CN101277681B - 微管蛋白抑制剂吲地布林的口服固体药物制剂 - Google Patents

微管蛋白抑制剂吲地布林的口服固体药物制剂 Download PDF

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Publication number
CN101277681B
CN101277681B CN2006800278114A CN200680027811A CN101277681B CN 101277681 B CN101277681 B CN 101277681B CN 2006800278114 A CN2006800278114 A CN 2006800278114A CN 200680027811 A CN200680027811 A CN 200680027811A CN 101277681 B CN101277681 B CN 101277681B
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CN
China
Prior art keywords
pharmaceutical preparation
inn
indibulin
capsule
micronization
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Expired - Fee Related
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CN2006800278114A
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English (en)
Chinese (zh)
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CN101277681A (zh
Inventor
B·罗斯勒
G·拉伯
T·莱斯曼
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Ziopharm Oncology Inc
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Ziopharm Oncology Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2006800278114A 2005-06-14 2006-06-07 微管蛋白抑制剂吲地布林的口服固体药物制剂 Expired - Fee Related CN101277681B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/151,459 US20060280787A1 (en) 2005-06-14 2005-06-14 Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
US11/151,459 2005-06-14
PCT/EP2006/005423 WO2006133835A2 (en) 2005-06-14 2006-06-07 Oral solid pharmaceutical formulation of the tribulin inhibitor indibulin

Publications (2)

Publication Number Publication Date
CN101277681A CN101277681A (zh) 2008-10-01
CN101277681B true CN101277681B (zh) 2013-03-20

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Family Applications (1)

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CN2006800278114A Expired - Fee Related CN101277681B (zh) 2005-06-14 2006-06-07 微管蛋白抑制剂吲地布林的口服固体药物制剂

Country Status (20)

Country Link
US (1) US20060280787A1 (cg-RX-API-DMAC7.html)
EP (1) EP1922061B8 (cg-RX-API-DMAC7.html)
JP (2) JP2008543798A (cg-RX-API-DMAC7.html)
KR (1) KR20080045110A (cg-RX-API-DMAC7.html)
CN (1) CN101277681B (cg-RX-API-DMAC7.html)
AT (1) ATE417603T1 (cg-RX-API-DMAC7.html)
AU (1) AU2006257428B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0613139A2 (cg-RX-API-DMAC7.html)
CA (1) CA2612288A1 (cg-RX-API-DMAC7.html)
DE (1) DE602006004365D1 (cg-RX-API-DMAC7.html)
DK (1) DK1922061T3 (cg-RX-API-DMAC7.html)
ES (1) ES2319929T3 (cg-RX-API-DMAC7.html)
IL (1) IL188164A (cg-RX-API-DMAC7.html)
MX (1) MX2007016081A (cg-RX-API-DMAC7.html)
NO (1) NO20076509L (cg-RX-API-DMAC7.html)
NZ (1) NZ564927A (cg-RX-API-DMAC7.html)
PT (1) PT1922061E (cg-RX-API-DMAC7.html)
RU (1) RU2008100236A (cg-RX-API-DMAC7.html)
WO (1) WO2006133835A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200711169B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
JP2010511041A (ja) * 2006-11-28 2010-04-08 ジオファーム オンコロジー， インコーポレイテッド インジブリンを含むインドリル−３−グリオキシル酸誘導体の癌を処置するための単独またはさらなる薬剤との組み合わせでの使用
TW201113266A (en) * 2009-09-02 2011-04-16 Ziopharm Oncology Inc Pharmaceutical formulations for indibulin
CN116832053B (zh) * 2023-06-06 2025-11-07 河北大学 Tppp3作为作用靶点在制备i型超敏反应药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006002887A1 (en) * 2004-06-29 2006-01-12 Baxter International Inc. Aqueous drink solution of indibulin (d-24851) and an organic acid

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JP2013151574A (ja) 2013-08-08
AU2006257428A1 (en) 2006-12-21
RU2008100236A (ru) 2009-07-20
KR20080045110A (ko) 2008-05-22
DK1922061T3 (da) 2009-04-20
NO20076509L (no) 2008-02-27
CA2612288A1 (en) 2006-12-21
ZA200711169B (en) 2009-01-28
CN101277681A (zh) 2008-10-01
IL188164A (en) 2010-11-30
BRPI0613139A2 (pt) 2010-12-21
ATE417603T1 (de) 2009-01-15
US20060280787A1 (en) 2006-12-14
NZ564927A (en) 2010-12-24
WO2006133835A8 (en) 2010-05-27
WO2006133835A2 (en) 2006-12-21
JP2008543798A (ja) 2008-12-04
DE602006004365D1 (de) 2009-01-29
EP1922061B1 (en) 2008-12-17
MX2007016081A (es) 2008-03-10
IL188164A0 (en) 2008-03-20
WO2006133835A3 (en) 2007-07-19
PT1922061E (pt) 2009-03-24
EP1922061B8 (en) 2010-09-08
HK1120739A1 (en) 2009-04-09
EP1922061A2 (en) 2008-05-21
AU2006257428B2 (en) 2012-03-22
ES2319929T3 (es) 2009-05-14

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