CN107279143B - A kind of miticide composition containing gossypol - Google Patents
A kind of miticide composition containing gossypol Download PDFInfo
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- CN107279143B CN107279143B CN201710563597.4A CN201710563597A CN107279143B CN 107279143 B CN107279143 B CN 107279143B CN 201710563597 A CN201710563597 A CN 201710563597A CN 107279143 B CN107279143 B CN 107279143B
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- gossypol
- envidor
- miticide composition
- composition containing
- miticide
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
Abstract
The present invention provides a kind of miticide composition containing gossypol, active ingredient is gossypol and Envidor；The gossypol and the mass ratio of Envidor are 1:10-50；The total content of the active ingredient is 5.5-52 w.t %, remaining is auxiliary material.The dosage form of the miticide composition is selected from one of wettable powder (WP), water dispersible granules (WDG), microemulsion (ME), aqueous emulsion (EW) or suspending agent (SC).Miticide composition containing gossypol of the invention, good to various crop phytophagous harmful mite effects, field efficacy is high, consumption of chemical agent is few, and to plant and safety of human and livestock, Practice for Pesticide Residue in Agricultural Products amount is low.
Description
Technical field
The present invention relates to a kind of miticide compositions containing gossypol, belong to chemical protection of plant field.
Background technique
Cotton spider mites are also known as cotton red spider, and based on Tetranychus cinnabarinus, there is generation in each cotton region in China, in addition to endangering cotton,
Also endanger corn, sorghum, wheat, soybean etc..Host is extensive.Cotton spider mites mainly in cotton leaf surface back piercing and sucking juice, make blade face
There are the hazard symptoms such as macula lutea, red autumnal leaves and fallen leaves, likeness in form is burnt, and " flue " is commonly called as.Cotton spider mites all may be used in cotton entire breeding time
Harm, breaks out the time, causes to drop in production over a large area and even have no harvest.Resistance is heavier at present, and effective agent is few.Tetranychus urticae is also known as white spider
Spider is a kind of important worldwide harmful mite.The mite is also easy to produce drug resistance to chemical pesticide, the Tetranychus urticae on Australian cotton
After Bi Fenning is registered 4 years, drug resistance is just produced.Tetranychus urticae the 1980s is passed to China.Due to excessively according to
Rely chemical prevention, Tetranychus urticae resistance is serious, and screening effective agent is still the main path of its prevention and treatment.
Gossypol is the product of carbon metablism in cotton plant body, there is important pest-resistant effect.Gossypol to the survival of pest, breeding and its
Population can produce apparent influence.When low concentration gossypol feeds bollworm, in larva internal organ with oxidoreductase activity phase
The transcriptional level of correlation gene is substantially change.The effective ingredient of Envidor is spirodiclofen, and mechanism of action is inhibited in pest mite body
Fatty synthesis.Its no interactions resistance between existing acaricide generates resistance to existing acaricide suitable for being used to prevent and treat
Harmful mite class.Envidor mite killing spectrum is wide, adaptable: Envidor is to red spider, yellow spider, blister mite, yellow tea mite, Tetranychus cinnabarinus
There is fine preventive effect with Tetranychus urticae etc., can be used for the mite of the solanaceous crops such as the fruit trees such as citrus, grape and eggplant, capsicum, tomato
Evil is administered.In addition, Envidor, which has the pests such as pear sucker, oystershell scale and leafhopper class, simultaneous controls effect well.It can be with big portion
Pesticide is divided now to mix current.The acaricide different from other mechanisms of action is mixed, the quick-acting of Envidor not only can be improved, but also be conducive to
The resistance management of mite evil.
Summary of the invention
The present invention is serious for the problem that mite class resistance, commonly uses pharmacy control efficacy decline, provides a kind of mite killing containing gossypol
Composition, the composition bioactivity is good, to crop safety height.
To achieve the above object, the present invention adopts the following technical scheme that.
A kind of miticide composition containing gossypol, active ingredient are gossypol and Envidor；The matter of the gossypol and Envidor
Amount is than being 1:10-50；The total content of the active ingredient is 5.5-52w.t%, remaining is auxiliary material.
Preferably, the active constituent gossypol and the mass ratio of Envidor are 1:20-25；Total content is 11-
26w.t%.
The dosage form of the miticide composition is selected from wettable powder (WP), water dispersible granules (WDG), microemulsion (ME), water
One of emulsion (EW) or suspending agent (SC), preferably suspending agent.
The present invention has following beneficial advantage: the miticide composition of the invention containing gossypol, to various crop phytophagous evil
Mite effect is good, field efficacy is high, and consumption of chemical agent is few, and to plant and safety of human and livestock, Practice for Pesticide Residue in Agricultural Products amount is low.
Specific embodiment
Below with reference to embodiment, the present invention will be further described, but the present invention is not limited by the following examples.
The preparation of miticide composition of the embodiment 1 containing gossypol
1.1 11% gossypol Envidor (1:10) aqueous emulsions
Weight percent composition: gossypol 1%；Envidor 10%；Solvent naphtha 27.0%；Neopelex 1.4%；
Phenethyl phenol polyethenoxy ether 3.6%；Butanol 1.0%；Ethylene glycol 5.0%；Organic silicon defoamer 0.05%；Pure water complements to
100%.
It prepares: by butanol, ethylene glycol, organic silicon defoamer formation water phase soluble in water；Gossypol, Envidor are dissolved in solvent
It in oil, adds emulsifier and is completely dissolved, form oily phase；During the oil phase is added to the aqueous phase under high-speed stirred, prepared after high speed shear
At 11% gossypol spirodiclofen water emulsion sample.
1.2 21% gossypol Envidor (1:20) microemulsions
Weight percent composition: gossypol 1%；Envidor 10%；Methyl oleate 25%；Neopelex 2%；Benzene
Ethyl phenol polyethenoxy ether 8%；Ethylene glycol 5.0%；Organic silicon defoamer 0.05%；Pure water complements to 100%.
It prepares: by ethylene glycol, organic silicon defoamer formation water phase soluble in water；Gossypol, Envidor are dissolved in methyl oleate
In, it adds emulsifier and is completely dissolved, form oily phase；During the oil phase is added to the aqueous phase under high-speed stirred, it is prepared into after high speed shear
21% gossypol spirodiclofen microemulsion sample.
1.3 24% gossypol Envidor (1:23) suspending agents
Weight percent composition: Envidor 23%；Gossypol 1%；SP-2700 3%；SP-SC29 1%；Aluminium-magnesium silicate
1%；Xanthan gum 0.15%；Ethylene glycol 3%；Organic silicon defoamer 0.5%；Pure water supplies 100%.
It prepares: Envidor, gossypol is dissolved in SP-2700 and SP-SC29；Xanthan gum, ethylene glycol, organic silicon defoamer is molten
Yu Shuizhong adds aluminium-magnesium silicate and blendes together suspension；It is sanded after mixing, until specified particle size is to get 24% gossypol Envidor
Suspending agent.
1.4 26% gossypol Envidor (1:25) water dispersible granules
Weight percent composition: gossypol 1%；Envidor 25%；Alkyl phenol ether sulfosuccinic acid ester sodium salt 1%；Polyoxy second
Alkene monostearate 5%；Xanthan gum 1.5%；Sodium lignin sulfonate 3%；Urea 1%；Attapulgite 10%；Kaolin is supplied
100%.
Prepare: by gossypol, Envidor, attapulgite, kaolin after mixing cross air-flow crushing, by surfactant with
Urea is soluble in water mixed with powder after extrusion granulation, dry moisture to get 26% gossypol spirodiclofen water dispersible granule.
2 indoor bioassay of embodiment
Gossypol and Envidor are measured respectively using spray-on process to the co-toxicity of Tetranychus cinnabarinus and Tetranychus urticae deutonymph: semen viciae fabae
Seedling connects female adult mite, lays eggs 1 day and rejects, 3 days after egg hatching, by 0.1% Tween 80 of solution of gossypol and Envidor different proportion
It is configured to the lotion of various concentration, it is spraying with Potter spray tower, dead borer population is checked after 48h, and LC is calculated using SPSS 13.050
With regression equation.Wherein, co-toxicity coefficient (CTC) >=120 indicates synergistic effect；80 < CTC < 120 indicate summation action；CTC
≤ 80 indicate antagonism.Test result is as shown in Table 1 and Table 2.
The co-toxicity of 1 gossypol of table and Envidor to Tetranychus cinnabarinus
| Reagent agent | LC50(mg/mL) | Regression equation | CTC |
| Gossypol (A) | 45.018 | Y=-2.769+1.675x | / |
| Envidor (B) | 0.627 | Y=0.298+1.472x | / |
| A:B=1:10 | 0.481 | Y=0.535+1.683x | 143.19 |
| A:B=1:15 | 0.462 | Y=0.572+1.709x | 144.63 |
| A:B=1:20 | 0.409 | Y=0.627+1.615x | 160.85 |
| A:B=1:22 | 0.361 | Y=0.735+1.660x | 181.46 |
| A:B=1:25 | 0.376 | Y=0.722+1.702x | 173.33 |
| A:B=1:30 | 0.413 | Y=0.655+1.705x | 156.80 |
| A:B=1:40 | 0.497 | Y=0.500+1.646x | 129.27 |
| A:B=1:50 | 0.515 | Y=-0.475+1.650x | 124.15 |
The co-toxicity of 2 gossypol of table and Envidor to Tetranychus urticae
| Reagent agent | LC50(mg/mL) | Regression equation | CTC |
| Gossypol (A) | 75.112 | Y=-3.745+1.997x | / |
| Envidor (B) | 0.935 | Y=0.060+2.030x | / |
| A:B=1:10 | 0.736 | Y=0.150+1.124x | 139.57 |
| A:B=1:15 | 0.697 | Y=0.163+1.040x | 142.97 |
| A:B=1:20 | 0.530 | Y=0.320+1.159x | 185.12 |
| A:B=1:22 | 0.572 | Y=0.294+1.214x | 170.80 |
| A:B=1:25 | 0.591 | Y=0.276+1.208x | 164.45 |
| A:B=1:30 | 0.613 | Y=0.238+1.121x | 157.55 |
| A:B=1:40 | 0.735 | Y=0.161+1.205x | 130.35 |
| A:B=1:50 | 0.772 | Y=0.133+1.188x | 123.51 |
From the data in the table, under indoor conditions, the LC of gossypol and Envidor to Tetranychus cinnabarinus50Respectively 45.018mg/
ML and 0.627mg/mL, to the LC of Tetranychus urticae50Respectively 75.112mg/mL and 0.935mg/mL.Ratio is the cotton of 1:10-50
Phenol LC to Tetranychus cinnabarinus and Tetranychus urticae mixed with Envidor50It is lower, and the co-toxicity index CTC numerical value of two medicaments is equal
120 or more, having apparent synergistic effect, especially ratio is that 1:20-25 synergy is more significant.
3 field control effectiveness test of embodiment
Cotton tetranychid is carried out using 24% gossypol Envidor suspending agent in embodiment 1.3 and 24% Envidor suspending agent
Prevention and treatment: each plot area is 50m2, it is repeated 4 times, is prevented and treated by spraying with power spraye, water consumption 1125kg/hm2, blank pair
According to spray equivalent clear water.The harmful mite radix of every processing, 1,3,7d after medicine are investigated before application, 5 leaf investigation, remaining are adopted in every processing at random
Work mite quantity, calculate corrected mortality, test result is shown in Table 3.
Field control effectiveness test of the 3 24% gossypol Envidor suspending agent of table to cotton tetranychid
Note: the different letters of same column indicate that the level difference of p < 0.05 is significant in table.
By upper table data it is found that after 24% Envidor gossypol SC medicine 1 day corrected mortality be 53.95% quick-acting compared with
24% Envidor SC is good, 3 days after medicine, 7 days corrected mortalities be all remarkably higher than 24% Envidor SC.Show 24% gossypol spiral shell
Mite ester suspending agent is good to the field efficacy of cotton tetranychid.
Claims (3)
1. a kind of miticide composition containing gossypol, which is characterized in that active constituent is gossypol and Envidor；The gossypol and spiral shell
The mass ratio of mite ester is 1:10-25；The total content of the active constituent is 5.5-52 wt %, remaining is auxiliary material.
2. miticide composition according to claim 1, which is characterized in that gossypol and the mass ratio of Envidor are 1:20-25；
Total content is 11-26 wt %.
3. according to claim 1 or 2 any miticide compositions, which is characterized in that the dosage form of the miticide composition is selected
From one of wettable powder, water dispersible granules, microemulsion, aqueous emulsion or suspending agent.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6773727B1 (en) * | 2001-08-13 | 2004-08-10 | The United States Of America As Represented By The Secretary Of Agriculture | Use of gossypol and related terpenes for control of urban and agricultural pests |
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| CN101406185A (en) * | 2008-10-31 | 2009-04-15 | 淄博新农基农药化工有限公司 | Compositional agent for killing insects and mites with synergistic interaction containing spirodiclofen |
| CN101578990A (en) * | 2009-06-29 | 2009-11-18 | 通化绿地农药化学有限公司 | Compound preparation of spiromesifen and antibiotic pesticide |
| CN105884634B (en) * | 2015-01-05 | 2019-06-04 | 南开大学 | The preparation of gossypol derivative and they, application and anticancer activity on pesticide |
| CN104561055B (en) * | 2015-01-12 | 2018-03-27 | 西南大学 | A kind of Tetranychus cinnabarinus cytochromes p450 genes and its application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6773727B1 (en) * | 2001-08-13 | 2004-08-10 | The United States Of America As Represented By The Secretary Of Agriculture | Use of gossypol and related terpenes for control of urban and agricultural pests |
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Effective date of registration: 20190716 Address after: Mulberry road Licheng District 250000 in Shandong city of Ji'nan province No. 2 Applicant after: Shandong Rice Research Institute Address before: 250014 No. 202 Industrial North Road, Jinan City, Shandong Province Applicant before: Shandong Cotton Research Center |
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