CN101297883B - Chinese medicinal composition for treating Canine parvovirus infection and preparation thereof - Google Patents
Chinese medicinal composition for treating Canine parvovirus infection and preparation thereof Download PDFInfo
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- CN101297883B CN101297883B CN200810052899A CN200810052899A CN101297883B CN 101297883 B CN101297883 B CN 101297883B CN 200810052899 A CN200810052899 A CN 200810052899A CN 200810052899 A CN200810052899 A CN 200810052899A CN 101297883 B CN101297883 B CN 101297883B
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Abstract
The invention relates to a traditional Chinese medicine composition for treatment for canine parvovirus infection, which is characterized in that the traditional Chinese medicine composition is prepared by the components with the following parts by weight by mixing: 12 to 18 parts of garden burnet root, 8 to 12 parts of golden thread, 8 to 12 parts of peach seed, 8 to 12 parts of whiteflower hogfennel root and 8 to 12 parts of membranous milkvetch root. The preferential mix ratio of the all components is as follows: 15 parts of garden burnet root, 10 parts of golden thread, 10 parts of peach seed, 10 parts of whiteflower hogfennel root and 10 parts of membranous milkvetch root. The preparation method is carried out according to the following steps: (1) the all ingredients in the formula are respectively smashed and screened by a sieve with 20 to 80 meshes; (2) 15 parts of garden burnet root, 10 parts of golden thread, 10 parts of peach seed, 10 parts of whiteflower hogfennel root and 10 parts of membranous milkvetch root are weighed according to the mix ratio by the parts by weight for even mixing. The traditional Chinese medicine composition has reasonable formula and simple preparation; the pure traditional Chinese medicine composition has no pollution, no medicine residue, low cost, broad material selection and very significant efficacy. The traditional Chinese medicine composition selects a plurality of pure traditional Chinese medicine preparations, thus having unique advantages compared with western medicines. The clinical application proves that the traditional Chinese medicine composition has special effects on canine parvovirus infection.
Description
Technical field
The present invention relates to a kind of Chinese medicine that is used for animal, particularly a kind of Chinese medicine composition of treating Canine parvovirus infection and preparation method thereof.
Background technology
Canine parvovirus infection (Canine parvovirus infection) is a kind of acute infectious disease of the dog that caused by Canine Parvovirus (CPV), with serious enteritis syndrome Canidae that is characteristic and the important infectious disease of mustelid.China confirms this after being ill in nineteen eighty-two by Liang Shizhe etc., northeastward, take place successively in geographic police dog such as East China and southwest and the breeding dog and spread.Particularly should disease be widely current in calendar year 2001, the provisions dog has already been caused great harm.CPV infect be that Canis animals is modal, one of topmost viral disease, be typical case's representative of carnivore parvovirus.
The Canine Parvovirus enteritis is that caused by the CPV viral infection a kind of is master's dog class infectious disease with hyperemesis, diarrhoea and heating.Its sickness rate, mortality rate are all higher, dead with pup for the highest.At present, still there is not the special treatment medicine.
1, epidemiology canine parvovirus disease, the dog at various ages all can infect, but more with the dog morbidity of firm ablactation to 90 age in days, the state of an illness is also heavier.Appeared in the myocarditis symptom that pup has and sudden death.From the kind of clinical onset dog, purebred dog and external dog are higher than soil species dog sickness rate.
2, pathogenic factor is main because raise scattered, look for food everywhere sordid food or feed unclean, hard (like bone, particularly Os Gallus domesticus, fish spicule etc.) or putrid and deteriorated animal fodder, or eat by mistake due to the noxious substance.
3, be generally 7-15 days the incubation period of clinical symptoms 3.1 acute hemorrhagic enteritis type natural infections, sick spirit just is depressed, and appetite is useless exhausted, fervescence to 39 ℃-41 ℃, and vomiting, the sick dog that has is flowed out the mucus of milky or yellow green water sample or blood sample from mouth.The intestinal sound strengthens, and falls ill about one day to begin diarrhoea, discharges brown blood sample loose stool, and taste is stench, for several times behind the hemafecia; Tenesmus, sick dog be often with slight stomachache, presents uneasiness or happiness is crouched, sick dog performance dewatering symptom, enophthalmos; Inner eye corner has the canescence sticky discharge, conjunctiva flushing or xanthochromia, and mouthful color is dark red, and the nose border is dry, and pulse increases number; Abdominal circumference tightens, and skin elastic force descends, and the oliguria color is dense, and body weight obviously alleviates.For the heavy acute sick dog of diarrhoea, cause that the body dehydration causes self poisoning, heart failure and death.The blood phase change; The leukocyte count of sick dog is few is more common in the dog about 40 ages in days to 60%-90% (1.2 ten thousand of normal dogs/cubic millimeter is reduced to below 4000 at once) 3.2 myocarditis types; Sick dog tendency property unclear symptoms shows the unexpected dyspnea that has, heart failure; Dead in short time, the dog that has is dead after it is thus clear that laxativeness is arranged.
4, cut open inspection and cut open the inspection discovery through the many cases death:
Thicken 4.1 the enteritis type major lesions is a small intestinal mucosa, enteric cavity narrows down, and shows fold or the ulcer kitchen range is arranged.Intestinal contents is red medicated porridge appearance, or is mixed with black purple grumeleuse, stench.Jejunum and ileal mucosa severe haemorrhage.Mesenteric adenophyma is big, congested.The gastric mucosa flushing is mixed with Ovum Gallus domesticus album appearance mucus.Hepatomegaly takes on a red color, and is dispersed in faint yellow focus, and tangent plane flows out noncondensing blood.Cholecystectasia has volume yellow green bile, and mucosa is smooth.Splenomegaly, surface have the big purple dot of foxtail millet grain (hemorrhagic infarct), or the canescence point is arranged.Kidney is lark, not enlargement. but there is greyish white mottle on the surface.The bladder neck mucosa hemorrhage.
4.2 myocarditis type major lesions is a cardiac dilatation, cardiac muscle and endocardium have the apyetous necrosis region.Serious edema of lung or consolidation.The histology is changed to the myocardium of left ventricle fiber and monocyte infiltration and interstitial fibrosis occur, in the myocardial cell of damage, often can see the intranuclear inclusion that differs in size.
5, prevention finds that primary disease should in time carry out isolated rearing, prevents that the disease dog from contacting with healthy dogs with sick dog breeders personnel, sterilizes with 2% Caustic soda water or 10%-20% bleaching powder etc. to doghouse repeatedly; Canine parvovirus disease is in early days with the treatment of Canine Parvovirus hyper-immune serum, and using clinically has certain therapeutic effect; To the same canine distemper vaccine of healthy dogs immune programme for children.
6, treatment Chinese medicine is main with the heat-clearing and toxic substances removing cooling blood for hemostasis.It is the Therapeutic Principle that Western medicine is removed foreign body in intestine with antibacterial, antiinflammatory, fluid infusion detoxifcation, heart tonifying.On method, be main, cooperate endo-medicine, auxiliary Western medicine, fluid infusion to treat with the deep retention enema.
6.1 common enema method
6.1.1 Chinese medicine: with the heat-clearing and toxic substances removing cooling blood for hemostasis is main.(1) Radix Pulsatillae 15 grams, Radix Scutellariae 10 grams, Rhizoma Coptidis 3 grams, Radix Isatidis 15 grams.Usage: fry in shallow oil soup to 100 milliliter, add Radix Notoginseng powder 2 grams, Pseudobulbus Bletillae (Rhizoma Bletillae) powder 2 grams mix the back coloclysis.Once a day, logotype is 3-4 time.(2) serrate holly leaf 50 grams.Usage: fry in shallow oil soup to 100 milliliter, add Radix Notoginseng powder 2 grams and mix the back coloclysis.Once a day, logotype is 3-4 time.
6.1.2 Western medicine: with antibacterial, antiinflammatory, pain relieving is main.
(1) meticortelone is 20 milligrams, 5 milliliters of 2% procaines.Usage: add 50 milliliters of coloclysis of warm water, the next day once, logotype 2-3 time.
100 milliliters of (2) 0.1% potassium permanganate liquids.Usage: with coloclysis behind the warm water dilution potassium permanganate, every day 1 time, logotype 2-3 days.
6.2 deep retention enema operational approach
6.2.1 method step: draw medicinal liquid (medicinal liquid is with medication in the common enema method) with 100 milliliters of syringes, sick dog is cooked the binding of standing, get a little catheter; Insert syringe; Slowly insert anal to little catheter then, the degree of depth reaches about 30 centimetres approximately, injects enteral to medicinal liquid.Be that anti-medicinal liquid discharges, can be pinched by the assistant and press disease bark root of the tail portion or waist, make medicinal liquid stop some times at enteral more as far as possible, or when sick dog fluid infusion, binding time is longer, coloclysis can carry out before fluid infusion.
6.2.2 endo-medicine: Herba Andrographis 4-6 sheet; Usage: every day twice, logotype 2-3 days.
6.2.3 300 milliliters of fluid infusion 10% glucose solutions; 200 milliliters of compound NaCls; 5 milliliters of hydrocortisone; 30 milliliters of 5% sodium bicarbonate; Ammonia joint penicillin 2,500,000.Usage: intravenous injection, once a day, logotype 1-3 time.
6.2.4 antiinflammatory, hemostasis, emesis: gentamycin 10,000 units/kg body weight, dexamethasone 0.5 mg/kg body weight is mixed intramuscular injection, or kanamycin 50,000 units/kg body weight add dexamethasone mixing intramuscular injection.Vitamin V K11 mg/kg body weight V K10.4 mg/kg body weight is mixed intramuscular injection.Metoclopramide 2 mg/kg body weight.
At present, the Chinese and Western associated methods of employing is used comparatively loaded down with trivial details, and the application of Western medicine has stronger toxic and side effects to animal body, and sick dog needs long convalescent period, and medical expense is comparatively expensive, causes bigger financial burden to the dog master.
Therefore, Chinese medicine composition of a kind of new treatment Canine parvovirus infection and preparation method thereof being provided, effectively preventing and treat Canine parvovirus infection, is one of this technical field scientific research personnel new problem of being badly in need of developing.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide a kind of effective minimizing residual, reduce toxic and side effects, reduce to pollute and treat safely and effectively Chinese medicine composition of Canine parvovirus infection and preparation method thereof.
The present invention realizes through following technical scheme:
A kind of Chinese medicine composition of treating Canine parvovirus infection, it is characterized in that by following component by weight mixed preparing form: Radix Sanguisorbae 12-18 part, Rhizoma Coptidis 8-12 part, Semen Persicae 8-12 part, Radix Peucedani 8-12 part, Radix Astragali 8-12 part.
Said various component optimum ratio amount is: 15 parts of Radix Sanguisorbaes, 10 parts of Rhizoma Coptidis, 10 parts in Semen Persicae, 10 parts of Radix Peucedanis, 10 parts of the Radixs Astragali.
A kind of method for preparing of treating the Chinese medicine composition of Canine parvovirus infection is characterized in that carrying out as follows:
(1) with crossing the 20-80 mesh sieve behind the various composition pulverize separately in the prescription;
(2) take by weighing Radix Sanguisorbae 12-18 part by above-mentioned parts by weight proportioning, Rhizoma Coptidis 8-12 part, Semen Persicae 8-12 part, Radix Peucedani 8-12 part, Radix Astragali 8-12 part, mix homogeneously.
The medicinal property of each component is following:
Radix Sanguisorbae: bitter, sour, be slightly cold.Return liver, stomach, large intestine channel.Cooling blood for hemostasis cures mainly multiple hemorrhage that bleeding due to blood-heat causes, as have blood in stool, disease such as hematuria, bleeding hemorrhoids and woman uterine bleeding.
Rhizoma Coptidis: clearing away heat-fire; Dampness; Detoxifcation.Cure mainly the calentura heresy and go into the hyperpyrexia of heart channel; Irritated; Delirium or the absurd row of intenseness of heat forcing blood tell nosebleed; Damp and hot breast painful abdominal mass; Have loose bowels; Dysentery; The vexed insomnia of hyperactivity of heart-fire; Gastropyretic vomiting or rapid digestion of food and polyorexia; The liver-fire conjunctival congestion and swelling pain; And pathopyretic ulcer; The furunculosis septicemia; Gingival swelling and pain; Aphtha of the mouth and tongue; The Ting ear; Swelling of the vulva; Hemorrhoidal bleeding; Eczema; Scald.
Semen Persicae: bitter, sweet, flat.Slightly poisonous.GUIXIN, liver, large intestine channel.Blood stasis removing and clots absorbing; Moisturize laxation.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood, so blood coagulation must be used.Heat in dehematizing again.
Radix Peucedani: bitter in the mouth, suffering, cold nature.Return lung, spleen, Liver Channel.Dispelling wind and heat pathogens, lowering the adverse-rising QI to resolve phlegm.Cure mainly affection due to external wind and heat, the lung-heat phlegm stagnancy, the cough with asthma abundant expectoration, the expectorant Huang is sticky, the vomiting lack of appetite, chest and diaphragm is full vexed.
The Radix Astragali: Gan Wen.Go into lung, spleen two warps.Invigorating QI to consolidate the body surface resistance.Control deficiency of spleen-QI, deficiency of blood and decline of QI, exterior deficiency spontaneous perspiration, edema, arthralgia due to stagnation of blood, carbuncle are burst for a long time and are not held back, or deficiency of vital energy disease such as be difficult for disappearing brokenly.
The Canine Parvovirus enteritis is seen from symptom, is to be amassed in gastrointestinal by pyretic toxicity, due to the bleeding due to blood-heat.Prescription Radix Sanguisorbae of the present invention, Rhizoma Coptidis heat-clearing and toxic substances removing, cooling blood for hemostasis, Semen Persicae blood stasis removing and clots absorbing, Radix Peucedani, the Radix Astragali QI invigorating of regulating the flow of vital energy, gather altogether cooling blood for hemostasis, regulate the flow of vital energy and receive the merit of blood.We's prescription is scientific and reasonable, treating both the principal and secondary aspects of a disease, and onset is rapid, can alleviate the intestinal symptom of disease dog rapidly, strengthens its resistivity to disease.
The invention has the beneficial effects as follows:
(1) absorbance, utilization rate height;
Have no side effect, (2) safely;
(3) good stability, lasting medicine;
(4) draw materials extensively, cost is low.
In a word, reasonable recipe, preparation is simple, and pure Chinese medicine composition is pollution-free, no drug residue, curative effect highly significant.Select the multi-flavor pure Chinese medicinal preparation for use, have the not available unique advantage of Western medicine.And making them form compound preparation according to best proportioning, clinical practice proves that the treatment Canine parvovirus infection is had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of Chinese medicine composition of treating Canine parvovirus infection, it is characterized in that by following component by weight (every part for 10g) mixed preparing form: Radix Sanguisorbae 150g, Rhizoma Coptidis 100g, Semen Persicae 100g, Radix Peucedani 100g, Radix Astragali 100g.
A kind of method for preparing of treating the Chinese medicine composition of Canine parvovirus infection is characterized in that carrying out as follows:
(1) with crossing the 20-80 mesh sieve behind the various composition pulverize separately in the prescription;
(2) take by weighing Radix Sanguisorbae Radix Sanguisorbae 150g by above-mentioned parts by weight proportioning (every part is 10g), Rhizoma Coptidis 100g, Semen Persicae 100g, Radix Peucedani 100g, Radix Astragali 100g, mix homogeneously.
Embodiment 2
A kind of Chinese medicine composition of treating Canine parvovirus infection, it is characterized in that by following component by weight (every part for 10g) mixed preparing form: Radix Sanguisorbae 125g, Rhizoma Coptidis 82g, Semen Persicae 80g, Radix Peucedani 80g, Radix Astragali 83g.
A kind of method for preparing of treating the Chinese medicine composition of Canine parvovirus infection is characterized in that carrying out as follows:
(1) with crossing the 20-80 mesh sieve behind the various composition pulverize separately in the prescription;
(2) take by weighing Radix Sanguisorbae 125g by above-mentioned parts by weight proportioning (every part is 10g), Rhizoma Coptidis 82g, Semen Persicae 80g, Radix Peucedani 80g, Radix Astragali 83g, mix homogeneously.
Embodiment 3
A kind of Chinese medicine composition of treating Canine parvovirus infection, it is characterized in that by following component by weight (every part for 10g) mixed preparing form: Radix Sanguisorbae 180g, Rhizoma Coptidis 118g, Semen Persicae 112g, Radix Peucedani 120g, Radix Astragali 120g.
A kind of method for preparing of treating the Chinese medicine composition of Canine parvovirus infection is characterized in that carrying out as follows:
(1) with crossing the 20-80 mesh sieve behind the various composition pulverize separately in the prescription;
(2) take by weighing Radix Sanguisorbae 180g by above-mentioned parts by weight proportioning (every part is 10g), Rhizoma Coptidis 118g, Semen Persicae 112g, Radix Peucedani 120g, Radix Astragali 120g, mix homogeneously.
Clinical practice instance 1:
Sick first spirit is depressed, and appetite is useless exhausted, fervescence, vomiting, the mucus of outflow milky or yellow green water sample from mouth.The enhancing of intestinal sound, falling ill about one day begins diarrhoea, discharges brown blood sample loose stool, and taste is stench, and sick dog presents uneasiness or likes symptoms such as for sleeping in, sick dog performance dehydration often with slight stomachache.With the ill dog of product feeding of the present invention, a day dose is: by every Kg body weight 10g, spice is fed or is decocted back Chinese medicine liquid and irritates clothes, takes 1-2 week continuously, and curative effect is very obvious, and sx is to recovery from illness, and oral back absorbs the purpose that reaches the treatment disease through gastrointestinal.
Clinical practice instance 2:
Dog about 40 ages in days, sick dog tendency property unclear symptoms shows, and the unexpected dyspnea that has has laxativeness; As do not take measures, will be very fast dead.Cut open the visible cardiac dilatation of inspection, cardiac muscle and endocardium have the apyetous necrosis region.Serious edema of lung or consolidation.The histology is changed to the myocardium of left ventricle fiber and monocyte infiltration and interstitial fibrosis occur, in the myocardial cell of damage, often can see the intranuclear inclusion that differs in size.With the ill dog of product feeding of the present invention, a day dose is: by every Kg body weight 10g, spice is fed or is decocted back Chinese medicine liquid and irritates clothes, takes 1-2 week continuously, and curative effect is very obvious, and sx is to recovery from illness, and oral back absorbs the purpose that reaches the treatment disease through gastrointestinal.Show that through a large amount of clinical experiment results prevention and therapeutic effect are all very outstanding, effective percentage can reach more than 93%.
Above-mentioned detailed description of the Chinese medicine composition and preparation method thereof of treatment Canine parvovirus infection being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. Chinese medicine composition of treating Canine parvovirus infection, it is characterized in that by following component by weight mixed preparing form: Radix Sanguisorbae 12-18 part, Rhizoma Coptidis 8-12 part, Semen Persicae 8-12 part, Radix Peucedani 8-12 part, Radix Astragali 8-12 part.
2. the Chinese medicine composition of treatment Canine parvovirus infection according to claim 1 is characterized in that said component forms by following parts by weight mixed preparing: 15 parts of Radix Sanguisorbaes, 10 parts of Rhizoma Coptidis, 10 parts in Semen Persicae, 10 parts of Radix Peucedanis, 10 parts of the Radixs Astragali.
3. the method for preparing of the Chinese medicine composition of a treatment Canine parvovirus infection according to claim 1 and 2 is characterized in that carrying out as follows:
(1) with crossing the 20-80 mesh sieve behind the various composition pulverize separately in the prescription;
(2) proportioning takes by weighing Radix Sanguisorbae, Rhizoma Coptidis, Semen Persicae, Radix Peucedani, the Radix Astragali by weight, mix homogeneously.
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| CN103599351B (en) * | 2013-10-31 | 2016-02-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicine composition for the treatment of canine parvovirus disease and preparation method thereof |
| CN104857050A (en) * | 2015-06-17 | 2015-08-26 | 产俊涛 | Traditional Chinese medicine composition for treating canine parvovirus and preparation method thereof |
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Non-Patent Citations (7)
| Title |
|---|
| .犬细小病毒性肠炎的综合诊治.湖北畜牧兽医.2006,(3),32,33. |
| 李兴云 |
| 李玉梅 |
| 杜龙 |
| 杜龙;李玉梅;李兴云;林红;马继芳;.犬细小病毒性肠炎的综合诊治.湖北畜牧兽医.2006,(3),32,33. * |
| 林红 |
| 马继芳 |
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