CN101273131A - 胰腺癌相关基因cst6和gabrp - Google Patents

胰腺癌相关基因cst6和gabrp Download PDF

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Publication number
CN101273131A
CN101273131A CNA200680035760XA CN200680035760A CN101273131A CN 101273131 A CN101273131 A CN 101273131A CN A200680035760X A CNA200680035760X A CN A200680035760XA CN 200680035760 A CN200680035760 A CN 200680035760A CN 101273131 A CN101273131 A CN 101273131A
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China
Prior art keywords
cst6
gabrp
cell
polypeptide
pdac
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Pending
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CNA200680035760XA
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English (en)
Chinese (zh)
Inventor
中村佑辅
中川英刀
中鹤修一
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Oncotherapy Science Inc
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Oncotherapy Science Inc
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Publication of CN101273131A publication Critical patent/CN101273131A/zh
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
CNA200680035760XA 2005-07-27 2006-07-14 胰腺癌相关基因cst6和gabrp Pending CN101273131A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70317105P 2005-07-27 2005-07-27
US60/703,171 2005-07-27

Publications (1)

Publication Number Publication Date
CN101273131A true CN101273131A (zh) 2008-09-24

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ID=37075104

Family Applications (1)

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CNA200680035760XA Pending CN101273131A (zh) 2005-07-27 2006-07-14 胰腺癌相关基因cst6和gabrp

Country Status (4)

Country Link
EP (1) EP1907547A2 (fr)
JP (1) JP2009505632A (fr)
CN (1) CN101273131A (fr)
WO (1) WO2007013360A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101985651A (zh) * 2010-04-30 2011-03-16 苏州工业园区为真生物医药科技有限公司 胃肠肿瘤诊断和预示的新分子标记
CN103361407A (zh) * 2012-04-06 2013-10-23 复旦大学 Brsk2在制备诊断胰腺癌的试剂中的应用
CN109564221A (zh) * 2016-05-10 2019-04-02 免疫媒介有限公司 方法、阵列及其用途
CN115814098A (zh) * 2022-12-09 2023-03-21 江南大学 耐药相关基因gabrp在结直肠癌耐药中的应用
CN117305269A (zh) * 2023-09-15 2023-12-29 湖北工业大学 基于styk1激酶结构的多肽及其在制备治疗癌症药物中的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5574258B2 (ja) * 2009-10-01 2014-08-20 学校法人東京女子医科大学 膵臓がん治療用の組成物
JP2023093779A (ja) * 2020-05-21 2023-07-05 国立研究開発法人理化学研究所 新規抗がん剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011012A (en) * 1995-06-05 2000-01-04 Human Genome Sciences, Inc. Human cystatin E
ES2303390B1 (es) * 2003-09-24 2009-08-17 Progenika Biopharma, S.A. Metodos para el diagnostico in vitro y pronostico in vitro del adenocarcinoma ductal de pancreas y/o de una pancreatitis; y para el desarrollo de farmacos contra el adenocarcinoma ductal de pancreas y/o contra una pancreatitis.

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101985651A (zh) * 2010-04-30 2011-03-16 苏州工业园区为真生物医药科技有限公司 胃肠肿瘤诊断和预示的新分子标记
CN103361407A (zh) * 2012-04-06 2013-10-23 复旦大学 Brsk2在制备诊断胰腺癌的试剂中的应用
CN109564221A (zh) * 2016-05-10 2019-04-02 免疫媒介有限公司 方法、阵列及其用途
CN115814098A (zh) * 2022-12-09 2023-03-21 江南大学 耐药相关基因gabrp在结直肠癌耐药中的应用
CN117305269A (zh) * 2023-09-15 2023-12-29 湖北工业大学 基于styk1激酶结构的多肽及其在制备治疗癌症药物中的应用
CN117305269B (zh) * 2023-09-15 2024-04-16 湖北工业大学 基于styk1激酶结构的多肽及其在制备治疗癌症药物中的应用

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Publication number Publication date
EP1907547A2 (fr) 2008-04-09
WO2007013360A3 (fr) 2007-08-30
WO2007013360A2 (fr) 2007-02-01
JP2009505632A (ja) 2009-02-12

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