KR101687973B1

KR101687973B1 - Method for manufacturing premix for livestock feed using microfilm coating

Info

Publication number: KR101687973B1
Application number: KR1020150174296A
Authority: KR
Inventors: 노상현; 김동연
Original assignee: 주식회사 씨티씨바이오
Priority date: 2015-12-08
Filing date: 2015-12-08
Publication date: 2016-12-21

Abstract

The present invention relates to a method for preparing a premix for animal feed using a microfilm coating and a premix for animal feed prepared thereby. When the premix prepared by the production method of the present invention is added to the feed, it is possible to add a premix having a large amount of antiparasitic activity, to improve the mixing property of the antiparasitic agent with the antiparasitic effect, Can be obtained.

Description

TECHNICAL FIELD The present invention relates to a method for manufacturing a premix for animal feed using a microfilm coating,

The present invention relates to a method for preparing a premix for animal feed using a microfilm coating and a premix for animal feed prepared thereby.

Animals such as mammals and birds are often susceptible to parasites. These parasites include ectoparasites such as insects, and endoparasites such as insects and insects. Domesticated animals such as cats and dogs can be infected with cats and dogs such as fleas, ticks, mite, and the like. Fleas are particularly problematic because they cause high psychological stress as well as adversely affecting the health of animals and humans. Furthermore, fleas are carriers of pathogens of animals and humans, such as Dipylidium caninum. Similarly, ticks are also detrimental to the physical and psychological health of animals or people. However, the most serious problem associated with ticks is the carrier of pathogens causing disease in both humans and animals. The main diseases that ticks can cause are Borrelia, Babes fever, and Rickettsia. Mites also secrete toxins that cause inflammation or paralysis in the host. Often, the toxin is fatal to the host, for example the case of the Australian paralyzed tick Ixodes holocyclus. In addition, it is particularly difficult to eradicate, since mite and this are rarely active substances that act on these parasites and require frequent treatment.

Likewise, farm animals are also susceptible to parasites. For example, cattle infect a large number of parasites. Similarly, arthropod pests, such as fleas, mites and ticks, infect poultry. The parasites most commonly found among farm animals are the tick mites (Boophilus), especially tick mites (cattle tick, decoloratus and anulatus) of the tick species.

In addition, animals and humans suffer from parasitic infections, including helminthiasis, most commonly caused by a group of parasitic worms described as nematodes or roundworms. These parasites are serious in pigs, sheep, horses and cattle, resulting in massive economic losses. In particular, in the case of pigs, the larvae infect the whole body through the portal vein, and in the case of abolished lungs, lay eggs in the lungs, causing mechanical damage to the lungs. In addition, these parasites cause induction of intestinal epithelial cell damage, smooth feed digestion, absorption interference, and absorption of energy in the intestinal feed instead, thereby lowering feed efficiency. In addition, the external parasite, om, affects the papillary zone of piglets, and ovulation treatment before delivery reduces the age of delivery by more than a week. These parasites also affect the immune system of the pigs and cause huge damage to the farmhouse. The beneficial effects of insecticide infestation on average can increase the number of survivors by 1.8 or more, reduce the number of quadrants by 1.5 or more, increase the mean value of money by 0.2 kg, It is reported that it can increase more than two and can increase the weight of the reason more than 0.8kg.

Also, when treating OM, you can get an economic benefit of 18,445 won per bird. Farmers are reported to be able to earn an average of 258,000 won per year. Therefore, it is a very important task in livestock industry.

Meanwhile, various insect repellents have been developed and are currently on the market. Penbendazole and fluvendazole are antiparasitic agents that inhibit parasitic nutrition by inhibiting parasitic nutrition. However, the range of parasitism is limited to internal parasites, and there is a side effect that can affect the microtubules of the pigs. Another insecticide, ivermectin, parasitizes parasympathetic nerves and muscles, excelling in parasite specificity, and effective in both internal and external parasites. Generally, the parasitic active ingredient is used with excipients. However, when the antiparasitic component and the excipient are simply mixed and used, the excipient and the active ingredient are present separately. Thus, the active ingredient is not evenly distributed in the drug. This poor mixability seriously lowers the insecticidal efficiency of insecticides. Therefore, it is considered that increasing the efficiency of the parrot is an important task in the parasite eradication.

Therefore, the inventors of the present invention have found that when the microfilm coating method is applied to the insect repellent, the mixing property is improved while continuing research to find a method for enhancing the antiparasitic effect of the antiparasitic agent.

U.S. Patent No. 4,310,519 Korean Patent Publication No. 10-2005-0059235

Accordingly, it is an object of the present invention to provide a premix for an animal feed and an improved method for preparing a premix with improved mixing of the excipient with parenteral efficacy.

A) a coating mixture comprising a liquefying agent, a binder, a stabilizer and a paracellitic active material; And

b) a first excipient layer comprised of a first excipient coated with the coating mixture.

When the premix of the present invention is added to a feed, it is possible to add a premix having a large amount of the antiparasitic activity, and the mixing effect of the antiparasitic agent with the antiparasitic agent is improved, and a highly effective antiparasitic effect can be obtained And Fig. 2).

Hereinafter, the present invention will be described in detail.

In the present invention, a premix refers to a mixture comprising a first excipient layer composed of a first excipient coated on a coating mixture comprising a paracetamol active material, and may be included in a single feed or a mixture thereof. The premix of the present invention can be added to the feed in the form of a feed concentrate. In the case of animals, the premix of the present invention can be included in feed through feed or beverage. The premixes of the present invention can be administered in the form of conventional concentrations and formulations with feed or feed formulations or beverages. Parasitic infections can be prevented, alleviated, and / or treated by the above methods, and particularly excellent efficacy of suppressing or eradicating parasites can be promoted to improve animal growth and feed utilization.

In the present invention, the term "premix" has been used as a preliminary mixture prior to addition to the feed. In the present invention, the animal is not particularly limited, but is preferably a livestock animal, more preferably a pig, a sheep, a horse and a cow.

The term " antiparasitic < / RTI > active ingredient "in the present invention means any substance having an activity capable of eradicating or suppressing parasites, including all other terms, preferably comprising an avermectin derivative, And is preferably ivermectin. The basic avermectin derivative can be obtained from the fermentation broth of the microorganism Streptomyces avermitilis, and the formula of the avermectin derivative is well described in Korean Patent No. 10-2000-0007611. The avermectin derivatives described in the above patent documents can be selectively reduced to produce ivermectin compounds. Ivermectin is a highly effective anti-parasitic agent useful against a wide variety of mammalian extracorporeal and internal parasites, as well as agricultural applications for various parasites in crops and soils. Ivermectin is a mixture of 22, 23-dihydro C-076B1a and B1b in a ratio of about 80:20. Ivermectin is isolated from the fermentation broth of microorganisms and is active against in vitro parasites and body parasites in livestock. The separation and purification of this compound is described in U.S. Patent No. 4,310,519, issued January 12, 1982. Since all of the avermectin derivative compounds described above are only slightly different in their biologically active range of ivermectin compounds, the processes and formulations of the present invention can be applied to all of them. Ivermectin of the present invention is an active substance that parasites parasites by inhibiting neuronal transmission between neurons and muscle cells by increasing GABA (gamma-aminobutyric acid).

The above-mentioned ivermectin may preferably be 0.6 to 5% of the total premix weight.

Also, in the present invention, the first excipient means an excipient coated on the surface by a coating mixture. In the present invention, when the first excipient is coated on the surface by the coating mixture, this is called the first excipient layer. The first excipient may also be an inorganic and organic material which is an inert replacement material. Inorganic materials include, for example, conventional salts, carbonates such as calcium carbonate, bicarbonates, aluminum oxide, silica, alumina, precipitated or colloidal silicon dioxide and phosphates. Organic materials include, for example, sugars, celluloses, food for feed and feed such as powdered milk, animal bovine, ground grain flour, and destroyed grain flour and starch. More preferably, corn borer may be used.

In addition, the premix of the present invention may additionally comprise a second excipient layer. In the present invention, the second excipient means an excipient which is used to dilute the first excipient layer after the coating process unlike the first excipient. Means an excipient that has not been coated by the coating mixture, and the ingredients may be the same as the first excipient. Thus, the premix of the present invention can consist of a first excipient layer coated with the coating mixture and a second excipient layer not coated with the coating mixture. If the second excipient layer is additionally included in the premix, the weight of the first excipient layer and the second excipient layer, excluding the weight of ivermectin in the premix, may be between 90% and 99.9%. Preferably, the weight of ivermectin may be 0.6%, and the weight of the first excipient layer and the second excipient excluding ivermectin is 99.4% of the total premix weight.

In the present invention, the stabilizer serves to prevent acid or base catalytic decomposition of the repellent substance, and serves as a lubricant and buffer in the coating liquid of the present invention. Stabilizers include acids or bases, and may be acids or bases. The organic acid and base used in the present invention can be an anhydride or a hydrate (mono-, di-, tri-, tetra-, penta-, hexa, hepta etc.). The term "acid " encompasses any pharmaceutical or veterinarily acceptable inorganic or organic acid. Inorganic acids include mineral acids such as hydrohalic acids such as hydrobromic acid and hydrochloric acid, sulfuric acid, phosphoric acid and nitric acid. Organic acids include all pharmacologically or veterinarily-acceptable aliphatic, cycloaliphatic and aromatic carboxylic acids, dicarboxylic acids, tricarboxylic acids and fatty acids. Preferred acids are linear or branched, saturated or unsaturated C1-C20 aliphatic carboxylic acids optionally substituted with halogen or hydroxy groups, or C6-C12 aromatic carboxylic acids. Examples of such acids are carbonic acid, formic acid, fumaric acid, acetic acid, propionic acid, isopropionic acid, valeric acid, alpha -hydroxy acids such as glycolic acid, thioglycolic acid and lactic acid, chloroacetic acid, benzoic acid, methanesulfonic acid, and salicylic acid. Examples of dicarboxylic acids include oxalic acid, malic acid, succinic acid, tartaric acid, and maleic acid. An example of a tricarboxylic acid is citric acid. Fatty acids include saturated or unsaturated aliphatic or aromatic carboxylic acids of any pharmaceutical or veterinarily-acceptable 4 to 24 carbon atoms. Examples include butyric, isobutyric, sec-butyric, lauric, palmitic, stearic, oleic, linoleic, linolenic, and phenylsteric acid. Other acids include gluconic acid, glycoheptonic acid and lactobionic acid, gallic acid, salicylic acid, malonic acid, ascorbic acid, isoascorbic acid, or mixtures thereof. The term "base " encompasses any pharmaceutical or veterinarily acceptable inorganic or organic base. Such bases include, for example, alkali metal and alkaline earth metal salts such as lithium, sodium, potassium, magnesium or calcium salts. Organic bases include conventional hydrocarbyl and heterocyclic amine salts, including, for example, morpholine and piperidine salts. In the present invention, the stabilizer is preferably propylene glycol. The weight of the stabilizer of the present invention is preferably 0.1 to 0.5% by weight based on the total weight of the premix, but is not limited thereto.

In the present invention, the binder acts as an adhesive to bond the coating mixture. The binder of the present invention is based on hypromellose (hydroxypropylmethyl cellulose), hydroxypropyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol (PVA), PVA Polyvinylpyrrolidone-vinyl acetate copolymer (copovidone), polyvinylacetate phthalate, methacrylic acid copolymers, methacrylate copolymer, and the like. Or a mixture thereof, but is most preferably hypromellose.

In the present invention, the liquefying agent serves to liquefy and dissolve the coating mixture, and may include all kinds of solvents, but is most preferably ethanol.

In the present invention, the absorption promoter can be produced by reacting a large number of surfactants having hydrophobic or hydrophilic properties with alcohols or polyalcohols with various natural and / or hydrogenated oils. The most commonly used oils are castor oil or hydrogenated castor oil or edible vegetable oils such as corn oil, olive oil, peanut oil, palm kernel oil, apricot seed oil, soybean oil, or almond oil. Preferred alcohols include glycerol, propylene glycol, ethylene glycol, polyethylene glycol, sorbitol, and pentaerythritol. Of these alcohol-oil transesterified surfactants, preferred hydrophilic surfactants are PEG-35 Incrocas-35, PEG-40 Hydrogenated Cremophor RH 40, PEG-25 Triolate PEG-60 corn glyceride (Crovol M70), PEG-60 almond oil (Crovol A70), PEG-40 palm kernel oil (Crovol PK70), PEG-50 castor oil (Emalex C- -50 hydrogenated castor oil (Emalex HC-50), PEG-8 caprylic / capric acid glyceride (Labrasol), and PEG-6 caprylic / capric acid glyceride (Softigen 767). Preferred hydrophobic surfactants in this class include PEG-5 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-9 hydrogenated castor oil, PEG-6 corn oil (Labrafil.TM. M 2125 CS), PEG- (Labrafil.RTM.M 1966 CS), PEG-6 apricot seed oil (Labrafil.RTM.M 1944 CS), PEG-6 olive oil (Labrafil.

RTM. M 1980 CS), PEG-6 peanut oil (Labrafil.RTM.M 1969 CS), PEG-6 hydrogenated palm kernel oil (Labrafil.RTM.M 2130 BS), PEG-6 palm kernel oil PEG-20 corn oil, PEG-20 corn glyceride (Crovol M40), and PEG-20 almond glyceride (Labrafil.RTM.M 2735 CS) (Crovol A40) (see Fig. 3).

The present invention also provides a method for preparing a premix for animal feed using microfilm coating.

The production method of the present invention will be described in detail. First, the micro-coater 100 will be described with reference to FIGS. 4 and 5. FIG. In the present invention, the term "microcoating machine " refers to a device that performs microfilm coating, preferably FLUDIZED BED COATER .

remind The coater includes a chamber 110, a rotor 120, a spray nozzle 130, an air inlet 140, an outlet 150, a metering pump 160, and the like.

The chamber 110 means a space for coating, and may further include an air outlet, a filter, and the like.

The rotor 120 facilitates the circulation of the air to facilitate the movement of the particles to facilitate coating

The coating liquid (coating mixture) is sprayed through the spray nozzle 130 using the metering pump 160. The spraying method includes a bottom spray, a top spray, and a drum spray. And this is a method well known in the art, and the injection method of the present invention is not limited to the above-mentioned one method.

The air inlet 140 is a passage through which air is introduced, and generally, dry air is introduced. In the present invention, when the coating is completed, the coated pre-mix can be obtained through the outlet (150).

Hereinafter, the manufacturing process of the present invention will be described in detail.

After the liquefying agent and the parasitic active material are stirred and dissolved for 10 to 30 minutes, the stabilizer and the binder are stirred and dissolved in the dissolved mixture for 140 to 200 minutes to prepare a coating liquid (coating mixture). Thereafter, the excipient is injected into the chamber 110 of the micro-coater, and the coating mixture is injected into the chamber 110 of the micro-coater through the spray nozzle 130 using the dosing pump 160. Thereafter, while spraying, the coating agent is allowed to react with the excipient in the chamber for 100 to 300 minutes. The coated premix can be discharged to the discharge port and packed (refer to FIG. 6).

In addition, the manufacturing process of the present invention may further include a step of diluting the discharged pre-coated coating with the excipient.

When a premix prepared by using the microfilm coating method of the present invention is added to a feed, it is possible to add a premix having a large amount of antiparasitic activity, and it is possible to add a premix having a large amount of antiparasitic activity, And the parasitic effect of high efficiency can be obtained.

FIG. 1 is a diagram illustrating a difference between a premix to which the technique of the present invention is applied and a premix to which the technique is not applied.
2 is a view showing a structure of a premix according to one embodiment of the present invention.
Fig. 3 shows the effect of adding the premix of the present invention to feed. Fig.
4 is a view illustrating a process of manufacturing the premix of the present invention.
5 is a view showing a micro-coater for manufacturing the premix of the present invention.
6 is a schematic view of a micro-coater for producing the premix of the present invention.

The following examples illustrate the preparation of the compositions of the present invention, but should not be construed as limiting the scope of the invention.

[ Example 1] Mixability Improved animal feed Premix Produce

29 kg of ethanol was mixed with 2.5 kg of ivermectin and dissolved by stirring for 20 minutes. Subsequently, 2 kg of Hypromellose 2910 (KG) and 0.2 kg of propylene glycol were added to the dissolved mixture, and the mixture was stirred and dissolved for 160 minutes to prepare a coating solution (coating mixture). Thereafter, the coating solution was sieved for 10 minutes, 100 kg of Kongris 3 (KG) as an excipient was introduced into the chamber of the micro-coater, and the coating mixture was injected into the chamber of the micro-coater through a spray nozzle using a metering pump Respectively. Thereafter, while the injection was proceeded, the excipient and the coating mixture were stirred and reacted in the chamber for 200 minutes. After the coated premix was discharged to the discharge port, the discharged premix was further diluted with ConglyS 3 and then packed. The premix of the present invention has improved mixing properties with excipients and ivermectin.

[ Example 2] Mixability Improved animal feed Premix Add to feed

The premix prepared in Example 1 and the feed were mixed. Specifically, the premix of the present invention was mixed and used as shown in Table 1 below.

[Table 1]

[ Experimental Example 1] Bonn Invention Pro Mix Identification of parasite eradication effects of included feed

After the feeds were prepared, feeds containing the premix of the present invention for the first 7 days were given, and the next 7 days were discontinued. After that, feeds containing the premix were given for 7 days. As a result, the larvae and larvae were not relieved in the first 7 days, but the larvae and larvae grew within 7 days of rest, The growing chest was rescued. Therefore, it was confirmed that parasites can be completely removed through the 7-7-7 program.

100: Micro Coater
110: chamber
120: rotor
130: Spray nozzle
140: air inlet
150: Outlet
160:

Claims

Wherein the first excipient is coated on the surface of the first excipient by a coating mixture comprising a liquefying agent, a binder, a stabilizer, and a paracetamol active material, wherein the first excipient is corn, the liquefying agent is ethanol, Characterized in that the binder is hyrommelose, the stabilizer is propylene glycol, the antiparasitic active substance is ivermectic, and the ivermectic is contained by 0.6% of the combined weight of the first excipient and the first excipient layer Premix for animal feed.

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The premix for animal feed according to claim 1, further comprising an absorption promoter in the mixture.

The premix for animal feed according to claim 1, characterized in that the premix further comprises a second excipient layer for diluting the first excipient layer.

The premix for animal feed according to claim 8, characterized in that the second carrier layer consists of corn.

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1) introducing the corn as a first excipient into the chamber of the micro-coater;
2) injecting a coating mixture containing ethanol as a liquefying agent, hi-promoose as a binder, propylene glycol as a stabilizer, and ivermectic as a retroviral active material into a chamber of a micro-coater through a spray nozzle using a metering pump;
3) reacting the first excipient and the coating mixture in the chamber for 100 minutes to 300 minutes,
The coating mixture may contain,
a) stirring and dissolving ethanol and ibuprofen for 10 to 30 minutes; And
b) dissolving propylene glycol and hypromellose in the mixture obtained in the process a) for 140 to 200 minutes to dissolve the mixture.

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12. The method according to claim 11, wherein the coating mixture in the second step further comprises an absorption promoter.

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12. The method of claim 11, further comprising discharging the reactant obtained through the reaction of the third step through the outlet, and diluting the discharged reactant with the second excipient.