5-60%, stabilizing agent 0.1-3%, antiseptic 0.5-2%, all the other are water, described stabilizing agent comprises sodium carboxymethyl cellulose, xanthan gum, and described antiseptic comprises benzyl alcohol.
7. according to the described antiparasitic of claim 1, the component and the content (is 100 in Emulsion weight) that it is characterized in that described Orally taken emulsion: avilamycin or ivermectin 0.01-1.5%, Albendazole 0.5-30%, glacial acetic acid 2-30%, surfactant 0.5-10%, glycerol 5-20%, ethanol 5-20%, stabilizing agent 0.1-20%, antiseptic 0.5-2%, the triethanolamine that is used to regulate PH is an amount of, all the other are water, described surfactant comprises tween 80, described stabilizing agent comprises sodium carboxymethyl cellulose, xanthan gum, described antiseptic comprises benzyl alcohol.
8. according to the described antiparasitic of claim 1, the component and the content (is 100 in Emulsion weight) that it is characterized in that described injectable emulsion: the triethanolamine that avilamycin or ivermectin 0.05-1.5%, Albendazole 2-25%, glacial acetic acid 2-20%, surfactant 0.5-10%, glycerol 5-50%, ethanol 5-50%, adjusting PH use is an amount of, all the other are water, and described surfactant comprises tween 80.
9. according to the described antiparasitic of claim 1, the component and the content (is 100 in injection weight) that it is characterized in that described oily injection: avilamycin or ivermectin 0.05-1.0%, Albendazole 2-10%, ethyl oleate 0-10%, all the other are Oleum sesami.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98108347 CN1214909A (en) | 1998-05-14 | 1998-05-14 | Complex anti-parasite medicine for animal use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98108347 CN1214909A (en) | 1998-05-14 | 1998-05-14 | Complex anti-parasite medicine for animal use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1214909A true CN1214909A (en) | 1999-04-28 |
Family
ID=5219603
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 98108347 Pending CN1214909A (en) | 1998-05-14 | 1998-05-14 | Complex anti-parasite medicine for animal use |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004043445A1 (en) * | 2002-11-11 | 2004-05-27 | Schering-Plough Ltd. | Topical parasiticide formulations and methods of treatment |
| CN101268810B (en) * | 2008-05-16 | 2012-02-29 | 赵光政 | Composite prebiotics feed additive |
| CN103083348A (en) * | 2012-05-10 | 2013-05-08 | 重庆金邦动物药业有限公司 | Albendazole/ivermectin powder for livestock |
| CN103599119A (en) * | 2012-05-10 | 2014-02-26 | 四川德润通生物科技有限公司 | Preparation method of veterinary albendazole/ivermectin dry suspension |
| CN103599118A (en) * | 2012-05-10 | 2014-02-26 | 四川德润通生物科技有限公司 | Veterinary albendazole/ivermectin dry suspension |
| CN108013239A (en) * | 2018-01-19 | 2018-05-11 | 福建小薇金匙科技孵化有限公司 | A kind of nutrition fermented feed processing method for having sheep endoparasite prophylactic-therapeutic effect concurrently |
| CN109329077A (en) * | 2018-09-27 | 2019-02-15 | 江苏省协同医药生物工程有限责任公司 | A kind of anti parasitic experimental animal padding and preparation method thereof |
-
1998
- 1998-05-14 CN CN 98108347 patent/CN1214909A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004043445A1 (en) * | 2002-11-11 | 2004-05-27 | Schering-Plough Ltd. | Topical parasiticide formulations and methods of treatment |
| CN101268810B (en) * | 2008-05-16 | 2012-02-29 | 赵光政 | Composite prebiotics feed additive |
| CN103083348A (en) * | 2012-05-10 | 2013-05-08 | 重庆金邦动物药业有限公司 | Albendazole/ivermectin powder for livestock |
| CN103599119A (en) * | 2012-05-10 | 2014-02-26 | 四川德润通生物科技有限公司 | Preparation method of veterinary albendazole/ivermectin dry suspension |
| CN103599118A (en) * | 2012-05-10 | 2014-02-26 | 四川德润通生物科技有限公司 | Veterinary albendazole/ivermectin dry suspension |
| CN108013239A (en) * | 2018-01-19 | 2018-05-11 | 福建小薇金匙科技孵化有限公司 | A kind of nutrition fermented feed processing method for having sheep endoparasite prophylactic-therapeutic effect concurrently |
| CN109329077A (en) * | 2018-09-27 | 2019-02-15 | 江苏省协同医药生物工程有限责任公司 | A kind of anti parasitic experimental animal padding and preparation method thereof |
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