CN101077337A - Vitamin injection used for promoting female animal estrus and Increasing breeding and preparation method thereof - Google Patents
Vitamin injection used for promoting female animal estrus and Increasing breeding and preparation method thereof Download PDFInfo
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- CN101077337A CN101077337A CNA2007100722737A CN200710072273A CN101077337A CN 101077337 A CN101077337 A CN 101077337A CN A2007100722737 A CNA2007100722737 A CN A2007100722737A CN 200710072273 A CN200710072273 A CN 200710072273A CN 101077337 A CN101077337 A CN 101077337A
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Abstract
The present invention discloses one kind of vitamin injection as female animal aphrodisiac and its preparation process. The vitamin injection has main components including vitamin A, vitamin D and vitamin E, and supplementary materials, including antioxidant, bacteriostat and oil for injection. It is suitable for cow, mare, sow, ewe and other female animal in the duration period, and has the functions of promoting growth, raising reproductive capacity, regulating immunity, etc.
Description
Technical field
The present invention relates to a kind of vitamin injection that is used for promoting female animal estrus and Increasing breedings such as cattle, horse, pig, sheep, the invention still further relates to a kind of preparation method of this injection.
Background technology
Animal breeding is most important source of finance of aquaculture and topmost benefit growth point, and the female animal high yield, newborn animal is strong also is culturist's greatest hope naturally.But, along with the continuous development and the expansion of aquaculture in recent years, a kind of strange phenomenon has all appearred in many places, nowadays short its effect of feelings method of Chang Yong domestic animal began to become more and more not obvious in the past, aplasia, false heat, oestrus do not ovulate, phenomenon such as pseudopregnancy also increases gradually, and the sickness rate of diseases such as female animal is off one's feed puerperal, weary feelings, placenta retention, endometritis, mastitis, postpartum paralysis is also in continuous rising, and this situation has all caused for the development of many local aquacultures and seriously influenced.This applicant had once been done earnest investigation, and found some very typical phenomenons: it is static that ovary appears in the multiparity female animal, 3-4 month puerperal even reach 9-10 month non-estrus, investigation sickness rate 8.2%; Breed female animal and postpone oestrus, according to the statistics of 208 yearling heifers, oestrusing first accounts for 38.2% person more than 26 months, on average postpones about 8 months.Formation reason the applicant about this serious consequence has also carried out corresponding investigation and analysis, at first be that great change has taken place feeding manner now, the amount of raising scattered of being not only domestic animal is quickly reducing, and main be also wretched insufficiency of blue or green fresh feed in the feedstuff, nutrient in the feedstuff is difficult to ensure that this has just caused serious inherence influence to the growth promoter of domestic animal.In addition, also having extenal causes that can not look down upon is exactly in feedstuff and medicine in recent years, and the consumption of growth, treatment hormone also increases not adding restriction ground, and the common influence of this two aspects factor is the basic reason that causes above-mentioned strange phenomenon generation.
Owing to, it is also just to be difficult to encouraging result naturally especially in the concrete scheme of being taked aspect treating, improving at present to the former for want of enough understanding of the formation of above-mentioned strange phenomenon.In addition, some single nutrients that replenished in the existing relevant programme are to adopt pre-mixing agent mostly, and drinking agent etc. are added as replenishing of feedstuff, therefore all need operation every day, it is few to exist active constituent content, and assimilation effect is not good, uses many shortcomings such as inconvenience.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of reproduction function that can effectively strengthen female animal, helps eliminating simultaneously the dysgenic a kind of vitamin injection that is used to promote promoting female animal estrus and Increasing breeding that causes because of hormone again.Another object of the present invention then is the preparation method that is to provide a kind of this injection.
For achieving the above object, the present invention is by the following technical solutions: the main component of this injection is vitamin A, vitamin D and vitamin E, and concrete weight proportion is:
Vitamin A 4%-15% vitamin D 0.05%-0.5%
Vitamin E 0.5%-5% antioxidant 0.4%-1%
All the other are oil for injection for antibacterial 1.5%-3%
The medical grade vitamin A amyl acetate of preferred 1,000,000 units/gram of above-mentioned vitamin A;
The medical grade vitamin D of preferred 4,000 ten thousand units/gram of above-mentioned vitamin D
3
The medical grade vitamin E of above-mentioned vitamin E preferred 98.5%;
The preferred injection soybean oil of above-mentioned oil for injection;
The preferred dibutyl antelope base of above-mentioned antioxidant toluene (BHT);
The preferred medical grade toluene of above-mentioned antibacterial alcohol, toluene alcohol also has the effect of local anesthetic.
Vitamin E claims tocopherol again, can keep the normal oxidizing process of female animal, prevents that the toxic action that is produced after the oxide accumulation increases from producing ill effect to the female livestock breed function.Can keep the normal secretion of normal antepituitary follicle stimulating hormone of uterus function and lutropin, improve the breeding conception rate, it is normal to keep the uterus function, the normal secretion of antepituitary follicle stimulating hormone and lutropin, improve the breeding conception rate, keep the normal development of embryo and fetus and Placenta Hominis, reduce recessive abortion ratio.Be a kind of known general knowledge the fertility that is used to strengthen female animal about above vitamin E obviously, but confirm through test, use single vitamin E to be used to improve existing this because of cultivating condition changes the female animal reproductive performance decline problem that causes, its result is many times often being got half the result with twice the effort.
Vitamin A is a carotene; reproductive development for female animal also is a kind of very important material; can keep the normal functional status of each lumen epithelial cell of female animal; normal reproductive capability is kept in participation; promote sexual maturity, oocyte growth and growth improve the hormone secretion level; keep the normal estrus cycle, improve fertility.Because people also lack enough attention for these functions of vitamin A and effect, thus use it for strengthen female animal fertility proliferation to repay examination also rare.
The topmost function of vitamin D is to keep the mineral of female animal, and the homergy of calcium salt and microcosmic salt makes in blood and the tissue mesostate oxidation complete, prevents acidosis, and this point is the especially attention of people institute.But relevant vitamin D has often all been ignored by people in the function aspect the reproduction of guarantee female animal, and therefore relevant application in this respect is also rare.Vitamin D not only can promote female animal to oestrus and the normal estrus cycle, but also helps the normal development of zygote and guarantee the normal function in uterus.In addition, vitamin D and be subjected to blood calcium concentration about it for resisting and weakening exogenous hormones and cause the important function of body of gland disorder also should special concern to female animal fertility system.
Investigation shows, because the wretched insufficiency of green forage causes the many vitamin in the feed stripped all inadequate, especially the shortage of vitamin E, A, D is more apparent serious, and these three kinds of fatsoluble vitamiies exactly all are that institute can not be synthetic in health for domestic animal.Female animal is the biological machine of livestock reproduction fertility, from required feedstuff, not only need to keep the base stock of self growing, breed the offspring but also need be specifically designed in a large number, and keep the particular matter of this function, and these three kinds of vitamin are the vital several compositions in relevant livestock reproduction fertility aspect, because the wretched insufficiency that these materials are supplied with, add interference, the attack of some exogenous hormoneses, domestic animal breeding occur aspect the fertility some serious tired out, slow down, poor efficiency obviously is inevitable.
Below be the preparation method of product of the present invention:
1, gets vitamin A, vitamin D, vitamin E, antioxidant, antibacterial and oil for injection ready according to above-mentioned given raw material type and percetage by weight thereof.
2, in rustless steel container, put into an amount of oil for injection, make the temperature of oil for injection keep 60 ℃-65 ℃ by heating.
3, add vitamin A, vitamin D, vitamin E, antioxidant and antibacterial in 60 ℃-65 ℃ oil for injection, stirring is fully dissolved supplementary material.
4, add oil for injection to 100% of use amount, carry out standardize solution.
5, the solution behind the standardize solution filters.Adopt the method for vacuumizing filtration, microporous filter membrane adopts 0.22 μ m-0.8 μ m.
6, after the embedding, sterilize.Sterilising conditions is to sterilize 30 minutes under 100 ℃ of vapor streams.
7, be cooled to room temperature after, carry out lamp inspection, labeling and outer package.
The quality standard of injection: appearance test is faint yellow clear and bright oily liquids; Contain the 93.0%-107.0% that vitamin A is a labelled amount; Contain the 93.0%-107.0% that vitamin D is a labelled amount; Contain the 93.0%-107.0% that vitamin E is a labelled amount.
From relevant prior art, though above-mentioned these three kinds of vitamin also once appeared in some technical scheme simultaneously, but merely the design that is effective therapeutic component with these three kinds of raw materials is found as yet, and the use that especially this combination is used to promote and improve female animal reproduction, reproductive function is not reported especially.
From the trial effect of product of the present invention, this injection is applicable to female animals such as the cattle, horse, pig, sheep of period of duration, has the promotion growth promoter, strengthens the effect of fertility; For the aplasia that causes because of feeding manner is improper, false heat, oestrus do not ovulate, pseudopregnancy, become thin, symptom such as hypoimmunity is effective, and to female animal be off one's feed puerperal, diseases such as weary feelings, placenta retention, endometritis, mastitis, postpartum paralysis also have better curative effect; Product of the present invention also can be used for safeguarding the normal physiological activity of domestic animals such as cattle, horse, sheep, pig, regulates immunity.Use not only can replenish the deficiency of the nutrient of being correlated with in the breeding feed by the composite injection of these three kinds of vitamin preparations, has also promoted the reproductive physiology index of female animal simultaneously.From functional effect is not the simple superposition of three kinds of nutrient effects yet, has significantly synergism mutually therebetween.
The specific embodiment
Embodiment 1
The raw material and the weight proportion of product of the present invention are as follows:
Vitamin A 40g vitamin D3 0.5g
Vitamin E 5g dibutyl antelope base toluene 4g
Benzyl alcohol 15g adds the injection soybean oil and is settled to 1000ml
Embodiment 2
The raw material and the weight proportion of product of the present invention are as follows:
Vitamin A 80g vitamin D3 1g
Vitamin E 10g dibutyl antelope base toluene 5g
Benzyl alcohol 15g adds the injection soybean oil and is settled to 1000ml
Embodiment 3
The raw material and the weight proportion of product of the present invention are as follows:
Vitamin A 120g vitamin D3 1.5g
Vitamin E 15g dibutyl antelope base toluene 6g
Benzyl alcohol 20g adds the injection soybean oil and is settled to 1000ml
Embodiment 4
The raw material and the weight proportion of product of the present invention are as follows:
Vitamin A 150g vitamin D3 5g
Vitamin E 50g dibutyl antelope base toluene 10g
Benzyl alcohol 30g adds the injection soybean oil and is settled to 1000ml
Embodiment 5
Injection of the present invention adopts following method preparation:
(1) gets vitamin A, vitamin D, vitamin E, antioxidant, antibacterial and oil for injection ready according to given raw material type and the mass fraction thereof of prescription.
(2) put into 50% oil for injection in rustless steel container, heating makes the temperature of oil for injection keep 60 ℃
(3) add vitamin A, vitamin D, vitamin E, antioxidant and antibacterial in 60 ℃ oil for injection, stirring is fully dissolved supplementary material.
(4) add oil for injection to 100%, carry out standardize solution.
(5) solution behind the standardize solution filters.Adopt the method for vacuumizing filtration, microporous filter membrane adopts 0.8 μ m.
(6) after the embedding, sterilize.Sterilising conditions is to sterilize 30 minutes under 100 ℃ of vapor streams.
(7) be cooled to room temperature after, carry out lamp inspection, labeling and outer package.
Example 6
This injection using method and effect:
Usage and consumption: intramuscular injection, once measure cattle, horse 10ml, pig, sheep 5ml.
Adopt compound vitamin ADE injection for treating infected animal of the present invention, after the general medication 1 time, sx, antisecosis, for the aplasia that causes because of feeding manner is improper, false heat, oestrus do not ovulate, pseudopregnancy, become thin, symptom effect such as hypoimmunity very obviously, and to female animal be off one's feed puerperal, diseases such as weary feelings, placenta retention, endometritis, mastitis, postpartum paralysis also have better curative effect.
Clinical usage example:
Science and Technology Ltd. has carried out therapeutic test on a small scale at the numerous rich animal reproduction of grand celebration, has chosen and has suffered from 15 of sterile milch cows, has carried out the clinical treatment test, wherein has 13 thoroughly to cure, and other 2 symptom also has clear improvement.Medicine of the present invention in addition also to 10 share the weal and woe together have become thin, 15 cow heads of hypoimmunity have carried out therapeutic test, and are evident in efficacy, but light disease is suffered from poultry mitigation symptoms on the same day.Short treating period, each intramuscular injection 1 time needn't duplicate injection in the two weeks.Cure rate height not only, total effective rate is 90%, and the treatment cost is also very low, is cultured the favorable comment of peasant household deeply, has good social and economic benefit.
Animal compound vitamin AD E injection of the present invention has carried out extensive therapeutic test to nearly thousand milch cows that suffer from infertility in Fu Laer base, Qiqihaer City, Heilongjiang Province and Daqing DORBOD area, has aggregate efficiency to be about 95%.Demonstrate short treating period, the high clear superiority of cure rate.
Claims (2)
1, a kind of vitamin injection that is used to promote promoting female animal estrus and Increasing breeding, the composition of this injection and percentage by weight are:
Vitamin A 4%-15% vitamin D 0.05%-0.5%
Vitamin E 0.5%-5% antioxidant 0.4%-1%
Antibacterial 1.5%-3%
All the other are oil for injection.
2, a kind of preparation preparation method that is used to promote the vitamin injection of promoting female animal estrus and Increasing breeding as claimed in claim 1 is characterized in that:
A, get vitamin A, vitamin D, vitamin E, antioxidant, antibacterial and oil for injection ready according to above-mentioned given raw material type and percetage by weight ratio thereof;
B, in rustless steel container, put into an amount of oil for injection, make its temperature keep 60 ℃-65 ℃ by heating;
C, in 60 ℃-65 ℃ oil for injection, add vitamin A, vitamin D, vitamin E, antioxidant and antibacterial, stir supplementary material is fully dissolved;
D, add oil for injection, carry out standardize solution to 100% of use amount;
Solution behind E, the standardize solution filters.Adopt the method for vacuumizing filtration, microporous filter membrane adopts 0.22 μ m-0.8 μ m;
After F, the embedding, sterilize, sterilising conditions is to sterilize 30 minutes under 100 ℃ of vapor streams;
G, be cooled to room temperature after, carry out lamp inspection, labeling and outer package.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100722737A CN101077337A (en) | 2007-05-22 | 2007-05-22 | Vitamin injection used for promoting female animal estrus and Increasing breeding and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100722737A CN101077337A (en) | 2007-05-22 | 2007-05-22 | Vitamin injection used for promoting female animal estrus and Increasing breeding and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN101077337A true CN101077337A (en) | 2007-11-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100722737A Pending CN101077337A (en) | 2007-05-22 | 2007-05-22 | Vitamin injection used for promoting female animal estrus and Increasing breeding and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247381A (en) * | 2010-12-31 | 2011-11-23 | 江西赣南海欣药业股份有限公司 | VitaminD2-and-vitaminE-containing medicinal composition for injection and preparation method thereof |
| RU2497509C1 (en) * | 2012-10-19 | 2013-11-10 | Государственное научное учреждение Научно-исследовательский ветеринарный институт Нечерноземной зоны Российской Федерации Российской академии сельскохозяйственных наук | Method for postpartum correction of reproductive function in cows |
| CN105030662A (en) * | 2015-06-04 | 2015-11-11 | 永信药品工业(昆山)有限公司 | Lipid-soluble vitamin D2 medicine composition and preparation method thereof |
| CN105748489A (en) * | 2014-12-20 | 2016-07-13 | 重庆布尔动物药业有限公司 | A composite vitamin ADE oil injection for veterinary use and a preparing method thereof |
| CN109498607A (en) * | 2018-12-04 | 2019-03-22 | 宁夏智弘生物科技有限公司 | A kind of vitaminAD E injection for animals and preparation method |
-
2007
- 2007-05-22 CN CNA2007100722737A patent/CN101077337A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247381A (en) * | 2010-12-31 | 2011-11-23 | 江西赣南海欣药业股份有限公司 | VitaminD2-and-vitaminE-containing medicinal composition for injection and preparation method thereof |
| RU2497509C1 (en) * | 2012-10-19 | 2013-11-10 | Государственное научное учреждение Научно-исследовательский ветеринарный институт Нечерноземной зоны Российской Федерации Российской академии сельскохозяйственных наук | Method for postpartum correction of reproductive function in cows |
| CN105748489A (en) * | 2014-12-20 | 2016-07-13 | 重庆布尔动物药业有限公司 | A composite vitamin ADE oil injection for veterinary use and a preparing method thereof |
| CN105030662A (en) * | 2015-06-04 | 2015-11-11 | 永信药品工业(昆山)有限公司 | Lipid-soluble vitamin D2 medicine composition and preparation method thereof |
| CN109498607A (en) * | 2018-12-04 | 2019-03-22 | 宁夏智弘生物科技有限公司 | A kind of vitaminAD E injection for animals and preparation method |
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Open date: 20071128 |