CN101264202A - Hericium erinaceus digestion-promoting Chinese medicinal composition and preparation thereof - Google Patents
Hericium erinaceus digestion-promoting Chinese medicinal composition and preparation thereof Download PDFInfo
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Abstract
The invention provides a composition of traditional Chinese medicine for taking Hericium erinaceus to strengthen the stomach, which is characterized in that the composition is prepared by following steps: taking proper nutrient material of Hericium erinaceus to obtain the clear paste of the Hericium erinaceus nutrient material, breaking the remanent Hericium erinaceus nutrient material and obtaining the extractive material after mixing and drying the broken Hericium erinaceus nutrient material and the clear paste; breaking separately the cuttlebone, the rhizoma corydalis, the cyperus tuber, the radix paeoniae alba and the radix glycyrrhizae, mixing the broken Chinese drugs with the extractive material of Hericium erinaceus nutrient material and receivable adjuvant to make into different pharmaceutics. The invention of Hericium erinaceus composition for strengthening the stomach has the advantages that the quantity of Hericium erinaceus nutrient material can be reduced in the precondition of not changing the product recipe, thereby, the production cost can be decreased, the dose can be reduced but the curative effect can be strengthened.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of hedgehog hydnum Chinese medicine for invigorating stomach composition and method of making the same.
Background technology
Hericium erinaceus (Bull. Ex Fr.) Pers. is considered as the delicacies treasure by the successive dynasties imperial palace, and the pharmacy man in successive dynasties thinks that all Hericium erinaceus (Bull. Ex Fr.) Pers. has high medical value, and the pharmacy masterpiece supplementary Amplifications of the Compendium of Materia Medica of China, " national Chinese medicine compilation " and " Chinese medicine voluminous dictionary " are all on the books.Hericium erinaceus (Bull. Ex Fr.) Pers. has effects such as antiinflammatory, relieving distension, detoxifcation, for various gastrointestinal disease of treatment and human body weakness unique curative effect is arranged, continual renovation along with science and technology development and medicine biological technique, Hericium erinaceus (Bull. Ex Fr.) Pers. is paid close attention to by the world day by day, become the focus of scientific research, Japan, Korea S and country in Southeast Asia are all in developmental research.
At first Hericium erinaceus (Bull. Ex Fr.) Pers. is used for the treatment of the Hericium Evimaccus slice of gastropathy, employing be the mycelium of liquid fermentation, the cycle is short, therapeutic effect is undesirable, there is no pain relieving, antacid and astriction, can not remove the cardinal symptom of gastropathy.The hedgehog hydnum stomachic of listing adopted solid culture Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium afterwards, cycle is about 45 days, the hyphostoma development maturation, beginning transforms to sporophore, the various macromolecular substances that help treating digestive tract disease form, particularly facilitating digestion is had the activated fibre enzyme of Chinese medicine effect, the abundantest at this phase content, treatment gastropathy there is significant curative effect.
The HOUTOU JIANWEI JIAONANG of 2005 editions pharmacopeia record adopts Hericium erinaceus culture all to extract, concentrate and add adjuvant and prepare Hericium erinaceus culture extractum, it is best that its curative effect does not reach, the Hericium erinaceus culture bioactive substance does not extract, biological transformation ratio is also not high, thereby also need to further improve, to reach optimum efficiency.Patent CN100345575C discloses hedgehog hydnum Chinese medicine for invigorating stomach compositions, make its biological transformation ratio and curative effect all increase, but this technology has changed the prescription of product, has strengthened the inventory of Hericium erinaceus culture, has increased cost.
The present invention is under the prerequisite that does not change the product prescription, the Hericium erinaceus culture part water extraction of employing proper proportion and residue the Hericium erinaceus culture not bonded method of extract phase prepare Hericium erinaceus culture extractum, both reduced the consumption of Hericium erinaceus culture, reduce cost, made the curative effect of product reach best again.
Summary of the invention
The purpose of this invention is to provide the hedgehog hydnum Chinese medicine for invigorating stomach compositions of the relieving gastric hyperacidity to alleviate stomachache of a kind of energy, elimination distension, stimulating appetite, this Chinese medicine composition has significant curative effect to chronic gastritis, gastric and duodenal ulcers.
Another object of the present invention provides the preparation method of above-mentioned Chinese medicine composition.
Chinese medicine composition provided by the present invention, it is to be prepared from as follows:
1) gets Hericium erinaceus culture 120-200 weight portion, preferred 160 weight portions, the wherein Hericium erinaceus culture of 40-60%, water extraction 2-3 time adds water 6-12 doubly at every turn, each 1-2h, merge extractive liquid, filters, and filtrate decompression is concentrated into the clear paste that relative density is 1.10-1.25;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum;
3) with Endoconcha Sepiae 60-100 weight portion, preferred 80 weight portions, Rhizoma Corydalis (system) 30-50 weight portion, preferred 40 weight portions, Rhizoma Cyperi (system) 30-50 weight portion, preferred 40 weight portions, the Radix Paeoniae Alba (system) 30-50 weight portion, preferred 40 weight portions, Radix Glycyrrhizae 30-50 weight portion, preferred 40 weight portions, beat powder respectively, mixing is with 2) middle Hericium erinaceus culture extractum mixing, make different preparations with pharmaceutically acceptable adjuvant.
Wherein, the preparation process of described Rhizoma Corydalis (system), the Radix Paeoniae Alba (system), Rhizoma Cyperi (system), Radix Glycyrrhizae is as follows:
Rhizoma Corydalis (system): per 10 weight portion Rhizoma Corydalis are with vinegar 2 weight portions, stir, vexed, put into medicine cookeding pot, fry to buff with slow fire, put into drying baker, 110 ℃ ± 5 ℃ dryings 5 hours;
The Radix Paeoniae Alba (system): per 10 weight portion Radix Paeoniae Albas, add yellow wine 1 weight portion, stir, vexed, put into medicine cookeding pot, fry to little yellow with slow fire, put into drying baker, 110 ℃ ± 5 ℃ dryings 4 hours;
Rhizoma Cyperi (system): per 10 weight portion Rhizoma Cyperis, with vinegar 2 weight portions, stir, vexed, put into medicine cookeding pot, fry to brown with slow fire, put into drying baker, 110 ℃ ± 5 ℃ dryings 5 hours;
Radix Glycyrrhizae: do not concoct, be about to Radix Glycyrrhizae and clean, cut off, 110 ℃ ± 5 ℃ dryings.
Chinese medicine composition provided by the present invention, its main pharmacodynamics composition is a Hericium erinaceus culture extractum, its preferable preparation process is:
1) get 50% Hericium erinaceus culture, decoct with water secondary, add 10 times of amounts of water for the first time, add 8 times of amounts of water for the second time, each 2 hours, collecting decoction filtered, and filtrate decompression is condensed into the clear paste that relative density is 1.15 (70 ℃);
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum.
The preferable preparation process of another of Hericium erinaceus culture extractum is:
1) get 50% Hericium erinaceus culture, decoct with water three times, add 8 times of amounts of water at every turn, each 1 hour, collecting decoction filtered, and filtrate decompression is condensed into the clear paste that relative density is 1.10 (70 ℃);
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum.
Chinese medicine composition provided by the present invention can be selected suitable adjuvant as required, as starch, dextrin, carboxymethyl starch sodium, lactose, magnesium stearate, Pulvis Talci etc., makes pharmaceutical fields such as tablet, capsule, granule or pill dosage form commonly used.
Research worker of the present invention is found in production practices, Hericium erinaceus (Bull. Ex Fr.) Pers. solid culture light specific gravity, when pulverizing very carefully, fly upward easily, the effective often mycelium of the composition that flies upward, admix in the part culture coarse powder after adopting part Hericium erinaceus culture water extraction to concentrate, pulverize the oven dry back, because the mucus of extracting solution has changed the physical behavior of culture, therefore produce and stablize, have controlled, operability.
Chinese medicine composition provided by the present invention is a monarch drug with Hericium erinaceus culture extractum, strengthens the spleen and stomach, and invigorating the spleen and benefiting QI helps the effect of the QI and blood biochemistry day after tomorrow.With the Radix Paeoniae Alba, Rhizoma Corydalis, Rhizoma Cyperi is ministerial drug, and wherein the Radix Paeoniae Alba has nourishing blood to suppress the hyperactive liver, strengthening the spleen analgesic effect; Rhizoma Corydalis has the effect of regulating QI to relieve pain, promoting blood circulation to remove blood stasis; Rhizoma Cyperi has the effect of liver-smoothing, qi-regulating, resolving depression; Three medicines share, and make QI movement being in harmonious way, and temper is healthy and vigorous, but the easing the affected liver regulating QI to relieve pain.With the Endoconcha Sepiae is adjuvant drug, and the effect of astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache is arranged.With the Radix Glycyrrhizae is messenger drug, and invigorating the spleen and benefiting QI, relieving spasm to stop pain are arranged, the effect of coordinating the actions of various ingredients in a prescription.Full side interacts, and brings out the best in each other, and amounts to the soothing liver-QI stomach function regulating, the antacid convergence, and anti-inflammatory analgetic, relieving distension removes full, the effect of appetite strengthening.
In addition, this prescription respectively distinguish the flavor of Chinese medicine aspect therapeutic effect, the contained peoniflorin of the Radix Paeoniae Alba can suppress gastric secretion, and can prevent to answer the acute ulcer disease; Rhizoma Corydalis contains multiple alkaloid, and wherein tetrahydropalmatine can have been led analgesia, sedation, the plain energy of dehydrogenation Rhizoma Corydalis first regulating QI to relieve pain, and promoting blood circulation to remove blood stasis, effective in cure to gastroenteritic ulcer; The alcohol extract of Rhizoma Cyperi has antiinflammatory, analgesic, analgesia, stabile effect; Flavonoid glycoside in the Radix Glycyrrhizae has significant protective effect to ulcer; Endoconcha Sepiae is used for the Peptic Ulcers hyperchlorhydria more, the antacid acid regurgitation.So all medicines share, chronic gastritis, gastric and duodenal ulcers there is significant curative effect.
The present invention has following improvement and characteristics than prior art:
1, under the prerequisite that does not change the product prescription, reduced the consumption of Hericium erinaceus culture, reduced cost;
2, adopted 40-60% Hericium erinaceus culture water extraction with the residue Hericium erinaceus culture not the bonded method of extract phase prepare Hericium erinaceus culture extractum, kept original mycelial peculiar composition, strengthened drug effect;
3, with Hericium erinaceus culture as monarch drug, the several kinds of Chinese medicinal materials of compatibility is concocted and is concentrated by the modern science and technology method, and dose is reduced, curative effect increases; By extracting, effective ingredient is easier to be absorbed by gastric mucosa, and pain relieving is fast, and the effect of antacid convergence, anti-inflammatory analgetic, liver-smoothing, qi-regulating is strengthened greatly.
Description of drawings
Fig. 1 is a hedgehog hydnum Chinese medicine for invigorating stomach preparation of compositions method flow diagram of the present invention.
The specific embodiment
The Chinese medicine composition that the present invention proposes is described as follows in conjunction with the embodiments.
Embodiment 1
Get Hericium erinaceus culture 160g, wherein the Hericium erinaceus culture of 80g decocts with water secondary, adds 10 times of amounts of water for the first time, adds 8 times of amounts of water for the second time, and each 2 hours, collecting decoction filtered, and filtrate decompression is condensed into the clear paste that relative density is 1.15 (70 ℃); Get the Hericium erinaceus culture of residue 80g and pulverize, mix thoroughly with above-mentioned Hericium erinaceus culture clear paste, drying is ground into fine powder, gets Hericium erinaceus culture extractum; Get Endoconcha Sepiae 80g, Rhizoma Corydalis (system) 40g, the Radix Paeoniae Alba (system) 40g, Rhizoma Cyperi (system) 40g, Radix Glycyrrhizae 40g are ground into fine powder, cross 100 mesh sieves, mixing, sterilization with above-mentioned Hericium erinaceus culture extractum and starch 4g mixing, incapsulates, and makes 1000.
Embodiment 2
Get Hericium erinaceus culture 160g, wherein the Hericium erinaceus culture of 80g decocts with water three times, adds 8 times of amounts of water at every turn, and each 1 hour, collecting decoction filtered, and filtrate decompression is condensed into the clear paste that relative density is 1.10 (70 ℃); Get the Hericium erinaceus culture of residue 80g and pulverize, mix thoroughly with above-mentioned Hericium erinaceus culture clear paste, drying is ground into fine powder, gets Hericium erinaceus culture extractum; Get Endoconcha Sepiae 80g, Rhizoma Corydalis (system) 40g, the Radix Paeoniae Alba (system) 40g, Rhizoma Cyperi (system) 40g, Radix Glycyrrhizae 40g are ground into fine powder, cross 100 mesh sieves, mixing, sterilization with above-mentioned Hericium erinaceus culture extractum and starch 5g mixing, incapsulates, and makes 1000.
Embodiment 3
Get Hericium erinaceus culture 200g, wherein the Hericium erinaceus culture of 100g decocts with water three times, adds 8 times of amounts of water at every turn, and each 1 hour, collecting decoction filtered, and filtrate decompression is condensed into the clear paste that relative density is 1.15 (70 ℃); Get the Hericium erinaceus culture of residue 100g and pulverize, mix thoroughly with above-mentioned Hericium erinaceus culture clear paste, drying is ground into fine powder, gets Hericium erinaceus culture extractum; Get Endoconcha Sepiae 100g, Rhizoma Corydalis (system) 30g, the Radix Paeoniae Alba (system) 30g, Rhizoma Cyperi (system) 30g, Radix Glycyrrhizae 30g are ground into fine powder, cross mesh sieve, mixing, sterilization with above-mentioned Hericium erinaceus culture extractum and starch 8g mixing, incapsulates, and makes 1000.
Embodiment 4
Get Hericium erinaceus culture 120g, wherein the Hericium erinaceus culture of 60g decocts with water three times, adds 8 times of amounts of water at every turn, and each 1 hour, collecting decoction filtered, and filtrate decompression is condensed into the clear paste that relative density is 1.15 (70 ℃); Get the Hericium erinaceus culture of residue 60g and pulverize, mix thoroughly with above-mentioned Hericium erinaceus culture clear paste, drying is ground into fine powder, gets Hericium erinaceus culture extractum; Get Endoconcha Sepiae 60g, Rhizoma Corydalis (system) 50g, the Radix Paeoniae Alba (system) 50g, Rhizoma Cyperi (system) 50g, Radix Glycyrrhizae 50g are ground into fine powder, cross mesh sieve, mixing, sterilization with above-mentioned Hericium erinaceus culture extractum and starch 3g mixing, incapsulates, and makes 1000.
Experimental example 1 active constituent content measuring
The main pharmacodynamics composition of Chinese medicine composition of the present invention is a Hericium erinaceus culture extractum, employing 40%-60% Hericium erinaceus culture part water extraction and residue the Hericium erinaceus culture not bonded method of extract phase prepare Hericium erinaceus culture extractum, its main cause is that Hericium erinaceus culture all reduces greatly through extracting the various active ingredients in back, though prior art has also adopted hedgehog hydnum culture extracting section and the bonded method of extract phase not to prepare Hericium erinaceus culture extractum, but its Hericium erinaceus culture consumption is big, the cost height.The present invention has reduced the consumption of Hericium erinaceus culture, has reduced cost, has the level suitable with prior art on each active constituent content.In order to confirm above viewpoint, we to Hericium erinaceus culture powder, Hericium erinaceus culture water extract, Hericium erinaceus culture extractum A (the present invention with 50% Hericium erinaceus culture part water extraction and remainder not the bonded method of extract phase make), Hericium erinaceus culture extractum B (patent CN100345575C with 83% Hericium erinaceus culture part water extraction and remainder not the bonded method of extract phase make) in active constituent content done following check:
1) amino acid content is as shown in table 1:
Table 1: the various amino acid contents under above-mentioned four kinds of situations
| The aminoacid title | Hericium erinaceus culture powder (mg/100mg) | Hericium erinaceus culture water extract (mg/100mg) | Hericium erinaceus culture extractum A (mg/100mg) | Hericium erinaceus culture extractum B (mg/100mg) |
| Aspartic acid | 1.71 | 0.10 | 1.78 | 1.71 |
| Threonine | 0.87 | 0.02 | 0.90 | 0.85 |
| Serine | 1.11 | 0.03 | 1.21 | 1.18 |
| Glutamic acid | 2.64 | 0.12 | 2.68 | 2.65 |
| Glycine | 1.12 | 0.02 | 1.22 | 1.26 |
| Alanine | 1.23 | 0.04 | 1.35 | 1.40 |
| Cystine | 0.48 | 0.00 | 0.62 | 0.65 |
| Valine | 1.50 | 0.01 | 1.68 | 1.58 |
| Methionine | 0.30 | 0.01 | 0.42 | 0.40 |
| Isoleucine | 0.80 | 0.01 | 0.90 | 0.85 |
| Leucine | 1.19 | 0.02 | 1.15 | 1.19 |
| Tyrosine | 0.59 | 0.00 | 0.68 | 0.65 |
| Phenylalanine | 1.12 | 0.01 | 1.25 | 1.18 |
| Lysine | 1.01 | 0.01 | 1.18 | 1.12 |
| Ammonia | 0.68 | 0.01 | 0.69 | 0.73 |
| Histidine | 0.51 | 0.00 | 0.60 | 0.61 |
| Arginine | 0.92 | 0.02 | 0.98 | 1.02 |
| Proline | 2.23 | 0.10 | 2.33 | 2.30 |
| Summation | 20.11 | 0.53 | 21.62 | 21.33 |
From above test data as can be seen, the whole water extraction of Hericium erinaceus culture, effective ingredient aminoacid does not extract substantially, and the amino acid content total amount of Hericium erinaceus culture extractum A and Hericium erinaceus culture extractum B is more or less the same.
2) protein content: after measured, the protein content of Hericium erinaceus culture powder is 22.0%; The protein content of Hericium erinaceus culture water extract is 0.58%, and the protein content that the protein content of Hericium erinaceus culture extractum A is 24.5%, Hericium erinaceus culture soaks B is 24.0%.Digestive enzyme abundant in the Hericium erinaceus culture is protein, that is to say, and protein total loss almost behind whole water extraction, the curative effect of product reduces greatly.Hericium erinaceus culture extractum A and Hericium erinaceus culture extractum B protein content are more or less the same, and have guaranteed the effect of relieving distension except that full, appetite strengthening, reparation gastric mucosa.
3) vitamin content is as shown in table 2:
Vitamin content under the above-mentioned four kinds of situations of table 2
| The vitamin title | Hericium erinaceus culture powder (mg/100mg) | Hericium erinaceus culture water extract (mg/100mg) | Hericium erinaceus culture extractum A (mg/100mg) | Hericium erinaceus culture extractum B (mg/100mg) |
| Ascorbic acid | 26.04 | Do not detect | 26.54 | 26.18 |
| Thiamine | 3.52 | 1.28 | 4.18 | 4.25 |
| Riboflavin | 2.85 | 0.58 | 3.15 | 3.08 |
| The Buddhist nun restrains propylhomoserin | 49.27 | 17.65 | 58.27 | 57.88 |
| Pyridoxol | 0.81 | 0.21 | 0.98 | 0.95 |
| Pantothenic acid | 10.88 | 2.15 | 12.21 | 12.15 |
| Folic acid | 0.32 | 0.10 | 0.39 | 0.40 |
Hericium erinaceus culture is to adopt solid culture method, and the cycle is 45 days, and hericium mycelium transfers meiosis to by mitosis, and knot appears in mycelium, and beginning transforms to sporophore.During this period, Hericium erinaceus (Bull. Ex Fr.) Pers. filament is grown ripe, and the various macromolecular substances for the treatment of digestive tract disease that are of value to form, and particularly facilitating digestion are had the active cellulase and the various digestive enzyme of important function, and are the abundantest at this phase content.And these compositions lose activity by water boiling and extraction is concentrated.Medium component originally forms a kind of homobium with mycelia through the mycelia decomposition and inversion, brings into play drug action jointly.
Chinese medicine composition employing 40-60% Hericium erinaceus culture part water extraction of the present invention and the remainder not bonded method of extract phase prepare Hericium erinaceus culture extractum, not only reduced the consumption of Hericium erinaceus culture, reduced cost, guarantee active constituent content in the Hericium erinaceus culture equally, had more practical value.
Experimental example 2 efficacy analysis at digestive system disease such as gastritis, gastric and duodenal ulcers
1, clinical data
1) ordinary circumstance: male's 115 examples, women's 55 examples; 23 examples below 30 years old, 31-60 year 119 examples, 28 examples more than 61 years old.
2) diagnosis basis: diagnosis is hepatobiliary system disease except medical history, symptom of digestive tract and sign mainly, and part patient makes a definite diagnosis through upper digestive tract canel barium meal contrast examination or fibergastroscope.
3) observational technique: most of patient is in out-patient treatment, and some cases is hospitalized for observation, each 4 of the hedgehog hydnum stomachic of the diagnosis clothes embodiment of the invention 1, three times on the one, period in a medicine is withdrawn other Western medicine, and the shortest person 5 days takes medicine, elder 60 days, average course of treatment 12.5 days.
2, efficacy analysis:
This is organized in 170 examples, chronic gastritis 121 examples, gastric and duodenal ulcers 35 examples, other 14 example.Therapeutic outcome and treatment back symptom variation situation are respectively as table 3, table 4:
Table 3 hedgehog hydnum Chinese medicine for invigorating stomach of the present invention compositions is to the therapeutic effect of chronic gastritis and Peptic Ulcers
| The sick kind | The example number | Clinical cure (%) | Take a turn for the better (%) | Total effective rate (%) | Invalid (%) |
| Chronic gastritis | 121 | 40.5 | 55.4 | 95.9 | 4.1 |
| Peptic Ulcers | 35 | 3.0 | 89.0 | 92.0 | 8.0 |
| Add up to | 156 | 32.1 | 62.8 | 94.9 | 5.1 |
In other 14 example: chronic enteritis 3 examples, 2 examples that take a turn for the better, invalid 1 example; Gastroptosis 1 example, 1 example takes a turn for the better; Esophageal carcinoma 3 examples, symptom 2 examples that take a turn for the better, invalid 1 example; Dyspepsia 5 examples, 5 examples take a turn for the better; Gastric cancer 2 examples, symptom 2 examples that take a turn for the better.By 170 examples, total effective rate is 94.1%, and invalid is 5.9%.
Table 4 treatment back symptom variation situation
| Cardinal symptom | The example number | Disappear (%) | Take a turn for the better (%) | Alleviate (%) | Total effective rate (%) | No change (%) |
| Epigastrium pain | 164 | 30.5 | 55.5 | 6.1 | 92.1 | 7.9 |
| Belch pantothenic acid | 103 | 48.5 | 42.7 | 3.9 | 95.1 | 4.9 |
| Abdominal distention | 61 | 21.3 | 67.2 | 3.3 | 91.8 | 8.2 |
| Melena | 24 | 12.5 | 62.5 | 4.2 | 79.2 | 20.8 |
3, conclusion
The clinical observation in 1 year proves that compositions of the present invention is to chronic gastritis, gastric and duodenal ulcers satisfactory effect, and effective percentage is respectively 95.9% and 92.0%, and is excellent good to the chronic gastritis curative effect.This medicine has tangible relieving gastric hyperacidity to alleviate stomachache, eliminates the effect of distension, stimulating appetite.Slightly poor to the upper gastrointestinal hemorrhage curative effect, other digestive system disease also there is certain effect.
Experimental example 3 hedgehog hydnum Chinese medicine for invigorating stomach compositions clinical control viewing tests of the present invention
1. case choice criteria
Employing is based on disease, the bonded mode of disease, and the selection Western medicine diagnose is chronic gastritis, gastroduodenal ulcer, differential diagnosis in tcm is that the syndrome of incoordination between liver and stomach patient is as the object of observation.
2. observational technique
Employing according to the layering of disease kind, pattern of syndrome elder generation after random packet, the design of the parallel double blinding controlled observation of positive drug.
The treatment group: 177 routine patients, 129 examples have the peptic ulcer disease, 141 examples detect helicobacter pylori (HP) positive, the Chinese medicinal composition capsules that all oral embodiment 1 of 177 routine patients makes, one time 4,3 times on the one, every the dress 0.34g.
Matched group: 61 routine patients, 47 examples have the peptic ulcer disease, 49 examples detect helicobacter pylori (HP) positive, the Chinese medicinal composition capsules that all oral patent CN100345575C of 61 routine patients makes, one time 4,3 times on the one, every the dress 0.34g.
Two groups is a course of treatment with 4 weeks of taking medicine continuously all, and after finishing the course of treatment, drug withdrawal was followed up a case by regular visits to 6 months.In the observation process, all include in observe case do not allow to take above observation disease be principal indication in, western drug and other therapy.All to avoid overworked and psychentonia during two groups of treatments, avoid diet irregular and pungent, cross into beverages such as food and strong tea, coffees.
3. observed result
3.1 clinical data
3.1.1 physical data: two groups of case sexes, personal lifestyle custom and age distribution situations, difference did not have significance meaning (P＞0.05) between handled two groups by statistics, had neat same comparability.
3.1.2 state of an illness data: the cardinal symptom grade before two groups of cases are treated and the course of disease, tcm syndrome differentiation and typing, gastroscope diagnostic result and helicobacter pylori (HP) check result, difference did not have significance meaning (P＞0.05) between handled two groups by statistics, had neat same comparability.
3.2 observation of curative effect result
3.2.1 two groups of traditional Chinese medicine composition for treating chronic gastritiss, peptic ulcer syndrome of incoordination between liver and stomach curative effects compare, and see Table 5:
Table 5; Two groups of traditional Chinese medicine composition for treating chronic gastritiss, gastroduodenal ulcer syndrome of incoordination between liver and stomach curative effects compare
| Group | The example number | Cure | Produce effects | Take a turn for the better | Invalid | Total obvious effective rate (%) | Total effective rate (%) |
| The treatment group | 177 | 65 | 48 | 46 | 18 | 63.84 | 89.83 |
| Matched group | 61 | 13 | 15 | 17 | 16 | 45.90 | 73.77 |
Treatment group curative effect obviously is better than matched group, and difference has statistical significance (P＜0.05).
3.2.3 two kinds of traditional Chinese medicine composition for treating peptic ulcer gastroscopy effects relatively see Table 6:
Two kinds of traditional Chinese medicine composition for treating gastroduodenal ulcer of table 6 gastroscopy effect relatively
| Group | n | Clinical cure | Produce effects | Effectively | Take a turn for the better | Total effective rate |
| The treatment group | 129 | 51 | 41 | 22 | 15 | 88.4 |
| Matched group | 47 | 11 | 9 | 15 | 12 | 74.5 |
Treatment group curative effect obviously is better than matched group, and difference has statistical significance (P＜0.05)
3.2.4 two groups of Chinese medicine compositions relatively see Table 7 to the HP eradication rate
The HP testing result relatively before and after the table 7 liang group treatment
| Group | Number positive before the treatment | Treatment back number positive | HP eradication rate (%) |
| The treatment group | 141 | 94 | 33.3 |
| Matched group | 49 | 42 | 14.3 |
Treatment group curative effect obviously is better than matched group, and difference has statistical significance (P＜0.05)
3.2.5 two groups of relapse rates relatively: case was observed stomach in 6 months through following up a case by regular visits to behind two groups of clinical cures, duodenal ulcer recurrence situation sees Table 8;
Table 8 liang group rate of relapse in patients relatively
| Group | Cure | Recurrence | Not recurrence | Relapse rate (%) |
| The treatment group | 88 | 17 | 71 | 19.32 |
| Matched group | 17 | 8 | 9 | 47.06 |
Group treatment group curative effect obviously is better than matched group, and difference has statistical significance (P＜0.05)
4 conclusions:
Clinical observation studies show that: hedgehog hydnum Chinese medicine for invigorating stomach combination treatment chronic gastritis of the present invention, the total obvious effective rate 63.84% of gastric and duodenal ulcers, and total effective rate 89.83% compares with matched group, and curative effect difference has statistical significance (P＜0.05) between group.There is not tangible untoward reaction in the observation process, the change that do not note abnormalities of check blood, urine, stool routine examination and hepatic and renal function.More than studies show that, hedgehog hydnum Chinese medicine for invigorating stomach compositions better efficacy of the present invention, safety is better.
Above embodiment only is used to illustrate the present invention; and be not limitation of the present invention; the those of ordinary skill in relevant technologies field; under the situation that does not break away from the spirit and scope of the present invention; can also make various variations and modification; therefore all technical schemes that are equal to also belong to category of the present invention, and scope of patent protection of the present invention should be defined by the claims.
Claims (10)
1, a kind of hedgehog hydnum Chinese medicine for invigorating stomach compositions, it is to be prepared from as follows:
1) get Hericium erinaceus culture 120-200 weight portion, wherein the Hericium erinaceus culture of 40-60% adds the water extraction that 6-12 doubly measures, and repeats 2-3 time, each 1-2h, and merge extractive liquid, filters, and filtrate decompression is concentrated into the clear paste that relative density is 1.10-1.25;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum;
3) with Endoconcha Sepiae 60-100 weight portion, Rhizoma Corydalis (system) 30-50 weight portion, Rhizoma Cyperi (system) 30-50 weight portion, the Radix Paeoniae Alba (system) 30-50 weight portion, Radix Glycyrrhizae 30-50 weight portion is beaten powder respectively, mixing is with 2) middle Hericium erinaceus culture extractum mixing, make different preparations with pharmaceutically acceptable adjuvant.
2, Chinese medicine composition as claimed in claim 1, wherein Hericium erinaceus culture is 160 weight portions, and Endoconcha Sepiae is 80 weight portions, and Rhizoma Corydalis (system) is 40 weight portions, and Rhizoma Cyperi (system) is 40 weight portions, and the Radix Paeoniae Alba (system) is 40 weight portions, and Radix Glycyrrhizae is 40 weight portions.
3, Chinese medicine composition as claimed in claim 1 or 2 is characterized in that, being prepared as follows of described Rhizoma Corydalis (system), the Radix Paeoniae Alba (system), Rhizoma Cyperi (system), Radix Glycyrrhizae:
Rhizoma Corydalis (system): per 10 weight portion Rhizoma Corydalis are with vinegar 2 weight portions, stir, vexed, put into medicine cookeding pot, fry to buff with slow fire, put into drying baker, 110 ℃ ± 5 ℃ dryings 5 hours;
The Radix Paeoniae Alba (system): per 10 weight portion Radix Paeoniae Albas, add yellow wine 1 weight portion, stir, vexed, put into medicine cookeding pot, fry to little yellow with slow fire, put into drying baker, 110 ℃ ± 5 ℃ dryings 4 hours;
Rhizoma Cyperi (system): per 10 weight portion Rhizoma Cyperis, with vinegar 2 weight portions, stir, vexed, put into medicine cookeding pot, fry to brown with slow fire, put into drying baker, 110 ℃ ± 5 ℃ dryings 5 hours;
Radix Glycyrrhizae: do not concoct, be about to Radix Glycyrrhizae and clean, cut off, 110 ℃ ± 5 ℃ dryings.
4, Chinese medicine composition as claimed in claim 1 or 2 is characterized in that, described Hericium erinaceus culture extractum is to prepare as follows:
1) get 50% Hericium erinaceus culture, decoct with water secondary, add 10 times of amounts of water for the first time, add 8 times of amounts of water for the second time, each 2 hours, collecting decoction filtered, and it is 1.15 clear paste that filtrate decompression is condensed into 70 ℃ of following relative densities;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum.
5, Chinese medicine composition as claimed in claim 1 or 2 is characterized in that, described Hericium erinaceus culture extractum is to prepare as follows:
1) get 50% Hericium erinaceus culture, decoct with water three times, add 8 times of amounts of water at every turn, each 1 hour, collecting decoction filtered, and it is 1.10 clear paste that filtrate decompression is condensed into 70 ℃ of following relative densities;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum.
6, as the arbitrary described Chinese medicine composition of claim 1-4, it is characterized in that, can make tablet, capsule, granule or pill with starch, dextrin, carboxymethyl starch sodium, lactose, magnesium stearate or Pulvis Talci.
7, a kind of hedgehog hydnum Chinese medicine for invigorating stomach preparation of compositions method is characterized in that, comprises the steps:
1) get Hericium erinaceus culture 120-200 weight portion, wherein the Hericium erinaceus culture of 40-60% adds the water extraction that 6-12 doubly measures, and repeats 2-3 time, each 1-2h, and merge extractive liquid, filters, and filtrate decompression is concentrated into the clear paste that relative density is 1.10-1.25;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum;
3) with Endoconcha Sepiae 60-100 weight portion, Rhizoma Corydalis (system) 30-50 weight portion, Rhizoma Cyperi (system) 30-50 weight portion, the Radix Paeoniae Alba (system) 30-50 weight portion, Radix Glycyrrhizae 30-50 weight portion is beaten powder respectively, mixing is with 2) middle Hericium erinaceus culture extractum mixing, make different preparations with pharmaceutically acceptable adjuvant.
8, preparation method as claimed in claim 7 is characterized in that, described Hericium erinaceus culture extractum is to prepare as follows:
1) get 50% Hericium erinaceus culture, decoct with water secondary, add 10 times of amounts of water for the first time, add 8 times of amounts of water for the second time, each 2 hours, collecting decoction filtered, and it is 1.15 clear paste that filtrate decompression is condensed into 70 ℃ of following relative densities;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum.
9, preparation method as claimed in claim 7 is characterized in that, described Hericium erinaceus culture extractum is to prepare as follows:
1) get 50% Hericium erinaceus culture, decoct with water three times, add 8 times of amounts of water at every turn, each 1 hour, collecting decoction filtered, and it is 1.10 clear paste that filtrate decompression is condensed into 70 ℃ of following relative densities;
2) get remaining Hericium erinaceus culture and pulverize, with 1) in clear paste mix thoroughly, drying is ground into fine powder, Hericium erinaceus culture extractum.
10, as each described preparation method of claim 7-9, wherein Hericium erinaceus culture is 160 weight portions, and Endoconcha Sepiae is 80 weight portions, Rhizoma Corydalis (system) is 40 weight portions, Rhizoma Cyperi (system) is 40 weight portions, and the Radix Paeoniae Alba (system) is 40 weight portions, and Radix Glycyrrhizae is 40 weight portions.
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| CN102641497A (en) * | 2012-05-17 | 2012-08-22 | 何述金 | Medicinal composition for treating gastrointestinal diseases |
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| CN100393344C (en) * | 2004-08-19 | 2008-06-11 | 湖南新汇制药有限公司 | Process for preparing concentration type stomach-invigorating medicine of hericium erinaceus |
| CN1883634B (en) * | 2005-06-22 | 2010-09-29 | 湖南新汇制药有限公司 | Preparation process of stomach-caring Chinese medicine with monkey head mushroom |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102641497A (en) * | 2012-05-17 | 2012-08-22 | 何述金 | Medicinal composition for treating gastrointestinal diseases |
| CN102641497B (en) * | 2012-05-17 | 2015-01-21 | 何述金 | Medicinal composition for treating gastrointestinal diseases |
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