CN100393344C - Process for preparing concentration type stomach-invigorating medicine of hericium erinaceus - Google Patents
Process for preparing concentration type stomach-invigorating medicine of hericium erinaceus Download PDFInfo
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- CN100393344C CN100393344C CNB2004100466811A CN200410046681A CN100393344C CN 100393344 C CN100393344 C CN 100393344C CN B2004100466811 A CNB2004100466811 A CN B2004100466811A CN 200410046681 A CN200410046681 A CN 200410046681A CN 100393344 C CN100393344 C CN 100393344C
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Abstract
The present invention relates to a technique for preparing a concentration type stomachic medicine prepared from hericium erinaceus. One part of hericium erinaceus culture is extracted by water, and the other part of hericium erinaceus culture is evenly stirred in a corase powder way and baked for standby; cuttlefish bone, corydalis tuber, radix paeoniae alba and nutgrass galingale rhizome are respectively prepared into powder passing through a sieve with 100 meshes, and the powder is sterilized by respectively using a normal pressure sealed type steam sterilization method to be baked and sealed for standby; one part of radix paeoniae alba and licorice root is completely extracted by water and is concentrated; the other part of corydalis tuber and nutgrass galingale rhizome is extracted by ethyl alcohol to merge and filter extracted solutions, and the ethyl alcohol is recovered; the cuttlefish bone is extracted by water, and the extracted solutions are merged, filtered and concentrated; the three kinds of concentrated solutions are merged and added into the five kinds of powder mixed evenly, and the medicine is obtained by stirring, baking, pulverizing and sealing. The specific ingredients of promycelium are reserved in the technique, which not only can effectively sterilize, but also can reserve the curative effect of the promycelium. Consequently, the biotransformation rate is greatly improved, and simultaneously, the curative effect of the medicine is further enhanced. Thus, the effects on converging acid generation, eliminating inflammation, relieving pain, soothing liver and rectifying qi of the medicine are greatly enhanced.
Description
Technical field
The present invention relates to a kind of preparation technology of Chinese medicine hedgehog hydnum stomachic.
Background technology
Hericium erinaceus (Bull. Ex Fr.) Pers. is considered as the delicacies treasure by the successive dynasties imperial palace, and the pharmacy man in successive dynasties thinks that all Hericium erinaceus (Bull. Ex Fr.) Pers. has high medical value, and the pharmacy masterpiece supplementary Amplifications of the Compendium of Materia Medica of China, " national Chinese medicine compilation " and " Chinese medicine voluminous dictionary " are all on the books.Hericium erinaceus (Bull. Ex Fr.) Pers. has effects such as antiinflammatory, relieving distension, detoxifcation, for various gastrointestinal disease of treatment and human body weakness unique curative effect is arranged, continual renovation along with science and technology development and medicine biological technique, Hericium erinaceus (Bull. Ex Fr.) Pers. is paid close attention to by the world day by day, become the focus of scientific research, Japan, Korea S and country in Southeast Asia are all in developmental research.
HOUTOU JIANWEI JIAONANG has been started the beginning that gastrointestinal disease is treated in famous and precious edible fungi and the smelting of plurality of Chinese compatibility at home, has filled up the blank for the treatment of gastrointestinal disease behind China's Chinese medicine and the edible fungi compatibility.
HOUTOU JIANWEI LING is national Chinese medicine protection kind, and its function cures mainly and is: soothing liver-QI stomach function regulating, regulating QI to relieve pain.Be used for incoordination between the liver and stomach, gastral cavilty distending pain over the hypochondrium, vomiting acid regurgitation; Chronic gastritis, gastric and duodenal ulcers belong to above-mentioned patient; It is the specific drug of a treatment gastropathy.Particularly stomach Helicobacter pylori there is the effect of press down killing, takes for a long time that canceration has certain preventive effect to digestive tract, and can relief of symptoms to gastric cancer, have no side effect, be the special medicine for the treatment of gastropathy in the market.
The HOUTOU JIANWEI JIAONANG production technology is above Six-element, and Hericium erinaceus culture extractum is Hericium erinaceus culture, decocts with water secondary, each 2 hours, collecting decoction filters, and it is 1.04 (70 ℃) that filtrate decompression is condensed into relative density, left standstill 24 hours, filter, filtrate decompression is condensed into the clear paste that relative density is 1.30 (70 ℃), and every 100g extractum adds the about 50g of adjuvant, mixing, drying; Ground spices such as all the other Rhizoma Cyperi, Rhizoma Corydalis, Radix Glycyrrhizae, the Radix Paeoniae Alba, Endoconcha Sepiae are broken into fine powder, sieve, and mixing, sterilization with above-mentioned powder mixing, incapsulates, that is, and referring to Fig. 1.
But it is best that its curative effect of HOUTOU JIANWEI LING does not reach, and bioactive substance and the Effective Components of Chinese Herb of Hericium erinaceus (Bull. Ex Fr.) Pers. fully do not remain, and biological transformation ratio is also not high, thereby also needs to further improve, to reach optimum efficiency.
Summary of the invention
The present invention aims to provide a kind of dose that reduces, and increases curative effect, the preparation technology that the concentrated type hedgehog hydnum that the effective ingredient in the medicine can remain to greatest extent is good for the stomach.
Preparation technology of the present invention is: wherein component is Hericium erinaceus culture 250-400 part Endoconcha Sepiae 150-220 part Rhizoma Corydalis (system) 80-150 part Radix Paeoniae Alba (system) 80-150 part Rhizoma Cyperi (system) 80-150 part Radix Glycyrrhizae (system) 80-150 part; By weight.
(1) get a part of hedgehog hydnum culture water extraction 2-3 time, add water 6-12 doubly at every turn, each 1-2h, merge extractive liquid, filters, and filtrate concentrates;
(2) get another part and under aseptic condition, mix thoroughly through the Hericium erinaceus culture coarse powder that second incubation obtains, oven dry, standby;
(3) get a part of Endoconcha Sepiae, Rhizoma Corydalis, Rhizoma Cyperi, the Radix Paeoniae Alba, beat powder respectively, sieve, respectively the sterilization, the oven dry, the sealing, standby;
(4) get another part Radix Paeoniae Alba, whole liquorice beverage extraction 2-3 time, add water 6-12 doubly at every turn, each 1-2h, merge extractive liquid, filters, and is concentrated;
(5) get another part Rhizoma Corydalis, Rhizoma Cyperi with 50-70% ethanol extraction 2-3 time, add amount of alcohol 4-8 doubly, each 1-2h, merge extractive liquid, filters, and reclaims ethanol, and is concentrated;
(6) the Endoconcha Sepiae water extraction is 2-3 time, adds water 6-12 doubly, each 1-2h, and merge extractive liquid, filters, and concentrates;
(7) with above-mentioned (4), (5), (6) in the step three kinds of concentrated solutions merge, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing, promptly.
Get Hericium erinaceus culture 250-400g Endoconcha Sepiae 150-220g Rhizoma Corydalis (system) the 80-150g Radix Paeoniae Alba (system) 80-150g Rhizoma Cyperi (system) 80-150g Radix Glycyrrhizae (system) 80-150g, make 1500 of capsules.
Described (1) gets a part of hedgehog hydnum culture water extraction 2-3 time in the step, adds water 8-10 doubly at every turn, each 2h, merge extractive liquid.
Described (4) get another part Radix Paeoniae Alba in the step, all liquorice beverage extracts 3 times, adds 8 times in water at every turn, each 1h, merge extractive liquid.
Described (5) get another part Rhizoma Corydalis, Rhizoma Cyperi with 60% ethanol extraction 3 times in the step, add 6 times of amount of alcohol, 1.5h at every turn, merge extractive liquid.
The Endoconcha Sepiae water extraction is 2-3 time in described (6) step, adds water 8-10 doubly, each 1-2h, merge extractive liquid.
Filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g in described (1) step.Described (4), (5), (6) are concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g in going on foot.
The preferable preparation technology of the present invention is: hedgehog hydnum culture water extraction 3 times, add 8 times in water at every turn, and each 2h, merge extractive liquid, filters, and filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g, mixes thoroughly with second half Hericium erinaceus culture coarse powder, oven dry, standby; Endoconcha Sepiae, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Cyperi beat powder respectively, cross 100 mesh sieves, adopt the sealed steam sterilization of normal pressure respectively, oven dry, and sealing, standby; Half Radix Paeoniae Alba of recipe quantity, the whole water extraction of Radix Glycyrrhizae 3 times add 8 times in water at every turn, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Half Rhizoma Corydalis of recipe quantity, Rhizoma Cyperi 60% ethanol extraction 3 times add 6 times of amount of alcohol, each 1.5h, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Endoconcha Sepiae water extraction 3 times adds 8 times in water, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Above-mentioned three kinds of concentrated solutions are merged, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing.Promptly.
Another preferable preparation technology of the present invention is: hedgehog hydnum culture water extraction 2 times, add 10 times in water at every turn, and each 2h, merge extractive liquid, filters, and filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g, mixes thoroughly with second half Hericium erinaceus culture coarse powder, oven dry, standby; Endoconcha Sepiae, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Cyperi beat powder respectively, cross 100 mesh sieves, adopt the sealed steam sterilization of normal pressure respectively, oven dry, and sealing, standby; Half Radix Paeoniae Alba of recipe quantity, the whole water extraction of Radix Glycyrrhizae 3 times add 8 times in water at every turn, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Half Rhizoma Corydalis of recipe quantity, Rhizoma Cyperi 60% ethanol extraction 3 times add 6 times of amount of alcohol, each 1.5h, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Endoconcha Sepiae water extraction 2 times adds 10 times in water, each 2h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Above-mentioned three kinds of concentrated solutions are merged, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing.Promptly.
The present invention has the characteristics of following uniqueness
1, hericium mycelium is adopted extracting section and the bonded unique technology of extract phase not, keep the endemic element of promycelium.
2, discarded high temperature and high pressure steam sterilizing methods commonly used, and use the sealed method for steam sterilization of normal pressure.The energy effective sterilizing can keep its curative effect again, keeps bioactive substance and the Effective Components of Chinese Herb (volatile oil) of Hericium erinaceus (Bull. Ex Fr.) Pers. effectively, and curative effect is attained a new height.
3, medicinal hericium mycelium utilization modern means of science and technology are carried out the second time and are cultivated under aseptic condition, promote its biological transformation ratio greatly, further strengthen drug effect.
4, the several kinds of Chinese medicinal materials of Hericium erinaceus (Bull. Ex Fr.) Pers. compatibility utilization modern science and technology method is concocted and is concentrated, and the effect of its antacid convergence, anti-inflammatory analgetic, liver-smoothing, qi-regulating is strengthened greatly.
By checking and facts have proved:
1, Hericium erinaceus culture has all reduced by 97% approximately through extracting the various effective ingredient in back, and each seed amino acid, protein, vitamin all reduce greatly, specifically see the following form:
1) amino acid content:
| The aminoacid title | Hericium erinaceus culture powder (mg/100mg) | Culture extracting solution (mg/100mg) |
| The ASP aspartic acid | 1.71 | 0.10 |
| The THR threonine | 0.87 | 0.02 |
| The SER serine | 1.11 | 0.03 |
| GLU glutamic acid | 2.64 | 0.12 |
| The GLY glycine | 1.12 | 0.02 |
| The ALA alanine | 1.23 | 0.04 |
| The CYS cystine | 0.48 | 0.00 |
| The VAL valine | 1.50 | 0.01 |
| The MET methionine | 0.30 | 0.01 |
| The ILE isoleucine | 0.80 | 0.01 |
| The LEU leucine | 1.19 | 0.02 |
| TYR tyrosine | 0.59 | 0.00 |
| The PHE phenylalanine | 1.12 | 0.01 |
| LYS lysine | 1.01 | 0.01 |
| NH3 ammonia | 0.68 | 0.01 |
| The HIS histidine | 0.51 | 0.00 |
| The ARG arginine | 0.92 | 0.02 |
| The PRO proline | 2.23 | 0.10 |
| Summation | 20.11 | 0.53 |
2) protein content: through protein content determination, analysis result is: the Hericium erinaceus culture powder: 22.0% Hericium erinaceus culture extracting solution: 0.58%
3) vitamin content: measure through vitamin content, analysis result is:
| The vitamin title | Hericium erinaceus culture powder (mg/100g) | Culture extracting solution (mg/100g) |
| VC (ascorbic acid) | 26.04 | Do not detect |
| VB1 (thiamine) | 3.52 | 1.28 |
| VB2 (riboflavin) | 2.85 | 0.58 |
| VB5 (Buddhist nun restrains propylhomoserin) | 49.27 | 17.65 |
| VB6 (pyridoxol) | 0.81 | 0.21 |
| VB3 (pantothenic acid) | 10.88 | 2.15 |
| VBc (folic acid) | 0.32 | 0.10 |
Can not all extract by above-mentioned testing data proof Hericium erinaceus culture, extract a half-dozen powder by half and fully keep effective ingredient, reach spissated purpose again.
2, adopt streaming steam method that the content of Radix Paeoniae Alba glycosides is reduced, facts have proved that peoniflorin can decompose under the temperature conditions of higher, content of paeoniflorin reduces, also influence simultaneously the active component in the Hericium erinaceus culture, volatile oil contents is reduced, volatile oil can regulating QI to relieve pain in the Rhizoma Cyperi, reduces the curative effect that volatile oil contents just influences product; And behind the sealed sterilizing methods of normal-pressure sterilization that adopts, fully keep active component and volatile oil in the Hericium erinaceus culture, and not influencing content of paeoniflorin, curative effect is more remarkable.
3, after Hericium erinaceus culture carries out second incubation under aseptic condition, active constituent contents such as aminoacid, protein, vitamin obviously improve, the Hericium erinaceus culture that adds second incubation again need not sterilized, and fully keeps the active component in the Hericium erinaceus culture, and curative effect is more remarkable.
4, concoct and concentrate by the modern science and technology method, dose is reduced, curative effect increases; By extracting, effective ingredient is easier to be absorbed by gastric mucosa, and pain relieving is fast, and the effect of antacid convergence, anti-inflammatory analgetic, liver-smoothing, qi-regulating is strengthened greatly.
Description of drawings
Fig. 1 is former HOUTOU JIANWEI LING process chart.
Fig. 2 is a process chart of the present invention.
The specific embodiment
Embodiment 1
Hedgehog hydnum culture water extraction 3 times adds 8 times in water at every turn, each 2h, and merge extractive liquid, filters, and filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g, mixes thoroughly with second half Hericium erinaceus culture coarse powder, oven dry, standby; Endoconcha Sepiae, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Cyperi beat powder respectively, cross 100 mesh sieves, adopt the sealed steam sterilization of normal pressure,, oven dry, sealing, standby; Half Radix Paeoniae Alba of recipe quantity, the whole water extraction of Radix Glycyrrhizae 3 times add 8 times in water at every turn, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Half Rhizoma Corydalis of recipe quantity, Rhizoma Cyperi 60% ethanol extraction 3 times add 6 times of amount of alcohol, each 1.5h, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Endoconcha Sepiae water extraction 3 times adds 8 times in water, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Above-mentioned three kinds of concentrated solutions are merged, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing.Promptly.
Embodiment 2
Hedgehog hydnum culture water extraction 2 times adds 10 times in water at every turn, each 2h, merge extractive liquid, filters, and filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g, mix thoroughly with second half Hericium erinaceus culture coarse powder, oven dry, standby: Endoconcha Sepiae, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Cyperi beat powder respectively, cross 100 mesh sieves, adopt the sealed steam sterilization of normal pressure,, oven dry, sealing, standby; Half Radix Paeoniae Alba of recipe quantity, the whole water extraction of Radix Glycyrrhizae 3 times add 8 times in water at every turn, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Half Rhizoma Corydalis of recipe quantity, Rhizoma Cyperi 60% ethanol extraction 3 times add 6 times of amount of alcohol, each 1.5h, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Endoconcha Sepiae water extraction 2 times adds 10 times in water, each 2h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Above-mentioned three kinds of concentrated solutions are merged, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing.Promptly.
Claims (4)
1. the preparation technology of concentrated type hedgehog hydnum stomachic, wherein crude drug is Hericium erinaceus culture 250-400 part Endoconcha Sepiae 150-220 part Rhizoma Corydalis (processed) 80-150 part system Radix Paeoniae Alba 80-150 part Rhizoma Cyperi (processed) 80-150 part system Radix Glycyrrhizae 80-150 part;
Hedgehog hydnum culture water extraction 3 times adds 8 times in water at every turn, each 2h, and merge extractive liquid, filters, and filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g, mixes thoroughly with second half Hericium erinaceus culture coarse powder, oven dry, standby; Endoconcha Sepiae, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Cyperi beat powder respectively, cross 100 mesh sieves, adopt the sealed steam sterilization of normal pressure respectively, oven dry, and sealing, standby; Half Radix Paeoniae Alba of recipe quantity, the whole water extraction of Radix Glycyrrhizae 3 times add 8 times in water at every turn, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Half Rhizoma Corydalis of recipe quantity, Rhizoma Cyperi 60% ethanol extraction 3 times add 6 times of amount of alcohol, each 1.5h, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Endoconcha Sepiae water extraction 3 times adds 8 times in water, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Above-mentioned three kinds of concentrated solutions are merged, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing.
2. the preparation technology of concentrated type hedgehog hydnum stomachic according to claim 1 gets Hericium erinaceus culture 250-400g Endoconcha Sepiae 150-220g Rhizoma Corydalis (processed) 80-150g system Radix Paeoniae Alba 80-150g Rhizoma Cyperi (processed) 80-150g system Radix Glycyrrhizae 80-150g, makes 1500 of capsules.
3. the preparation technology of concentrated type hedgehog hydnum stomachic, wherein crude drug is Hericium erinaceus culture 250-400 part Endoconcha Sepiae 150-220 part Rhizoma Corydalis (processed) 80-150 part system Radix Paeoniae Alba 80-150 part Rhizoma Cyperi (processed) 80-150 part system Radix Glycyrrhizae 80-150 part; Hedgehog hydnum culture water extraction 2 times adds 10 times in water at every turn, each 2h, and merge extractive liquid, filters, and filtrate is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1.3g, mixes thoroughly with second half Hericium erinaceus culture coarse powder, oven dry, standby; Endoconcha Sepiae, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Cyperi beat powder respectively, cross 100 mesh sieves, adopt the sealed steam sterilization of normal pressure respectively, oven dry, and sealing, standby; Half Radix Paeoniae Alba of recipe quantity, the whole water extraction of Radix Glycyrrhizae 3 times add 8 times in water at every turn, each 1h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Half Rhizoma Corydalis of recipe quantity, Rhizoma Cyperi 60% ethanol extraction 3 times add 6 times of amount of alcohol, each 1.5h, and merge extractive liquid, filters, and reclaims ethanol, is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Endoconcha Sepiae water extraction 2 times adds 10 times in water, each 2h, and merge extractive liquid, filters, and is concentrated into the crude drug that the 1g medicinal liquid is equivalent to 1g; Above-mentioned three kinds of concentrated solutions are merged, add in the 5 flavor powder of mixing, mix thoroughly, oven dry is pulverized, sealing.
4. the preparation technology of concentrated type hedgehog hydnum stomachic according to claim 2 gets Hericium erinaceus culture 250-400g Endoconcha Sepiae 150-220g Rhizoma Corydalis (processed) 80-150g system Radix Paeoniae Alba 80-150g Rhizoma Cyperi (processed) 80-150g system Radix Glycyrrhizae 80-150g, makes 1500 of capsules.
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